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Dr Nik Kotecha OBE - Distinguished Alumni Award Winner 2022 - 0 views

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    Dr Nik Kotecha OBE, chairman of Morningside Pharmaceuticals and the Randal Charitable Foundation, has won the Distinguished Alumni Award at Imperial College London's Alumni Awards 2022. The annual awards honour outstanding alumni who have demonstrated sustained excellence in their personal and professional achievements and have made a substantial impact on society. Dr Kotecha, who founded Morningside in 1991, which manufactures and supplies generic and branded medicines to the UK and globally, said: "I'm thrilled to be honoured by the university in this way. "As a child growing up in Leicester my family had very little, but I was fortunate to be given opportunities to gain a good education. After finishing my degree in Newcastle; Professor Steve Ley FRS at Imperial College took a chance in accepting me into his eminent group and this really was the opportunity I needed to forge a career.
pharmacybiz

Campaign To Encourage Pregnant Women To Take Covid-19 Jabs - 0 views

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    The government has launched a new campaign over social media and radio today (January 10) to encourage pregnant women to take their first, second and third dose of Covid-19 vaccine. Joined by experts at the Royal College of Obstetricians and Gynaecologists (RCOG) and the Royal College of Midwives (RCM), the campaign highlights the risks of the infection and benefits of vaccination. According to the latest data from the UK Health Security Agency (UKHSA), Covid-19 vaccinations are safe for pregnant women. Department of Health and Social Care (DHSC) chief scientific adviser professor Lucy Chappell, said: "We have extensive evidence now to show that the vaccines are safe and that the risks posed by Covid-19 are far greater," calling upon pregnant women who have yet to have their jabs. The campaign will also run testimonies of pregnant women who have had their jabs.
Nathan Goodyear

Effects of protein supplementation on muscular performance and resting hormonal changes... - 1 views

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    protein supplementation in college football players
Nathan Goodyear

Management of Helicobacter pylori Infection | American College of Gastroenterology - 0 views

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    American college of Gastroenterology review on H.pylori.  The treatment regimens are significant issues as tetracycline is no longer available.
Nathan Goodyear

Assessment of cardiovascular risk in collegiate fo... [J Am Coll Health. 2010 Nov-Dec] ... - 0 views

  • the increased prevalence of the metabolic syndrome and its components in the collegiate linemen may increase cardiovascular disease risk.
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    college lineman with increased cardiovascular disease risk
Nathan Goodyear

Metabolic syndrome and insulin resistance in Divis... [Med Sci Sports Exerc. 2009] - Pu... - 0 views

  • Linemen are at significant risk for metabolic syndrome and insulin resistance compared with other positions. This may be predictive of future health problems in Division 1 collegiate football players, especially linemen
  • There is a strong association between obesity and both metabolic syndrome and insulin resistance in Division 1 collegiate football players
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    college football lineman at increased risk of obesity, insulin resistance, and future health problems
Nathan Goodyear

American College of Cardiology Foundation | Journal of the American College of Cardiolo... - 0 views

  • Although currently no drugs that specifically target mitochondrial biogenesis in HF are available, acceleration of this process through adenosine monophosphate–activated kinase (AMPK), endothelial nitric oxide synthase (eNOS), and other pathways may represent a promising therapeutic approach
  • Mitochondrial biogenesis can be enhanced therapeutically with the use of adenosine monophosphate kinase (AMPK) agonists, stimulants of nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway (including phosphodiesteraes type 5 inhibitors), or resveratrol
  • metformin, a commonly used antidiabetic drug that activates AMPK signaling
  • ...10 more annotations...
  • Recent evidence suggests that the eNOS/NO/cGMP pathway is an important activator of mitochondrial biogenesis
  • BH4 (tetrahydrobiopterin) supplementation can prevent eNOS uncoupling and was found to reduce left ventricular hypertrophy
  • folic acid is known to replenish reduced BH4 and has been shown to protect the heart through increased eNOS activity
  • Both folate deficiency and inhibition of BH4 synthesis were associated with reduced mitochondrial number and function
  • Resveratrol, a polyphenol compound responsible for the cardioprotective properties of red wine, was recently identified as a potent stimulator of mitochondrial biogenesis
  • epidemiological studies reveal a reduced risk of cardiovascular disease in premenopausal, but not post-menopausal, women compared with men
  • post-menopausal women
    • Nathan Goodyear
       
      I would hypothesis that a change in the predominance of ER expression is one of ER beta to ER alpha: creating a more pro-inflammatory signal.
  • The majority of ROS in the heart appear to come from uncoupling of mitochondrial electron transport chain at the level of complexes I and III
  • Because the majority of ROS in HF comes from mitochondria, these organelles are the primary target of oxidative damage.
  • cardioprotective therapies such as angiotensin-converting enzyme inhibitors and ATII receptor blockers were shown to possess antioxidant properties, although it is not known whether they target mitochondrial ROS directly or indirectly
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    great review of mitochondrial biogenesis, oxidative stress and heart failure.  
Nathan Goodyear

American College of Cardiology Foundation | Journal of the American College of Cardiolo... - 0 views

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    Small study, but well designed study shows that statins inhibit CoQ10 mediated oxidative phosphorylation through decrease in CoQ10.  This points directly at a decrease in mitochondrial function as a result of statin therapy.
Nathan Goodyear

Creatine supplementation during college foo... [Mol Cell Biochem. 2003] - PubMed - NCBI - 0 views

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    phosphocreatine supplementation in Division 1A football players found to have no increased incidence of cramping or other injuries.
Nathan Goodyear

American College of Cardiology Foundation | Journal of the American College of Cardiolo... - 1 views

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    Endothelial progenitor cells (EPCs) as the future of cardiovascular treatment?
Nathan Goodyear

American College of Cardiology Foundation | Journal of the American College of Cardiolo... - 0 views

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    Study finds that Testosterone therapy improves insulin sensitivity, muscle strength and function in women with advanced CHF.  No levels were noted.  If this is similar to men, I would expect a low Testosterone, which Testosterone replacement would then increase physiologic performance. 
Nathan Goodyear

Prevalence of Metabolic Syndrome Among College Football Linemen - 0 views

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    14% of offensive lineman found to have MetS in small study.
Nathan Goodyear

American College of Cardiology Foundation | Journal of the American College of Cardiolo... - 0 views

  • Lp(a) is a circulating lipoprotein composed of liver-derived apo(a) covalently bound to apoB, which is similar in lipid composition to apoB of LDL
  • multiple studies have shown that elevated Lp(a) levels are independently and linearly predictive of future CVD
  • higher levels were continuously related to risk of myocardial infarction.
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    good discussion of Lipoprotein(a) and its associated cardiovascular risk.
krsnaphysio1

Physiotherapist in Gurgaon - 0 views

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    Since its establishment in the year 2011, Krshna Physio Plus is aimed to provide patients with comprehensive, high quality and professional physiotherapy treatments and rehabilitation to people in need. The efficient team of three, Dr. Ravi Sahauta - A very well-known complex trauma surgeon and Orthopaedician, Dr. Dharm Pal Sharma - an ex-Air force Physio trainer and Dr. Parmila Sharma - an experienced and talented physio expert, Krshna Physio Plus is counted among the well-known Physiotherapy clinic in Gurgaon and Delhi/NCR regions.  This clinic is one of the oldest organizations which was started with a vision to help people suffering from diverse dysfunctionalities with proper guidance and treatment which encompasses mainly physical, psychological, emotional, and social well being. With 8 centers in Delhi/NCR and Bihar, we are aimed at setting over 300 centers across Asia by 2020 and become the Physiotherapy clinic in Gurgaon.  Moreover, KRSNA Physio Plus is well equipped with various advanced facilities and equipment used to treat people to assure patient satisfaction and fast recovery. We have with us Top Physiotherapist in Gurgaon and Delhi/NCR regions with us who are specialized in offering treatment in physiotherapy dealing with Orthopedic, Neurological, Pediatric, Cardio-pulmonary, and Sports Injury, etc. All the experts here put their best for providing the best results.  Our experienced team of doctors and physiotherapists in Gurgaon who would be better able to diagnose what might be making it impossible for you to crane your neck, or pick articles off the floor, or simply kneel before your deity. Sports-Related Injuries Could Happen to Anyone It could be just that badminton match on a winter evening, or an office football match. Before you realize what is happening you've pulled a back muscle or your hamstring. Playing tug-of-war in colleges and office parties is fraught with the risk of a rotator cuff injury. Cricketers diving to save
Nathan Goodyear

ScienceDirect.com - Journal of the American College of Cardiology - High Serum Testoste... - 0 views

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    This study found that high serum testosterone associated with a reduction of cardiovascular events in elderly men.  Studies have shown that low T is associated with increased cardiovascular mortality and in cardiovascular events, but this study takes it one step further: testosterone reduces those risks. 
Nathan Goodyear

Using Multicountry Ecological and Observational Studies to Determine Dietary Risk Facto... - 0 views

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    Western diet appears to be major risk association/factor in Alzheimer's disease risk.
kyra smith

Facilitation of Medical Research and Communication FMRC - 0 views

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    Medical research in India is still limited to some apex medical institutes and central laboratories to a large extent. India contributes a meagre 1.2% to the total published medical research, in nearly 6800 journals, worldwide. Moreover, approximately 70% of this research literature comes only from 10 medical colleges.
Nathan Goodyear

Dietary Strategies for Improving Post-Prandial Glucose, Lipids, Inflammation, and Cardi... - 0 views

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    Diet can be a direct cause of inflammation.  A anti-inflammatory diet is a must in those with chronic, inflammatory diseases.    In this study, triglycerides, oxidative stress, and inflammation was found immediately after a single meal of saturated fat.
Nathan Goodyear

Repeated thermal therapy improves impaired vascular endothelial function in patients wi... - 0 views

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    IR sauna improves vascular function
Nathan Goodyear

Subclinical Thyroid Dysfunction, Cardiac Function, and the Risk of Heart Failure: The C... - 0 views

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    increased risk of heart failure found in patients with TSH > 10.
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