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Nathan Goodyear

Social Support and Salivary Cortisol in Women With Metastatic Breast Cancer - 0 views

www.psychosomaticmedicine.org/...337.abstract

saliva salivary cortisol HPA axis breast cancer metastatic hormone hormones test testing evaluation

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Nathan Goodyear on 28 Nov 11
     
    better cortisol pattern seen in women with good social support.  This is indicative of a better balanced HPA axis and thus immune system balance.  Significant implications in women with metastatic breast cancer.  Cortisol evaluated by saliva
Nathan Goodyear

Circadian disruption in cancer: a neuroend... [Brain Behav Immun. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12946654

Cortisol saliva salivary hormone hormones test testing HPA cancer stress

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Nathan Goodyear on 28 Nov 11
     
    disrupted cortisol rhythm or pattern due to stress is a pathway to disease.  A disrupted HPA axis is a disrupted immune system.
Nathan Goodyear

NCJRS Abstract - National Criminal Justice Reference Service - 0 views

www.ncjrs.gov/...abstract.aspx

PTSD HPA dysfunction cortisol saliva salivary hormone hormones testing evaluation

shared by Nathan Goodyear on 03 Feb 12 - No Cached
  • Nathan Goodyear on 03 Feb 12
     
    PTSD is not just a short term issue.  The HPA dysfunction can persist long-term causing symptoms that extend far beyond the time of injury/healing.  What is interesting, is that the cortisol was evaluated with cortisol.  The new gold standard.
Nathan Goodyear

Anxiety disorders and salivary cort... [Psychoneuroendocrinology. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22776419

hormone hormones saliva salivary cortisol HPA anxiety

shared by Nathan Goodyear on 30 Jul 12 - No Cached
  • Nathan Goodyear on 30 Jul 12
     
    low am cortisol, found in adults with "long-lasting" anxiety.  The proposed reason is a physiologic down regulation of the HPA axis.
Nathan Goodyear

The Androgen 5α-Dihydrotestosterone and Its Metabolite 5α-Androstan-3β, 17β-Diol Inhibit the Hypothalamo-Pituitary-Adrenal Response to Stress by Acting through Estrogen Receptor β-Expressing Neurons in the Hypothalamus - 0 views

www.jneurosci.org/...1448.long

DHT metabolite metabolites 3-beta androstanediol 3-beta-diol HPA stress ER estrogen receptor ER beta ER-beta hormone hormones

shared by Nathan Goodyear on 03 Feb 14 - No Cached
  • Nathan Goodyear on 03 Feb 14
     
    Full article of previously posted abstract.  DHT metabolite 3beta-diol inhibits HPA stress response via ER beta.  
Nathan Goodyear

The stress response and the hypothalamic‐pituitary‐adrenal axis: from molecule to melancholia - 0 views

qjmed.oxfordjournals.org/...323.long

stress response HPA cortisol immune system inflammation inflammatory cytokines

shared by Nathan Goodyear on 01 Oct 13 - No Cached
  • Nathan Goodyear on 01 Oct 13
     
    Good review of the interaction between the HPA stress response and the immune system.
Nathan Goodyear

Hormones.gr - 0 views

www.hormones.gr/...article.html

HPA surgery Pituitary hypothalamus adrenal hormones

shared by Nathan Goodyear on 10 Dec 13 - No Cached
  • Nathan Goodyear on 10 Dec 13
     
    Good discussion of the HPA response to major surgery.  
Nathan Goodyear

Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses : Nature Communications : Nature Publishing Group - 0 views

www.nature.com/...ncomms7266.html

Leptin HPA hormone hormones

shared by Nathan Goodyear on 19 Jun 15 - No Cached
  • Nathan Goodyear on 19 Jun 15
     
    Leptin does have inhibitory activity at the level at the HPA; in addition to the inhibition at the gonadal level.
Nathan Goodyear

Informa Healthcare - Systems Biology in Reproductive Medicine - 52(2):97 - Summary - 0 views

informahealthcare.com/...01485010500315479

Testosterone Estadiol Testosterone:Estradiol ratio HPA estrogen dominance low T aromatase obesity overweight

shared by Nathan Goodyear on 10 Oct 11 - No Cached
  • Nathan Goodyear on 10 Oct 11
     
    a decreasing Testosterone:Estradiol ratio leads to decreased sperm production.  This effectively occurs through the interaction of the elevated Estradiol and the HPA.
Nathan Goodyear

Salivary cortisol as a biomarker in stress researc... [Psychoneuroendocrinology. 2009] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...19095358

saliva salivary cortisol hormone testing HPA

shared by Nathan Goodyear on 13 Jul 11 - No Cached
  • psychobiological mechanisms, which trigger the hypothalamus-pituitary-adrenal axis (HPAA) can only indirectly be assessed by salivary cortisol measures. The different instances that control HPAA reactivity (hippocampus, hypothalamus, pituitary, adrenals) and their respective modulators, receptors, or binding proteins, may all affect salivary cortisol measures.
  • linear relationship with measures of plasma ACTH and cortisol in blood or urine does not necessarily exist
  • Nathan Goodyear on 13 Jul 11
     
    saliva cortisol testing is a better assessment tool for HPA axis function, compared to serum cortisol
Nathan Goodyear

The morning salivary cortisol response in burnout. [J Psychosom Res. 2005] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...16186006

cortisol saliva salivary hormone testing stress HPA

shared by Nathan Goodyear on 13 Jul 11 - No Cached
  • Nathan Goodyear on 13 Jul 11
     
    cortisol salivary testing.  elevated am cortisol reflective of HPA axis dysfunction due to stress.
Nathan Goodyear

Clomiphene citrate effects on testosterone/estroge... [J Sex Med. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16422830

clomid HPA low T testosterone estrogen estradiol hypogonadism men male hormone hormones

shared by Nathan Goodyear on 24 Jul 14 - No Cached
  • Nathan Goodyear on 24 Jul 14
     
    small cohort with low serum Total Testosterone improved T:E2 ratio with clomid.  Clomid restores the HPA through inhibition of the negative feedback of Estradiol on the Hypothalamus and Pituitary in men.  This allows for an increase in gonadotropin production and thus increase in testosterone production.  Aromatase inhibition therapy would likely still prove beneficial in this situation.
Nathan Goodyear

Hypothalamic-Pituitary-Testicular Axis Disruptions in Older Men Are Differentially Linked to Age and Modifiable Risk Factors: The European Male Aging Study: The Journal of Clinical Endocrinology & Metabolism: Vol 93, No 7 - 0 views

press.endocrine.org/...jc.2007-1972

low T low Testosterone low T Testosterone aging LH hormone hormones men male SHBG

shared by Nathan Goodyear on 03 Sep 14 - No Cached
  • 0.4–2% annual decline
  • the age trend in free T was more substantial (−1.3% per annum)
  • The core hormonal pattern with increasing age is suggestive of incipient primary testicular dysfunction with maintained total T and progressively blunted free T associated with higher LH.
  • ...16 more annotations...
  • Obesity was associated with progressively lower total and free T independent of the simultaneous decrease in SHBG.
  • our data highlight the fact that LH was unchanged or even lower in older men in the face of lower T in obesity, suggesting that there may be a failure at the hypothalamic-pituitary level.
  • a change in BMI from nonobese to obese may be equivalent to a 15 yr fall in T.
  • This pattern supports the hypothesis that different underlying mechanisms influence the functions of the HPT axis: age predominantly affects testicular function, whereas obesity impairs hypothalamic/pituitary function.
  • the effects of aging on testicular function can be moderated by increased LH compensation for many decades
  • obesity impairs hypothalamic/pituitary function independent of age, arguably an adaptive response for which there should be no compensatory mechanism.
  • the concurrent but opposite (and separate) effects of obesity and age on SHBG
  • SHBG was negatively associated with increasing strata of obesity
  • Obesity is associated with insulin resistance (28), and the increased circulating insulin inhibits hepatic SHBG synthesis
  • the SHBG increase with age may be related to relative IGF-I deficiency (27), although this has not been directly proven.
  • Obesity is associated with peripheral and central insulin resistance (30) and proinflammatory cytokine production (TNFα and IL-6) from adipocytes (31) and central nervous system endocannibinoid release (32), all of which are potential candidates for abrogating hypothalamic endocrine and downstream reproductive axis functions.
    • Nathan Goodyear
      Nathan Goodyear on 03 Sep 14
       
      The HPA axis effect may be the result of inflammation.
  • The relationship between obesity and T can be bidirectional: low T may be the cause rather than consequence of obesity
  • chronic alcohol abuse is known to suppress LH (40), our data showed no significant association among the three hormones or SHBG and alcohol intake.
  • increase in total T in smokers occurs through a primary increase in SHBG with a compensatory rise in LH
  • the effects of obesity (BMI or waist circumference) was by far the most important determinant of variance in total T, whereas age per se was important for SHBG, LH, and free T with comorbidity and smoking being comparatively minor contributors
  • It is noteworthy that these predisposing lifestyle and health factors are modifiable. This implies that the apparent age-related decline in T may constitute a barometer of health and thus be potentially preventable and/or reversible.
  • Nathan Goodyear on 03 Sep 14
     
    Age induced decline in Testosterone is more associated with a decline in leydig cell function and thus elevated LH will be associated.  In contrast, obesity is more of a HPA axis disruption and thus LH may be normal to low.  The pulse amplitude is decrease.  No change in pulse frequency is noted.   With obesity, a decline in TT and fT was independent of SHBG. Aging is associated with a greater decrease in fT versus TT.
Nathan Goodyear

Sex hormone synthesis, regulation, and function | McMaster Pathophysiology Review - 0 views

www.pathophys.org/sexhormones

hormones HPA Testosterone DHEA estradiol LH FSH Progesterone androgens estrogen

shared by Nathan Goodyear on 02 Oct 17 - No Cached
  • Nathan Goodyear on 02 Oct 17
     
    Good review of the HPA-sex hormone pathways, called the Hypothalamic-Pituitary-Gondal axis, including HP feedback.  This is not a study but has nice diagrams. This is based on 14 referenced articles and 1 book chapter.
Nathan Goodyear

A Cohort Effect on Serum Testosterone Levels in Finnish Men - 0 views

eje-online.org/...EJE-12-0288.abstract

testosterone low T low testosterone low T finnish serum

shared by Nathan Goodyear on 08 Dec 12 - No Cached
  • Nathan Goodyear on 08 Dec 12
     
    Finnish study of 3,271 men found that there was a decline in serum free testosterone levels in recently born boys compared to previous generations.  Additionally, they found inappropriate HPA response to this decline in testicular testosterone.
Nathan Goodyear

Salivary cortisol monitoring: de... [Allergy Asthma Proc. 2012 Jul-Aug] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22856637

saliva salivary cortisol testing hormone hormones

shared by Nathan Goodyear on 04 Jan 13 - No Cached
  • Nathan Goodyear on 04 Jan 13
     
    This study found salivary cortisol testing is a better technique for children, in evaluating HPA axis function in children with asthma.
Nathan Goodyear

Acute and delayed effects of a single-dose inject... [Metabolism. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9781636

TSH thyroid TSH suppression IL-6 cytokine inflammation inflammatory

shared by Nathan Goodyear on 01 Feb 13 - No Cached
  • Nathan Goodyear on 01 Feb 13
     
    IL-6 is known to stimulate the HPA and increase cortisol production.  Both, IL-6 and cortisol can decrease TSH production.
Nathan Goodyear

Activation of the hypothalamo-pituitary-a... [Intensive Care Med. 1999] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10660848

TSH TSH suppression thyroid inflammation inflammatory cytokines IL-1Beta IL-6 TNF-alpha

shared by Nathan Goodyear on 01 Feb 13 - No Cached
  • Nathan Goodyear on 01 Feb 13
     
    Septic illnesses found to be associated with suppression of TSH centrally in the HPA axis. The cytokines found to be elevated were IL-1beta, TNF-alpha, and IL-6.
Nathan Goodyear

Thyrotropin suppression by metformin in a cohort of patients with differentiated thyroid cancer in follow-up - 0 views

www.endocrine-abstracts.org/...ea0020p141.htm

TSH thyroid metformin

shared by Nathan Goodyear on 31 Jan 13 - No Cached
  • Nathan Goodyear on 31 Jan 13
     
    Again, showing that metformin suppresses TSH secretion without change in actual thyroid hormone levels.  We know that inflammation plays a role in HPA suppression, why not with TSH?
Nathan Goodyear

HPA Axis Reactivity and Lymphocyte Glucocorticoid Sensitivity in Fibromyalgia Syndrome and Chronic Pelvic Pain - 0 views

www.psychosomaticmedicine.org/...65.abstract

fibromyalgia saliva salivary cortisol urinary metabolites stress HPA

shared by Nathan Goodyear on 24 Apr 12 - No Cached
  • Nathan Goodyear on 24 Apr 12
     
    Individuals with Fibromyalgia shown to have lowered salivary cortisol levels.  This study suggested that this could be due to reduced adrenal reactivity to ACTH.  Another thought, is there increased metabolism of cortisol in these clients.  This would be found in the urinary metabolites.
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