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Nathan Goodyear

Clinical experience with intravenous administration of ascorbic acid: achievable levels... - 0 views

www.ncbi.nlm.nih.gov/...PMC3751545

IV vitamin C dosing ascorbic acid inflammation disease cancer IV vitamin C intravenous vitamin C IV intravenous vitamin C vitamin C CRP therapy treatment alternative

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Patients with higher tumor markers are likely to have higher tumor burden, higher oxidative stress and, therefore, are more likely to have lower post IVC plasma levels.
  • Our data also showed that cancer patients with metastasis tend to have lower post-IVC vitamin C levels than those without metastasis
  • Lower peak plasma concentrations are obtained in cancer patients than in healthy subjects. Cancer patients who are deficient in vitamin C prior to therapy tend to achieve lower plasma levels post infusion.
  • ...25 more annotations...
  • Patients with higher inflammation or tumor burdens, as measured by CRP levels or tumor antigen levels, tend to show lower peak plasma ascorbate levels after IVC.
  • Patients with metastatic tumors tend to achieve lower post infusion plasma ascorbate levels than those with localized tumors.
  • Meta-analyses of clinical studies involving cancer and vitamins also conclude that antioxidant supplementation does not interfere with the efficacy of chemotherapeutic regiments
  • Most of the prostate cancer patients studied, 75±19% (95% confidence), showed reductions in PSA levels during the course of their IVC therapy
  • Laboratory studies suggest that, at high concentrations, ascorbate does not interfere with chemotherapy or irradiation and may enhance efficacy in some situations
  • Cameron and Pauling observed fourfold survival times in terminal cancer patients treated with intravenous ascorbate infusions followed by oral supplementation
  • The inflammatory microenvironment of cancer cells leads to increasing oxidative stress, which apparently depletes vitamin C, resulting in lower plasma ascorbate concentrations in blood samples post IVC infusion. Another explanation for this finding may be that cancers are themselves more metabolically active in their uptake of vitamin C, causing subjects to absorb more of the vitamin, and as a results show lower plasma ascorbate concentrations in blood post IVC infusion.
  • patients with severely elevated CRP levels attain plasma ascorbate concentrations after IVC infusions that are only 65% of those attained for subjects with normal CRP levels
  • The finding of decreased plasma ascorbate levels in cancer patients may relate to the molecular structure of ascorbic acid; in particular, the similarity of its oxidized form, dihydroascorbic acid, to glucose
  • Since tumor have increased requirement for glucose [67], transport of dehydroascorbate into the cancer cells via glucose transport molecules and ascorbate through sodium-dependent transporter may be elevated
  • Increased accumulation of ascorbic acid in the tumor site was supported by measurements of the level of ascorbic acid in tumors in animal experiments
  • patients with advanced malignancies may have lower level of ascorbic acid in tissue, creating a higher demand for the vitamin C
  • IVC therapy appears to reduce CRP levels in cancer patients.
  • CRP concentrations directly correlate with disease activity in many cases and can contribute to disease progression through a range of pro-inflammatory properties.
  • Being an exquisitely sensitive marker of systemic inflammation and tissue damage, CRP is very useful in screening for organic disease and monitoring treatment responses
  • ncreases in CRP concentrations have been associated with poorer prognosis of survival in cancer patients, particularly with advance disease independent of tumor stage
  • Regarding inflammation, 73±13% of subjects (95% confidence) showed a reduction in CRP levels during therapy. This was an even more dramatic 86±13% (95% confidence) in subjects who started therapy with CRP levels above 10 mg/L
  • patients treated by IVC with follow-up several year showed that suppression of inflammation in cancer patients by high-dose IVC is feasible and potentially beneficial
  • Inflammation is a marker of high cancer risk, and poor treatment outcome
  • The subjects with highly elevated CRP concentrations have a three-fold elevation “all-cause” mortality risk and a twenty-eight fold increase in cancer mortality risk
  • cancer patients may need higher doses to achieve a given plasma concentration.
  • patients with lower vitamin C levels may see more distribution of intravenously administered ascorbate into tissues and thus attain less in plasma.
  • When treating patients with IVC, the first treatment likely serves to replenish depleted tissue stores, if those subjects were vitamin C deficient at the beginning of the treatment. Then, in subsequent treatments, with increasing doses, higher plasma concentrations can be attained. On-going treatments serve to progressively reduce oxidative stress in cancer patients.
  • large doses given intravenously may result in maximum plasma concentrations of roughly 30 mM, a level that has been shown to be sufficient for preferential cytotoxicity against cancer cells
  • oral intake of vitamin C exceeded 200 mg administered once daily, it was difficult to increase plasma and tissue concentrations above roughly 200 μM.
  • Nathan Goodyear on 26 Aug 14
     
    Great review on the use of IV vitamin C in cancer and to reduce inflammation.  The article does a great job of discussing the mechanism of vitamin C therapy in cancer as well as the proposed reasons for low vitamin C in cancer patients.  The study also highlights the obstacles to rise in vitamin C levels post IV vitamin C in cancer patients.
Nathan Goodyear

High-dose Vitamin C (Ascorbic Acid) Therapy in the Treatment of Patients with Advanced ... - 1 views

ar.iiarjournals.org/...809.long

IV vitamin C IV vitamin C therapy antioxidant antioxidants cancer

shared by Nathan Goodyear on 25 Sep 13 - No Cached
  • Nathan Goodyear on 25 Sep 13
     
    IV vitamin C dosing shown to be safe and effective.  The levels achieved by IV therapy supercedes that able to achieve by oral therapy by several factors.  This review of the data in this study is of high dose IV vitamin C--safety is reassured.
Nathan Goodyear

Intravenous Fluid Use in Athletes - 0 views

www.ncbi.nlm.nih.gov/...PMC3435915

IV nutrition intravenous fluids exercise sports medicine sports athlete athletes

shared by Nathan Goodyear on 13 Jan 15 - No Cached
  • The current data suggest that IV rehydration is faster than oral
  • There may be physiological benefits of decreased heart rate and norepinephrine in athletes rehydrated via IV route
  • Muscle damage during exercise in the heat was assessed by myoglobin and creatine kinase
  • ...4 more annotations...
  • Postexercise blood 1 hour and 24 hours showed no differences in circulating myoglobin or creatine kinase
  • IV administration of fluids can rapidly replace plasma volume
  • The rapid increase in plasma volume is transient, and no measureable difference between IV and oral prehydration exists after 15 minutes of exercise
  • The use of IV fluid may be beneficial for a subset of fluid sensitive athletes
  • Nathan Goodyear on 13 Jan 15
     
    IV nutrition pre-event, intra-event, and post-event for recovery.
Nathan Goodyear

Intravenous Vitamin C and Cancer: A Syste... [Integr Cancer Ther. 2014] - PubMed - NCBI - 1 views

www.ncbi.nlm.nih.gov/...24867961

IV vitamin C intravenous vitamin C vitamin C IV intravenous cancer IVC ascorbic acid

shared by Nathan Goodyear on 27 Aug 14 - No Cached
  • Nathan Goodyear on 27 Aug 14
     
    So help me out here:  If IV vitamin C has been shown to prolong time to cancer relapse, aid in reducing tumor size, improve survival with chemotherapy, improve quality of life, improve physical function, reduce chemo side effects, improve energy, reduce nausea, aid insomnia, reduce constipation, and improve depression in cancer patient--then why does the author say that IV vitamin C is contentious?  Add that IV vitamin C has not been implicated in any deaths in cancer therapy.  Contrast that with chemotherapy.  Why again is this contentious?  Whom is best served by this being contentious?
Nathan Goodyear

High-dose Vitamin C (Ascorbic Acid) Therapy in the Treatment of Patients with Advanced ... - 0 views

ar.iiarjournals.org/...809.short

IV vitamin C cancer therapy treatment

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    vitamin C therapy has been shown to benefit cancer patients in much of the literature, though some research has been published to the contrary. High dose vitamin C IV therapy needs to be re-evaluated as potential therapy in cancer patients
Nathan Goodyear

Antioxidants as Therapeutic Agents for Liver Disease - 0 views

www.ncbi.nlm.nih.gov/...PMC3228367

IV vitamin C IV intravenous C antioxidant therapy antioxidants hepatitis liver

shared by Nathan Goodyear on 25 Sep 13 - No Cached
  • Nathan Goodyear on 25 Sep 13
     
    This study concludes that evidence is small and inadequate despite consistent reductions of elevated liver enzymes.  The review of the data here includes both IV and oral therapy.  These modalities are not comparable.  IV vitamin C has been shown to reduce elevated liver enzymes where oral does not.
Nathan Goodyear

Treatment of Postherpetic Neuralgia with Intravenous Administration of Vitamin C - 0 views

www.anesthesia-analgesia.org/...1616.2.long

IV IV therapy IV vitamin C inflammation neuropathic pain post-herpetic neuralgia Nutritional therapy nutrition vitamin C vitamin C pain

shared by Nathan Goodyear on 23 Jan 13 - No Cached
  • Nathan Goodyear on 23 Jan 13
     
    IV vitamin C therapy found to be beneficial in aiding neuropathic pain from postherpetic neuralgia.
Nathan Goodyear

Effect of intravenous ascorbic acid in hemod... [Am J Kidney Dis. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16564942

IV vitamin C IV vitamin C antioxidant antioxidants anemia

shared by Nathan Goodyear on 25 Sep 13 - No Cached
  • Nathan Goodyear on 25 Sep 13
     
    High dose IV vitamin C shown to be well tolerated in those on hemodialysis.  Liver enzymes were followed throughout the course of the 6 month trial.  In fact, IV vitamin C was shown to improve the response of the EPO therapy.
Nathan Goodyear

Intravenously administered vitamin C as cancer therapy: three cases - 0 views

www.cmaj.ca/...937.full

IV vitamin C intravenous therapy treatment cancer

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    high dose IV vitamin C therapy shown to benefit patients with cancer.  Three cases documented vitamin C therapy in patients with cancer
Nathan Goodyear

Intravenous administration of vitamin C in the... [Med Sci Monit. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20424557

IV IV therapy IV vitamin C nutritional therapy vitamin C herpetic neuralgia vitamins vitamin vitamin therapy

shared by Nathan Goodyear on 23 Jan 13 - No Cached
  • Nathan Goodyear on 23 Jan 13
     
    Two case studies that show IV vitamin C aided in the resolution of herpetic neuralgia.
Nathan Goodyear

The use of antioxidants with first-line chemotherapy in two cases of ovarian cancer - 0 views

www.jacn.org/...118.full.pdf

IV IV vitamin C vitamin C ovarian cancer ovarian cancer antioxidants

shared by Nathan Goodyear on 30 Jan 13 - No Cached
  • Nathan Goodyear on 30 Jan 13
     
    IV, high dose, vitamin C adjunct therapy shown to aid in the remission in to women with ovarian cancer. These two cases studies do only looked and high dose antioxidant therapy as an adjunct in ovarian cancer and they found good results.
Nathan Goodyear

Massive Doses of Vitamin C and the Virus Diseases - 0 views

www.seanet.com/...med_surg-1951-v103-n4-p101.htm

IV therapy IV C virus viral illness nutrition nutritional therapy

shared by Nathan Goodyear on 23 Jan 13 - No Cached
  • Nathan Goodyear on 23 Jan 13
     
    High dose IV vitamin C beneficial in viral illnesses.  This is a case study article, but it discusses how viral illnesses are associated with low vitamin C levels and how high dose vitamin C therapy benefits the immune activity against viral invaders.
Nathan Goodyear

Influence of postoperative enteral nutrition on postsurgical infections. -- Beier-Holge... - 0 views

gut.bmj.com/833

IV IV therapy nutritional therapy nutrition

shared by Nathan Goodyear on 23 Jan 13 - No Cached
  • Nathan Goodyear on 23 Jan 13
     
    IV nutritional therapy postoperatively helps prevent post surgical infections.
Nathan Goodyear

Intravenous Vitamin C Administration Improves Quality of Life in Breast Cancer Patients... - 0 views

iv.iiarjournals.org/...983.abstract

vitamin C IV intravenous therapy treatment cancer

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    IV vitamin C shown to improve quality of life measures in breast cancer patients during chemo/radiation.  What this shows, is that IV vitamin C is not only safe for healthy individuals, but healthy for cancer patients.
Nathan Goodyear

Plasma vitamin C is lower in postherpetic neural... [Clin J Pain. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19692796

IV IV therapy IV vitamin C vitamin C vitamin vitamins nutritional therapy pain post-herpetic neuralgia

shared by Nathan Goodyear on 23 Jan 13 - No Cached
  • Nathan Goodyear on 23 Jan 13
     
    IV vitamin C aids pain control in postherpetic neuralgia.
Nathan Goodyear

ANTENATAL MAGNESIUM SULFATE FOR THE PREVENTION OF CEREBRAL PALSY IN PRETERM INFANTS <34... - 0 views

www.ncbi.nlm.nih.gov/...PMC3459676

IV magnesium IV magnesium cerebral palsy CP IV therapy nutritional therapy

shared by Nathan Goodyear on 07 Feb 13 - No Cached
  • Nathan Goodyear on 07 Feb 13
     
    IV magnesium shown to reduce risk of cerebral palsy in meta-analysis.
Nathan Goodyear

Evaluation of the clinical use of magnesium s... [Obstet Gynecol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23344271

IV therapy IV nutritional therapy IV Magnesium magnesium CP cerebral palsy

shared by Nathan Goodyear on 07 Feb 13 - No Cached
  • Nathan Goodyear on 07 Feb 13
     
    IV magnesium used for cerebral palsy PREVENTION.
Nathan Goodyear

The Role of Vitamin C in Human Immunity and Its Treatment Potential Against COVID-19: A... - 0 views

www.ncbi.nlm.nih.gov/...PMC9925039

COVID-19 SARS-CoV-2 COVID WBC ascorbic acid vitamin C

shared by Nathan Goodyear on 01 Sep 23 - No Cached
  • vitamins A, B, C, E, B6, B12, folate, zinc, iron, copper, and selenium
  • White blood cells, including neutrophils and monocytes, accumulate concentrations of vitamin C up to 100 times greater than that of plasma
  • Vitamin C is a crucial component of both the innate (nonspecific) and adaptive (specific) portions of the immune system
  • ...52 more annotations...
  • play a role during the initial chemotactic response of neutrophils shortly after infection
  • following vitamin C supplementation, a 20% increase in neutrophil chemotactic activity was observed
  • also contributes to the phagocytosis and killing of microbes by neutrophils
  • low levels of vitamin C occurring in high-stress situations
  • maturation, proliferation, and viability of T cells have all been shown to be upregulated by the presence of normal physiologic concentrations of vitamin C
  • Vitamin C has been shown to directly affect the number of Igs released from B cells
  • vitamin C among healthy young adult males showed a significant increase in serum levels of IgA, IgG, and IgM
  • effects of high-dose vitamin C on cytokine levels in cancer patients, finding decreased amounts of the cytokines Interleukin-1 alpha (IL-1 alpha), IL-2, IL-8, and tumor necrosis factor-alpha (TNF-alpha) after high-dose vitamin C infusion
  • when vitamin C was supplemented with vitamin E in healthy adults, it increased the production of cytokines IL-1 beta and TNF-alpha
  • vitamin C acts to modulate the levels of cytokines to prevent them from fluctuating in either direction
  • vitamin C also acts as an important antioxidant to the cells of the immune system.
  • human leukocytes, neutrophils, in particular, possess the ability to transport the oxidized form of vitamin C across its membrane to use as a defense mechanism against ROS produced during an immune response
  • Vitamin C also can recover other endogenous antioxidants in the body such as vitamin E and glutathione, returning them to their active state
  • vitamin C can decrease the activation of NF-kB
  • can reduce harmful nitrogen-based compounds such as N-nitrosamines and nitrosamides, both of which are carcinogenic&nbsp;
  • subjects taking oral vitamin C supplementation saw a 60% to 90% reduction in oxidative stress compared to a placebo control
  • subjects infused with vitamin C alone had a 516% increase in glutathione levels compared to subjects not provided the 500 mg daily supplementation
  • hydroxylating proline and lysine
  • mature and stabilize the tissue of a healing wound
  • healing
  • oral surgery
  • improved soft tissue regeneration
  • vitamin C increases the mRNA levels of type I and type III collagen in the human dermis
  • Studies have demonstrated that those with low levels of vitamin C are at a significantly higher risk of respiratory infection compared to those with normal levels
  • viral cold duration was reduced by about 8% in adults and 13.5% in children using prophylactic daily doses of 200 mg of oral vitamin C
  • prophylactically supplementing vitamin C decreases the risk of infection with respiratory viruses such as the common cold
  • combined with probiotics, oral vitamin C supplementation showed a 33% decrease in the incidence of respiratory tract infections in preschool-age children [
  • high-dose oral supplementation of vitamin C managed to prevent or reduce symptoms if taken before or just after the onset of cold- or flu-like symptoms
  • improvements in oxygen saturation and decreased IL-6 levels (a marker of inflammation) in the treatment group compared to the control group
  • 8 g doses of oral vitamin C
  • there is a negative correlation between age and serum levels of vitamin C
  • Patients with COVID-19 will likely also experience depletion in serum levels of vitamin C as a direct result of the upregulation of the immune system to combat the infection
  • Colunga et al. suggested that oral vitamin C can be combined with oral Quercetin, an antiviral flavonoid, to improve Quercetin’s ability to block viral membrane fusion of SARS-CoV-2
  • high doses of 1-2 g/day of oral vitamin C could prevent other upper respiratory infections
  • It appears vitamin C supplementation by itself does not provide a striking benefit in preventing COVID-19 infection for those without a deficiency
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Flawed statement. What is normal? Vitamin D. Many variables effect levels and dose, including the two compartment kinetics and absorption.
  • Hiedra et al. were able to show decreases in inflammatory biomarkers, such as D-dimer and ferritin
  • some evidence to support that prophylactic use of vitamin C helps reduce the severity of respiratory infection symptoms once a subject has already been infected
  • oral vitamin C in combination with zinc provided the largest amount of antibody titers 42 days
  • linear relationship between days of vitamin C therapy and survival duration
  • other studies were unable to find any definitive improvement concerning therapy with vitamin C
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Either these studies are designed to fail or the authors are lacking some basic understanding of pharmacokinetics and pharmacodynamics with vitamin C.
  • Fowler et al. aimed to see if a high-dose vitamin C infusion would benefit patients affected by ARDS, but they were unable to conclude that vitamin C infusion, compared to a placebo, could decrease vascular inflammation and damage in ARDS
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      At what dose, duration, frequency???
  • in a sample of 67 COVID-19-positive ICU patients, 82% of them displayed plasma vitamin C levels below 0.4 mg/dL
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      They are kind of make the point from my earlier note.
  • continuous vitamin C infusion at a rate of 60 mg/kg/day for four days decreased the need for mechanical ventilation and vasopressor use but had no significant effect on overall mortality
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      Again, designed to fail or ignorance designed the study which failed
  • Carr et al. suggested that high-dose IV vitamin C is most effective when treating sepsis as septic patients receiving the normal daily recommendations through diet still showed decreased vitamin C levels
  • High-dose IV vitamin C treatment has also been shown by Kakodkar et al. to decrease syndecan-1, an endothelial glycocalyx that contributes to mortality in septic patients
  • combined with hydrocortisone and thiamine, septic patients treated with 1.5 g of IV vitamin C every six hours showed a distinct decrease in their SOFA&nbsp;scores and none of the patients treated developed organ failure
  • combined with hydrocortisone and thiamine, septic patients treated with 1.5 g of IV vitamin C every six hours showed a distinct decrease in their SOFA&nbsp;scores and none of the patients treated developed organ failure
  • reduced overall mortality
  • reduced overall mortality
  • propose the use for high-dose vitamin C to aid in the treatment of septic shock-induced hypotension
  • treatment of severe sepsis using a high dose (up to 200 mg/kg/day) of IV vitamin C was explored in phase I, a double-blind, randomized, placebo-controlled trial by Fowler et al. [75]. Their findings included a reduction in SOFA scores and decreased vascular injury compared to a placebo control group, all while showing minimal adverse side effects
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      High dose here is laughable. Again, duration and frequency also.
  • Maintaining a daily intake of 75 and 100 mg for men and women, respectively, as recommended by the U.S. Institute of Medicine
    • Nathan Goodyear
      Nathan Goodyear on 01 Sep 23
       
      This recommendation is FRANK IGNORANCE
Nathan Goodyear

Cureus | Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet,... - 1 views

www.cureus.com/...-triple-negative-breast-cancer

ketogenic diet hbot hyperbaric oxygen hyperbaric therapy diet nutrition cancer hyperthermic therapy chemotherapy

shared by Nathan Goodyear on 09 Jul 17 - No Cached
  • Nathan Goodyear on 09 Jul 17
     
    Asking questions that challenge dogma is difficult.  This individual case study just does that.  Case study finds that ketogenic diet, hyperthermic therapy, and hyperbaric oxygen reduce the side effects of chemo, improved quality of life, and at the time of the publication, remission of disease.
Nathan Goodyear

Orthomolecular Oncology Review: Ascorbic Acid and Cancer 25 Years Later - 0 views

ict.sagepub.com/...32.abstract

vitamin C cancer treatment therapy

shared by Nathan Goodyear on 19 Jul 11 - No Cached
  • Nathan Goodyear on 19 Jul 11
     
    IV vitamin C shown to be highly effective in cancer therapy.  This article is a great review of the literature for IV vitamin C
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