study shows that progesterone directly inhibits pro-inflammatory cytokine signaling in rat dendritic cells. Progesterone here shows to be directly involved in a anti-inflammatory effect.
Dendritic therapy, I think the use of vaccine is completely inappropriate here, found to extend life in those with methylated MGMT. This phase III trial is still on going, but this is a very positive future therapy in the immunotherapy attack against cancer.
Treg act to prevent spontaneous autoimmunity and to limit collateral damage to healthy tissues during adaptive immunity. However, these cells also have the potential to sabotage protective antimicrobial responses
Great T cell activiation review: Il-2 stimulates NK cells primarily release from TH1 cells and T cytotoxic lymphocytes are under the control of IL-12 released primarily from dendritic cells. Inflammatory cytokines in the presence of Treg to stimulate CD4+CD25- T cell activation.