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Matti Narkia

Niacin best for raising good cholesterol | ZDNet Healthcare | ZDNet.com - 0 views

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    "Want more of that good HDL cholesterol?

    Try a timed-release niacin, and be skeptical if your doctor gives the sales pitch for Zetia or Vytorin.

    The authority for this is a study dubbed ARBITER-6, which was stopped suddenly this summer, with the study's authors insisting safety had nothing to do with it.

    It was a question of efficacy.

    The results, described in the New England Journal of Medicine, make clear that niacin does better at the main job, keeping arteries open"
Matti Narkia

The Effect of Select Nutrients on Serum High-Density Lipoprotein Cholesterol and Apolip... - 0 views

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    The effect of select nutrients on serum high-density lipoprotein cholesterol and apolipoprotein A-I levels.
    Mooradian AD, Haas MJ, Wong NC.
    Endocr Rev. 2006 Feb;27(1):2-16. Epub 2005 Oct 21. Review.
    PMID: 16243964

    One of the factors contributing to the increased risk of developing premature atherosclerosis is low plasma concentrations of high-density lipoprotein (HDL) cholesterol (HDLc). Multiple potential mechanisms account for the cardioprotective effects of HDL and its main protein apolipoprotein A-I (apo A-I). The low plasma concentrations of HDL could be the result of increased fractional clearance and reduced expression of apo A-I. To this end, nutrients play an important role in modulating the fractional clearance rate, as well as the rate of apo A-I gene expression. Because medical nutrition therapy constitutes the cornerstone of management of dyslipidemias, it is essential to understand the mechanisms underlying the changes in HDL level in response to alterations in dietary intake. In this review, we will discuss the effect of select nutrients on serum HDLc and apo A-I levels. Specifically, we will review the literature on the effect of carbohydrates, fatty acids, and ketones, as well as some of the nutrient-related metabolites, such as glucosamine and the prostanoids, on apo A-I gene expression. Because there are multiple mechanisms involved in the regulation of serum HDLc levels, changes in gene transcription do not necessarily correlate with clinical observations on serum levels of HDLc.
Matti Narkia

Dietary cholesterol from eggs increases plasma HDL cholesterol in overweight men consum... - 0 views

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    Dietary cholesterol from eggs increases plasma HDL cholesterol in overweight men consuming a carbohydrate-restricted diet.
    Mutungi G, Ratliff J, Puglisi M, Torres-Gonzalez M, Vaishnav U, Leite JO, Quann E, Volek JS, Fernandez ML.
    J Nutr. 2008 Feb;138(2):272-6.
    PMID: 18203890

    Carbohydrate-restricted diets (CRD) significantly decrease body weight and independently improve plasma triglycerides (TG) and HDL cholesterol (HDL-C) .

    [..]

    Eighteen subjects were classified as having the metabolic syndrome (MetS) at the beginning of the study, whereas 3 subjects had that classification at the end. These results suggest that including eggs in a CRD results in increased HDL-C while decreasing the risk factors associated with MetS.
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