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http://www.biomed.cas.cz/physiolres/pdf/prepress/932627.pdf - 0 views

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    good discussion of the effects of resistance training on Testosterone and cortisol in obese men.  The literature is more more clear on the effects of resistance training on healthy men, but the evidence in obese men is less clear--likely due to the disrupted metabolism.
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PPARγ and human metabolic disease - 0 views

  • PPARα and PPARδ appear primarily to stimulate oxidative lipid metabolism
  • PPARγ is principally involved in the cellular assimilation of lipids via anabolic pathways
  • PPARs are members of the nuclear hormone receptor superfamily
  • ...7 more annotations...
  • Expression of PPARγ is highest in adipose tissue,
  • PPARγ also plays a key role in the entraining of adipose tissue lipid metabolism to nutritional state
  • Its expression is highest postprandially
  • its activation leads to upregulation of genes that mediate FA uptake and trapping
  • PPARγ may also promote futile cycling in adipocytes between triglyceride (TG) esterification and de-esterification
  • its high expression in macrophages, which are now known to infiltrate the dysfunctional adipose tissue of obese subjects
    • Nathan Goodyear
       
      PPAR gamma is associated with adipocyte differentiation and lipid storage.
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    review of PPAR gamma
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    very informative! Thanks for sharing!
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Pattern recognition of estradiol, testosterone and dihydrotestosterone in children's sa... - 0 views

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    Sochastic sensors and pattern recognition proposed to improve levels of Estradiol, Testosterone, and DHT in salivary sampling in young children.  These levels are very low in pre-pubertal children and makes detection by ELIZA difficult.  This proposed mechanism improves hormone detection.
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Methadone induces testosterone suppression in patients with opioid addiction : Scientif... - 0 views

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    Methadone use in men is associated with significant reduction in serum Total Testosterone levels in men.  In women, just the opposite is true, though this did not reach statistical significance.  The higher the dose of methadone in men, the lower the Testosterone.  The link between opiates and low T in men is very strong.  This is the first that I am aware of that points to the opposite effect in women.
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Prevention and management of type 2 diabetes: dietary components and nutritional strate... - 0 views

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    Unfortunately, on the summary is available to public, but review of nutrition for Diabetes points to Mediterranean diet, high vegetable intake, olive oil, and non-red meat intake for protein--particularily beans and legumes.  Compare this to the average counseling for those with Diabetes today.  
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Aromatase P450 Gene Expression in Human Adipose Tissue. ROLE OF A Jak/STAT PATHWAY IN R... - 0 views

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    aromatase activity regulation in men and women.
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Ovarian insufficiency and early pregnancy loss induced by activation of the innate immu... - 0 views

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    low Progesterone as a result of luteal phase defects results in an increase in TNF-alpha production.  The result is impaired fertility and increased first trimester miscarriage rates.
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Anti-Inflammatory Effects of Progesterone in Lipopolysaccharide-Stimulated BV-2 Microglia - 0 views

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    Progesterone and its anti-inflammatory effects.
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Transdermal progesterone cream for vasomotor ... [Obstet Gynecol. 1999] - PubMed - NCBI - 0 views

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    Transdermal BHRT in the form of Progesterone found to reduce hot flashes by 83%.
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http://www.enotes.us/hotflashes2002.pdf - 0 views

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    hot flashes.
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Prevalence of Metabolic Syndrome Among College Football Linemen - 0 views

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    14% of offensive lineman found to have MetS in small study.
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Coronary Artery Calcium Scores: Current Thinking and Clinical Applications - 0 views

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    coronary artery calcium scores
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Nerve growth factor receptor immunoreactivit... [Mech Ageing Dev. 1993] - PubMed - NCBI - 0 views

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    alpha-GPC appears to increase nerve growth factor receptors in rat brains. 
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Behavioral effects of L-alpha-glycer... [Pharmacol Biochem Behav. 1992] - PubMed - NCBI - 0 views

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    animal study finds improvement in learning and memory with alpha-GPC after 20 days of therapy.
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Effect of treatment with choline alphoscerate on h... [Brain Res. 2006] - PubMed - NCBI - 0 views

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    alpha-GPC, in rat model found to protect brain from glial reaction damage in cerebrovascular disease.
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Multicentre study of l-alpha-glyceryl-ph... [Drugs Aging. 1993 Mar-Apr] - PubMed - NCBI - 0 views

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    alpha-GPC and to a lesser degree acetyl-l-carnitine improved dementia in multi-center trial.
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Fructose consumption: potential mechanisms for its effects t... : Current Opinion in Li... - 0 views

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    fructose leads to direct increase in lipid liver load, post prandial hypertriglyceridemia, and hepatic insulin resistance.
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Functional Properties and Genomics of Glucose Transporters - 0 views

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    Good discussion of Glucose transporters--GLUT.
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Fructose: A Key Factor in the Development of Metabolic Syndrome and Hypertension - 0 views

  • HFCS consists of fructose and glucose mixed in a variety of concentrations, but most commonly as 55% fructose and 45% glucose
  • In the United States, HFCS and sucrose are the major sources of fructose in the diet, and HFCS is a major ingredient in soft drinks, pastries, desserts, and various processed foods
  • fructose and glucose are metabolized in completely different ways and utilize different GLUT transporters
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  • In the liver, fructose bypasses the two highly regulated steps of glycolysis, catalyzed by glucokinase/hexokinase and phosphofructokinase both of which are inhibited by increasing concentrations of their byproducts. Instead, fructose enters the pathway at a level that is not regulated and is metabolized to fructose-1-phosphate primarily by fructokinase or ketohexokinase
  • Fructokinase has no negative feedback system, and ATP is used for the phosphorylation process. As a result, continued fructose metabolism results in intracellular phosphate depletion, activation of AMP deaminase, and uric acid generation which is harmful at the cellular level
  • Uric acid, a byproduct of fructose degradation,
  • Uric acid inhibits endothelial NO both in vivo and in vitro, [15] and directly induces adipocyte dysfunction
  • Serum uric acid increases rapidly after ingestion of fructose, resulting in increases as high as 2 mg/dL within 1 hour
  • Uncontrolled fructose metabolism leads to postprandial hypertriglyceridemia, which increases visceral adipose deposition. Visceral adiposity contributes to hepatic triglyceride accumulation, protein kinase C activation, and hepatic insulin resistance by increasing the portal delivery of free fatty acids to the liver
  • Several reviews have concluded that intake of both fructose and HFCS by children and adults was associated with an increased risk of obesity and metabolic syndrome
  • Sucrose is a disaccharide that is comprised of fructose and glucose
  • Figure 2
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    great read and review of the role of fructose in metabolic syndrome.
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Prevalence of Hyperuricemia and the Relationship between Serum Uric Acid and Metabolic ... - 0 views

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    Waist circumference and triglycerides correlate with serum uric acid levels.  Men in this study had higher hyperuricemic rates compared to women.  Elevated uric acid levels were associated with increased MetS in both sexes and higher normal uric acid levels were also associated with a higher risk of MetS.
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