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Nathan Goodyear

ScienceDirect - Toxicology and Applied Pharmacology : The potential biological mechanis... - 0 views

www.sciencedirect.com/...S0041008X04001309

arsenic exposure diabetes potential pharmacology

shared by Nathan Goodyear on 06 Dec 11 - No Cached
  • Recent studies have shown that, in subjects with chronic arsenic exposure, oxidative stress is increased and the expression of tumor necrosis factor α (TNFα) and interleukin-6 (IL-6) is upregulated
  • these two cytokines have been well known for their effect on the induction of insulin resistance
  • Oxidative stress has been suggested as a major pathogenic link to both insulin resistance and β cell dysfunction through mechanisms involving activation of nuclear factor-κB (NF-κB), which is also activated by low levels of arsenic
  • Nathan Goodyear on 06 Dec 11
     
    discussion of possible mechanisms of arsenic induced diabetes
Nathan Goodyear

Arsenic Exposure and Prevalence of Type 2 Diabetes in US Adults, August 20, 2008, Navas... - 0 views

jama.ama-assn.org/...814

arsenic exposure diabetes

shared by Nathan Goodyear on 14 Feb 11 - No Cached
  • After adjustment for biomarkers of seafood intake, total urine arsenic was associated with increased prevalence of type 2 diabetes. This finding supports the hypothesis that low levels of exposure to inorganic arsenic in drinking water, a widespread exposure worldwide, may play a role in diabetes prevalence
  • Nathan Goodyear on 14 Feb 11
     
    Arsenic and type 2 Diabetes link
Nathan Goodyear

Consumer Reports tests juices for arsenic and lead - 0 views

news.consumerreports.org/...ices-for-arsenic-and-lead.html

apple juice Arsenic Lead toxicity

shared by Nathan Goodyear on 01 Dec 11 - No Cached
  • Nathan Goodyear on 01 Dec 11
     
    Ten percent of apple juice has unacceptable levels of Arsenic and Lead.
Nathan Goodyear

Curcumin prevents DNA damage and enhances ... [Eur J Cancer Prev. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21332098

curcumin tumeric Arsenic cancer

shared by Nathan Goodyear on 17 Sep 13 - No Cached
  • Nathan Goodyear on 17 Sep 13
     
    Interesting study.  Curcumin shown to prevent oxidative damage as a result of Arsenic exposure.  Good therapy choice for those living in areas with high Arsenic exposure.
Nathan Goodyear

PLOS ONE: Towards Prenatal Biomonitoring in North Carolina: Assessing Arsenic, Cadmium,... - 0 views

www.plosone.org/...10.1371%2Fjournal.pone.0031354

heavy metals Mercury Arsenic Lead Pb Hg As Cadmium Cd pregnancy

shared by Nathan Goodyear on 30 Sep 13 - No Cached
  • Nathan Goodyear on 30 Sep 13
     
    study finds women living in North Carolina exposed to Cadmium, Mercury, Arsenic, and Lead in the prenatal period.  These levels exceed that considered "safe".
Nathan Goodyear

Environmental Health | Abstract | Arsenic in drinking water and cerebrovascular disease... - 0 views

www.ehjournal.net/...abstract

Arsenic drinking water environmental health

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • suggest that exposure to low-to-moderate levels of arsenic in drinking water may be associated with several of the leading causes of mortality
  • Nathan Goodyear on 08 Mar 11
     
    low levels of Arsenic in drinking water contribute to cerebrovascular disease, diabetes, and cancer
Nathan Goodyear

Arsenic Exposure and Prevalence of Type 2 Diabetes in US Adults, August 20, 2008, Navas... - 0 views

jama.ama-assn.org/...814.abstract

arsenic diabetes low-level exposure Type II 2

shared by Nathan Goodyear on 06 Dec 11 - No Cached
  • Nathan Goodyear on 06 Dec 11
     
    low levels of Arsenic exposure is associated with increase risk of diabetes
Nathan Goodyear

Environmental Health | Full text | Arsenic in drinking water and cerebrovascular diseas... - 0 views

www.ehjournal.net/4

arsenic diabetes environmental health disease mortality drinking

shared by Nathan Goodyear on 07 Dec 11 - No Cached
  • Nathan Goodyear on 07 Dec 11
     
    low levels of Arsenic in drinking water in Michigan shown to increase diabetes and other diseases
Nathan Goodyear

ScienceDirect - Toxicology and Applied Pharmacology : Arsenic and diabetes and hyperten... - 0 views

www.sciencedirect.com/...S0041008X07000026

Arsenic hypertension HTN HgbA1C diabetes

shared by Nathan Goodyear on 06 Dec 11 - No Cached
  • Nathan Goodyear on 06 Dec 11
     
    long-term exposure to low levels of Arsenic associated with increased hypertension, elevated HgbA1C and many studies Diabetes.
Nathan Goodyear

ScienceDirect - Environmental Research : Inorganic arsenic exposure and type 2 diabetes... - 0 views

www.sciencedirect.com/...S0013935107000746

Arsenic diabetes inorganic environmental exposure

shared by Nathan Goodyear on 06 Dec 11 - No Cached
  • Nathan Goodyear on 06 Dec 11
     
    Arsenic exposure, inorganic, shown to be diabetogenic.
Nathan Goodyear

Toxic metals and antioxidants: Part II. The role of antioxidants in arsenic and cadmium... - 0 views

cat.inist.fr/?aModele=afficheN&cpsidt=14869409

antioxidants toxic metals arsenic cadmium

shared by Nathan Goodyear on 19 Apr 11 - No Cached
  • Nathan Goodyear on 19 Apr 11
     
    antioxidants aid in cadmium and arsenic chelation
Nathan Goodyear

Targeting gut microbiota in obesity: effects of prebiotics and probiotics. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21826100

leptin leptin resistance obesity probiotics metabolic syndrome gut gut flora gut microbiota

shared by Nathan Goodyear on 05 Jun 16 - No Cached
  • Nathan Goodyear on 05 Jun 16
     
    Only abstract available here.  Review finds probiotics can be used in the arsenal to treat obesity and metabolic syndrome.  The authors conclude that leptin sensitivity is one of the possible mechanisms.
Nathan Goodyear

Neurobehavioural effects of developmental toxicity : The Lancet Neurology - 0 views

www.thelancet.com/...abstract

flourine toxins environmental brain neurology ADD ADHD autism ASD pediatrics children

shared by Nathan Goodyear on 11 Mar 14 - No Cached
  • Nathan Goodyear on 11 Mar 14
     
    new study out of the Lancet labels Flouride as neurotoxicant, along with lead, methyl mercury, PCBs, arsenic, toluene and others.   This is not a political issue and needs to be reviewed scientifically.  These toxicants impair neurodevelopment and may be one reason for the rapidly rising conditions associated: i.e. ADD, ADHD, autism...
Nathan Goodyear

Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine | PNAS - 0 views

www.pnas.org/10238

AML leukemia acute myeloid leukemia MDS vitamin C cancer

shared by Nathan Goodyear on 12 May 18 - No Cached
  • Vitamin C alone at concentrations up to 57 μM had little effect on cell growth but was toxic at 228 μM (SI Appendix, Fig. S1B), in line with recent studies of high vitamin C concentrations (125–2,000 μM)
  • In our combination approach, vitamin C increased the effects of low doses of 5-aza-CdR, with 57 μM vitamin C almost doubling the growth inhibition
  • Using the Chou–Talalay method (28), we found that the two compounds indeed acted synergistically, rather than additively, to inhibit cancer cell growth over the physiological ranges of vitamin C in healthy individuals (26–84 μM)
  • ...12 more annotations...
  • These results show that targeting the cancer DNA methylome by combining low-dose 5-aza-CdR and vitamin C stimulates the expression of ERVs, the induction of a cell-autonomous immune activation response, and increased apoptosis of cancer cells
  • The addition of vitamin C to treatment protocols therefore may be a straightforward way to increase the clinical efficacy of such drugs in MDS and leukemia patients
  • Vitamin C deficiency has been seen previously in patients with multiple types of cancer, including hematological malignancies (35⇓–37). We predict that these patients might receive the most benefits from the combination treatment.
  • induction of an innate immune response
  • We therefore measured plasma concentrations of vitamin C in a small number of patients with miscellaneous hematologic malignancies. Strikingly, 58% of patients with hematological neoplasia who were not taking vitamin C supplements had severe vitamin C deficiency (serum concentration <11.4 μM, at which clinical features of scurvy may be manifested) (34), and 33% had vitamin C levels below the normal range
  • it is possible that vitamin C was oxidized to DHA before it was transported into the cells
  • Oral administration of vitamin C should be sufficient for the therapeutic strategy, because the concentrations reported in this study would not require i.v. administration.
    • Nathan Goodyear
      Nathan Goodyear on 12 May 18
       
      This statement lacks a basic understanding of vitamin C pharmacokinetics.
  • Vitamin C is an essential nutrient for humans and has been reported to increase IFN levels in human cells upon virus infection
  • daily treatment with vitamin C alone at physiological concentrations enhanced the expression of viral-defense genes relative to untreated cells
  • When combined with low-dose 5-aza-CdR, physiological concentrations of vitamin C synergistically inhibited cancer-cell growth and induced apoptosis. Such synergy was associated with increased ERV expression and dsRNA in treated cells. The mechanism of action differs from that of vitamin C at higher doses, which involves its pro-oxidant activity, including GSH inhibition, to generate reactive oxygen species
  • This activity has been shown to induce DNA damage and to enhance the sensitivities of myeloid malignancies, multiple myeloma, and cutaneous T-cell lymphoma to arsenic trioxide (41⇓⇓–44). It also can increase chemosensitivity of ovarian cancer cells (27) and selectively kill KRAS or BRAF mutant colorectal cancer cells by inhibiting GAPDH
  • reactive oxygen species
  • Nathan Goodyear on 12 May 18
     
    91% of patients with hematologic malignancies have vitamin C levels that are either low or severly deficient. This study found that vitamin C plus low dose DNA methyltransferase inhibitors have synergistic inhibition of cancer cell proliferation and increased apoptosis.  Unfortunately, the authors claimed that oral vitamin C would be sufficient which indicates an incredible lack of understanding of vitamin C pharmacokinetics.
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