Group items tagged

IV vitamin B12 shown to safe and effective treatment of neuropathy in diabetic patients.

vitamin B6 was shown to improve peripheral neuropathy in renal failure patients.  

B vitamin deficiency following gastric bypass resulting in neuropathy.

Vitamin C plus rutin, in combination, shown to reduce oxidative stress markers in sciatic nerve.  Vitamin C will be an aid in therapy to treat peripheral neuropathy.

Cochrane review did show that B vitamins improve peripheral neuropathy; though less than alpha lipoic acid.  And B vitamins are well tolerated.

older study.  High dosage vitamin B6 associated with short term ataxia and and neuropathy.  This resolved following removal.   Dosage unknown.

Study links peripheral neuropathy and ED in men.  Though, both are likely a reflection of low Testosterone as elevated aromatase activity.

mitochondrial damage associated with neuropathy

alpha lipoic acid for diabetic neuropathy.

Peripheral neuropathy involved in/associated with the pathogenesis of ED proposed by this study.

Progesterone shown to improve neuropathy in animal model.

alpha Lipoic Acid improves Diabetic Neuropathy

alpha lipoic acid provides great support in diabetic neuropathy treatment

Great article.  Really shows the depth of the androgens and androgen metabolites in diabetes and diabetic complications.  In this study, DHT and its metabolis 3-alpha androstanediol were shown to reduce inflammation and pain associated with diabetic neuropathy.  Significant reduction in inflammation signaling (IL-1beta, TNF-alpha) was seen as was potential neurodegenerative processes (glutamate release and astrocyte immunoreactivity).

This study follows others: Diabetes associated with low Total Testosterone.  The question is whether this is a cause and effect or merely an association? This study also found age, income, BMI, and diabetic neuropathy as risk for low Testosterone.

Case study finds that Testosterone improved neuropathy in hypergonadotropin hypogonadism syndrome.

Animal study finds that CBD reduces chemotherapy induced neuropathy and pain.

alpha lipoic acid shown to reduce diabetic neuropathy in this review of 15 clinical trials.  The trials included both IV and oral administration of alpha lipoic acid.  Both routes of administration revealed positive reduction of neuropathic symptoms.

Case report of 3 cases finds improvement in diabetic foot complications, including neuropathy, in men treated with Testosterone.  This makes sense as the Testosterone will improve insulin function, improve HgbA1c and reduce inflammation in these men.

Study points to obesity and low Testosterone contribution of neuroinflammation.  No effect of body weight was seen with TRT.  This animal model found similar positive effects of TRT in insulin sensitivity.  Obesity and low T increase inflammatory cytokine production: this study found an increase in TNF-alpha and IL-1beta and TRT reduced TNF-alpha and IL-1beta to near base-line.  Testosterone is neuroprotective and this study reviewed the small volume of evaded that pointed to benefit from estradiol.  Testosterone's effect on glial survival was positive but not significant.  Obesity and low T were found to be associated with increased macrophage infiltration in the PNS with increased TNF-alpha and IL-1beta.   Testosterone therapy improved peripheral neuropathy via its positive effects on nocicieption.