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Matti Narkia

The Heart Scan Blog: Small LDL: Perfect index of carbohydrate intake - 0 views

    "Measuring the number of small LDL particles is the best index of carbohydrate intake I know of, better than even blood sugar and triglycerides.

    In other words, increase carbohydrate intake and small LDL particles increase. Decrease carbohydrates and small LDL particles decrease.


    Carbohydrates increase small LDL via a multistep process:

    First step: Increased fatty acid and apoprotein B production in the liver, which leads to increased VLDL production. (Apoprotein B is the principal protein of VLDL and LDL)

    Second step: Greater VLDL availability causes triglyceride-rich VLDL to interact with other particles, namely LDL and HDL, enriching them in triglycerides (via the action of cholesteryl-ester transfer protein, or CETP). Much VLDL is converted to LDL.

    Third step: Triglyceride-rich LDL is "remodeled" by enzymes like hepatic lipase, which create small LDL"
Matti Narkia

Ketogenic diets and physical performance - Nutrition & Metabolism | Full text - 0 views

    Ketogenic diets and physical performance.
    Phinney SD.
    Nutr Metab (Lond). 2004 Aug 17;1(1):2.
    PMID: 15507148

    Impaired physical performance is a common but not obligate result of a low carbohydrate diet. Lessons from traditional Inuit culture indicate that time for adaptation, optimized sodium and potassium nutriture, and constraint of protein to 15-25 % of daily energy expenditure allow unimpaired endurance performance despite nutritional ketosis.

    Both observational and prospectively designed studies support the conclusion that submaximal endurance performance can be sustained despite the virtual exclusion of carbohydrate from the human diet. Clearly this result does not automatically follow the casual implementation of dietary carbohydrate restriction, however, as careful attention to time for keto-adaptation, mineral nutriture, and constraint of the daily protein dose is required. Contradictory results in the scientific literature can be explained by the lack of attention to these lessons learned (and for the most part now forgotten) by the cultures that traditionally lived by hunting. Therapeutic use of ketogenic diets should not require constraint of most forms of physical labor or recreational activity, with the one caveat that anaerobic (ie, weight lifting or sprint) performance is limited by the low muscle glycogen levels induced by a ketogenic diet, and this would strongly discourage its use under most conditions of competitive athletics.
Matti Narkia

NephroPal: Summer vs Winter mode - 0 views

    "My goal is to gather the basic science and apply it to nutrition - NUTRIGENOMICS. What do I mean? How does what we eat signal our genes in the nucleus. By our food choices, we are sending different signals to our genes. High carbohydrate and high fructose intake signals it is summer time and winter is coming -- grow and store the energy (insulin). High fat, low carbohydrate diet with calorie restriction signals our genes that winter is here -- use the stored energy, repair the genes, and slow down growth (i.e. Sirt1/Foxo pathway). The Sirt1/FoxO1 pathway is important as it aids in repairing DNA. Damaged DNA can lead to uncontrolled cellular replication (i.e. cancers). The immune system (phagocytes) has a mechanism to remove old and unwanted cells called apoptosis (cellular death). "
Matti Narkia

Animal Pharm: Palmitic Acid+ CARBS = Mouse Skeletal Muscle IR - 0 views

    "Peter at Hyperlipid and Stephan at Whole Health have dispelled yet again myths regarding the indictment of the 16:0 long-chained saturated fatty acid Palmitic Acid as the prime instigator of insulin resistance (IR). Researchers are always wrong -- it's... HIGH CARBS PLUS Palmitic acid.

    Their brilliant posts discuss below:
    --Sportzaid (FRUCTOSE) + Palmitate = IR RETARDNESS
    --High Carb Lab Chow + Palmitate = IR in the brain

    Yes. Such inferences applied to low carbers (LCers) is pure ridiculousness. Non-applicable.

    Low/no carb + Palmitic Acid = GOOD THING. All the low-carb/high saturated fat (palmitic acid) and ketosis trials by Hays JH, Volek JS, and Krauss RM have shown reductions in blood insulin, blood glucoses (BG) and peripheral tissue insulin resistance (IR). Directly contrary to the high carb animal or human studies.

    Palmitic acid has a special evolutionary, adaptive role in mammalian metabolism. Stephan showed that it likely 'fills in' when blood glucose starts to decline. "
Matti Narkia

How High Carbohydrate Foods Can Raise Risk For Heart Problems - 0 views

    ScienceDaily (June 27, 2009) - Doctors have known for decades that too much carbohydrate-laden foods like white bread and corn flakes can be detrimental to cardiac health. In a landmark study, new research from Tel Aviv University now shows exactly how these high carb foods increase the risk for heart problems.
Matti Narkia

Carbohydrate restriction may slow prostate tumor growth - - 0 views

    DURHAM, N.C. -- Restricting carbohydrates, regardless of weight loss, appears to slow the growth of prostate tumors, according to an animal study being published this week by researchers in the Duke Prostate Center.

    "Previous work here and elsewhere has shown that a diet light in carbohydrates could slow tumor growth, but the animals in those studies also lost weight, and because we know that weight loss can restrict the amount of energy feeding tumors, we weren't able to tell just how big an impact the pure carbohydrate restriction was having, until now," said Stephen Freedland, M.D., a urologist in the Duke Prostate Center and lead investigator on this study.

    The researchers believe that insulin and insulin-like growth factor contribute to the growth and proliferation of prostate cancer, and that a diet devoid of carbohydrates lowers serum insulin levels in the bodies of the mice, thereby slowing tumor growth, Freedland said.
Matti Narkia

Nutritional Situation of the Elderly in the European Union: Data of the European Nutrit... - 0 views

    Nutritional Situation of the Elderly in the European Union: Data of the European Nutrition and Health Report (2004)
    Elisabeth Fabian, Ibrahim Elmadfa
    Ann Nutr Metab 2008;52 (Suppl. 1):57-61 (DOI: 10.1159/000115352)
Matti Narkia

Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 ... - 0 views

    Conclusion: The associations suggest that replacing SFAs with PUFAs rather than MUFAs or carbohydrates prevents CHD over a wide range of intakes.

    Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies.
    Jakobsen MU, O'Reilly EJ, Heitmann BL, Pereira MA, Bälter K, Fraser GE, Goldbourt U, Hallmans G, Knekt P, Liu S, Pietinen P, Spiegelman D, Stevens J, Virtamo J, Willett WC, Ascherio A.
    Am J Clin Nutr. 2009 May;89(5):1425-32. Epub 2009 Feb 11.
    PMID: 19211817
Matti Narkia

Carbohydrate - Wikipedia, the free encyclopedia - 0 views

    Carbohydrates or saccharides (Greek sakcharon meaning "sugar") are simple molecules that are straight-chain aldehydes or ketones with many hydroxyl groups added, usually one on each carbon atom that is not part of the aldehyde or ketone functional group.
Matti Narkia

Protein Power - 0 views

    The Official Web Site of Drs. Michael and Mary Dan Eades.
    Advocacy fo low carbohydrate diets.
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