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Nathan Goodyear

HE3286 as Treatment for Parkinson's Disease | The Michael J. Fox Foundation - 0 views

www.michaeljfox.org/...grant-detail.php

DHEA Parkinson's disease Parkinson's

shared by Nathan Goodyear on 02 Jun 13 - No Cached
  • Nathan Goodyear on 02 Jun 13
     
    Synthetic analogue of DHEA metabolite, HE3286, analyzed as treatment in Parkinson.s disease.
Nathan Goodyear

Dehydroepiandrosterone in systemic lupus erythematosus - 0 views

www.ncbi.nlm.nih.gov/...PMC2701249

DHEA hormone hormones autoimmune disease autoimmune Lupus SLE

shared by Nathan Goodyear on 02 Jun 13 - No Cached
  • Nathan Goodyear on 02 Jun 13
     
    DHEA therapy has provided benefit in autoimmune disease.  IN this study they review the previous articles and physiology behind DHEA's proposed benefit in autoimmune disease.
Nathan Goodyear

Androgens and sexual function: a placebo-controll... [Aging Male. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19883295

aging male men DHEA ED low libido impotence sexual dysfunction

shared by Nathan Goodyear on 12 Jun 13 - No Cached
  • Nathan Goodyear on 12 Jun 13
     
    This study found no benefit from DHEA at 50 mg twice daily for those with androgen deficiency and sexual dysfunction.
Nathan Goodyear

NYU Langone Medical Center - 0 views

www.med.nyu.edu/content

DHEA hormone hormones

shared by Nathan Goodyear on 12 Jun 13 - No Cached
  • Nathan Goodyear on 12 Jun 13
     
    good summary of data on DHEA benefits.
Nathan Goodyear

Low Dehydroepiandrosterone Sulfate is Associated With Increased Risk of Ischemic Stroke Among Women - 0 views

stroke.ahajournals.org/...STROKEAHA.111.000485.abstract

DHEAS stroke women ischemic stroke deydroepiandrosterone sulfate

shared by Nathan Goodyear on 18 Jun 13 - No Cached
  • Nathan Goodyear on 18 Jun 13
     
    Lower DHEAS in women (25 percentile) in this study associated with increased risk of stroke.  
Nathan Goodyear

Endocrinology of the Aging Male - 0 views

www.ncbi.nlm.nih.gov/...PMC3073592

aging male hormone hormones

shared by Nathan Goodyear on 30 Apr 13 - No Cached
  • All steps beyond the formation of pregnenolone take place in the smooth endoplasmic reticulum
  • Cytochrome P450 enzyme, CYP11A is located on the inner mitochondrial membrane and catalyses the rate limiting step of pregnenolone synthesis
  • Estrogen and related steroids, thyroid hormone and insulin increase SHBG levels.
  • ...21 more annotations...
  • SHBG decreases in response to androgens, and in the presence of hypothyroidism, and insulin resistance.
  • Plasma SHBG levels tend to increase with increasing age
  • The apparent metabolic clearance rate of testosterone is decreased in elderly as compared to younger men
  • Testosterone circulates predominantly bound to the plasma proteins SHBG and albumin, with high and low affinity respectively
  • Testosterone is secreted in a pulsatile fashion
  • Current clinical guidelines suggest at least two measurements
  • In adult men, there is a well-documented diurnal variation (particularly in younger subjects) in testosterone levels, which are highest in the early morning and progressively decline throughout the day to a nadir in the evening
  • In older men, the diurnal variation is blunted
  • it is standard practice for samples to be obtained between 0800 and 1100 h.
  • Testosterone and DHEA decline, whereas LH, FSH, and SHBG rise
  • DHT remains constant despite the decline of its precursor testosterone
  • Longitudinal studies show an average annual decline of 1–2% total testosterone levels, with decline in free testosterone more rapid because of increases in SHBG with aging
  • Massachusetts Male Aging Study (MMAS) data show DHEA, DHEAS, and Ae declining at 2–3% per year
  • DHT showed no cross-sectional age trend
  • Androstanediol glucuronide (AAG) declined cross-sectionally with age in the MMAS sample, at 0.6% per year
  • The EMAS data show that, consistent with the longitudinal findings of MMAS (Figure 1), the core hormonal pattern with increasing age is suggestive of incipient primary testicular dysfunction with maintained total testosterone and progressively blunted free testosterone associated with higher LH
    • Nathan Goodyear
      Nathan Goodyear on 01 May 13
       
      This author proves the point in the review of these two studies, that TT may remain constant in aging men, however, FT drops.
  • obesity impairs hypothalamic/pituitary function
  • Androgen deprivation in men with prostate cancer has been associated with increased insulin resistance, worse glycemic control, and a significant increase in risk of incident diabetes
  • Low serum testosterone is associated with the development of metabolic syndrome 116, 117 and type 2 diabetes. 118 SHBG has been inversely correlated with type 2 diabetes
  • Improvement in insulin sensitivity with testosterone treatment has been reported in healthy 121 and diabetic 122 adult men
  • In studies conducted in men with central adiposity, testosterone has been shown to inhibit lipoprotein lipase activity in abdominal adipose tissue leading to decreased triglyceride uptake in central fat depots. 123
  • Nathan Goodyear on 30 Apr 13
     
    great review of hormone changes associated with aging in men.
Nathan Goodyear

Simultaneous determination of salivary testosterone and dehydroepiandrosterone using LC-MS/MS:... - Abstract - UK PubMed Central - 0 views

ukpmc.ac.uk/19010090

saliva salivary testosterone LC-MS_MS DHEA testing test evaluation

shared by Nathan Goodyear on 31 Oct 12 - No Cached
  • Nathan Goodyear on 31 Oct 12
     
    salivary testosterone and DHEA using LC-MS/MS accuracy exceeds 98.5%.  Compare that with historical 50% resolution of pain with a hysterectomy.  There is no perfect test, but if accuracy exceeds 98%, you have  reliable test.
Nathan Goodyear

Salivary Sex Hormone Measurement in a National, Population-Based Study of Older Adults - 0 views

www.ncbi.nlm.nih.gov/...PMC2763516

hormone hormones saliva salivary estradiol progesterone testosterone DHEA testing

shared by Nathan Goodyear on 16 Oct 12 - No Cached
  • Nathan Goodyear on 16 Oct 12
     
    Another study supports saliva hormone testing.  This study involved 2,722 individuals and tested estradiol, progesterone, DHEA and testosterone in men and women.  All of these are sex hormones.  Someone needs to tell the insurance companies that the overwhelming evidence supports saliva hormone testing.  But, that would mean they are even interested in the science.
Nathan Goodyear

http://rheumatology.oxfordjournals.org/content/38/6/488.full.pdf#page=1&view=FitH - 0 views

rheumatology.oxfordjournals.org/...488.full.pdf

DHEA hormones lupus RA inflammation

shared by Nathan Goodyear on 09 May 16 - No Cached
  • Nathan Goodyear on 09 May 16
     
    Chronic inflammatory disease states, such as Lupus and RA associated with low DHEA.
Nathan Goodyear

http://onlinelibrary.wiley.com/store/10.1002/art.11105/asset/11105_ftp.pdf;jsessionid=4C65AF80E4193903EA1042174A607429.f03t01?v=1&t=iomr25hd&s=21ef8244f39f50c74a498f0b304f97b75c90268c - 0 views

onlinelibrary.wiley.com/...4193903EA1042174A607429.f03t01

Lupus Testosterone DHEA Progesterone autoimmune disease

shared by Nathan Goodyear on 25 May 16 - No Cached
  • Nathan Goodyear on 25 May 16
     
    good review of sex hormones and LUPUS; whether it is causative or not, sex hormones trends exist in LUPUS i.e. low DHEA in both sexes, low progesterone in women, and low Testosterone in women>men.
Nathan Goodyear

Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placebo-controlled Trial: The Journal of Clinical Endocrinology & Metabolism: Vol 101, No 11 - 0 views

press.endocrine.org/...jc.2016-1858

resveratrol PCOS polycystic ovarian syndrome Testosterone DHEA hormones women insulin sensitivity insulin

shared by Nathan Goodyear on 30 Nov 16 - No Cached
  • Nathan Goodyear on 30 Nov 16
     
    Only abstract available.  Resveratrol found to reduce total Testosterone by 23% and DHEAS by 22% in women with PCOS;  a decrease in insulin by 32% and improved insulin sensitivity was also noted.
Nathan Goodyear

Dehydroepiandrosterone reduces preadipocyte proliferation via androgen receptor - 0 views

ajpendo.physiology.org/...E694.abstract

DHEA obesity adipose tissue adipocytes fat diabetes androgen receptor

shared by Nathan Goodyear on 17 Mar 12 - No Cached
  • Nathan Goodyear on 17 Mar 12
     
    DHEA reduces preadipocytes growth through the androgen receptor.
Nathan Goodyear

Increased muscular dehydroepiandrosterone levels are associated with improved hyperglycemia in obese rats - 0 views

ajpendo.physiology.org/...E274.abstract

exercise DHEA glucose DHT GLUT4 dihydrotestosterone

shared by Nathan Goodyear on 17 Mar 12 - No Cached
  • Nathan Goodyear on 17 Mar 12
     
    Exercise, DHEA, and DHT increased GLUT4 uptake of glucose, increasing glycemic control.
Nathan Goodyear

An update: salivary hormones and physical exercise - Gatti - 2010 - Scandinavian Journal of Medicine & Science in Sports - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...full

salivary cortisol DHEA testosterone hormone evaluation hormones exercise athletes

shared by Nathan Goodyear on 26 Nov 11 - No Cached
  • Nathan Goodyear on 26 Nov 11
     
    salivary cortisol, testosterone, DHEA testing is a "real alternative" to serum testing in the scrutiny of athletes.
Nathan Goodyear

Is dehydroepiandrosterone a hormone? - 0 views

joe.endocrinology-journals.org/...169.full.pdf

DHEA dehydroepiandrosterone hormone hormones

shared by Nathan Goodyear on 20 Feb 12 - No Cached
  • Nathan Goodyear on 20 Feb 12
     
    Great review on dehydroepiandrosterone (DHEA): what it is, what it does, and the literature behind our current understanding.
Nathan Goodyear

Adiponectin is involved in the protective effect of... [Steroids. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18534650

DHEA adiponectin overweight obesity omega-6 omega-3 n-6 n-3

shared by Nathan Goodyear on 01 Mar 12 - No Cached
  • Nathan Goodyear on 01 Mar 12
     
    DHEA increased adiponectin, improved omega 6/omega 3 ratios, and improved body fat content.
Nathan Goodyear

More evidence intratumoral DHT synthesis drives castration-resistant prostate cancer Wilson EM - Asian J Androl - 0 views

www.ajandrology.com/article.asp

DHEA DHT prostate cancer 3 beta HSD

shared by Nathan Goodyear on 17 Jan 14 - No Cached
  • Nathan Goodyear on 17 Jan 14
     
    Mouse model shows that intratumor conversion of DHEA to DHT stimulates tumor growth in prostate cancer model.
Nathan Goodyear

The effects of compounded bioident... [Int J Pharm Compd. 2013 Jan-Feb] - PubMed - NCBI - 1 views

www.ncbi.nlm.nih.gov/...23627249

bioidentical hormone hormones menopause peri-menopause progesterone Bi-est DHEA Testosterone women

shared by Nathan Goodyear on 03 Feb 14 - No Cached
Nan Sprouse liked it
  • Nathan Goodyear on 03 Feb 14
     
    3 year study finds improvement in classic menopausal symptoms for women in perimenopause and menopause with improvement in other parameters: fasting glucose, cholesterol, MMP-9, CRP, fibrinogen and other clotting factors.  This study used bioidentical Bi-est, progesterone, and in some DHEA and Testosterone.
Nathan Goodyear

Reproducibility of Plasma Steroid Hormones, Prolactin, and Insulin-like Growth Factor Levels among Premenopausal Women over a 2- to 3-Year Period - 0 views

cebp.aacrjournals.org/...972.long

hormone hormones androgens Testosterone DHEAS IGF-1 prolactin IGFBP-3 women female

shared by Nathan Goodyear on 21 Mar 14 - No Cached
  • Nathan Goodyear on 21 Mar 14
     
    Very interesting study finds that a single value assessment of androgens, DHEAS, prolactin, IGF-1 and IGFBP-3 can be used to assess 3 year average in pre-menopause women.  Estrogen and progesterone need to be assessed through the cycle.
Nathan Goodyear

Administration of Dehydroepiandrosterone Suppresses Experimental Allergic Encephalomyelitis in SJL/J Mice - 0 views

www.jimmunol.org/...7094.long

MS multiple Sclerosis DHEA dehydroepiandrosterone inflammation TNF-alpha IFN-gamma

shared by Nathan Goodyear on 30 Jul 13 - No Cached
  • Nathan Goodyear on 30 Jul 13
     
    DHEA found to decrease IFN-gamma, IL-12, and TNF-alpha through inhibition of NF-kappaB in animal model of MS.
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