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Nathan Goodyear

Thyrotropin Suppression by Metformin - 0 views

jcem.endojournals.org/...225.long

TSH thyroid metformin

shared by Nathan Goodyear on 31 Jan 13 - No Cached
  • Nathan Goodyear on 31 Jan 13
     
    Metformin shown to suppress TSH secretion without change in free t4 or free t3 levels.  This again, shows the lack of reliability of the test TSH.  With the suppression of TSH indicated in this study, the free t4 and t3 should have been elevated, but were obviously not.
Nathan Goodyear

Thyrotropin suppression by metformin in a cohort of patients with differentiated thyroi... - 0 views

www.endocrine-abstracts.org/...ea0020p141.htm

TSH thyroid metformin

shared by Nathan Goodyear on 31 Jan 13 - No Cached
  • Nathan Goodyear on 31 Jan 13
     
    Again, showing that metformin suppresses TSH secretion without change in actual thyroid hormone levels.  We know that inflammation plays a role in HPA suppression, why not with TSH?
Nathan Goodyear

Interleukin-1 inhibits thyrotrophin-induced hum... [J Endocrinol. 1989] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2788696

TSH TSH suppression IL-1 cytokine inflammation inflammatory thyroid

shared by Nathan Goodyear on 01 Feb 13 - No Cached
  • Nathan Goodyear on 01 Feb 13
     
    IL-1, an inflammatory cytokine, down regulates TSH gene activity.  Take home: inflammation via IL-1 supresses TSH production.  
Nathan Goodyear

Activation of the hypothalamo-pituitary-a... [Intensive Care Med. 1999] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10660848

TSH TSH suppression thyroid inflammation inflammatory cytokines IL-1Beta IL-6 TNF-alpha

shared by Nathan Goodyear on 01 Feb 13 - No Cached
  • Nathan Goodyear on 01 Feb 13
     
    Septic illnesses found to be associated with suppression of TSH centrally in the HPA axis. The cytokines found to be elevated were IL-1beta, TNF-alpha, and IL-6.
Nathan Goodyear

Suppression of Rat Thyrotroph and Thyroid Cell Function by Tumor Necrosis Factor-&#x3b1... - 0 views

online.liebertpub.com/...thy.1993.3.325

TNF-alpha inflammation inflammatory cytokines TSH TSH suppression thyroid

shared by Nathan Goodyear on 01 Feb 13 - No Cached
  • Nathan Goodyear on 01 Feb 13
     
    TNF-alpha inhibits TSH secretion in response to TRH stimulus.
Nathan Goodyear

Approach to a low TSH level: Patience is a virtue - 0 views

www.ccjm.org/...803.full

TSH thyroid

shared by Nathan Goodyear on 31 Jan 13 - No Cached
  • Nathan Goodyear on 31 Jan 13
     
    IN the key points: "a low TSH level is not always the result of suppression by elevations in circulating thyroid hormones"
Nathan Goodyear

TSH secretion in Cushing's syndrome: r... [Clin Endocrinol (Oxf). 1990] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2128925

TSH cortisol Cushing's syndrome

shared by Nathan Goodyear on 01 Oct 13 - No Cached
  • Nathan Goodyear on 01 Oct 13
     
    elevated cortisol associated with Cushing's syndrome suppresses TSH.
Nathan Goodyear

Acute and delayed effects of a single-dose inject... [Metabolism. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9781636

TSH thyroid TSH suppression IL-6 cytokine inflammation inflammatory

shared by Nathan Goodyear on 01 Feb 13 - No Cached
  • Nathan Goodyear on 01 Feb 13
     
    IL-6 is known to stimulate the HPA and increase cortisol production.  Both, IL-6 and cortisol can decrease TSH production.
Nathan Goodyear

Prolonged effects of tumor necrosis factor-alpha on... [Peptides. 1995] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7479297

TSH TSH suppression TNF-alpha inflammation inflammatory cytokine thyroid

shared by Nathan Goodyear on 01 Feb 13 - No Cached
  • Nathan Goodyear on 01 Feb 13
     
    TNF-alpha shown to inhibit TSH release from the anterior pituitary.
Nathan Goodyear

The pathophysiologic roles of interleukin-6 i... [Ann Intern Med. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9441573

TSH IL-6 inflammation inflammatory cytokines

shared by Nathan Goodyear on 01 Oct 13 - No Cached
  • Nathan Goodyear on 01 Oct 13
     
    IL-6 suppresses TSH.
Nathan Goodyear

Suppression of thyrotropin-releasing horm... [Neuroendocrinology. 1994] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8127401

TRH thyroid IL-1 IL-1Beta inflammation inflammatory cytokine

shared by Nathan Goodyear on 01 Feb 13 - No Cached
  • Nathan Goodyear on 01 Feb 13
     
    IL-1beta inhibits TRH gene activity.  Previous study has shown that IL-1 suppresses TSH production also.
Nathan Goodyear

Peripheral metabolism of thyroid hormones: a revie... [Altern Med Rev. 2000] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...10956378

hypothyroidism hypothyroid T4 T3

shared by Nathan Goodyear on 20 Dec 10 - No Cached
  • The common feature of these disorders is a low level of circulating T3, with generally normal to slightly elevated blood T4 levels and either normal or slightly suppressed TSH levels. This pattern of altered thyroid hormone levels is generally agreed to be a result of impairment in extra-thyroidal peripheral metabolism
  • Nathan Goodyear on 20 Dec 10
     
    thyroid replacement is not just about T4 (synthroid); but about T3, which is 5.4 x more potent
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