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Matti Narkia

Fish Oil-Derived Fatty Acids, Docosahexaenoic Acid and Docosapentaenoic Acid, and the R... - 0 views

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    Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events: the Kuopio ischaemic heart disease risk factor study.
    Rissanen T, Voutilainen S, Nyyssönen K, Lakka TA, Salonen JT.
    Circulation. 2000 Nov 28;102(22):2677-9.
    PMID: 11094031

    Methods and Results-We studied this association in the Kuopio Ischaemic Heart Disease Risk Factor Study, a prospective population study in Eastern Finland. Subjects were randomly selected and included 1871 men aged 42 to 60 years who had no clinical coronary heart disease at baseline examination. A total of 194 men had a fatal or nonfatal acute coronary event during follow-up. In a Cox proportional hazards' model adjusting for other risk factors, men in the highest fifth of the proportion of serum DHA+DPA in all fatty acids had a 44% reduced risk (P=0.014) of acute coronary events compared with men in the lowest fifth. Men in the highest fifth of DHA+DPA who had a low hair content of mercury (<=2.0 µg />2.0 µg/g). There was no association between proportion of eicosapentaenoic acid and the risk of acute coronary events.

    Conclusions-Our data provide further confirmation for the concept that fish oil-derived fatty acids reduce the risk of acute coronary events. However, a high mercury content in fish could attenuate this protective effect.
Matti Narkia

Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized tr... - 0 views

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    Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis.
    Salonen JT, Nyyssönen K, Salonen R, Lakka HM, Kaikkonen J, Porkkala-Sarataho E, Voutilainen S, Lakka TA, Rissanen T, Leskinen L, Tuomainen TP, Valkonen VP, Ristonmaa U, Poulsen HE.
    J Intern Med. 2000 Nov;248(5):377-86.
    PMID: 11123502
    DOI: 10.1046/j.1365-2796.2000.00752.x

    Conclusions. Our study shows that a combined supplementation with reasonable doses of both vitamin E and slow-release vitamin C can retard the progression of common carotid atherosclerosis in men. This may imply benefits with regard to other atherosclerosis-based events.
Matti Narkia

Berberine - Altern Med Rev. 2000 Apr;5(2):175-7. - 0 views

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    Berberine.
    [No authors listed]
    Altern Med Rev. 2000 Apr;5(2):175-7.
    PMID: 10767672

    Berberine is a plant alkaloid with a long history of medicinal use in both Ayurvedic and Chinese medicine. It is present in Hydrastis canadensis (goldenseal), Coptis chinensis (Coptis or goldenthread), Berberis aquifolium (Oregon grape), Berberis vulgaris (barberry), and Berberis aristata (tree turmeric). The berberine alkaloid can be found in the roots, rhizomes, and stem bark of the plants. Berberine extracts and decoctions have demonstrated significant antimicrobial activity against a variety of organisms including bacteria, viruses, fungi, protozoans, helminths, and chlamydia. Currently, the predominant clinical uses of berberine include bacterial diarrhea, intestinal parasite infections, and ocular trachoma infection
Matti Narkia

Tofu and Cognitive Function: Food for Thought -- Grodstein et al. 19 (2): 207 -- Journa... - 0 views

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    Tofu and cognitive function: food for thought.
    Grodstein F, Mayeux R, Stampfer MJ.
    J Am Coll Nutr. 2000 Apr;19(2):207-9. Review.
    PMID: 10763901

    In addition, a plausible biologic hypothesis is generally an important part of judging epidemiologic relations. While high tofu intake may lead to lower plasma estrogen levels [12], we do not know how tofu influences estrogen levels in the brain; we also know very little about estrogen effects in men. Furthermore, data have not even consistently indicated that low endogenous estrogen levels are directly related to cognitive function in non-demented subjects [13]. The authors also posit a non-estrogen mediated hypothesis for the effects of tofu, namely that soy inhibits hippocampal tyrosine kinase and may block long-term potentiation (the likely mechanism by which humans learn and remember). Still, considerably more work must be done to substantiate this hypothesis.

    Finally, the single measures of outcome used in this study may have limited value, as cognitive function and brain structure change over time. Factors which predict these measures at one point may or may not be the same as those which predict decline over time; fundamentally, the public health interest is in preventing cognitive decline, as the steepness of the decline trajectory likely provides an early marker for risk of the more clinically relevant result-dementia.
Matti Narkia

Decreased bioavailability of vitamin D in obesity -- Wortsman et al. 72 (3): 690 -- Ame... - 0 views

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    Decreased bioavailability of vitamin D in obesity.
    Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF.
    Am J Clin Nutr. 2000 Sep;72(3):690-3. Erratum in: Am J Clin Nutr. 2003 May;77(5):1342.
    PMID: 10966885

    Conclusions: Obesity-associated vitamin D insufficiency is likely due to the decreased bioavailability of vitamin D3 from cutaneous and dietary sources because of its deposition in body fat compartments.
Matti Narkia

Nutritional Contribution of Eggs to American Diets -- Song and Kerver 19 (Supplement 5)... - 0 views

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    Nutritional contribution of eggs to American diets.
    Song WO, Kerver JM.
    J Am Coll Nutr. 2000 Oct;19(5 Suppl):556S-562S.
    PMID: 11023007

    Conclusions: In this cross-sectional and population-based study, egg consumption made important nutritional contributions to the American diet and was not associated with high serum cholesterol concentrations.
Matti Narkia

Introduction: Nutritional and Functional Roles of Eggs in the Diet -- Applegate 19 (Sup... - 0 views

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    Introduction: nutritional and functional roles of eggs in the diet.
    Applegate E.
    J Am Coll Nutr. 2000 Oct;19(5 Suppl):495S-498S. Review.
    PMID: 11022998

    For years, eggs have been held up as a powerhouse of nutrition. This reputation has been due to eggs' exceptional nutrition profile as a nutrient-dense food containing high quality protein and a substantial amount of many essential vitamins and minerals. Unfortunately their position on the nutrition pedestal fell with the discovery that they are also a source of dietary cholesterol. The most recent scientific research not only returns eggs to their golden past, but elevates their position as a functional food and ultimately provides more reasons than ever to consume eggs.

    In February 2000, scientists convened at a conference in Amelia Island, Florida, to discuss the latest research about the role of eggs in disease prevention and the promotion of health. This supplement of the Journal of the American College of Nutrition (JACN) presents compelling scientific evidence about eggs' functional food attributes, reaffirms that eggs have a minimal effect on blood cholesterol levels and presents new research on the contribution of eggs to the American diet. For health professionals, this issue provides a new scientifically based viewpoint on eggs and their role in health and nutrition, a viewpoint that should be imparted to all consumers in an effort to ensure optimal health and well-being.
Matti Narkia

Vitamin D receptor gene polymorphisms influence susceptibility to type 1 diabetes melli... - 0 views

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    Vitamin D receptor gene polymorphisms influence susceptibility to type 1 diabetes mellitus in the Taiwanese population.
    Chang TJ, Lei HH, Yeh JI, Chiu KC, Lee KC, Chen MC, Tai TY, Chuang LM.
    Clin Endocrinol (Oxf). 2000 May;52(5):575-80.
    PMID: 10792336
    DOI: 10.1046/j.1365-2265.2000.00985.x

    CONCLUSIONS

    Vitamin D receptor gene polymorphisms were associated with type 1 diabetes in a Taiwanese population. However, functional studies are needed to establish the role of the vitamin D receptor in the pathogenesis of type 1 diabetes mellitus.
Matti Narkia

Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunte... - 0 views

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    Plant-animal subsistence ratios and macronutrient energy estimations in worldwide hunter-gatherer diets.
    Cordain L, Miller JB, Eaton SB, Mann N, Holt SH, Speth JD.
    Am J Clin Nutr. 2000 Mar;71(3):682-92.
    PMID: 10702160

    Our analysis showed that whenever and wherever it was ecologically possible, hunter-gatherers consumed high amounts (45-65% of energy) of animal food. Most (73%) of the worldwide hunter-gatherer societies derived >50% (> or =56-65% of energy) of their subsistence from animal foods, whereas only 14% of these societies derived >50% (> or =56-65% of energy) of their subsistence from gathered plant foods. This high reliance on animal-based foods coupled with the relatively low carbohydrate content of wild plant foods produces universally characteristic macronutrient consumption ratios in which protein is elevated (19-35% of energy) at the expense of carbohydrates (22-40% of energy).
Matti Narkia

Vitamin D: a natural inhibitor of multiple sclerosis - 0 views

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    Vitamin D: a natural inhibitor of multiple sclerosis.
    Hayes CE.
    Proc Nutr Soc. 2000 Nov;59(4):531-5. Review.
    PMID: 11115787
Matti Narkia

Stress fractures in the Israeli defense forces fro...[Clin Orthop Relat Res. 2000] - Pu... - 0 views

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    Stress fractures in the Israeli defense forces from 1995 to 1996.
    Givon U, Friedman E, Reiner A, Vered I, Finestone A, Shemer J.
    Clin Orthop Relat Res. 2000 Apr;(373):227-32.
    PMID: 10810481

    Serum levels of bone specific alkaline phosphatase and osteocalcin were elevated in patients with high grade stress fractures compared with control subjects with no symptoms: 37.6 versus 26.2 units/L, and 10.8 versus 8.8 ng/mL, respectively. Levels of 25-hydroxy vitamin D were lower in patients with high grade stress fractures (25.3 ng/mL) than in control subjects (29.8 ng/mL). This study revealed that several parameters can distinguish soldiers with high grade stress fractures, but their predictive value and precise pathogenetic role remain unclear.
Matti Narkia

Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland). - Ca... - 0 views

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    Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland).
    Ahonen MH, Tenkanen L, Teppo L, Hakama M, Tuohimaa P.
    Cancer Causes Control. 2000 Oct;11(9):847-52.
    PMID: 11075874
    DOI: 10.1023/A:1008923802001

    CONCLUSIONS: We conclude that low levels of 25-VD associated with an increased risk for subsequent earlier exposure and more aggressive development of prostate cancer, especially before the andropause.
Matti Narkia

Improved Cholecalciferol Nutrition in Rats Is Noncalcemic, Suppresses Parathyroid Hormo... - 0 views

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    Improved cholecalciferol nutrition in rats is noncalcemic, suppresses parathyroid hormone and increases responsiveness to 1, 25-dihydroxycholecalciferol.
    Vieth R, Milojevic S, Peltekova V.
    J Nutr. 2000 Mar;130(3):578-84.
    PMID: 10702588

    We conclude suppression of 1,25(OH)(2)D and PTH, and higher renal VDR mRNA and 24-hydroxylase did not involve higher free 1,25(OH)(2)D concentration or a first pass effect at the gut. Thus, 25(OH)D or a metabolite other than 1,25(OH)(2)D is a physiological, transcriptionally and biochemically active, noncalcemic vitamin D metabolite.

    When viewed from a perspective that starts with higher vitamin D nutrition, the results indicate that low vitamin D nutrition may bring about a form of resistance to 1,25(OH)2D. This situation would explain why, in humans, nutritional rickets and osteomalacia are commonly associated with normal or increased levels of 1,25(OH)2D (Chesney et al. 1981Citation , Eastwood et al. 1979Citation , Garabedian et al. 1983Citation ,Rasmussen et al. 1980Citation )-these are not like the low hormone levels associated with any other endocrine-deficiency disorder. A connection between lower vitamin D nutrition and vitamin D resistance helps to explain why the supposedly inactive compound 25(OH)D is more relevant in diagnosing nutritional rickets than is the active hormone 1,25(OH)2D.

    If the features of improved vitamin D nutrition shown here were demonstrated for any newly synthesized compound, the compound would be classified as a noncalcemic 1,25(OH)2D analogue (Brown et al. 1989Citation , Finch et al. 1999Citation , Goff et al. 1993Citation , Koshizuka et al. 1999Citation ). Thus, we contend that 25(OH)D or a metabolite of it other than 1,25(OH)2D exists as a physiological and biologically-active noncalcemic vitamin D metabolite whose effects require further examination, particularly in relationship to studies involving the synthetic analogs of 1,25(OH)2D.
Matti Narkia

Dietary influences on bone mass and bone metabolism: further evidence of a positive lin... - 0 views

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    Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health?
    New SA, Robins SP, Campbell MK, Martin JC, Garton MJ, Bolton-Smith C, Grubb DA, Lee SJ, Reid DM.
    Am J Clin Nutr. 2000 Jan;71(1):142-51.
    PMID: 10617959

    Conclusion: The BMD results confirm our previous work (but at peripheral bone mass sites), and our findings associating bone resorption with dietary factors provide further evidence of a positive link between fruit and vegetable consumption and bone health.
Matti Narkia

Vitamin D in an ecological context. [Int J Circumpolar Health. 2000] - PubMed Result - 0 views

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    Vitamin D in an ecological context.
    Björn LO, Wang T.
    Int J Circumpolar Health. 2000 Jan;59(1):26-32.
    PMID: 10850004
Matti Narkia

Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure i... - 0 views

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    Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited.
    Glerup H, Mikkelsen K, Poulsen L, Hass E, Overbeck S, Thomsen J, Charles P, Eriksen EF.
    J Intern Med. 2000 Feb;247(2):260-8.
    PMID: 10692090

    Conclusions. Severe vitamin D deficiency is prevalent amongst sunlight-deprived individuals living in Denmark. In veiled Arab women, vitamin D deficiency is the result of a combination of limitations in sunlight exposure and a low oral intake of vitamin D. The oral intake of vitamin D amongst veiled ethnic Danish Moslems was, however, very high, at 13.53 µg (approximately 600 IU), but they were still vitamin D-deficient. Our results suggest that the daily oral intake of vitamin D in sunlight-deprived individuals should exceed 600 IU; most probably it should be 1000 IU day-1 to secure a normal level of 25-hydroxyvitamin D. This finding is in contrast with the commonly used RDA (recommended daily allowance) for adults in Europe: 200 IU day-1.
Matti Narkia

Vitamin D receptor gene polymorphism: association with Crohn's disease susceptibility -... - 0 views

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    Vitamin D receptor gene polymorphism: association with Crohn's disease susceptibility.
    Simmons JD, Mullighan C, Welsh KI, Jewell DP.
    Gut. 2000 Aug;47(2):211-4.
    PMID: 10896912
    doi:10.1136/gut.47.2.211
Matti Narkia

Selenium and immunocompetence in patients with head and neck cancer. - Biol Trace Elem ... - 0 views

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    Selenium and immunocompetence in patients with head and neck cancer.
    Kiremidjian-Schumacher L, Roy M, Glickman R, Schneider K, Rothstein S, Cooper J, Hochster H, Kim M, Newman R.
    Biol Trace Elem Res. 2000 Feb;73(2):97-111.
    PMID: 11049203
    DOI: 10.1385/BTER:73:2:97
Matti Narkia

Effect of stable fish oil on arterial thrombogenesis, platelet aggregation, and superox... - 0 views

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    Effect of stable fish oil on arterial thrombogenesis, platelet aggregation, and superoxide dismutase activity.
    Chen LY, Jokela R, Li DY, Bavry AA, Sandler H, Sjöquist M, Saldeen T, Mehta JL.
    J Cardiovasc Pharmacol. 2000 Mar;35(3):502-5. Erratum in: J Cardiovasc Pharmacol 2000 May;35(5):829. Bowry A [corrected to Bavry AA].
    PMID: 10710138
Matti Narkia

Egg consumption and coronary heart disease: an epidemiologic overview. - J Am Coll Nutr... - 0 views

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    Egg consumption and coronary heart disease: an epidemiologic overview.
    Kritchevsky SB, Kritchevsky D.
    J Am Coll Nutr. 2000 Oct;19(5 Suppl):549S-555S. Review.
    PMID: 11023006

    When dietary confounders were considered, no association was seen between egg consumption at levels up to 1 + egg per day and the risk of coronary heart disease in non-diabetic men and women.
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