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Nathan Goodyear

Figure 5 : Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes : Nature Reviews Molecular Cell Biology - 0 views

www.nature.com/...nrm2391_F5.html

obesity insulin resistance diabetes TNF-alpha PPAR free fatty acids FFA inflammation

shared by Nathan Goodyear on 22 Dec 11 - No Cached
  • Nathan Goodyear on 22 Dec 11
     
    proposed TNF-alpha downregulation of PPAR and resultant increase in FFA and thus inflammation, insulin resistance, diabetes...
Nathan Goodyear

Obesity - Inducible Toll-like Receptor and NF-[kappa]B Regulatory Pathway Expression in Human Adipose Tissue - 0 views

www.nature.com/...oby200825a.html

TLR-4 TLR Toll-like receptors NF-kapppB inflammation obesity

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • TLRs are functionally inducible and associated with downstream NF-B activation and proinflammatory cytokine production.
  • TLRs represent a family of receptors that are critical to the innate immune response against foreign pathogens and microorganisms
  • LPS has been shown to induce proinflammatory chemokine gene expression in differentiated human adipocytes through TLR and NF-B action
  • ...2 more annotations...
  • Stimulation of TLRs initiates intracellular signaling cascades resulting in downstream NF-B and mitogen-activated protein kinase activation and production of proinflammatory chemokines associated with mechanisms of metabolic dysfunction and cardiovascular disease progression.
  • Elevated fatty acids levels associated with obesity activate TLR4 signaling in fat cells and macrophages, and induce insulin resistance in murine models
  • Nathan Goodyear on 19 Jan 12
     
    TLR, especially TLR-4, is directly involved in NF-KappaB activation and release of inflammatory cytokines
Nathan Goodyear

Omega-3 polyunsaturated fatty acid suppl... [J Nutr Health Aging. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21267519

omega-3 cognitive decline Alzheimer's disease dementia aging brain health

shared by Nathan Goodyear on 17 Nov 11 - No Cached
  • Nathan Goodyear on 17 Nov 11
     
    omega-3 supplementation shown to slow cognitive decline in study of elderly Chinese women and men
Nathan Goodyear

High consumption of Ω-3 polyunsaturated fatty acid... [Nutrition. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21501950

omega-3 homocysteine hyperhomocysteinemia supplementation

shared by Nathan Goodyear on 17 Nov 11 - No Cached
  • Nathan Goodyear on 17 Nov 11
     
    meta-analysis reveals that omega-3 supplementation can decrease levels of homocysteine
Nathan Goodyear

GPR120 is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-Inflammatory and Insulin Sensitizing Effects - 0 views

www.ncbi.nlm.nih.gov/...PMC2956412

Omega-3 n-3 DHA EPA inflammation insulin diabetes DM GPR120 receptor cytokines

shared by Nathan Goodyear on 16 Jul 12 - No Cached
  • Nathan Goodyear on 16 Jul 12
     
    Omega-3, DHA and EPA, exert anti-inflammatory effects through GPR120 receptor.  This improved insulin sensitivity and had diabetes effects in-vivo model.  The effect was through the reduction of macrophage-induced inflammatory cytokines.
Nathan Goodyear

'Metabolic syndrome' in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition - 0 views

jp.physoc.org/2485

HFCS high-fructose corn syrup n-3 omega-3 metabolic syndrome brain insulin MetS

shared by Nathan Goodyear on 16 May 12 - No Cached
  • Nathan Goodyear on 16 May 12
     
    diets with high high-fructose corn syrup and low omega-3 shown to slow cognitive processing in rat model.  This is basically, metabolic syndrome of the brain, as it is the result of hyperinsulinemia.
Nathan Goodyear

International Journal of Obesity - The type and quantity of dietary fat and carbohydrate alter faecal microbiome and short-chain fatty acid excretion in a metabolic syndrome /`at-risk/' population - 0 views

www.nature.com/...ijo201233a.html

carbohydrates diet indued obesity DIO fats fat dietary metabolic syndrome obesity

shared by Nathan Goodyear on 09 Sep 13 - No Cached
  • Nathan Goodyear on 09 Sep 13
     
    Diet intake effects gut bacterial balance which effects metabolism and obesity risk.
Nathan Goodyear

Blood Level Omega-3 Fatty Acids as Risk Determinant Molecular Biomarker for Prostate Cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC3621295

prostate cancer prostate cancer omega 3 omega-3 n-3

shared by Nathan Goodyear on 11 Jul 13 - No Cached
  • Nathan Goodyear on 11 Jul 13
     
    study, that I have yet to fully analyze, claims increased risk of prostate cancer in men with the highest levels of omega-3.
Nathan Goodyear

Prophylactic and therapeutic effects of n-3 polyunsaturated fatty acids, capsaicin, and curcumin on adjuvant induced arthritis in rats - 0 views

www.jnutbio.com/...abstract

n-3 fish oil omega 3 capsaicin curcumin tumeric arthritis inflammation

shared by Nathan Goodyear on 13 Sep 13 - No Cached
  • Nathan Goodyear on 13 Sep 13
     
    Rat study, but it finds that n-3, capsaicin, and curcumin can not only decrease the inflammation associatied with arthritis, but it can delay it all together.
Nathan Goodyear

Effect of the long-term feeding of dietary lipids on the learning ability, fatty acid composition of brain stem phospholipids and synaptic membrane fluidity in adult mice: a comparison of sardine oil diet with palm oil diet - 0 views

www.sciencedirect.com/...S0047637497001693

DHA learning fish oil n-3 omega 3 omega-3 memory

shared by Nathan Goodyear on 01 Nov 13 - No Cached
  • Nathan Goodyear on 01 Nov 13
     
    mouse study finds high DHA diet improved learning.
Nathan Goodyear

Dietary omega-3 fatty acids normalize BDNF lev... [J Neurotrauma. 2004] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15672635

BDNF n-3 omega 3 omega-3 oxidative stress inflammation brain derived neurotrophic factor

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    Another rat study as alot of the studies are with BDNF.  Dietary n-3 reduce oxidative stress and inflammation and increase BDNF.
Nathan Goodyear

Omega-3 fatty acid supplementation and reduction... [J Neurosurg. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20635852

n-3 omega 3 omega-3 fish oil brain neuroplasticity

shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    Animal model shows that n-3 intake reduced axonal injury after injury insult.  This implies a use in n-3 intake even after an insult has occured. This implies a role for n-3 in neuroplasticity.
Nathan Goodyear

Metabolic Effects of Dietary Fiber Consumption and Prevention of Diabetes - 0 views

jn.nutrition.org/...439.long

soluble insoluble fiber dietary diet nutrition diabetes

shared by Nathan Goodyear on 22 Oct 13 - No Cached
  • DF are highly complex substances that can be described as any nondigestible carbohydrates and lignins not degraded in the upper gut
  • Commonly, DF are classified according to their solubility in water, even though grading according to viscosity, gel-forming capabilities, or fermentation rate by the gut microbiota might be physiologically more relevant
  • Main sources of soluble DF are fruits and vegetables
  • ...8 more annotations...
  • n increased intake of total DF was inversely associated with markers of insulin resistance in several studies
  • consumption of insoluble DF increased whole body glucose disposal independent of changes in body weight in both short-term and more prolonged studies
  • Short-chain fatty acids (SCFA) such as acetate, propionate, and butyrate are produced by bacterial fermentation of indigestible DF polysaccharides in the colon
  • increased production of SCFA is assumed to be beneficial by reducing hepatic glucose output and improving lipid homeostasis
  • a high DF diet (oligofructose) reduced gram-negative bacterial content and body weight, whereas a high fat diet increased the proportion of a gram-negative bacterial lipopolysaccharides (LPS) containing microbiota in humans
  • Prospective cohort studies indicate that diets high in insoluble cereal DF and whole grains might reduce diabetes risk
  • soluble DF (i.e., pectin, inulin, and β-glucans)
  • cereal DF (i.e., cellulose and hemicelluloses)
  • Nathan Goodyear on 22 Oct 13
     
    Good discussion of dietary fiber intake and Diabetes.  
Nathan Goodyear

ω-3 Fatty Acid Supplementation as a Potential Therapeutic Aid for the Recovery from Mild Traumatic Brain Injury/Concussion - 0 views

advances.nutrition.org/...268.full

omega 3 DHA EPA fish oil TBI traumatic brain injury concussions concussion brain injury

shared by Nathan Goodyear on 30 Aug 15 - No Cached
  • There is a growing body of preclinical literature suggesting that ω-3 FAs, and DHA in particular, may play a therapeutic role in mTBI
  • the potential for ameliorating or possibly even preventing the complications associated with concussions
  • DHA is the predominant ω-3 FA present in the brain, and, consistent with this finding, DHA, and not EPA, has been demonstrated to be critical for brain development and cognitive function throughout life
  • ...7 more annotations...
  • the concentration of EPA in the brain is negligible (77–80), suggesting that EPA plays a limited role in mediating the beneficial effects of LCPUFA supplementation on mTBI pathology
  • the current state of the science regarding LCPUFA supplementation for the treatment of concussion is based primarily on animal models
  • there is evidence that the amount of DHA in brain tissue is decreased after mTBI (65, 66), suggesting an elevated need for DHA in mTBI recovery.
  • the well-established role of DHA in supporting the structure and function of the brain throughout the lifespan (26, 27, 46, 47, 53) provides encouragement that LCPUFAs may also prove beneficial in the context of concussion recovery.
  • no therapies are currently available to aid the recovery from this injury
  • Previously discussed reports outlining the use of ω-3 FAs in the recovery from severe TBIs (reviewed in Ref. 92) described the use of very-high doses of LCPUFAs (16.2 g/d EPA plus DHA) in the recovery of these patients
  • Within the context of mTBIs/concussions, translating a DHA intake used in several rat studies of mTBI recovery (40 mg ⋅ kg−1 ⋅ d−1 DHA) (57, 63, 64) using body surface area conversion methods (93) amounts to an estimated human intake of 387 mg/d DHA
  • Nathan Goodyear on 30 Aug 15
     
    nice review of the evidence of n-3, particularily DHA, in concussions and concussion recovery.
Nathan Goodyear

Dietary Supplementation With the Omega-3 Fatty Acid Docosahe... : Neurosurgery - 0 views

journals.lww.com/...with_the_omega_3_fatty.31.aspx

brain injury brain TBI traumatic brain injury DHA

shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • Nathan Goodyear on 31 Aug 15
     
    Animal study finds pre-emptive DHA at 40 mg/kg reduced injury response during medically induced TBI.  Not only can DHA be used with TBI, but this study suggests it can be used in a prevention mode.
Nathan Goodyear

Omega Research - 0 views

www.omega-research.com/researchview.php

Omega-3 vitamin C E antioxidants oxidative stress infertility

shared by Nathan Goodyear on 15 Dec 10 - No Cached
  • These data have important implications for the supplementation of a combination of omega-3 fatty acids and antioxidants in the successful management of female infertility.
  • Nathan Goodyear on 15 Dec 10
     
    omega 3 and antioxidants aid in infertility
Nathan Goodyear

The Effect of Dietary Supplementation with n-3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells - NEJM - 0 views

www.nejm.org/...NEJM198902023200501

Omega-3 inflammation anti-inflammatory

shared by Nathan Goodyear on 11 Feb 11 - No Cached
  • Nathan Goodyear on 11 Feb 11
     
    Omega-3 is anti-inflammatory
Nathan Goodyear

(n-3) Fatty Acids and Cancer Therapy - J. Nutr. - 0 views

jn.nutrition.org/...3427S.abstract

Omega-3 cancer

shared by Nathan Goodyear on 11 Feb 11 - No Cached
  • Used alone, an (n-3) supplement may be a useful alternative therapy for patients who are not candidates for standard toxic cancer therapies.
  • Nathan Goodyear on 11 Feb 11
     
    Omega-3 reduce inflammation, inhibit tumor growth, inhibit angiogenesis, induce cancer cell death, and inhibit estrogen signaling
Nathan Goodyear

Effect of dietary GLA+/−tamoxifen on the growth, ER expression and fatty acid profile of ER positive human breast cancer xenografts - Kenny - 2001 - International Journal of Cancer - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...pdf

GLA breast cancer estrogen receptor positive tamoxifen

shared by Nathan Goodyear on 11 Feb 11 - No Cached
  • Nathan Goodyear on 11 Feb 11
     
    GLA enhances the effectiveness of tamoxifen in the treatment of ER + breast cancer
Nathan Goodyear

Dietary supplementation with eicosapentaenoic and ... [Int J Cancer. 1998] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...9495237

Omega-3 DHA EPA cancer

shared by Nathan Goodyear on 11 Feb 11 - No Cached
  • t is concluded from the results of the present study that the anti-tumoral effect of EPA is related mainly to its inhibition of cell proliferation, whereas that of DHA corresponds with its induction of apoptosis. The alterations in fatty-acid composition induced by EPA or DHA appear to be factors underlying their differential actions on cell proliferation and apoptosis.
  • Nathan Goodyear on 11 Feb 11
     
    Omega-3, DHA and EPA, work differently in their anti-cancer effects
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