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Nathan Goodyear

Omega-3 fatty acids as treatments for mental illness: which disorder and which fatty ac... - 0 views

www.dietaryfiberfood.com/...atty-acid-mental-disorders.php

Omega-3 mood disorders depression bi-polar

shared by Nathan Goodyear on 15 Feb 11 - No Cached
  • The most convincing evidence for beneficial effects of omega-3 PUFA is to be found in mood disorders. A meta-analysis of trials involving patients with major depressive disorder and bipolar disorder provided evidence that omega-3 PUFA supplementation reduces symptoms of depression. Furthermore, meta-regression analysis suggests that supplementation with eicosapentaenoic acid may be more beneficial in mood disorders than with docosahexaenoic acid,
  • Nathan Goodyear on 15 Feb 11
     
    Omega-3 beneficial in depression and bi-polar clients
Nathan Goodyear

Kynurenine Pathway Metabolites in Humans: Disease and Healthy States - 0 views

www.la-press.com/and-healthy-stat-article-a1204

kynurenine pathway neurodegenerative disorders excitotoxicity ALS Parkinson's disease Alzheimer's mood disorder depression anxiety quinolinate picolinate disordered tryptophan metabolism

shared by Nathan Goodyear on 27 Oct 11 - No Cached
  • Nathan Goodyear on 27 Oct 11
     
    review of studies looking at kyneurenine pathway and it's contribution to neurodegenerative disorders and mood disorders
Nathan Goodyear

Mood Disorders and Obesity: Understanding Inflammation as a Pathophysiological Nexus | ... - 0 views

www.academia.edu/..._as_a_Pathophysiological_Nexus

obesity overweight mood disorders depression anxiety weight loss' leptin adiponectin inflammation cytokines

shared by Nathan Goodyear on 22 Jan 13 - No Cached
  • Nathan Goodyear on 22 Jan 13
     
    good review of the interaction between the immune system and the neuroendocrine system in obesity and mood disorders.  
Nathan Goodyear

Salivary testosterone: Associations with depression, anxiety disorders, and antidepress... - 0 views

www.jpsychores.com/...abstract

saliva salivary low testosterone depression anxiety mood disorders

shared by Nathan Goodyear on 25 Apr 12 - No Cached
  • Nathan Goodyear on 25 Apr 12
     
    large study revealed that low salivary testosterone is associated with increased depression, anxiety, and other mood disorders.
Nathan Goodyear

Nutritional therapies for mental disorders - 0 views

www.ncbi.nlm.nih.gov/...PMC2248201

vitamins nutritional therapy vitamin mood disorders depression anxiety bipolar shizophrenia OCD

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    Nutritional therapies for mood disorders.
Nathan Goodyear

Neurobiological effects of the green tea constituent theanine and its potential role in... - 0 views

www.maneyonline.com/...1476830513Y.0000000079

green tea tea l-theanine anxiety brain mood BDNF

shared by Nathan Goodyear on 27 May 15 - No Cached
  • Nathan Goodyear on 27 May 15
     
    Only abstract available: l-Theanine appears to be a glutamate receptor antagonist.  The effects of l-Theanine have shown to be positive with mood disorders, psychiatric conditions, and neurodegenerative diseases.  L-Theanine increases BDNF.
Nathan Goodyear

Effect of Testosterone Replacement Therapy on Cognitive Performance and Depression in M... - 0 views

www.ncbi.nlm.nih.gov/...PMC5209560

low T Low testosterone Testosterone male hormones Testosterone therapy depression brain cognition ED erectile dysfunction

shared by Nathan Goodyear on 09 Jan 17 - No Cached
  • Azad et al [15] used single photon emission computed tomography and showed that, after 3~5 weeks of TRT, cerebral perfusion was increased in the midbrain and the superior frontal gyrus in seven men with hypogonadism
  • After 12~14 weeks, increased perfusion was still observed in the midbrain as well as in the midcingulate gyrus
  • TDS patients who received TRT showed significant improvement in cognitive function only if mild cognitive impairment was present at baseline
  • ...4 more annotations...
  • Cherrier et al [17] evaluated a sample of 32 subjects, which included 17 men with mild cognitive impairment and 15 with Alzheimer's disease. At the 6-week follow-up, patients who received TRT showed significantly better scores regarding spatial memory, constructional abilities, and verbal memory compared to those noted in the placebo group. Taken together, these results suggest that TRT has a beneficial effect on cognitive function
  • TRT improved mood and well-being, and reduced fatigue and irritability in hypogonadal men
  • The study by Pope et al [20] involved men with depression refractory to standard anti-depressants, and found that TRT lowered the Hamilton Depression score,
  • depression tends to increase as testosterone levels decrease [21], it is highly likely that TRT improved symptoms of depression by increasing testosterone levels.
  • Nathan Goodyear on 09 Jan 17
     
    men with Testosterone <300 ng/dl with levels after 8 months of therapy achieving +680 ng/dl.
Nathan Goodyear

'Maternity blues' and hormone levels in saliva. [J Affect Disord. 1984] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...6235265

saliva salivary hormones hormone testing progesterone bioidentical

shared by Nathan Goodyear on 24 Nov 10 - No Cached
  • This pilot study has demonstrated the potential value of using a non-invasive technique (obtaining specimens of saliva) in conjunction with determinations of a predictable mood change.
  • Nathan Goodyear on 24 Nov 10
     
    salivary progesterone validated in mood evaluations
Nathan Goodyear

Vitamin D3 enhances mood in healthy subjects durin... [Psychopharmacology (Berl). 1998]... - 0 views

www.ncbi.nlm.nih.gov/...9539254

vitamin D seasons affective disorder depression

shared by Nathan Goodyear on 09 Dec 10 - No Cached
  • Nathan Goodyear on 09 Dec 10
     
    Vitamin D3 enhances mood in healthy subjects during winter.
Nathan Goodyear

Allopregnanolone and mood disorders. [Prog Neurobiol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23978486

allopregnanolone progesterone metabolite metabolites hormone hormones GABA PMDD women mood disorders

shared by Nathan Goodyear on 28 Jan 14 - No Cached
  • Nathan Goodyear on 28 Jan 14
     
    The progesterone metabolite allopregnanolone is shown to play a significant role in the PMDD symptoms.  The mechanism is via a paradoxical GABA-A effect.
Nathan Goodyear

Vitamin D status and ill health: a systematic review : The Lancet Diabetes & Endocrinology - 0 views

www.thelancet.com/...abstract

vitamin D vitamin d health

shared by Nathan Goodyear on 09 Dec 13 - No Cached
  • Nathan Goodyear on 09 Dec 13
     
    Another ill conceived conclusion by the authors.  IF you are going to study something, know everything about it.  They authors make a major statement about vitamin D, yet they seem to understand a basic understanding of vitamin dosing.  The authors stated that dosing 2,000 IU of vitamin D in those with levels < 50 provided no benefit.  That is of course correct, because 2,000 IU daily won't hold any levels stable, let alone increase levels to 70-80 where they need to be.  The authors of this study are stuck in the traditional RDC thinking here. What is interesting is that low vitamin D was associated with CVD, MS, dyslipidemia, inflammation, glucose dysmetabolism, infections, mood disorders, decline in cognition, impaired physical functioning, and all-cause mortality,  But, vitamin D supplementation is only good for bones.  The authors of this study make a mockery of medicine.
Nathan Goodyear

Estrogen Levels Are Associated with Extinction Deficits in Women with Posttraumatic Str... - 0 views

www.biologicalpsychiatryjournal.com/...abstract

estrogen Estradiol E2 anxiety PTSD mood disorders posttraumatic stress disorder women stress

shared by Nathan Goodyear on 15 Jul 13 - No Cached
  • Nathan Goodyear on 15 Jul 13
     
    Women with lower estrogen levels more likely to develop PTSD.  This study looked at estradiol.  So, when this study references estrogen, it is referencing estradiol.
Nathan Goodyear

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic... - 0 views

www.ncbi.nlm.nih.gov/...PMC3962576

microglia LDN low dose naltrexone pain inflammation

shared by Nathan Goodyear on 05 Jul 17 - No Cached
  • orally active competitive opioid receptor antagonist
  • 4.5&nbsp;mg, though the dosage can vary a few milligrams below or above that common value
  • At the low dosage level, naltrexone exhibits paradoxical properties, including analgesia and anti-inflammatory actions
  • ...10 more annotations...
  • LDN may be an effective treatment for FM
  • In addition to the antagonist effect on mu-opioid and other opioid receptors, naltrexone simultaneously has an antagonist effect on non-opioid receptors (Toll-like receptor 4 or TLR4) that are found on macrophages such as microglia
  • It is via the non-opioid antagonist path that LDN is thought to exert its anti-inflammatory effects
  • Once activated, microglia produce inflammatory and excitatory factors that can cause sickness behaviors such as pain sensitivity, fatigue, cognitive disruption, sleep disorders, mood disorders, and general malaise
  • The neuroprotective action appears to result when microglia activation in the brain and spinal cord is inhibited
  • By suppressing microglia activation, naloxone reduces the production of reactive oxygen species and other potentially neuroexcitatory and neurotoxic chemicals
  • suppressed TNF-alpha, IL-6, MCP-1, and other inflammatory agents in peripheral macrophages
  • individuals with greater ESR at baseline experienced a greater drop in pain when taking LDN
  • LDN has been reported to reduce not only self-reported pain in that condition but also objective markers of inflammation and disease severity
  • Naltrexone has also shown some promise in improving disease severity in multiple sclerosis
  • Nathan Goodyear on 05 Jul 17
     
    LDN maybe useful in treating chronic pain via anti-inflammatory effects on microglia.
Nathan Goodyear

CNS Spectrums: Inflammation, Glutamate, and Glia in Depression: A Literature Review - 0 views

www.cnsspectrums.com/...articledetail.aspx

inflammation depression excitotoxicity glutamate glutamic acid mood disorders

shared by Nathan Goodyear on 20 Jan 12 - No Cached
  • Nathan Goodyear on 20 Jan 12
     
    inflammation, glutamate excitotoxicity and depression.  A very nice review of how inflammation can remotely contribute to other arenas of dysfunction, ie. depression.
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