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Matti Narkia

Vitamin D receptor (VDR) gene polymorphisms and haplotypes, interactions with plasma 25... - 0 views

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    Vitamin D receptor (VDR) gene polymorphisms and haplotypes, interactions with plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, and prostate cancer risk.
    Mikhak B, Hunter DJ, Spiegelman D, Platz EA, Hollis BW, Giovannucci E.
    Prostate. 2007 Jun 15;67(9):911-23.
    PMID: 17440943
    DOI: 10.1002/pros.20570

    RESULTS
    No association was found between these SNPs or their associated haplotypes and all PC subtypes except that haplotype 2 (A-f-b) with Cdx2 A, Fok1 f, and Bsm1 b alleles and haplotype 3 (A-F-B) with Cdx2 A, Fok1 F and Bsm1 B alleles compared to the most common haplotype (A-F-b), were associated with reduced risk of aggressive PC (high stage or Gleason sum 7; P = 0.02), both with two alleles suspected of being low risk. Carriers of the variant Cdx2 A allele who were deficient in plasma 25-hydroxyvitamin D (15 ng/ml) compared to non-carriers with normal 25-hydroxyvitamin D, had a lower risk of total and poorly differentiated PCs (Gleason sum 7) (P for interaction = 0.02 and 0.04, respectively). Plasma 1,25-dihydroxyvitamin D deficiency (26 pg/ml) was associated with a threefold risk of poorly differentiated PC (P for interaction = 0.01) when comparing carriers of the Cdx2 A allele to non-carriers with normal 1,25-dihydroxyvitamin D.

    CONCLUSION
    In this population of men, none of the VDR polymorphisms studied was associated with susceptibility to PC.

    Carriers of the variant Cdx2 A allele with low plasma 25-hydroxyvitamin D may experience a reduction in risk of total and poorly differentiated prostate cancers compared to non-carriers with adequate 25-hydroxyvitamin D.
Matti Narkia

Benefit-risk assessment of vitamin D supplementation. - Osteoporos Int. 2009 Dec 3. - S... - 0 views

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    Benefit-risk assessment of vitamin D supplementation.
    Bischoff-Ferrari HA, Shao A, Dawson-Hughes B, Hathcock J, Giovannucci E, Willett WC.
    Osteoporos Int. 2009 Dec 3. [Epub ahead of print]
    PMID: 19957164

    Conclusion Our analysis suggests that mean serum 25(OH)D levels of about 75 to 110 nmol/l provide optimal benefits for all investigated endpoints without increasing health risks. These levels can be best obtained with oral doses in the range of 1,800 to 4,000 IU vitamin D per day; further work is needed, including subject and environment factors, to better define the doses that will achieve optimal blood levels in the large majority of the population.
Matti Narkia

GrassrootsHealth | Vitamin D Action - Vitamin D Scientists' Call to Action Statement - 0 views

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    "We are aware of substantial scientific evidence supporting the role of vitamin D in prevention of cancer. It has been reasonably established that adequate serum vitamin D metabolite levels are associated with substantially lower incidence rates of several types of cancer, including those of the breast, colon, and ovary, and other sites.

    We have concluded that the vitamin D status of most individuals in North America will need to be greatly improved for substantial reduction in incidence of cancer. Epidemiological studies have shown that higher vitamin D levels are also associated with lower risk of Type I diabetes in children and of multiple sclerosis. Several studies have found that markers of higher vitamin D levels are associated with lower incidence and severity of influenza and several other infectious diseases."
Matti Narkia

Vitamin D and prevention of breast cancer: pooled analysis. - ScienceDirect - The Journ... - 0 views

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    Vitamin D and prevention of breast cancer: pooled analysis.
    Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, Newmark H, Holick MF, Garland FC.
    J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):708-11.
    PMID: 17368188

    CONCLUSIONS: Intake of 2000 IU/day of Vitamin D(3), and, when possible, very moderate exposure to sunlight, could raise serum 25(OH)D to 52 ng/ml, a level associated with reduction by 50% in incidence of breast cancer, according to observational studies.
Matti Narkia

Prospective Study of Predictors of Vitamin D Status and Cancer Incidence and Mortality ... - 0 views

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    Prospective study of predictors of vitamin D status and cancer incidence and mortality in men.
    Giovannucci E, Liu Y, Rimm EB, Hollis BW, Fuchs CS, Stampfer MJ, Willett WC.
    J Natl Cancer Inst. 2006 Apr 5;98(7):451-9.
    PMID: 16595781
    doi:10.1093/jnci/djj101

    Conclusions: Low levels of vitamin D may be associated with increased cancer incidence and mortality in men, particularly for digestive-system cancers. The vitamin D supplementation necessary to achieve a 25(OH)D increment of 25 nmol/L may be at least 1500 IU/day.
Matti Narkia

Epidemic influenza and vitamin D. - Epidemiol Infect. 2006 Dec;134(6):1129-40. (full t... - 0 views

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    Epidemic influenza and vitamin D.
    Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, Garland CF, Giovannucci E.
    Epidemiol Infect. 2006 Dec;134(6):1129-40. Epub 2006 Sep 7. Review.
    PMID: 16959053
Matti Narkia

Cod liver oil, vitamin A toxicity, frequent respiratory infections, and the vitamin D d... - 0 views

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    Cod liver oil, vitamin A toxicity, frequent respiratory infections, and the vitamin D deficiency epidemic.
    Cannell JJ, Vieth R, Willett W, Zasloff M, Hathcock JN, White JH, Tanumihardjo SA, Larson-Meyer DE, Bischoff-Ferrari HA, Lamberg-Allardt CJ, Lappe JM, Norman AW, Zittermann A, Whiting SJ, Grant WB, Hollis BW, Giovannucci E.
    Ann Otol Rhinol Laryngol. 2008 Nov;117(11):864-70. Review.
    PMID: 19102134

    Until we have better information on doses of vitamin D that will reliably provide adequate blood levels of
    25(OH)D without toxicity, treatment of vitamin D deficiency in otherwise healthy children should be individualized
    according to the numerous factors that affect 25(OH)D levels, such as body weight, percent body fat,
    skin melanin, latitude, season of the year, and sun exposure.2 The doses of sunshine or oral vitamin D3 used
    in healthy children should be designed to maintain 25(OH)D levels above 50 ng/mL. As a rule, in the absence
    of significant sun exposure, we believe that most healthy children need about 1,000 IU of vitamin D3 daily
    per 11 kg (25 lb) of body weight to obtain levels greater than 50 ng/mL. Some will need more, and others less.
    In our opinion, children with chronic illnesses such as autism, diabetes, and/or frequent infections should be
    supplemented with higher doses of sunshine or vitamin D3, doses adequate to maintain their 25(OH)D levels
    in the mid-normal of the reference range (65 ng/mL) - and should be so supplemented year round. Otolaryngologists
    treating children are in a good position to both diagnose and treat vitamin D deficiency.
Matti Narkia

Vitamin D Is Associated with Improved Survival in Early-Stage Non-Small Cell Lung Cance... - 0 views

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    Vitamin D is associated with improved survival in early-stage non-small cell lung cancer patients.
    Zhou W, Suk R, Liu G, Park S, Neuberg DS, Wain JC, Lynch TJ, Giovannucci E, Christiani DC.
    Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2303-9.
    PMID: 16214909

    In conclusion, the joint effects of surgery season and recent vitamin D intake seem to be associated with the survival of early-stage non-small cell lung cancer patients.
Matti Narkia

Prospective study of predictors of vitamin D status and survival in patients with color... - 0 views

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    Prospective study of predictors of vitamin D status and survival in patients with colorectal cancer
    K Ng, B M Wolpin, J A Meyerhardt, K Wu, A T Chan, B W Hollis, E L Giovannucci, M J Stampfer, W C Willett and C S Fuchs
    Br J Cancer 101: 916-923; advance online publication, August 18, 2009; doi:10.1038/sj.bjc.6605262
Matti Narkia

Circulating 25-Hydroxyvitamin D Levels and Survival in Patients With Colorectal Cancer ... - 0 views

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    Circulating 25-hydroxyvitamin d levels and survival in patients with colorectal cancer.
    Ng K, Meyerhardt JA, Wu K, Feskanich D, Hollis BW, Giovannucci EL, Fuchs CS.
    J Clin Oncol. 2008 Jun 20;26(18):2984-91.
    PMID: 18565885
    DOI: 10.1200/JCO.2007.15.1027

    Conclusion Among patients with colorectal cancer, higher prediagnosis plasma 25(OH)D levels were associated with a significant improvement in overall survival. Further study of the vitamin D pathway and its influence on colorectal carcinogenesis and cancer progression is warranted.
Matti Narkia

JAMA -- Fracture Prevention With Vitamin D Supplementation: A Meta-analysis of Randomiz... - 0 views

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    Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials.
    Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B.
    JAMA. 2005 May 11;293(18):2257-64. Review.
    PMID: 15886381

    Conclusions Oral vitamin D supplementation between 700 to 800 IU/d appears to reduce the risk of hip and any nonvertebral fractures in ambulatory or institutionalized elderly persons. An oral vitamin D dose of 400 IU/d is not sufficient for fracture prevention.
Matti Narkia

25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men: A Prospective Study, June... - 0 views

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    25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study.
    Giovannucci E, Liu Y, Hollis BW, Rimm EB.
    Arch Intern Med. 2008 Jun 9;168(11):1174-80.
    PMID: 18541825

    Conclusion Low levels of 25(OH)D are associated with higher risk of myocardial infarction in a graded manner, even after controlling for factors known to be associated with coronary artery disease.
Matti Narkia

On the epidemiology of influenza - Virology Journal | Full text - 0 views

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    On the epidemiology of influenza.
    Cannell JJ, Zasloff M, Garland CF, Scragg R, Giovannucci E.
    Virol J. 2008 Feb 25;5:29. Review.
    PMID: 18298852
    doi:10.1186/1743-422X-5-29
Matti Narkia

A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of co... - 0 views

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    A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer.
    Wu K, Feskanich D, Fuchs CS, Willett WC, Hollis BW, Giovannucci EL.
    J Natl Cancer Inst. 2007 Jul 18;99(14):1120-9. Epub 2007 Jul 10.
    PMID: 17623801
Matti Narkia

Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health o... - 0 views

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    Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B.
    Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes.
    Am J Clin Nutr. 2006 Jul;84(1):18-28. Review.
    PMID: 16825677
Matti Narkia

Epidemic influenza and vitamin D - CJO - Abstract - 0 views

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    Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, Garland CF, Giovannucci E. Epidemic influenza and vitamin D.Epidemiol Infect. 2006 Dec;134(6):1129-40. Epub 2006 Sep 7.PMID: 16959053
    doi:10.1017/S0950268806007175
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