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HCG used to stimulate endogenous testosterone production in young men with idiopathic hypogonadotrophic hypogonadism.

As obesity increases, so Testosterone decreases.  Hypogondatrophic hypogonadism is associated is found in obesity.  This is no surprise, as aromatase activity is increased in fat resulting in elevated Estrogen, which provides negative feedback to the hypothalamic-pituitary axis.  This results in decrease LH and thus Testosterone production.

men with idiopathic hypogonadotropic hypogonadism have increased carotid IMT--atherosclerosis.  Testosterone therapy reduced carotid IMT.  

This is the abstract from oral presentation at AACE in Las Vegas from May.  Small study finds reduction in fat mass, increase in muscle mass, increase in insulin sensitivity, and reduction in inflammation signaling with Testosterone therapy in men with low Testosterone.  These men were type 2 diabetics.  This is consistent with prior published literature.  However, men without diabetes, this association is hard to reproduce. The degree of glucose control also effects the response to Testosterone therapy i.e. the worse the glucose control, the more the response from Testosterone.   Also of note, those men with hypogonatrophic hypogonadism had decreased insulin receptor expression, decreased insulin sensitivity, and decreased GLUT-4 expression versus eugonadal men.  Remember from prior studies, it is the conversion of Testosterone to DHT that increases GLUT-4 transcription, translocation, and expression.