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methylmercury mediates neurotoxicity via mitochondrial damage, inflammation, and oxidative stress.  Astrocytes accumulated the methyl mercury.  The destruction of the astrocytes will result in an increase in glutamate.  Methylmercury is synergistic with other toxins in the development of immunoexcitotoxicity.

Blood lead levels correlate with homocysteine levels.  Methylation (B12, Folate, B6) plays a role regulating homocysteine levels as well. 

Lower 2-OH estrone metabolism associated with lower risk of breast cancer, but 4-OH estrone associated with increased risk of breast cancer.

selenium intake shown to improve motor function in those with high methyl Mercury and lead levesl; study of riverside populations with known high mercury levels

methylated estradiol has vascular antimitogenic effects

detoxification impairment and the markers to assess it in children with ASD

10 year f/u study of combined conjugated esterified estrogen and methyl testosterone in postmenopausal women finds no increase breast cancer risk.

Study finds statistically increased methylation of many genes in women with PCOS: it is called epigenetics.

Dendritic therapy, I think the use of vaccine is completely inappropriate here, found to extend life in those with methylated MGMT.  This phase III trial is still on going, but this is a very positive future therapy in the immunotherapy attack against cancer.

Sleep deprivation, defined as 1 night of no sleep, changed epigenetic expression of BMAL via increased methylation. Other findings: decreased cortisol, increased glucose...

good discussion of histamine and histamine intolerance.  All centers around diamine oxidase function (DAO).

physical contact with infants effects changes in genetic expression--epigenetics.  In this study, methylation patters were altered in the evaluation of 4 genes by "maternal contact" with infants 4-5 years later indicating a lasting and possible life-long effect of genetic expression from a mother's hug.

Only abstract available here.  Maternal nutrition, high fat diet in this study, altered genetic expression of offspring to increase future disease risk.  This study would have been better served if they had differentiated fats i.e. PUFA, MUFA, SF, TF....

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diet changes gut microbiota, which changes genetic expression--it is called epigenetics.  This is an animal study.

hypomethylation and carcinogenesis.

SAMe show a decrease in gastric cell growth in vitro and in vivo studies. This appears to be secondary to the resolved hypomethylation status of the c-myc and the uPA genes.

Very nice study.  The authors looked at normal prostate, early disease and late stage prostate cancer.  The authors found that ER beta expression, as a general rule, was lost as progression occurred to the high-grade dysplasias and grad 4/5 carcinomas of the prostate.  Early low/moderate dysplasia was associated with an increase in ER beta--the authors propose that this was due to an attempt of the basal epithelium to counter the paracrine effect of ER alpha.   In contrast, androgen receptors appeared to be equally expressed across all.

Hg induces hypertension in rat model.

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