ENDOGENOUS SEX HORMONES, BLOOD PRESSURE CHANGE, AND RISK OF HYPERTENSION IN POSTMENOPAU... - 0 views
www.ncbi.nlm.nih.gov/...PMC3428144
hormone hormones Testosterone Estradiol Estrogen women CVD cardiovascular disease female SHBG hypertension post-menopause blood pressure
shared by Nathan Goodyear on 02 Feb 15
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Among postmenopausal women, serum T was elevated in hypertensive participants [9, 11, 12], and total T, free T, and DHEA were positively correlated with SBP
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T and DHEA were attenuated by adjustment for BMI, reflecting either a confounding or a mediating effect of obesity
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SHBG concentration was inversely associated with risk of hypertension and longitudinal rise of BP over time
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In intervention studies, successful weight loss and weight maintenance increased SHBG in men with obesity
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strong association between E2 and measures of insulin resistance in postmenopausal women, independent of adiposity
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In postmenopausal women that received hormone replacement therapy, estrogen therapy increased mononuclear cell secretion of tumor necrosis factor alpha (TNF-α)
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higher baseline concentrations of endogenous E2, total and bioavailable T, and DHEA and lower concentration of SHBG were associated with a higher incidence of hypertension and a greater increase in BP during follow-up