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Menopausal rats and rats that had ovaries removed have increased low grade inflammatory signaling.  This study treated the rats in question with either Estradiol and Losartan and both decreased inflammatory signaling.

Study finds that inhibition of aromatase activity in diabetic male rats provided renal protection. There has been debate about the effects of testosterone therapy on the renal system. However, I propose that aromatase activity and conversion to estrogen is the negative effects of Testosterone. Other than over dosing men. Though this is a rat study, this study does support the theory.

animal study finds that Testosterone therapy is cardioprotective in a preventative mode and with myocardial injury.  Normalization of Testosterone in these animals with low T reduced infant injury size and improved heart function.  

Ginger reduces oxidative stress in diabetic rat model

Animal model finds that Testosterone improves ventricular remodeling and function following myocardial infarction in male rats.  This similar finding has been found in human studies as well.   Testosterone therapy was found to lower BNP in this rat study.

animal study finds Testosterone likely improves ACL strength.  This study looked at castrated rats versus non-castrated rats.  The Testosterone levels were significant between the two groups.  The stress load tolerated by the ACL was different between the 2 groups. One wonders how the C:T ratio may have an impact here?

First long-term study on GMO effects on rats. The majority of studies on GMO have been on animals with the end point at < 90 days.  This study followed the rats for 2 years.  Increased mammary tumors were found.  Is this definitive?  Of course not, but this is the first study to look at long term effects.

In rat model, Estradiol shown to increase inflammation in lateral lobes of the prostate.  Androgens, Testosterone > DHT, shown to inhibit this inflammatory response.  

Fascinating article: DHEA found to decrease NF-KappaB activity in the hippocampus region of the brain.  This has implications in protecting the brain.  In this study, the implication was reduction in inflammation in the hippocampus region in diabetic rat model.

low exposure to glyphosate-based herbicide (round up) decreases Testosterone production by 35%.   This occurs at very low exposure levels of 1 ppm.  In a rat study, large doses causes ACUTE rat TESTICULAR TOXICITY. I think both men and women should be very careful around this chemical

Curcumin shown to inhibit oxidative stress, inflammation, and mitochondrial damage caused by Aluminum in rat brain.  Aluminum's effect is not just confined to rat models.  It is well known to cause similar results in the human brain as well.  what is interesting about this article is the clear pathway disruption described as a result of Aluminum exposure.

Rat study suggests that sugar is just as addictive as cocaine.  So, is the food industry knowingly pushing addiction on the public?

Very interesting study.  High fat diet in rats induced gut flora change that resulted in LPS which induced appetite through leptin resistance and reduced cholecystokinin signaling.

study shows that progesterone directly inhibits pro-inflammatory cytokine signaling in rat dendritic cells.  Progesterone here shows to be directly involved in a anti-inflammatory effect.

acupuncture decreases HPA sympathetic drive.  Acupuncture calms the HPA axis and relieves stress.  Granted this is in a rat model.

Rat model shows that vitamin C reduces oxidative damage from lead.  Thus, vitamin C provides antioxidant effect.

very interesting study in rats.  LH induced a dose-dependent increase in testicular estrogen production through aromatase activity.  Yes, LH stimulates the leydig cells to produce testosterone, but there is a point at which LH will actually increase aromatase activity and thus estrogen production at the testicular level.

estrogen receptors are transported to the cell membrane after production in the rat hippocampus.  The membrane receptors have the same origin as the intracellular receptors.

T3 in the post MI individual decreases the MI infarct size and the progression to heart failure. What is really  interesting about this study is that the T3 induced mitochondrial biogenesis and activity which is a great thing in recovery of MI and also in disease i.e. cancer.  However, it appears to increase HIF-1alpha and angiogenesis which is stimulated by retrograde signaling.  There is a muddied picture here.  Because T3 stimulates oxidative phosphorylation and mitochondria biogenesis which is favorable for health.  However, in this study of rats, it induced HIF-1alpha and angiogenesis in post MI, which is favorable to recovery, yet this is unfavorable for cancer.    Yet oxidative phosphorylation is favorable to cancer prevention/elimination and MI recovery.

In a rat study, Bisphenol A shown to increase the ER alpha expression in the hypothalamus of the offspring.  So, the effects occur in utero, prior to birth.  The impact is this: the signal interpretation, by the tissue, of the hormone signal is altered prior to birth?