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Nathan Goodyear

Nature Clinical Practice Endocrinology & Metabolism | Testosterone and ill-health in ag... - 0 views

  • Levels of total and bioavailable testosterone and SHBG were reported to be inversely correlated with the prevalence of the metabolic syndrome in men aged 40–80 years
  • as were total testosterone and SHBG in men aged 65–96 years
  • and in a cross-sectional analysis of a large cohort of non-diabetic men aged 70–89 years
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  • In longitudinal studies, decreased levels of total testosterone and SHBG predicted an increased incidence of metabolic syndrome in nonobese men
  • Free testosterone level is not associated with the prevalence of metabolic syndrome in middle-aged and older men
  • Levels of free, bioavailable and total testosterone are lower in men with T2DM than in age-matched controls,34, 35 and decreased total testosterone level predicts incident T2DM in middle-aged men.
  • men with T2DM commonly have low total or free testosterone levels
  • Total, bioavailable and free testosterone levels are inversely correlated with fasting insulin level and insulin resistance in middle-aged men without T2DM
  • total testosterone is positively correlated with insulin sensitivity in men with normal or impaired glucose tolerance or T2DM
  • low SHBG level is more strongly associated with metabolic syndrome than low total testosterone in aging men
  • the recognized association between low SHBG level and insulin resistance
  • Low levels of SHBG are also associated with smaller, denser LDL-cholesterol molecules in nondiabetic men,58 and were found to predict increased cardiovascular disease mortality in one study of older men
  • Low levels of SHBG might reflect obesity, insulin resistance and overall poor health
  • Compared with those who have normal testosterone levels, men aged 40 years or more with total testosterone levels <9.8 nmol/l or elevated LH level have greater CIMT
  • In men aged 73–94 years, total testosterone was inversely correlated with CIMT
  • a prospective analysis of men aged 73–91 years, progression of CIMT was not related to total testosterone level, but it was inversely related to free testosterone level
  • A study of men aged 55 years or more found that those with total and bioavailable testosterone levels in the highest tertile had a lower risk of severe aortic atherosclerosis (detected by radiography as abdominal aortic calcification) than those with the lowest testosterone levels.
  • a large study of men aged 69–80 years, those with total or free testosterone in the lowest quartile had increased odds of lower-extremity peripheral arterial disease
  • the possibility of reverse causation has to be considered, as systemic illness can result in decreased testosterone levels
  • previous case–control studies and longitudinal studies have failed to identify low testosterone levels as strong predictors of clinically significant coronary disease
  • Reviews of trials on testosterone therapy in men with either low or low-to-normal testosterone levels have not shown consistent beneficial effects either on lipid profiles or on actual cardiovascular events.24, 54, 55 These trials, however, have not been designed or powered to detect treatment-related differences in cardiovascular outcome
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    Declining Testosterone or low Testosterone is clearly associated with poor health in men.   Very nice review of the association between low Testosterone and metabolic dysfunction.  Low T is associated with increased metabolic syndrome, Diabetes, weight gain, insulin resistance...
Nathan Goodyear

Androgen Deprivation Therapy, Insulin Resistance, and Cardiovascular Mortality: An Inco... - 0 views

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    Androgen deprivation therapy is associated with increased diabetes, metabolic syndrome, insulin resistance, and cardiovascular mortality.  The longer the duration of therapy, the more the progression of metabolic dysfunction.  This process seems similar to chemotherapy i.e. secondary cancer due to chemotherapy.  The treatment of one disease, prostate cancer in this case, leads to an increase in the risk of the #1 killer in men--logic seems severely flawed there.
Nathan Goodyear

Inverse Association of Testosterone and the Metabolic Syndrome in Men Is Consistent acr... - 0 views

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    Total Testosterone and SHBG inversely associated with Metabolic Syndrome.
Nathan Goodyear

Aging, Androgens, and the Metabolic Syndrome in a Longitudinal Study of Aging: The Jour... - 0 views

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    Study finds Total Testosterone and SHBG inversely associated with Metabolic Syndrome.  Free Testosterone and BMI were positively associated with MetS.
Nathan Goodyear

http://www.spectracell.com/media/uploaded/2/0e2938319_1393442221_2132abstract2014nzmedj... - 0 views

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    IV vitamin C at 50 grams twice weekly shown to reduce side effects associated with chemotherapy.  Granted, this is a single case study without comparison, but this is supported by other studies.
Nathan Goodyear

Sex hormones and hemostatic risk factors for cor... [J Hypertens. 1993] - PubMed - NCBI - 0 views

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    Testosterone inversely associated with increased cardiovascular risk in men--hypertension in this study.
Nathan Goodyear

Association between plasma total tes... [J Clin Endocrinol Metab. 1997] - PubMed - NCBI - 0 views

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    low Total Testosterone associated with increased BMI, systolic blood pressure, glucose, triglycerides, total cholesterol, LDL apolipoprotien B and A1. Low Testosterone is associated with increased cardiovascular disease.  Men at risk for cardiovascular disease must be evaluated for hormones.
Nathan Goodyear

Endogenous sex hormones and cardiovascular disease in men. A prospective population-bas... - 0 views

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    This study found that Testosterone levels were inversely associated with hypertension, fasting glucose, triglycerides, and BMI.
Nathan Goodyear

Changes in fat and lean body mass during androgen-de... [Urology. 2004] - PubMed - NCBI - 0 views

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    Androgen deprivation therapy resulted in an 11% increase in fat mass and just under 4% decrease in lean muscle mass in men.  
Nathan Goodyear

Changes in body composition during a... [J Clin Endocrinol Metab. 2002] - PubMed - NCBI - 0 views

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    Androgen deprivation therapy was found to decrease lean muscle mass and increase abdominal adipose tissue, not visceral.  Significant change in body composition in men depleted of androgens in androgen deprivation therapy.
Nathan Goodyear

Testosterone deficiency syndrome and cardiovascular health: An assessment of beliefs, k... - 0 views

  • The vast majority (88%) did not screen cardiac patients for TDS.
  • Testosterone deficiency has a prevalence of 7% in the general population, rising to 20% in elderly males
  • Males with CAD have lower testosterone levels than those with normal coronary angiograms of the same age,5 suggesting that the prevalence of testosterone deficiency is much higher in the CAD population
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  • Men with hypertension, another established risk factor for CAD, have lower testosterone compared to normotensive men
  • Recent meta-analyses showed that testosterone levels are generally lower among patients with metabolic syndrome, regardless of the various definitions of metabolic syndrome that are used
  • Testosterone (total and bioavailable) and sex-hormone binding globulin (SHBG) are inversely associated with the prevalence of metabolic syndrome in men between the ages of 40 and 80, and this association persists across racial and ethnic backgrounds
  • ower levels of testosterone and SHBG predict a higher incidence of metabolic syndrome.
  • Low testosterone levels have been related to increased insulin resistance and cardiovascular mortality,12 even in the absence of overt type 2 diabetes mellitus.
  • testosterone levels (total and bioavailable) in middle-aged men are inversely correlated with insulin resistance
  • The Massachusetts Male Aging Study (MMAS) demonstrated that low levels of testosterone and SHBG are independent risk factors for the development of type 2 diabetes,
  • Andropausal men (age 58 ± 7 years) have a higher maximal carotid artery intima-media thickness
  • There is an inverse linear correlation between body mass index (BMI) and wait-to-hip ratio with testosterone and insulin-like growth factor-1 levels.
  • Testosterone supplementation for 1 year in hypogonadal men has been shown to cause a significant improvement in body weight, BMI, waist size, lipid profile, and C-reactive protein levels
  • TRT for 3 months in hypogonadal men with type 2 diabetes significantly improved fasting insulin sensitivity, fasting blood glucose and glycated hemoglobin.
  • Testosterone replacement can improve angina symptoms and delay the onset of cardiac ischemia, likely through a coronary vasodilator mechanism
  • ADT is associated with an increased risk of cardiovascular events, including myocardial infarction and cardiovascular mortality.
  • ADT significantly increases fat mass, decreases lean body mass,29,30 increases fasting plasma insulin and decreases insulin sensitivity31 and increases serum cholesterol and triglyceride levels
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    Startling study on the knowledge of Testosterone and cardiovascular disease in general practitioners and cardiologists in Canada.  Eight-eight percent did not screen patients with cardiovascular disease for low Testosterone.  A whopping 67% of physicians did not know that low T was a risk factor for cardiovascular disease, yet 62% believed Testosterone would increase exercise tolerance. The lack of knowledge displayed by physicians today is staggering and is an indictment of the governing bodies.  This was a survey conducted in Canada so there are obvious limitations to the strength/conclusion of this study.
Nathan Goodyear

Estrogen excess associated with novel gain-of-f... [N Engl J Med. 2003] - PubMed - NCBI - 0 views

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    Presentation of a familial incidence of male gynecomastia and hypogonadotropic hypogonadism via peripheral aromatase activity.
Nathan Goodyear

Testosterone therapy delays cardiomyocyt... [Braz J Med Biol Res. 2011] - PubMed - NCBI - 0 views

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    Study finds that low Testosterone contributes to cardiomyocyte agine in mouse model.  Low Testosterone was associated with a shorter telomere length.  "Physiologic" Testosterone therapy slowed this aging effect of the cardiomyocyte via an AR independent pathway as the Tfm mice have nonfunctional AR.  The authors propose that it may be via aromatase activity.
Nathan Goodyear

Lower-But-Normal Serum TSH level Is Associated With the Development or Progression of C... - 0 views

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    This study points to an association between a low-normal TSH and cognitive decline in the elderly.  An association is not causative, but functional hypothyroidism does result in cognitive impairment, so the association would logically fit.  The results of this study do as well.
Nathan Goodyear

Oxidative Stress, Testosterone, and Cognition among Caucasian and Mexican-American Men ... - 0 views

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    Interesting study. This study points out the differences between individuals and groups i.e. Mexian-Americans and Caucasians in this study.  Men with low oxidative stress, Testosterone was associated with no cognitive dysfunction.  In contrast, with high oxidative stress, Testosterone therapy was associated with cognitive impairment in caucasians only.
Nathan Goodyear

Ovarian estradiol production and lipid metabolism ... [Menopause. 2014] - PubMed - NCBI - 1 views

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    contrary to popular thought, the ovaries dont' shrivel up and die post menopause.  This study finds Estradiol production on going post menopause.
Nathan Goodyear

Testosterone deficiency and severity of erectile d... [Andrology. 2014] - PubMed - NCBI - 0 views

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    Study finds that low Testosterone (total, free, and bioavailable) associated with reduced quality of life in men with Diabetes.  So was ED.
Nathan Goodyear

Glucose and lipopolysaccharide regulate pro... [J Reprod Immunol. 2014] - PubMed - NCBI - 0 views

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    elevated androgens (male hormones) correlated with low grade inflammation and atherogenesis in women with PCOS.  This was found more in those women that were obese.
Nathan Goodyear

Dark chocolate consumption improves leukocyte adhesion factors and vascular function in... - 0 views

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    dark chocolate improves vascular function in short study.
Nathan Goodyear

Urinary bisphenol A, phthalates, and couple fecundity: the Longitudinal Investigation o... - 0 views

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    Study finds phthalate exposure associated with a 20% decline in fertility in men not women.
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