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Matti Narkia

"[Vitamin K and Bone Update. The biological effects of vitamin K(2) on bone quality.] -... - 0 views

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    "[Vitamin K and Bone Update. The biological effects of vitamin K(2) on bone quality.]
    Amizuka N, Li M, Guo Y, Liu Z, Suzuki R, Yamamoto T.
    Clin Calcium. 2009 Dec;19(12):1788-96. Japanese.
    PMID: 19949270

    Post-transcriptional maturation with the presence of vitamin K(2) promotesgamma-carboxylation of osteocalcin, enabling further binding to hydroxyapatite, from which one could infer that vitamin K(2) increased the quality of bone matrix. For instance, vitamin K(2) rescued the impaired collagen mineralization caused by Mg insufficiency, by promoting a re-association of the process of collagen mineralization with mineralized nodules. Sodium warfarin, which antagonizes the function of vitamin K(2), reduced the binding of osteocalcin to bone matrices, and consequently resulted in crystalline particles being dispersed throughout the osteoid without forming mineralized nodules. Therefore,gamma-carboxylated Gla proteins mediated by vitamin K(2) appear to play a pivotal role in normal mineralization in bone."
Matti Narkia

N-3 Fatty Acids and Cardiovascular Disease: Actions and Molecular Mechanisms - 0 views

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    n-3 Fatty acids and cardiovascular disease: actions and molecular mechanisms.
    Torrejon C, Jung UJ, Deckelbaum RJ.
    Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec;77(5-6):319-26. Epub 2007 Dec 3. Review. Erratum in: Prostaglandins Leukot Essent Fatty Acids. 2008 Feb;78(2):157.
    PMID: 18060753

    In conclusion, a growing body of evidence, encompassing human to cellular and molecular studies are defining the roles for n-3 FA as bioactive agents for reducing the risks of and treating CVD.
Matti Narkia

Improvement of the recurrence-free interval using biological adjuvant therapy in uveal ... - 0 views

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    Improvement of the recurrence-free interval using biological adjuvant therapy in uveal melanoma.
    Tallberg T, Uusitalo R, Sarna S, Seregard S, Werschnik C.
    Anticancer Res. 2000 May-Jun;20(3B):1969-75.
    PMID: 10928136
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