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Nathan Goodyear

Impaired transsulfuration and oxidative stress in autistic children: Improvement with t... - 0 views

www.autism.com/o_research_oxidativestress.asp

ASD autism sulfation nutrition

shared by Nathan Goodyear on 12 Jul 11 - No Cached
  • Nathan Goodyear on 12 Jul 11
     
    The importance of Sulfation and nutrition in autism spectrum disorders
Nathan Goodyear

Low Dehydroepiandrosterone Sulfate is Associated With Increased Risk of Ischemic Stroke... - 0 views

stroke.ahajournals.org/...STROKEAHA.111.000485.abstract

DHEAS stroke women ischemic stroke deydroepiandrosterone sulfate

shared by Nathan Goodyear on 18 Jun 13 - No Cached
  • Nathan Goodyear on 18 Jun 13
     
    Lower DHEAS in women (25 percentile) in this study associated with increased risk of stroke.  
Nathan Goodyear

Differential Effects of Dehydroepiandrosterone and Testosterone in Prostate and Colon C... - 0 views

press.endocrine.org/...en.2012-2249

testosterone prostate colon colon cancer cancer NGF nerve growth factor dhea dehydroepiandrosterone

shared by Nathan Goodyear on 19 Nov 14 - No Cached
  • Several studies indicate that DHEA may enhance cancer-promoting activities in several prostate cancer cell lines acting as agonist or antagonist for the intracellular AR
  • the estrogenic metabolites of DHEA, 5a-androstane-3b, 17b-diol (3b-Adiol) and E2 bind to estrogen receptors but not to AR
  • no specific receptor has been identified for DHEA
  • ...16 more annotations...
  • Different members of neurotrophins are expressed during cancer progression, suggesting their involvement in cell proliferation, anoikis protection, and malignancy
  • Regulation of the apoptotic machinery in prostate and colon cancer cells by testosterone occurs rapidly and is initiated at the plasma membrane level through specific membrane-binding sites not involving the classical cytoplasmic AR
  • testosterone exerts potent regulatory effects on prostate and colon cancer cell apoptosis
  • Testosterone increased cell death in a dose-dependent manner
  • testosterone antagonizes the prosurvival effects of DHEA in neuronal cells, blocking its binding to NGF receptors
  • treatment of cells with DHEA exerted a strong antiapoptotic effect,
  • Androgens hold a central role in prostate and colon cancer biology
  • elevated levels of DHEA or its sulfate ester DHEA-sulfate in young adults are associated to low incidence of androgen-dependent tumors
  • DHEA may play a protective role in young prostate
  • The decline of DHEA with aging may contribute to prostate cancer progression associated with advanced age
  • DHEA is an effective antiapoptotic factor, reversing the serum deprivation-induced apoptosis in prostate cancer cells (DU145 and LNCaP cell lines) as well as in colon cancer cells
  • NGF appears to exert similar antiapoptotic actions in both prostate and color cancer cells
  • exposure of prostate DU145 and colon Caco2 cancer cells to testosterone totally blocked the protective effects of both DHEA and NGF. These findings suggest that testosterone acts as an antagonist of DHEA and NGF
  • These findings support the hypothesis that testosterone may inhibit cancer cell growth by antagonizing the proliferative, antiapoptotic effects of endogenous factors, such as DHEA or NGF, in the case of prostate and colon cancer cells
  • intratumor hormonal microenvironment may play a critical role in tumor progression.
  • The paracrine interactions of androgens with locally produced NGF may define tumor cell fate
  • Nathan Goodyear on 19 Nov 14
     
    Full article of previously posted abstract.  Cancers are unique.  Not all cancers are alike.  Whether they are tissue specific or not, cancers are unique.  This article describes the uniqueness of DHEA and Testosterone cancer, with particular attention to colon.
Nathan Goodyear

Neurobiological and Neuropsychiatric Effects of Dehydroepiandrosterone (DHEA) and DHEA ... - 0 views

www.ncbi.nlm.nih.gov/...PMC2725024

DHEA DHEA-S neurology neuropsychiatry

shared by Nathan Goodyear on 11 Dec 12 - No Cached
  • Nathan Goodyear on 11 Dec 12
     
    Everything you wanted to know about DHEA, DHEA-S in general and as they relate to neuropsychiatry.
Nathan Goodyear

ANTENATAL MAGNESIUM SULFATE FOR THE PREVENTION OF CEREBRAL PALSY IN PRETERM INFANTS <34... - 0 views

www.ncbi.nlm.nih.gov/...PMC3459676

IV magnesium IV magnesium cerebral palsy CP IV therapy nutritional therapy

shared by Nathan Goodyear on 07 Feb 13 - No Cached
  • Nathan Goodyear on 07 Feb 13
     
    IV magnesium shown to reduce risk of cerebral palsy in meta-analysis.
Nathan Goodyear

Tumor necrosis factor inhibits conversion of dehydroepiandrosterone sulfate (DHEAS) to ... - 0 views

www.ncbi.nlm.nih.gov/...15934093

RA rheumatoid arthritis TNF-alpha DHEA hormones

shared by Nathan Goodyear on 09 May 16 - No Cached
  • Nathan Goodyear on 09 May 16
     
    TNF-alpha inhibited activation of DHEA in RA.
Nathan Goodyear

Effect of DHEA-sulfate on adiponectin gene expression in adipose tissue from different ... - 0 views

www.eje.org/...593.full

DHEA-S DHEAS adiponectin adipose tissue adipocytes fat cells insulin resistance obesity

shared by Nathan Goodyear on 17 Mar 12 - No Cached
  • Nathan Goodyear on 17 Mar 12
     
    DHEA-S shown to increase genetic expression of adiponectin in human adipose tissue.  This has enormous implications on the link between DHEA and insulin resistance induce obesity. This is a peripheral tissue problem, not a central problem.
Nathan Goodyear

Dehydroepiandrosterone-Sulfate Inhibits Nuclear Factor-κB-Dependent Transcrip... - 0 views

jcem.endojournals.org/...3449.long

DHEA DHEA-S inflammation NF-KappaB antioxidant

shared by Nathan Goodyear on 17 Mar 12 - No Cached
  • Nathan Goodyear on 17 Mar 12
     
    DHEA inhibits NF-kappaB, thus inhibiting inflammation.
Nathan Goodyear

BPA, BPA glucuronide, and BPA sulfate in... [Environ Sci Technol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23941471

BPA Bisphenol A Bisphenol-A endocrine disruptor EDC

shared by Nathan Goodyear on 04 Sep 13 - No Cached
  • Nathan Goodyear on 04 Sep 13
     
    Startling finding: 100% of all pregnancies in this study were found to have detectable BPA levels.  BPA is a known endocrine disruptor.
Nathan Goodyear

Estrone sulfate (E1S), a prognosis marker for tumor aggressiveness in prostate cancer (... - 0 views

www.sciencedirect.com/...S0960076008000289

Estrogen Estrone aromatase aromatase activity prostate cancer disease men male health

shared by Nathan Goodyear on 21 Aug 13 - No Cached
  • Nathan Goodyear on 21 Aug 13
     
    High Estrone (E1) associated with increased prostate cancer risk.  This occurs through high aromatase activity.
Nathan Goodyear

Low Dehydroepiandrosterone Sulfate is Associated With Increased Risk of Ischemic Stroke... - 0 views

stroke.ahajournals.org/...1784.full

DHEA DHEAS DHEA-S dehydroepiandrosterone stroke women female hormone hormones cardiovascular disease

shared by Nathan Goodyear on 22 Jul 14 - No Cached
  • Nathan Goodyear on 22 Jul 14
     
    Lower DHEAS, not below normal, levels associated with increased risk of ischemic stroke in women when compared to higher DHEAS levels.
Nathan Goodyear

Dehydroepiandrosterone and its sulfate predict the 5-year risk of coronary heart diseas... - 0 views

www.ncbi.nlm.nih.gov/...25443702

heart disease DHEA dehydroepiandrosterone hormone hormones DHEAS DHEA-S men male CHD

shared by Nathan Goodyear on 23 Apr 15 - No Cached
  • Nathan Goodyear on 23 Apr 15
     
    low DHEA and DHEA-S associated with increased risk of Coronary Heart Disease in elderly men.
Nathan Goodyear

EHP - Sulfated Metabolites of Polychlorinated Biphenyls Are High-Affinity Ligands for t... - 0 views

ehp.niehs.nih.gov/1206198

polychlorinated biphenyls PCBs thyroid xenoestrogens hormone hormones

shared by Nathan Goodyear on 19 Jun 13 - No Cached
  • Nathan Goodyear on 19 Jun 13
     
    Polychlorinated biphenyl (PCBs) shown to disrupt thyroid hormone function through disruption of the transthyretin binding sites.  Not only is it a xenoestrogen, but it disrupts thyroid function too.
Nathan Goodyear

Abnormal transmethylation/transsulfuration metabolism and DNA hypomethylation among par... - 0 views

www.ncbi.nlm.nih.gov/...PMC2584168

autism spectrum disorders children detoxifcation methylation sulfation glutathione

shared by Nathan Goodyear on 05 Jul 11 - No Cached
  • Nathan Goodyear on 05 Jul 11
     
    abnormal detoxification at heart of autism
Nathan Goodyear

The association between serum dehydroepiandrosterone sulfate (DHEA-... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25692973

DHEA DHEA-S DHEAS BMD osteoporosis men male hormone hormones

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • Nathan Goodyear on 02 Mar 15
     
    Only abstract available here, but lower DHEA-S (still in reference normal range) associated with lower bone mineral density and increased osteoporosis risk.
Nathan Goodyear

Stability of Magnesium Sulfate in 0.9% Sodium Chloride and Lactated Ringers solutions -... - 0 views

pubmed.ncbi.nlm.nih.gov/23989704

LR NS Magnesium

shared by Nathan Goodyear on 30 Jan 24 - No Cached
  • Nathan Goodyear on 30 Jan 24
     
    No incompatibility
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