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Nathan Goodyear

The Toxicology of Mercury - Current Exposures and Clinical Manifestations - NEJM - 0 views

www.nejm.org/...NEJMra022471

Mercury toxins toxicology

shared by Nathan Goodyear on 15 Dec 10 - No Cached
  • The Toxicology of Mercury — Current Exposures and Clinical Manifestations
  • Nathan Goodyear on 15 Dec 10
     
    Nice review of the toxicology of Mercury
Nathan Goodyear

ScienceDirect.com - Food and Chemical Toxicology - Long term toxicity of a Roundup herb... - 0 views

www.sciencedirect.com/...S0278691512005637

GMO GMO foods genetically modified foods

shared by Nathan Goodyear on 21 Jan 13 - No Cached
  • Nathan Goodyear on 21 Jan 13
     
    First long-term study on GMO effects on rats. The majority of studies on GMO have been on animals with the end point at < 90 days.  This study followed the rats for 2 years.  Increased mammary tumors were found.  Is this definitive?  Of course not, but this is the first study to look at long term effects.
Nathan Goodyear

ScienceDirect.com - Toxicology - Estrogen receptor-α mediates the detrimental... - 0 views

www.sciencedirect.com/...S0300483X04003658

ER alpha ER estrogen receptor DES diethylstilbestrol

shared by Nathan Goodyear on 03 Apr 13 - No Cached
  • Nathan Goodyear on 03 Apr 13
     
    Study shows that the harmful effects of DES exposure is primarily through ER alpha stimulation.
Nathan Goodyear

Estrogen receptor-alpha mediates the detrimental ... [Toxicology. 2004] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15458790

DES ER alpha ER estrogen receptor estrogen receptor hormone hormones

shared by Nathan Goodyear on 11 Apr 13 - No Cached
  • Nathan Goodyear on 11 Apr 13
     
    DES exposure feminizes male mice through ER alpha receptor.
Nathan Goodyear

Reproductive toxicologic evaluations of Bulbine natalensis Baker stem extract in albino... - 0 views

www.ncbi.nlm.nih.gov/...19410284

Bulbine natalensis Baker stem natural therapies natural Testosterone LH hormones

shared by Nathan Goodyear on 18 Jan 17 - No Cached
  • Nathan Goodyear on 18 Jan 17
     
    Bulbine natalensis Baker stem extract found to increase LH and Testosterone in wistar rats in 7 days at doses of 25 to 50 mg/kg; this effect was not found at 100 mg/kg.  The result was an increase in testes size, rate of mating, libido, and fertility.
Nathan Goodyear

Tolerance and safety of vitamin E: a toxicological position report. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...1628854

vitamin E vitamins alternative medicine

shared by Nathan Goodyear on 13 Jun 16 - No Cached
  • Nathan Goodyear on 13 Jun 16
     
    Only abstract available here.  The quote that "the toxicity of vitamin E is very low" tells the story.  Always have levels evaluated to ensure need.  In this review of human studies, doses up to 3,200 IU daily "led to no consistent adverse effects".  Also consider the effects of vitamin K effects in those on vitamin E therapy.
Nathan Goodyear

ScienceDirect - Toxicology and Applied Pharmacology : The potential biological mechanis... - 0 views

www.sciencedirect.com/...S0041008X04001309

arsenic exposure diabetes potential pharmacology

shared by Nathan Goodyear on 06 Dec 11 - No Cached
  • Recent studies have shown that, in subjects with chronic arsenic exposure, oxidative stress is increased and the expression of tumor necrosis factor α (TNFα) and interleukin-6 (IL-6) is upregulated
  • these two cytokines have been well known for their effect on the induction of insulin resistance
  • Oxidative stress has been suggested as a major pathogenic link to both insulin resistance and β cell dysfunction through mechanisms involving activation of nuclear factor-κB (NF-κB), which is also activated by low levels of arsenic
  • Nathan Goodyear on 06 Dec 11
     
    discussion of possible mechanisms of arsenic induced diabetes
Nathan Goodyear

ScienceDirect - Toxicology and Applied Pharmacology : Arsenic and diabetes and hyperten... - 0 views

www.sciencedirect.com/...S0041008X07000026

Arsenic hypertension HTN HgbA1C diabetes

shared by Nathan Goodyear on 06 Dec 11 - No Cached
  • Nathan Goodyear on 06 Dec 11
     
    long-term exposure to low levels of Arsenic associated with increased hypertension, elevated HgbA1C and many studies Diabetes.
Nathan Goodyear

Glyphosate Formulations Induce Apoptosis and Necrosis in Human Umbilical, Embryonic, an... - 0 views

pubs.acs.org/...tx800218n

glyphosate herbicide herbicides roundup infertility women pregnancy miscarriage

shared by Nathan Goodyear on 10 Jan 12 - Cached
  • Nathan Goodyear on 10 Jan 12
     
    Glyphosate-based herbicides (commonly found in roundup) shown to cause damage to placenta cells.  This has major implications in infertility and pregnancy health
Nathan Goodyear

Parabens in male infertility-Is there a mitochondrial connection? 10.1016/j.reprotox.20... - 0 views

www.sciencedirect.com/...S0890623808002682

male infertility parabens mitochondrial mitochondria xenobiotics environmental toxins

shared by Nathan Goodyear on 02 Feb 12 - No Cached
  • Nathan Goodyear on 02 Feb 12
     
    parabens effect through mitochondrial disruption in testes?
Nathan Goodyear

Bisphenol A may cause testosterone reduction by adversely affecting both testis and pit... - 0 views

www.sciencedirect.com/...S0378427410000561

testosterone Bisphenol-A Bisphenol A BPA low T leydig cells pituitary

shared by Nathan Goodyear on 01 Feb 12 - No Cached
  • Nathan Goodyear on 01 Feb 12
     
    Bisphenol-A inhibits testosterone production through direct inhibition of the pituitary and the leydig cells.  This is similar to the way E2 acts on the the pituitary and the leydig cells.  
Nathan Goodyear

Susceptibility of mitochondrial superoxide dismut... [Toxicology. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19010380

SOD superoxide disumutase aluminum AL oxidative damage

shared by Nathan Goodyear on 09 Oct 13 - No Cached
  • Nathan Goodyear on 09 Oct 13
     
    Aluminum induces oxidative damage through a reduction in SOD.
Nathan Goodyear

Efficacy of quercetin derivatives in prevention of ulcerative colitis in rats : Interdi... - 0 views

www.degruyter.com/...intox-2013-0002.xml

ulcerative colitis UC quercetin inflammation natural

shared by Nathan Goodyear on 02 Sep 15 - No Cached
  • Nathan Goodyear on 02 Sep 15
     
    animal study finds natural quercetin, a flavonoid reduces inflammation in rats with UC.
Nathan Goodyear

Endocrine Disruption: Historical Perspectives and Its Impact on the Future of Toxicolog... - 0 views

toxsci.oxfordjournals.org/...S93.full

endocrine disruptors environmental toxins

shared by Nathan Goodyear on 05 Sep 11 - No Cached
  • Nathan Goodyear on 05 Sep 11
     
    deep read on the environment and endocrine disruptors
Nathan Goodyear

ScienceDirect - Toxicology Letters : Ex vivo study of incorporation into adipocytes and... - 0 views

www.sciencedirect.com/science

PBA obesity overweight polycyclic aromatic hydrocarbons

shared by Nathan Goodyear on 06 Apr 11 - No Cached
  • we therefore suggest that B[a]P may play a central role in carcinogenesis not only by inducing cancer through its mutagenic properties, but also by increasing the bioaccumulation capacity of the adipose tissue mass.
  • Nathan Goodyear on 06 Apr 11
     
    PBA plays role in increased fat mass
Nathan Goodyear

ScienceDirect - Food and Chemical Toxicology : Neuroprotective effect of ginger on anti... - 0 views

www.sciencedirect.com/science

Ginger diabetes oxidative stress

shared by Nathan Goodyear on 27 Apr 11 - No Cached
  • A marked decrease in anti-oxidant marker enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), reduced glutathione (GSH) and increase in malondialdehyde (MDA) was observed in the diabetic rats
  • inger may be used as therapeutic agent in preventing complications in diabetic patients.
  • These results suggest that ginger exhibit a neuroprotective effect by accelerating brain anti-oxidant defense mechanisms and down regulating the MDA levels to the normal levels in the diabetic rats
  • Nathan Goodyear on 27 Apr 11
     
    Ginger reduces oxidative stress in diabetic rat model
Nathan Goodyear

Combined effects in toxicology--a rapid systematic testing procedure: cadmium, mercury,... - 0 views

www.ncbi.nlm.nih.gov/...731728

heavy metals mercury lead aluminum

shared by Nathan Goodyear on 06 Oct 18 - No Cached
  • Nathan Goodyear on 06 Oct 18
     
    heavy metals are synergistic in lower toxicity levels.
Nathan Goodyear

Elimination of Ascorbic Acid After High‐Dose Infusion in Prostate Cancer Pati... - 1 views

onlinelibrary.wiley.com/...bcpt.12323

prostate cancer vitamin C IV vitamin C

shared by Nathan Goodyear on 21 Aug 19 - No Cached
  • Nathan Goodyear on 21 Aug 19
     
    Small study finds that plasma AA levels increase with accumulating doses of weekly IV vitamin C only at 60 gram.
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