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Vitamin D in preventive medicine: are we ignoring the evidence? Zittermann A. Br J Nutr. 2003 May;89(5):552-72. Review. PMID: 12720576 Vitamin D is metabolised by a hepatic 25-hydroxylase into 25-hydroxyvitamin D (25(OH)D) and by a renal 1alpha-hydroxylase into the vitamin D hormone calcitriol. Calcitriol receptors are present in more than thirty different tissues. Apart from the kidney, several tissues also possess the enzyme 1alpha-hydroxylase, which is able to use circulating 25(OH)D as a substrate. Serum levels of 25(OH)D are the best indicator to assess vitamin D deficiency, insufficiency, hypovitaminosis, adequacy, and toxicity. European children and young adults often have circulating 25(OH)D levels in the insufficiency range during wintertime. Elderly subjects have mean 25(OH)D levels in the insufficiency range throughout the year. In institutionalized subjects 25(OH)D levels are often in the deficiency range. There is now general agreement that a low vitamin D status is involved in the pathogenesis of osteoporosis. Moreover, vitamin D insufficiency can lead to a disturbed muscle function. Epidemiological data also indicate a low vitamin D status in tuberculosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, hypertension, and specific types of cancer. Some intervention trials have demonstrated that supplementation with vitamin D or its metabolites is able: (i) to reduce blood pressure in hypertensive patients; (ii) to improve blood glucose levels in diabetics; (iii) to improve symptoms of rheumatoid arthritis and multiple sclerosis. The oral dose necessary to achieve adequate serum 25(OH)D levels is probably much higher than the current recommendations of 5-15 microg/d.

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Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions. Pereira GC, Branco AF, Matos JA, Pereira SL, Parke D, Perkins EL, Serafim TL, Sardão VA, Santos MS, Moreno AJ, Holy J, Oliveira PJ. J Pharmacol Exp Ther. 2007 Nov;323(2):636-49. Epub 2007 Aug 17. PMID: 17704354 doi: 10.1124/jpet.107.128017 The present work shows that berberine is accumulated by mitochondria of a mouse melanoma cell line, leading to mitochondrial fragmentation and dysfunction, accompanied by decreased cellular energy charge. When the effect was compared with the results obtained on isolated mitochondrial fractions, it is observed that regardless of the system used, berberine is toxic for mitochondria. One major limitation of the present study (as in many others) is the lack of knowledge of the real concentration of berberine that reaches mitochondria in intact cells. Although we do not possess data regarding this aspect, it is wise to speculate that mitochondrial berberine concentrations will be much higher than in the bulk cytosol due to electrophoretic accumulation. We believe that the range of berberine concentrations accumulated by mitochondria in intact cells is within the range of concentrations used on isolated mitochondrial fractions in the present study. The present work not only provides insights on the mechanism by which berberine interferes with tumor cell proliferation, demonstrating previously unknown effects on mitochondrial physiology, but also raises a note of caution on the use of berberine as a nontoxic "natural" over-the-counter medication.

Fruit Juice Leading Exporter and Distributor from Indore and Bhopal, Our products are available in a wide range of flavours and pack sizes, such as Mango Juice, Litchi Juice, Nimbu Juice, Sqeeze Mango Juice, PET Bottle Mango Juice, PET Bottle Nimbu Juice (Lemon Drink), PET Bottles Litchi Juice and many more items. All our products are made with real fruit juice or pulp. Mango Pulp used for making the drinks is made from choicest mangoes brought from South India which is the World's largest producer of Mangoes. Our assortment of juicy mango and other drinks offer essential minerals, antioxidants, fiber and vitamin A and C, and is an excellent way of repletion of lost potassium. With the help of professionals, we are capable in offering a wide range of Fruit Juice. Our offered product is processed under hygienic and pure conditions. Regular consumption of our product helps to improve energy level. Apart from this, our product is processed under the guidance of our skilled professionals keeping in mind set industry norms. We have several flavors of juice, which includes mango, litchi, Nimbu etc. Apart from this, clients can avail this product from us at a reasonable price. Features: Freshness Mouth watering taste Rich in minerals Mango Juice We are involved in the distribution, import and export of high-quality Mango Juice and Mango Drinks to our clients. Made using the best quality Mangoes, this juice is rich in nutritional content and contains no preservatives or added flavors. It is completely natural. This product is in compliance with the latest food hygiene and safety norms and is tested for its quality by certified professionals. The juice is packaged efficiently by us to retain the nutritional contents and is delivered in a timely manner through various shipment and transport modes. Features: Timely delivery and export Made from best quality Mangoes Rich nutrient content 100% natural Preservative-free Litchi Juice We distri

Known as leading protein powder manufacturer in Ahmedabad, Gujarat, we offer wide range of protein powder and protein supplements to clients at best price. Aster Lifescience is pleased to provide you with a wide range of protein powder manufacturing alternatives.

Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. Heaney RP, Dowell MS, Hale CA, Bendich A. J Am Coll Nutr. 2003 Apr;22(2):142-6. PMID: 12672710

Summer is one of the only times when one can enjoy the true ecstasy of fresh mango juice. Usually bottled mango juices and drinks have a kind of uniform taste and flavor. But you can make fresh mango juice at home with different types of mangoes, and enjoy different flavors in mango juice. Juice made from fresh mangoes has very refreshing taste. You can decrease or increase the quantity of water in the recipe. It depends on how intense or less mango flavor you want in your juice. I would not recommend making juice thin like maaza or slice. Because store bought beverage has artificial flavor. While we are using fresh mangoes without any artificial flavors. So to make intense mango flavored juice, keep it little thick (not thick like milkshake or smoothie). I wanted only mango flavor in the juice, so I have not added any other flavoring ingredient. Ingredients for artificial Mango Juice: Nutrition Facts of Mango Juice per 100 ml Energy: 58 Kcal Fat: NIL Carbohydrate: 14.6 g Vitamin C: 10.34 mg Sugar: 14.5 g Iron: 0.3 mg Protein: 0.11 g Sodium: 15mg Mango Juice Recipe 500ml water 1 cup sugar (P32.50 per kilo) 1/4 teaspoon xanthan gum (P60 per 60 grams) 1/8 teaspoon sodium benzoate (P16 per 100 grams) 1/2 teaspoon citric acid (P66 per kilo) 1/8 teaspoon flavoring Mango juice Product Range We are an eminent manufacturer, supplier and exporter of an array of quality Juices. The juices we are offer are processed from fresh fruits in a clean and hygienic environment. These products are made available in various packs of different quantities for meet the requirements of our clients hence making them completely satisfied. In order to retain the natural taste and rich aroma of the juices, these are packed in moisture proof packs. Our product line goes as below: Mango Juice ( 125 ml ) Mango Juice ( 180 ml ) Nimbu (Lemon) Juice ( 200 ml ) Mango Juice ( 250 ml ) Mango Juice ( 500 ml ) Mango Juice ( 1.Lt. )

The curing properties of oranges have been linked with a wide range of health benefits, risks and nutrition facts. The juicy citrus fruits that are in season throughout the winter are loaded with vitamin C and the pigment beta-cryptoxanthin.

The curing properties of oranges have been linked with a wide range of health benefits, risks and nutrition facts. The juicy citrus fruits that are in season throughout the winter are loaded with vitamin C and the pigment beta-cryptoxanthin.

We deal in our best for Indian and Chinese cuisines. Delicious Pizzas, with large number of Indian and Chinese range of options. http://bit.ly/1qrdRyH

We deal in our best for Indian and Chinese cuisines. Delicious Pizzas, with large number of Indian and Chinese range of options. http://bit.ly/1qrdRyH

All our products are made with real fruit juice or pulp. Mango Pulp used for making the drinks is made from choicest mangoes brought from South India which is the World's largest producer of Mangoes. Our assortment of juicy mango and other drinks offer essential minerals, antioxidants, fiber and vitamin A and C, and is an excellent way of repletion of lost potassium. Our products are available in a wide range of flavors and pack sizes. PET Bottles: Mango Fruit Drink Mango Dash in PET Bottles 125 ml Mango Dash in PET Bottles 180 ml Mango Dash in PET Bottles 200 ml Mango Dash in PET Bottles 250 ml Mango Dash in PET Bottles 500 ml Mango Dash in PET Bottles 1 liter Nutrition Facts of Mango Dash per 100 ml Mango DashEnergy: 58 Kcal Fat: NIL Carbohydrate: 14.6 g Vitamin C: 10.34 mg Sugar: 14.5 g Iron: 0.3 mg Protein: 0.11 g Sodium: 15mg PET Bottles: Nimbu Dash (Lemon Drink) Nimbu Dash in PET Bottles 200 ml Nutrition Facts of Nimbu Dash per 100 ml Nimbu DashEnergy: 46 Kcal Protein: 0 g Carbohydrate: 11.5 g Fat: 0 g Sugar: 11.2 g V-Pak: Mango Dash India Juice Mango Dash V-Pak 100 ml Mango Dash V-Pak 180 ml Nutrition Facts of Mango Dash V-Pak per 100 ml Mango Dash V-PakEnergy: 58 Kcal Fat: NIL Carbohydrate: 14.6 g Vitamin C: 10.34 mg Sugar: 14.5 g Iron: 0.3 mg Protein: 0.11 g Sodium: 15mg Standy Pouch: Sqeeze Mango Mango Dash Standy Pouch 100 ml Mango Dash Standy Pouch 200 ml Nutrition Facts of Sqeeze Mango per 100 ml Sqeeze MangoEnergy: 58 Kcal Fat: NIL Carbohydrate: 14.6 g Vitamin C: 10.34 mg Sugar: 14.5 g Iron: 0.3 mg Protein: 0.11 g Sodium: 15mg PET Bottles: Litchi Dash PET Bottles: Litchi Dash 200 ml Nutrition Facts of Litchi Dash per 100 ml Litchi DashEnergy: 60 Kcal Fat: 0 gm Carbohydrate: 14.8 gm Protein: 0 gm Sugar: 12.5 g Our Factory The products are made in a state-of-art fully automatic manufacturing plant situated at Mandideep near Bhopal (M.P.) India. The products are untouched by

Medicines2U brings a complete new range of online prescription pharmacy for people suffering from Haemorrhoids and associated symptoms.

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Garlic is a simple and powerful health solution for a number of illnesses and as health benefits that cover a range of ailments because of the several unique compounds it contains, especially the allicin.

Vitamin D provides a wide range of health benefits. It is effective in preventing rickets and treating other bone diseases such as osteoporosis. According to the Mayo Clinic, getting enough vitamin D may prevent high blood pressure and protect against certain types of cancer. It may also promote weight loss for women.

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