Skip to main content

Home/ Dr. Goodyear/ Group items tagged miscarriage

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Studies on activity of... [J Huazhong Univ Sci Technolog Med Sci. 2004] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15641696

preeclampsia NK cell immune tolerance pregnancy recurrent miscarriage miscarriages

shared by Nathan Goodyear on 19 Apr 12 - No Cached
  • Nathan Goodyear on 19 Apr 12
     
    As NK over activity has been shown to play in role in recurrent miscarriages, so it appears that loss if immune tolerance (elevated NK activity) may play a role in preeclampsia
Nathan Goodyear

Natural Killer Cells in Pregnancy and Recurrent Pregnancy Loss: Endocrine and Immunolog... - 0 views

edrv.endojournals.org/...44.full

natural killer cells pregnancy loss recurrent immune system miscarriage NK

shared by Nathan Goodyear on 15 Apr 12 - No Cached
  • NK cells have been the cells most extensively studied, primarily because they constitute the predominant leukocyte population present in the endometrium at the time of implantation and in early pregnancy
  • parental chromosomal abnormalities, uterine anatomic anomalies, endometrial infections, endocrine etiologies (luteal phase defect, thyroid dysfunction, uncontrolled diabetes mellitus), antiphospholipid syndrome, inherited thrombophilias, and alloimmune causes
  • estrogen
  • ...28 more annotations...
  • progesterone
  • prolactin
  • In summary, in vivo animal experiments have shown an inhibitory role of estrogen on peripheral NK cell lytic activity, which is partly due to suppression of NK cell output by the bone marrow and partly due to suppression of individual NK cell cytotoxicity. However, in vitro studies so far have failed to show conclusively a direct effect of estrogen on NK cells.
  • At the progesterone concentrations believed to be present in the uterus [up to 10−5 m at the maternal-fetal interface (35)], studies consistently show inhibition of lymphocyte proliferation (33) and inhibition of NK cytolytic activity in vitro
  • The exact role of prolactin in NK cell regulation is unknown.
  • The overall effects of estrogen on NK cells are likely multifactorial, therefore, and depend on the type of cell affected as well as the kind of ER expressed by that cell.
  • It is known that progesterone can directly affect T cell differentiation in vitro, suppressing development of the Th1 pathway and enhancing differentiation along the Th2 pathway (44)
  • Th1 cells predominantly produce interferon-γ (IFN-γ), IL-2, and TNF-β and are involved in cell-mediated immunity. Th2 cells produce IL-4, IL-5, IL-6, IL-10, and IL-13 and stimulate humoral immunity
  • Furthermore, in response to progesterone, γδ T cells produce progesterone-induced blocking factor (PIBF) (54
  • A defining characteristic of NK cells is their ability to lyse target cells without prior sensitization and without restriction by HLA antigens.
  • NK cell function is mainly regulated by IL-2 and IFN-γ
  • IL-2 causes both NK cell proliferation and enhanced cytotoxicity. IFN-γ augments NK cytolytic activity, but does not cause NK proliferation. The two cytokines act synergistically to augment NK cytotoxicity (6).
  • The largest leukocyte population in the endometrium consists of NK cells named large granulated lymphocytes
  • there is a significant increase in the number of uNK cells throughout the secretory phase, which peaks in early pregnancy when uNK cells comprise about 75% of uterine leukocytes (62)
  • Second, uNK cell phenotype changes during the normal menstrual cycle and early pregnancy (68)
  • general proinflammatory effect of estrogen, causing an influx of macrophages and neutrophils, which is antagonized by progesterone through its receptor (70, 71).
  • The mechanism of such a progesterone-induced local immunosuppression is unclear.
  • progesterone plays an important role in proliferation and differentiation of uNK cells (32).
  • Through promotion of a uterine Th2 environment, progesterone could indirectly affect uNK cell function
  • The mechanism of this increase in uNK cell numbers has been addressed in both human and mouse models, and is likely the result of: 1) recruitment of peripheral NK cells to the uterus, and 2) proliferation of existing uNK cells
  • prolactin system plays an important role in implantation and the maintenance of pregnancy
  • the exact pathways of hormonal regulation of NK cells remain to be delineated.
  • The exact function of uNK cells has not yet been unequivocally determined
  • uNK cells express a different cytokine profile, compared with resting peripheral NK cells. mRNAs for granulocyte CSF, M-CSF, GM-CSF, TNF-α, IFN-γ, TGF-β, and leukemia inhibitory factor (LIF) have been found in decidual CD56+ cells
  • Their increased numbers in early pregnancy, their hormonal dependence, and their close proximity to the infiltrating trophoblast all suggest that they play an important role in the regulation of the maternal immune response to the fetal allograft and the control of trophoblast growth and invasion during human pregnancy
  • role of uNK cell-derived cytokines on trophoblast growth and differentiation (114, 115, 116, 117).
  • Th1 immunity to trophoblast is associated with RPL, whereas Th2 immunity is associated with a successful pregnancy
  • RPL is associated with Th1 immunity, for which NK cells are partly responsible.
  • Nathan Goodyear on 15 Apr 12
     
    dysregulated immune system plays role in recurrent miscarriage.  Specifically, this article discusses natural killer cells (NK).
Nathan Goodyear

Molecular Control of Immune/Inflammatory Responses: Interactions Between Nucl... - 0 views

edrv.endojournals.org/...435.long

progesterone NK macrophage T cell activity inflammation immune system

shared by Nathan Goodyear on 09 Nov 12 - No Cached
  • Nathan Goodyear on 09 Nov 12
     
    Benefits of progesterone, are in part, due to its function on the immune system.  Progesterone shown to decrease T cell activity, macrophage activity and NK cell activity.  Aside, NK cell activity has been found to be increased in those with recurrent first trimester miscarriages and progesterone defects.  So, low progesterone allows for a rise in NK cell activity and inflammation that is detrimental to a developing pregnancy.  If that is the case in pregnancy, what about the rest of the body?
Nathan Goodyear

The risks of selective serotonin reuptake inhibitor use in infertile women: a review of... - 0 views

humrep.oxfordjournals.org/...humrep.des383.short

SSRI serotonin reuptake inhibitor anti-depressants pregnancy health fertility

shared by Nathan Goodyear on 02 Nov 12 - No Cached
  • Nathan Goodyear on 02 Nov 12
     
    There is just no reason to take SSRIs during pregnancy.  SSRIs increase risk of miscarriage, birth defects, preterm birth, newborn behavior problems, pulmonary hypertension...All women considering pregnancy should removed, yet SSRIs are prescribed as if they are candy.
Nathan Goodyear

Coenzyme Q10 in pregnancy. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8823607

CoQ10 pregnancy

shared by Nathan Goodyear on 25 Apr 16 - No Cached
  • Nathan Goodyear on 25 Apr 16
     
    low CoQ10 associated with spontaneous miscarriage in abstract.  The authors of this paper found CoQ10 levels increased throughout "normal pregnancy".  Only abstract available here.
harshitatyagi

Know the essential foods to eat during IVF treatment - 0 views

top-ivf-clinic-in-india.blogspot.com/...-eat-during-ivf-treatment.html

foods to eat during IVF treatment foods to eat during ivf implantation diet during ivf stimulation foods to eat during ivf

shared by harshitatyagi on 31 Aug 22 - No Cached
  • harshitatyagi on 31 Aug 22
     
    As a human being, you should know that everyone has a different body type, and no diet can be perfect for everyone. Hence, An efficacious diet is significant to maintain after thoroughly researching what foods to eat during IVF to avoid severe complications of negativity and miscarriage in an IVF process.
Nathan Goodyear

Luteal start vaginal micronized progesterone improves pregnancy success in women with r... - 0 views

www.fertstert.org/...abstract

progesterone infertility miscarriage pregnancy hormones women

shared by Nathan Goodyear on 18 Jan 17 - No Cached
  • Nathan Goodyear on 18 Jan 17
     
    Recurrent early pregnancy losses can be prevented not with provera, not with progestin, but with progesterone. The use of progesterone by the functional medicine movement has long been advocated and supported in the science; now the allopathic medicine will try to claim it as its own.
Nathan Goodyear

Pregnancy Outcome After Intralipid Infusion Among Women Experiencing Recurrent Pregnanc... - 0 views

www.fertstert.org/...fulltext

intralipid therapy treatment recurrent pregnancy loss miscarriage

shared by Nathan Goodyear on 16 Apr 12 - No Cached
  • Nathan Goodyear on 16 Apr 12
     
    no abstract, but intralipid therapy was shown to improve pregnancy rate.
Nathan Goodyear

Glyphosate Formulations Induce Apoptosis and Necrosis in Human Umbilical, Embryonic, an... - 0 views

pubs.acs.org/...tx800218n

glyphosate herbicide herbicides roundup infertility women pregnancy miscarriage

shared by Nathan Goodyear on 10 Jan 12 - Cached
  • Nathan Goodyear on 10 Jan 12
     
    Glyphosate-based herbicides (commonly found in roundup) shown to cause damage to placenta cells.  This has major implications in infertility and pregnancy health
harshitatyagi

Why is getting pregnant so difficult? - 0 views

sco.lt/73xTBg

Why Can't I Get Pregnant? Why It's So Hard to Get Pregnant Reason for not getting pregnant when everything is normal Why didn t I get pregnant if I ovulated signs you can't get pregnant why is it so hard to get pregnant after a miscarriage

shared by harshitatyagi on 06 Oct 22 - No Cached
  • harshitatyagi on 06 Oct 22
     
    Usually, when getting pregnant becomes difficult, it leads to a situation where a woman faces infertility issues. As infertility is a never-ending illness in which conceiving becomes impossible either due to health conditions or a poor environment. Here find out the reasons why it becomes challenging to become pregnant?
1 - 10 of 10
Showing 20▼ items per page