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spineneuro

Révolution du couteau gamma : un examen plus approfondi des taux de réussite en neurochirurgie indienne - 0 views

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    Le meilleur neurochirurgien gamma knife de Fortis est connu parmi les meilleurs au monde. Sa dextérité et sa vaste expérience dans le traitement de différents cas de cancer le distinguent des neurochirurgiens présents aux quatre coins du monde.
spineneuro

French to India Medical Travel: Du Rwanda à Delhi : voyage de Moneko Twahirwa avec le meilleur neurochirurgien Gamma Knife en Inde - 0 views

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    L'expérience de Mboneko Twahirwa avec le meilleur neurochirurgien au couteau gamma à Delhi, en Inde, résume la convergence d'une technologie médicale avancée, de soins experts et d'un coût abordable de radiochirurgie au couteau gamma en Inde.
spineneuro

French to India Medical Travel: Retour au bien-être : pourquoi les patients mozambicains optent pour une chirurgie de fusion vertébrale en Inde - 0 views

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    Récemment, l'Inde est devenue un point focal pour les patients mozambicains recherchant une chirurgie de fusion vertébrale, principalement en raison du rapport coût-efficacité de la chirurgie robotique de la colonne vertébrale dans le pays. Le facteur coût joue un rôle central pour inciter les patients mozambicains à opter pour une chirurgie de fusion vertébrale, car les dépenses sont environ 55 à 85 % inférieures à celles des pays développés comme les États-Unis et le Royaume-Uni.
Nathan Goodyear

The impact of the microbiome in cancer: Targeting metabolism of cancer cells and host - PMC - 0 views

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    Studies have found that high-salt diet can enhance the function of natural killer (NK) cells by enriching the abundance of Bifidobacterium, thus inhibiting tumor growth (63). High dietary fiber can enrich A. muciniphila, activate innate immunity, reshape the tumor microenvironment, and exert the function of inhibiting tumor (64). Notably, Wargo et al. have confirmed that high-dietary fiber diet can enhance anti-tumor immunity and increase the infiltration of tumor-killing T cells, while commercial probiotics treatment alone does not enhance the efficacy of immunotherapy. This study suggests that probiotics intervention is strain-specific and should be put in a specific dietary environment to make sense, to some extent (65).
Nathan Goodyear

Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome - 0 views

  • Activation of the innate immune system controls macronutrient metabolism
  • the innate immune response is the first line of defense against invading pathogens, wherein highly conserved pathogen-associated molecular patterns (PAMPs) are recognized by cognate pattern recognition receptors (PRRs
  • many studies have supported the idea that cytokine signaling directly promotes insulin resistance
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  • innate immune system may be causally linked to obesity
  • adipose tissue contains a substantial population of macrophages, and macrophage-driven adipose inflammation contributes significantly to the pathogenesis of obesity
  • Collectively, activation of the innate immune system is strongly associated with ASCVD, insulin resistance, and obesity, and recent evidence suggests that much of this association can be traced to a unique family of PRRs known as TLRs
  • TLRs are a family of type I transmembrane receptors, currently thought to comprise at least 13 members in mammals, that specifically recognize a variety of microbial PAMPs and trigger host cellular responses
  • Free SFAs have indeed been demonstrated to elicit TLR4-dependent and TLR2-dependent responses in several cell types.
  • Endogenous SFAs released from adipocytes activate cocultured macrophages via TLR4 [18], indicating the potential for cellular crosstalk in adipose tissue. Collectively, there is a growing body of evidence that SFAs promote, whereas long chain PUFA antagonize, TLR4-dependent and TLR2-dependent signaling in multiple cell models
  • In an elegant study, Shi et al. [16] demonstrated that SFAs activate TLR4-dependent signaling in both macrophages and adipocytes, and mice lacking TLR4 are protected against insulin resistance driven by intravenous lipid infusion
  • In addition to effects in macrophages and adipocytes, SFAs can activate TLR4 in the hypothalamus, which triggers a central inflammatory response that results in resistance to anorexigenic signals
  • endogenous SFAs can indeed promote innate immunity and inflammatory disease
  • This finding strongly supports the work of Hwang and coworkers [19–22] demonstrating that ω-3 PUFAs can effectively counteract SFA-induced TLR4 activation in cultured macrophages and dendritic cells.
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    high dietary fatty acids linked to metabolic syndrome through TLR.
Nathan Goodyear

Efficacy of Rg3-Enriched Korean Red Ginseng (Steamed Panax Ginseng C.A. Meyer) Extract on Arterial Stiffness and Blood Pressure in Healthy Volunteers -- Bhardwaj et al. 24 (1): 739.5 -- The FASEB Journal - 0 views

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    not only does Rg3 appear to be good for a stressed brain, but this study links it to a reduction blood pressure.
Nathan Goodyear

Low serum testosterone and increased mortality in men with coronary heart disease -- Malkin et al. 96 (22): 1821 -- Heart - 0 views

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    low serum testosterone associated with increased mortality in men with coronary disease. This study used "bio-available" testosterone and total testosterone.
Nathan Goodyear

LRRK2 G2019S Impairs Chaperone-Mediated Autophagy in Neurons (S13.003) -- Kuo et al. 80 (1001): S13.003 -- Neurology - 0 views

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    impaired auto destruction process leads to the Lewy bodies found in Parkinson's disease.
Nathan Goodyear

Does increased aromatase activity in adipose fibroblasts cause low sexual desire in patients with HIV lipodystrophy? -- Goldmeier et al. 78 (1): 64 -- Sexually Transmitted Infections - 0 views

  • high oestrogen levels in men do not necessarily result in a fall in androgen levels
  • These high oestrogen levels, therefore, seem capable of decreasing sexual libido and lowering sexual activity
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    Increased aromatase activity and resultant estrogen production negatively effects libido in HIV men.  I don't believe that this effect is just found in those with HIV, but can be extrapolated to all.
Nathan Goodyear

Human semen quality in the new millennium: a prospective cross-sectional population-based study of 4867 men -- Jørgensen et al. 2 (4) -- BMJ Open - 0 views

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    2012 study that shows a slight uptick in sperm count/concentration in Danish men.  However, as the conclusion states, on 25% have optimal sperm quality.  When you look at the numbers deeper, the current general population sperm count/concentration was lower than that of men of infertile couples from 1940-1943 cohort.  Additionally, when the general population sperm count/concentration was lower than that of compared recent fertile men.
Nathan Goodyear

Hypnotics' association with mortality or cancer: a matched cohort study -- Kripke et al. 2 (1) -- BMJ Open - 0 views

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    prescription sleep aids and hypnotics associated with 3 fold increase in death.  Scary thought considering how many use sleep aids today.  First do no harm is suppose to be a physician's moto.
Nathan Goodyear

Estrogen Regulates Tumor Growth Through a Nonclassical Pathway that Includes the Transcription Factors ER{beta} and KLF5 -- Nakajima et al. 4 (168): ra22 -- Science Signaling - 0 views

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    ER-beta inhibits prostate tumor growth through the tumor suppression factor KLF5.
Nathan Goodyear

Crossroads of Estrogen Receptor and NF-{kappa}B Signaling -- Biswas et al. 2005 (288): pe27 -- Science Signaling - 0 views

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    This study looked at estrogen receptors and breast cancer.  But, they found anti estrogen therapy might actually increase NF-KappB activity i.e.inflammation.  In contrast, ER inhibited NF-kappaB and resultant inflammation.
Nathan Goodyear

Physical activity and exercise for erectile dysfunction: systematic review and meta-analysis -- Silva et al. -- British Journal of Sports Medicine - 0 views

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    review study points out that exercise, predominantly cardio, improved ED in men.
Nathan Goodyear

Benefit of pregnancy in inflammatory arthritis -- Straub et al. 64 (6): 801 -- Annals of the Rheumatic Diseases - 0 views

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    Pregnancy shifts the immune system to a balance of Th2 expression.  Pregnancy is associated with decrease inflammation i.e. an immunosuppressive state.  Estriol and Progesterone are dominantly produced during pregnancy.   An associated decrease in autoimmune disease is present as a result of the immunosuppressive state of pregnancy.
Nathan Goodyear

High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome -- De Filippis et al. 65 (11): 1812 -- Gut - 0 views

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    Mediterranean diet improve gut flora and SCFA
Nathan Goodyear

Gender and sex hormones in multiple sclerosis pathology and therapy - 0 views

  • It is now well recognized that the disease manifestation is reduced in pregnant women with relapsing-remitting MS
  • This occurs particularly during the third trimester when levels of estrogens (estradiol and estriol) and progesterone (see Table 2) are elevated up to about 20 times
  • This seems well correlated with a decrease in active white matter lesions detected by MRI
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  • This clinical improvement is however followed by temporary rebound exacerbations at post-partum, when the hormone levels decline
  • a shift from Th1 to Th2 immune response, expansion of suppressive regulatory T lymphocytes and decrease in the number of circulating CD16+ natural killer (NK)-cells
  • Th1 lymphocytes secrete proinflammatory cytokines (e.g. IL-2, IFNgamma, lymphotoxin) while Th2 cells secrete anti-inflammatory cytokines (e.g. IL-4, IL-5, IL-10), which favor humoral-mediated responses
  • Th2 cytokines are associated with down-regulation of Th1 cytokines and this Th2 shift is believed to provide protection from allograft rejection during pregnancy as well as from Th1-mediated autoimmune disease
  • it is worth noting that the levels of other hormones with anti-inflammatory activity (1,25-dihydroxy-vitamin D3, norepinephrine, cortisol) also increase by 2 to 4 times during late pregnancy
  • 1,25-dihydroxy vitamin D3 induces regulatory T-cell function important for development of self-tolerance
  • breast-feeding does not alter the relapse rate in women with MS
  • Leptin is a pleiotropic hormone produced primarily by adipocytes but also by T lymphocytes and neurons
  • Several lines of evidence indicate that leptin contributes to EAE/MS pathogenesis, influencing its onset and clinical severity, by acting as a proinflammatory cytokine which promotes regulatory T cell (Treg) anergy and hyporesponsiveness, resulting in increased Th1 (TNFalpha, INFgamma) and reduced Th2 (IL-4) cytokine production
  • circulating leptin levels are increased in relapsing-remitting MS patients (men and women analyzed together) while the CD4+CD25+Treg population decreases
  • As the leptin plasma concentrations are proportional to the amount of fat tissue, obese/overweight individuals produce higher levels of leptin
  • Nielsen et al found that estradiol and progesterone exert neuroprotection against glutamate neurotoxicity, while MPA antagonizes the neuroprotective effect of estradiol and exacerbated neuron death induced by glutamate excitotoxicity
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    very good review of the differences in MS and hormones between the sexes.
Nathan Goodyear

Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review -- Ravnskov et al. 6 (6) -- BMJ Open - 0 views

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    review study of 263 studies finds no association between LDL and mortality in elderly.  In fact, the review found an inverse association between LDL and mortality i.e. increasing LDL associated with lower mortality in elderly.
Nathan Goodyear

Serum Androgen Bioactivity During 5{alpha}-Dihydrotestosterone Treatment in Elderly Men -- Raivio et al. 23 (6): 919 -- Journal of Andrology - 0 views

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    transdermal DHT shown to increase DHT levels and shown to increase  androgenic effects in elderly men.
Nathan Goodyear

Circulating Inflammatory Cytokine Expression in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy -- Maggio et al. 27 (6): 725 -- Journal of Andrology - 0 views

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    this study found no increase in inflammatory cytokines in those men on androgen deprivation therapy for prostate cancer.  The question, is they evaluated testosterone in the serum, so did they really see a decrease in androgens or just a decrease in the transport of androgens.  Saliva would have detected a true androgen deficient state.
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