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Effects of progesterone administration on infarct volume and functional deficits follow... - 0 views

www.ncbi.nlm.nih.gov/...PMC2656912 progesterone hormone hormones brain neurology
shared by Nathan Goodyear on 10 Jul 12 - No Cached
  • Nathan Goodyear on 10 Jul 12
     
    progesterone shown to provide substantial reduction in volume of infarct in rat stroke model.  This is very promising, and with with other studies revealing the same benefit in the human brain, progesterone should become a part of initial treatment in those with acute brain injuries and should be evaluated for those with aging diseases of the brain.
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Salivary Cortisol Responsivity to an Intravenous Catheter Insertion in Children with At... - 0 views

jpepsy.oxfordjournals.org/...902.abstract salivary testing saliva cortisol ADHD pediatrics
shared by Nathan Goodyear on 27 Nov 11 - No Cached
  • Nathan Goodyear on 27 Nov 11
     
    salivary cortisol used to assess cortisol levels in ADHD
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PsychiatryOnline | The Journal of Neuropsychiatry and Clinical Neurosciences | The Neur... - 0 views

neuro.psychiatryonline.org/article.aspx TBI traumatic brain injury pituitary neuroendocrine deficits injury brain sex hormone HGH growth
shared by Nathan Goodyear on 03 Feb 12 - No Cached
  • Nathan Goodyear on 03 Feb 12
     
    TBI results in hormone disruption in 25-69% of those effected.  The major cause is a pituitary/neuro-endocrine effect.  This has been described since the early 20th century.
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Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 trans... - 0 views

www.ncbi.nlm.nih.gov/...PMC2725435 IV vitamin C brain Alzheimer's disease dementia cognition cognitive function learning
shared by Nathan Goodyear on 08 Mar 12 - No Cached
  • Nathan Goodyear on 08 Mar 12
     
    IV vitamin C improves cognitive function in mice model.  
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D-Chiro-Inositol - Its Functional Role in Insulin Action and its Deficit in Insulin Res... - 0 views

www.ncbi.nlm.nih.gov/...PMC2478565 D-chiro-inositiol IR insulin resistance sensitivity
shared by Nathan Goodyear on 19 Nov 11 - No Cached
  • Nathan Goodyear on 19 Nov 11
     
    d-chiro-inositol improves insulin sensitivity and thus reduces insulin resistance
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Estrogen Levels Are Associated with Extinction Deficits in Women with Posttraumatic Str... - 0 views

www.biologicalpsychiatryjournal.com/...abstract estrogen Estradiol E2 anxiety PTSD mood disorders posttraumatic stress disorder women stress
shared by Nathan Goodyear on 15 Jul 13 - No Cached
  • Nathan Goodyear on 15 Jul 13
     
    Women with lower estrogen levels more likely to develop PTSD.  This study looked at estradiol.  So, when this study references estrogen, it is referencing estradiol.
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The history of attention deficit hyperactivity disorder - 0 views

www.ncbi.nlm.nih.gov/...PMC3000907 ADD ADHD history
shared by Nathan Goodyear on 07 Oct 13 - No Cached
  • Nathan Goodyear on 07 Oct 13
     
    History of ADD/ADHD
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[Androgenic deficit and its treatment in stroke male patients with diabetes mellitus ty... - 0 views

www.researchgate.net/...with_diabetes_mellitus_type_II low T Testosterone hypogonadism diabetes type II diabetes stroke therapy treatment men male hormone hormones
shared by Nathan Goodyear on 13 May 14 - No Cached
  • Nathan Goodyear on 13 May 14
     
    Small study of 154 men post 1rst stroke finds a reduction in a second ischemic stroke with Testosterone therapy.  That equals a 7.1% risk of secondary stroke in the Testosterone treated group (diagnosed with low T) versus 16.6% in the untreated group.  Testosterone was started one week after the first stroke event.
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Golden Motor Electric Wheelchair - 0 views

www.wheelchairindia.com/...GM-LITE-POWER-WHEELCHAIR Power Wheelchairs Controlled Wheelchair Users accessories and equipment Best Power Wheelchair reduces downward sliding motorized Standing Wheelchair Golden Motor Electric Wheelchair
shared by wheelchairindia9 on 19 Apr 15 - No Cached
  • wheelchairindia9 on 19 Apr 15
     
    Powerchairs are generally four-wheeled or six-wheeled and non-folding, however some folding designs exist and other designs may have some ability to partially dismantle for transit. Four general styles of powerchair drive systems exist: front, centre or rear wheel drive and all-wheel drive. Powered wheels are typically somewhat larger than the trailing/castoring wheels, while castoring wheels are typically larger than the castors on a manual chair. Centre wheel drive powerchairs have castors at both front and rear for a six-wheel layout. Angel Wheelchair Electric standing wheelchair Standing up, driving function by power. Head and signal light (controlled by joystick). Adjustable headrest. Adjustable footplate. Detachable backrest Rigid steel framework W/liquid coating Flip-backward armrest Max speed: 9.15KM/H Front castor: 2.80/2.50-4 pneumatic castor (9") Rear wheels: 3.00-8 pneumatic tire (14") Available seat width: A (46 cm), D (42 cm) Max loading: A size: 135 kg Net weight w/o battery: 62.7 kg A powerchairs is a wheelchair that is propelled by means of an electric motor rather than manual power. Power wheelchairs are useful for those unable to propel a manual wheelchair or who may need to use a wheelchair for distances or over terrain which would be fatiguing in a manual wheelchair. They may also be used not just by people with 'traditional' mobility impairments, but also by people with cardiovascular and fatigue based condition. An powerwheelchair powers more than just chair. It gives the power to safely travel long distances on own. It empowers to navigate through home, backyard, school, workplace or local park. It gives power to do the things,want to do. It gives power. When accidents occur that leave permanent leg injuries, or as age sets in and joint pain becomes unbearable, the power chair acts as a gateway to continue living life to the fullest. The powerwheelchairs in our lineup are all battery powered, yet each device fills
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PLOS ONE: Depletion of Brain Docosahexaenoic Acid Impairs Recovery from Traumatic Brain... - 0 views

journals.plos.org/...article DHA TBI traumatic brain injury omega 3 brain injury brain omega-3
shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • The polyunsaturated fatty acids linoleic (LA, 18:2n-6) and linolenic acid (LNA, 18:3n-3) are essential fatty acids that cannot be synthesized by the body.
  • LNA serves as the precursor for long chain omega-3 fatty acids such as docosahexaenoic acid (DHA) while LA is converted into long chain omega-6 fatty acids such as arachidonic acid (AA)
  • DHA and AA are abundantly found in the brain, where these are stored mainly in membrane phospholipids
  • ...10 more annotations...
  • DHA has been shown to increase neurite outgrowth and synaptogenesis, and promotes glutamatergic neurotransmission through increase in glutamate receptor subunit expression
  • DHA has been shown to be converted to anti-inflammatory, proresolving and neuroprotective mediators, such as resolvins [7] and protectins
  • AA is converted by cyclooxygenases into 2-series prostaglandins and 4-series leukotrienes, most of which exert pro-inflammatory effects
  • Supplementation of DHA exerts neuroprotective effects and has been reported to afford protection from diffuse axonal injury [11] and mixed brain injury [12] as well
  • severe depletion of membrane DHA in the brain renders mice significantly more susceptible to TBI and impairs recovery following the injury
  • Omega-3 fatty acids may serve as nutraceutical agents and precondition the brain to make it more resilient to injury
  • it can be suggested that enriching DHA in the brain may be prophylactic and protective against brain injury
  • severe DHA deficiency in the brain impairs functional recovery from TBI in terms of vestibulo-motor and cognitive deficits
  • DHA deficiency further elevates TBI-induced production of SBDPs
  • less neurons were found around the injury site of DHA deficient brain after TBI compared to the omega-3 fatty acid adequate group
  • Nathan Goodyear on 31 Aug 15
     
    mouse study finds prolonged recovery in DHA deficient mice compared to controls.
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Dietary Strategy to Repair Plasma Membrane After Brain Trauma - 0 views

nnr.sagepub.com/...75.long curcumin DHA TBI traumatic brain injury brain injury neuroinflammation BDNF brain derived neurotrophic factor brain
shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • concussive brain injury is a major cause of neuropsychological disability in spite of no obvious neuronal death
  • TBI elicits oxidative damage to plasma membrane phospholipids
  • DHA is the most abundant polyunsaturated fatty acid (PUFA) in the brain, where the DHA-containing phospholipids contribute to plasma membrane biogenesis and receptor signaling
  • ...10 more annotations...
  • curcumin has potent anti-inflammatory and antioxidant activities that can function to reduce oxidative damage and cognitive deficits associated with neurological disorders
  • Curcumin provided in the diet before TBI can reduce oxidative damage and counteract TBI-related cognitive dysfunction
  • Our previous study indicated that n-3 fatty acids supplemented in the diet counteracted learning disability after TBI
  • curcumin contributes to enhance the effects of DHA on TBI by promoting phosphorylation of the BDNF receptor TrkB in the hippocampus
  • previous evidence indicates that curcumin10 and DHA5 counteract TBI-related learning disability by involving BDNF
  • Our findings indicate that curcumin counteracted the TBI-related reduction in n-3 DPA.
  • curcumin may promote the conversion of n-3 DPA to DHA
  • the combination of both nutrients has been reported to produce anti-inflammatory action
  • the enhanced actions of curcumin and DHA in reducing cholesterol levels could be interpreted as preservation of levels of phospholipids in the plasma membrane
  • curcumin and DHA may contribute to reduce inflammation associated with the action of cholesterol in the pathology of TBI.
  • Nathan Goodyear on 31 Aug 15
     
    Curcumin and DHA shown to protect against TBI through a reduction in inflammation and maintenance of brain phospholipid membranes.  BDNF is increases also.
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Fructose decreases physical activity and increases body fat without affecting hippocamp... - 0 views

www.nature.com/...srep09589.html fructose obesity fat diet nutrition activity physical activity
shared by Nathan Goodyear on 03 Aug 15 - No Cached
  • the fructose animals gained significantly more weight than the glucose animals
  • The average liver mass of mice in the fructose treatment group was 20% heavier than for mice in the glucose group
  • The fat pads of mice consuming the fructose diet were 69% heavier than the fat pads of animals consuming the glucose diet
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  • there are many studies showing that consumption of fructose in comparison to other monosaccharides results in increased de novo lipogenesis, dyslipidemia, insulin resistance, BW6, 7 and, most recently, impaired cognitive function
  • in the present study, the intake of fructose by mice was more similar to that of typical human consumption in comparison to previous studies
  • prolonged consumption of diets containing fructose (11 weeks) increased BW and body fat deposition
  • studies in humans confirm that fructose, but not glucose (when provided as 25% of energy requirements), in the context of an energy-balanced diet increases de novo lipogenesis and visceral adiposity along with dyslipidemia, decreases insulin sensitivity10, 12 and decreases in fat oxidation
  • we hypothesize that fructose may reduce voluntary energy expenditure in terms of physical activity.
  • significant reduction (~20%) in physical activity in the fructose-fed animals in comparison to glucose
  • a recent study reported that ingestion of fructose (25% energy intake, 10 weeks) in human volunteers also resulted in reduced energy expenditure in relation to a diet with the same glucose dose
  • There is certainly evidence to suggest that, for example, exercise is able to prevent dyslipidemia in healthy subjects fed a weight-maintenance high-fructose diet (30%)54, which strongly suggests a protective role of physical activity in metabolic regulation.
  • the potential negative effects of fructose in brain and cognitive function have been investigated, with a series of studies showing cognitive deficits in spatial memory and learning in adolescent and adult animals following access to a high fructose diet
  • access to both fructose and sucrose, but not glucose, results in a 40% reduction in hippocampal neurogenesis
  • Collectively these studies seem to suggest that fructose consumption can have a considerable impact on hippocampal function and learning, which is in direct contrast with what we observed.
  • the impact of fructose is apparent only in BW, liver mass and body fat, but not in cognitive measures or rates of neurogenesis
  • Nathan Goodyear on 03 Aug 15
     
    animal study finds that fructose increased liver mass, abdominal fat and decreased physical activity when compared to glucose.  The study groups were iso caloric, but one group was fed 18% fructose and the other 18% glucose.
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Coenzyme Q10 in neuromuscular and neurodegenerativ... [Curr Drug Targets. 2010] - PubMe... - 0 views

www.ncbi.nlm.nih.gov/...20017723 CoQ10 Alzheimer's Parkinson's ALS Dementia Neurodegenerative disease
shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • a deficit in CoQ10 status has been determined in a number of neuromuscular and neurodegenerative disorders
  • A secondary loss of CoQ10 status following HMG-Coa reductase inhibitor (statins) treatment has be implicated in the pathophysiology of the myotoxicity associated with this pharmacotherapy
  • Nathan Goodyear on 07 Feb 11
     
    CoQ10 contributes to neurodegenerative disease, Parkinson's, Alzheimer's, ALS..., in some
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Coenzyme Q10 as a possible treatment for neurodege... [Free Radic Res. 2002] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...12069110 coenzyme q10 CoQ10 Huntington's disease neurodegenerative
shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • CoQ10 can significantly extend survival, delay motor deficits and delay weight loss and attenuate the development of striatal atrophy in a transgenic mouse model of HD
  • Nathan Goodyear on 07 Feb 11
     
    CoQ10 shown to shown to slow progression of the neurodegenerative disease: Huntington's disease
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Attention-Deficit/Hyperactivity Disorder and Urinary Metabolites of Organophosphate Pes... - 0 views

pediatrics.aappublications.org/...e1270 ADHD pesticide exposure Organophosphates
shared by Nathan Goodyear on 21 Mar 11 - No Cached
  • Nathan Goodyear on 21 Mar 11
     
    ADHD and pesticide exposure
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Oral Treatment With α-Lipoic Acid Improves Symptomatic Diabetic Polyneuropathy - 0 views

care.diabetesjournals.org/...2365.abstract alpha Lipoic Acid diabetic neuropathy
shared by Nathan Goodyear on 05 Apr 11 - No Cached
  • Oral treatment with ALA for 5 weeks improved neuropathic symptoms and deficits in patients with DSP
  • Nathan Goodyear on 05 Apr 11
     
    alpha Lipoic Acid improves Diabetic Neuropathy
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How environmental and genetic factors combine to c... [Neurotoxicology. 2008] - PubMed ... - 0 views

www.ncbi.nlm.nih.gov/...18031821 autism spectrum disorders ASD
shared by Nathan Goodyear on 05 Jul 11 - No Cached
  • Genetic polymorphisms adversely affecting sulfur metabolism, methylation, detoxification, dopamine signaling and the formation of neuronal networks occur more frequently in autistic subjects.
  • a "redox/methylation hypothesis of autism" is described, in which oxidative stress, initiated by environment factors in genetically vulnerable individuals, leads to impaired methylation and neurological deficits secondary to reductions in the capacity for synchronizing neural networks.
  • Nathan Goodyear on 05 Jul 11
     
    proposed hypothesis of autism
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Intravenous Fluid Use in Athletes - 0 views

www.ncbi.nlm.nih.gov/...PMC3435915 IV intravenous fluid nutrition athletes athlete sports medicine sports exercise
shared by Nathan Goodyear on 13 Jan 15 - No Cached
  • Treatment of exercise-associated hyponatremia with hypertonic IV infusion to correct plasma sodium levels is also a standard and accepted use of IV fluid infusions
  • athletes who present for medical care with hypernatremia who cannot tolerate oral fluids can benefit from IV fluids
  • Vaporization of sweat accounts for 80% of heat loss in hot, dry atmospheric conditions. This mechanism of water loss is the major contributor for exercise-associated dehydration
  • ...30 more annotations...
  • The rate of water loss can be quantified through measurement of sweat rate
  • Pre- and postexercise body weight measurements are the most common means to estimate overall water loss but are condition specific
  • It appears that 1% to 2% body weight loss is well tolerated by the exercising athlete
  • Dehydration, defined as greater than 2% loss of body weight, can negatively affect performance
  • In highly trained endurance athletes, plasma volume and sodium serum concentration were preserved despite a 5% body weight loss
  • In Ironman triathletes, dehydration to 5% body weight loss did not correlate with occurrence of medical complications
  • hydration should begin hours prior to exercise, especially if known deficits are present, and fluids should be consumed at a slow, steady rate, with 5 to 7 mL/kg taken 4 hours prior to exercise
  • Sodium concentration did not produce significant changes in the rate of absorption but was primarily dependent on carbohydrate concentration
  • Replacing 150% of body weight loss over 60 minutes has been tolerated without complications
  • IV treatment of severe dehydration (>7% body weight loss), exertional heat illness, nausea, emesis, or diarrhea, and in those who cannot ingest oral fluids for other reasons, is clinically indicated
  • A recent survey of the National Football League teams revealed that 75% (24 of 32) of the teams utilized IV infusion of fluids for prehydration in at least some otherwise healthy individuals
  • In the National Football League, an average of 1.5 L of normal saline was administered approximately 2.5 hours prior to competition
  • after 2 hours of exercise, the rectal temperature was 0.6° higher in the group not receiving IV infusion. Also, stroke volume and cardiac output were 11% to 16% lower in the control group versus the IV infusion group.
  • Recent evidence suggests the etiology of EAMC is related to muscle fatigue and neuronal excitability
  • no correlation between hydration status or electrolyte concentrations with EAMC
  • there may be a subset of muscle cramping that is associated with a loss of both body fluid and sodium
  • Glycerol is the primary agent for oral hyperhydration
  • elevation of plasma volume by 200 to 300 mL via dextran infusion resulted in 15% increase in stroke volume, 4% increase in VO2 max, and an increase in the exercise time to fatigue
  • Neither the tonicity nor mode of hydration resulted in improved speed of rehydration, greater fluid retention, or improved performance
  • There are beneficial anecdotal reports of EAMC treatment in elite and professional-level athletes with IV hydration during the course of an event
  • Plasma volume was better restored during rehydration with IV fluids at preexercise and 5 minutes of exercise. At 15 minutes, there was no difference between IV and oral rehydration
  • More rapid restoration of plasma volume was accomplished in the IV treatment group with no advantages over oral rehydration in physiological strain, heat tolerance, ratings of perceived effort, or thermal sensations
  • No difference was found in exercise time to exhaustion. IV and oral rehydration methods were equally effective. Heart rates were statistically higher in the oral rehydration group through 75 minutes of exercise, and there were higher increases in norepinephrine plasma concentrations
  • No significant differences between the groups were found for time to recovery, number of days with pain, number of days with stiffness, sleep disturbance, fatigue, rectal temperature, and loss of appetite
  • The current data suggest that IV rehydration is faster than oral
  • There may be physiological benefits of decreased heart rate and norepinephrine in athletes rehydrated via IV route
  • Postexercise blood 1 hour and 24 hours showed no differences in circulating myoglobin or creatine kinase
  • The use of IV fluid may be beneficial for a subset of fluid sensitive athletes
  • this should be reserved for high-level athletes with strong histories of symptoms in well-monitored settings.
  • Volume expanders may also be beneficial for some athletes
  • Nathan Goodyear on 13 Jan 15
     
    to be read
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Magnesium L-threonate prevents and restores memory deficits associated with n... - 0 views

www.ncbi.nlm.nih.gov/...24077207 magnesium threonate magnesium memory brain brain health
shared by Nathan Goodyear on 26 Sep 17 - No Cached
  • Nathan Goodyear on 26 Sep 17
     
    Magnesium threonate useful in reducing TNF-alpha  and improve memory in animal model.  Magnesium threonate crosses the BBB well.
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