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Matti Narkia

Western diet triggers genes that cause the body to store more fat - 0 views

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    "(NaturalNews) New research published in The Journal of the Federation of American Societies for Experimental Biology (FASEB) has found that the "Western" diet, typically high in sugar and fat, may be responsible for activating genes that signal the body to become fatter. According to scientists, the body's response to high amounts of energy-dense food is to activate the kappa opioid receptor which triggers increased fat storage.

    Researchers arrived at this conclusion by conducting an experiment on two groups of mice. One group had its kappa opioid receptors genetically deactivated while the other remained intact. Both groups were fed diets high in fat and sugar for 16 weeks. At the end of 16 weeks, the group with the deactivated receptor remained lean while the control group gained significant weight.

    Besides limiting their bodies' ability to store energy-dense food in their fat stores, the mice whose receptors had been deactivated were noted to also have a limited ability to assimilate and store nutrients from the foods they ingested.

    Traci Ann Czyzyk-Morgan, one of the study's researchers, indicated that the findings prove the hypothesis long held by many in the scientific community that the kappa opioid receptor may be responsible for causing widespread obesity in Western countries. She and others continue to encourage people to avoid diets high in fat and sugar.
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Matti Narkia

Fat in diet won't affect weight gain over time | Reuters - 1 views

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    "NEW YORK (Reuters Health) - People who want to maintain a healthy weight over time shouldn't obsess about their fat intake, new research shows.

    The percentage of calories that a person got from fat, as opposed to protein or carbohydrates, had nothing to do with how much weight they gained in the coming years, the research team found.

    The kinds of fat they ate didn't matter either, Dr. Nita Forouhi of the Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK and her colleagues found.

    The findings, Forouhi noted in an email to Reuters Health, show that "it is more important to aim for a healthy lifestyle including a balanced healthy diet and regular physical activity, than to focus on fat intake alone as a factor for weight gain.""
Matti Narkia

Decreased bioavailability of vitamin D in obesity -- Wortsman et al. 72 (3): 690 -- Ame... - 0 views

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    Decreased bioavailability of vitamin D in obesity.
    Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF.
    Am J Clin Nutr. 2000 Sep;72(3):690-3. Erratum in: Am J Clin Nutr. 2003 May;77(5):1342.
    PMID: 10966885

    Conclusions: Obesity-associated vitamin D insufficiency is likely due to the decreased bioavailability of vitamin D3 from cutaneous and dietary sources because of its deposition in body fat compartments.
Matti Narkia

Metabolic effects of conjugated linoleic acid in humans: the Swedish experien... - 0 views

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    Metabolic effects of conjugated linoleic acid in humans: the Swedish
    experience.
    Riserus U, Smedman A, Basu S, Vessby B.
    Am J Clin Nutr. 2004 Jun;79(6 Suppl):1146S-1148S.
    PMID: 15159248

    CONCLUSIONS
    CLA and specifically the isolated isomers are interesting model fatty acids for studies of the effects of (structural differences of) unsaturated fatty acids in humans. Today, there is no clear indication for human use of CLA concentrates. The possible importance of the small reduction of body fat after supplementation with the commercially available CLA products, without evidence of an associated improvement in the metabolic profile, has to be weighed against the apparent reduction of HDL cholesterol and an increased lipid peroxidation. The possible health consequences of prolonged treatment periods are at present unknown. Human supplementation with high doses of the trans-10,cis-12 CLA isomer should be avoided while awaiting further information on possible effects and side effects. However, it cannot be excluded that future studies could point to clinical applications, eg, as a result of antitumorigenic properties or as a tool to prevent weight gain. This possibility certainly requires more research to increase the understanding of the mechanisms behind the effects of CLA and specific CLA isomers on a molecular level. More controlled studies in defined populations are needed, as are controlled studies for comparisons of the effects of different and well-defined (mixtures of) isomers and human studies of longer duration to secure long-term effects and safety.
Matti Narkia

Conjugated Linoleic Acid Impairs Endothelial Function -- Taylor et al. 26 (2): 307 -- A... - 0 views

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    Conjugated linoleic acid impairs endothelial function.
    Taylor JS, Williams SR, Rhys R, James P, Frenneaux MP.
    Arterioscler Thromb Vasc Biol. 2006 Feb;26(2):307-12. Epub 2005 Dec 8.
    PMID: 16339498

    CONCLUSIONS: A CLA isomeric mixture had at most modest effects on adiposity and worsened endothelial function. On the basis of these results, the use of the isomeric mixture of CLA as an aid to weight loss cannot be recommended
Matti Narkia

Conjugated linoleic acid supplementation for 1 y does not prevent weight or body fat re... - 0 views

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    Conjugated linoleic acid supplementation for 1 y does not prevent weight or body fat regain.
    Larsen TM, Toubro S, Gudmundsen O, Astrup A.
    Am J Clin Nutr. 2006 Mar;83(3):606-12.
    PMID: 16522907

    CONCLUSION: A 3.4-g daily CLA supplementation for 1 y does not prevent weight or fat mass regain in a healthy obese population.
Matti Narkia

Relation of body fat indexes to vitamin D status and deficiency among obese adolescents... - 0 views

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    Relation of body fat indexes to vitamin D status and deficiency among obese adolescents.
    Lenders CM, Feldman HA, Von Scheven E, Merewood A, Sweeney C, Wilson DM, Lee PD, Abrams SH, Gitelman SE, Wertz MS, Klish WJ, Taylor GA, Chen TC, Holick MF; Elizabeth Glaser Pediatric Research Network Obesity Study Group.
    Am J Clin Nutr. 2009 Sep;90(3):459-67. Epub 2009 Jul 29.
    PMID: 19640956

    RESULTS: The mean (+/-SD) age of the adolescents was 14.9 +/- 1.4 y; 38 (66%) were female, and 8 (14%) were black. The mean (+/-SD) body mass index (in kg/m(2)) was 36 +/- 5, FM was 40.0 +/- 5.5%, and VAT was 12.4 +/- 4.3%. Seventeen of the adolescents were vitamin D deficient, but none had elevated PTH concentrations. Bone mineral content and bone mineral density were within 2 SDs of national standards. In a multivariate analysis, 25(OH)D decreased by 0.46 +/- 0.22 ng/mL per 1% increment in FM (beta +/- SE, P = 0.05), whereas PTH decreased by 0.78 +/- 0.29 pg/mL per 1% increment in VAT (P = 0.01). CONCLUSIONS: To the best of our knowledge, our results show for the first time that obese adolescents with 25(OH)D deficiency, but without elevated PTH concentrations, have a bone mass within the range of national standards (+/-2 SD). The findings provide initial evidence that the distribution of fat may be associated with vitamin D status, but this relation may be dependent on metabolic factors
Matti Narkia

25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input ... - 0 views

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    25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions.
    Heaney RP, Armas LA, Shary JR, Bell NH, Binkley N, Hollis BW.
    Am J Clin Nutr. 2008 Jun;87(6):1738-42.
    PMID: 18541563

    Conclusions: At physiologic inputs, there is rapid conversion of precursor to product at low vitamin D3 concentrations and a much slower rate of conversion at higher concentrations. These data suggest that, at typical vitamin D3 inputs and serum concentrations, there is very little native cholecalciferol in the body, and 25(OH)D constitutes the bulk of vitamin D reserves. However, at supraphysiologic inputs, large quantities of vitamin D3 are stored as the native compound, presumably in body fat, and are slowly released to be converted to 25(OH)D.
Matti Narkia

Not enough vitamin D in the diet could mean too much fat on adolescents - 0 views

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    AUGUSTA, Ga. - Too little vitamin D could be bad for more than your bones; it may also lead to fatter adolescents, researchers say.\n\nA Medical College of Georgia study of more than 650 teens age 14-19 has found that those who reported higher vitamin D intakes had lower overall body fat and lower amounts of the fat in the abdomen, a type of fat known as visceral fat, which has been associated with health risks such as heart disease, stroke, diabetes and hypertension
Matti Narkia

A Role of DNA-PK for the Metabolic Gene Regulation in Response to Insulin - ScienceDire... - 0 views

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    A Role of DNA-PK for the Metabolic Gene Regulation in Response to Insulin
    Roger H.F. Wong, Inhwan Chang, Carolyn S.S. Hudak, Suzanne Hyun, Hiu-Yee Kwan, Hei Sook Sul
    Cell 20 March, 2009 Volume 136, Issue 6, p1056
    doi:10.1016/j.cell.2008.12.040    
Matti Narkia

Genetically Altered Mice Stay Lean With High-Carb Diet - 0 views

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    Researchers at the University of California, Berkeley, have identified a gene that plays a critical regulatory role in the process of converting dietary carbohydrates to fat. In a new study, they disabled this gene in mice, which consequently had lower levels of body fat than their normal counterparts, despite being fed the equivalent of an all-you-can-eat pasta buffet.

    The authors of the study, to be published in the March 20 issue of the journal Cell, say the gene, called DNA-PK, could potentially play a role in the prevention of obesity related to the over-consumption of high-carbohydrate foods, such as pasta, rice, soda and sugary snacks..
Matti Narkia

BBC NEWS | Health | Being fat 'is as bad as smoking' - 0 views

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    Being overweight or seriously underweight as a teenager curbs life expectancy as much as smoking 10 cigarettes a day, a study suggests.\nSwedish researchers followed 46,000 men from the age of 18 for 38 years.
Matti Narkia

Vitamin D status and its relationship to body fat, final height, and peak bone mass in ... - 0 views

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    Vitamin D status and its relationship to body fat, final height, and peak bone mass in young women.\nKremer R, Campbell PP, Reinhardt T, Gilsanz V.\nJ Clin Endocrinol Metab. 2009 Jan;94(1):67-73. Epub 2008 Nov 4.\nPMID: 18984659
Matti Narkia

Getting The Ideal Body Fat - 0 views

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    Fitness Health blog offers you tips and useful information on Fitness, Exercise, Diet and Nutrition. It provides you latest information on fitness & exercise equipment, yoga, meditation, vitamins and supplements.
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