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Nathan Goodyear

Chronic inorganic mercury induced peripheral neuropathy. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9875628

herbs herbal therapies Hg mercury polyneuropathy neuropathy

shared by Nathan Goodyear on 16 Mar 15 - No Cached
  • Nathan Goodyear on 16 Mar 15
     
    Only abstract available: chronic inorganic Hg associated with demyelinating sensorimotor polyneuropathy.  The exposure in this case study was through herbal supplements.
Nathan Goodyear

Mortality and Other Important Diabetes-Related Outcomes With Insulin vs Other Antihyper... - 0 views

jcem.endojournals.org/...668

type II DM type II diabetes diabetes insulin mortality rate mortality

shared by Nathan Goodyear on 21 Feb 13 - No Cached
  • Nathan Goodyear on 21 Feb 13
     
    not sure if I posted this previously, but new study finds that insulin should be the last thing given to a type II diabetic.  Insulin doubles mortality rate.
Nathan Goodyear

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type... - 0 views

edrv.endojournals.org/...599.long

free radicals oxidative stress damage inflammation type II DM alpha lipoic acid alpha-lipoic-acid diabetes

shared by Nathan Goodyear on 02 Aug 12 - No Cached
  • In patients with diabetes, LA levels are reduced (48, 74, 103). LA has long been used for the treatment of diabetic neuropathy in Germany
  • evidence indicates that it increases insulin sensitivity in patients with type 2 diabetes
  • LA has been shown to 1) quench free radicals, 2) prevent singlet oxygen-induced DNA damage, 3) exhibit chelating activity, 4) reduce lipid peroxidation, 5) increase intracellular glutathione levels, and 6) prevent glycation of serum albumin (73, 74). LA is able to reduce oxidative stress-mediated NF-κB activation in vitro (74, 108, 109) and in patients with type 2 diabetes
  • ...2 more annotations...
  • Activation of NF-κB can also be blocked by several other thiol-containing antioxidants including N-acetyl-l-cysteine (NAC)
  • Other clinically available antioxidants reported to have antiinflammatory, antioncogenic, and/or antiatherogenic properties that have been shown to block the activation of NF-κB include resveratrol (115, 116), (-)-epicatechin-3-gallate (117), pycnogenol (118), silymarin (119), and curcumin (120)
  • Nathan Goodyear on 02 Aug 12
     
    Great read!  If you want to see how free radicals and oxidative stress contribute to inflammation and disease (DM in this case), read this article.
Nathan Goodyear

MedLink - 0 views

www.medlink.com/medlinkcontent.asp

mercury Hg polyneuropathy CNS neuropathy

shared by Nathan Goodyear on 16 Mar 15 - Cached
  • Nathan Goodyear on 16 Mar 15
     
    Mercury exposure associated with polyneuropathy. Sensory is more recent exposure with long term exposure associated with motor.
Nathan Goodyear

Unintended effects of statins from observational studies in the general population: sys... - 0 views

www.ncbi.nlm.nih.gov/...PMC3998050

statin therapy statins myopathy cholesterol side effects diabetes liver liver enzymes

shared by Nathan Goodyear on 19 Mar 15 - No Cached
  • A markedly increased risk of myopathy was observed
  • One cohort study (Women’s Health Initiative) of higher quality and larger sample size found stronger evidence of an increased risk of self-reported T2DM (OR=1.47; 95% CI 1.32 to 1.64) for the groups of women who reported statin use at baseline and three years later
  • Hippisley-Cox et al. found an increased risk of liver enzyme changes
  • ...5 more annotations...
  • weak evidence of an increased risk of type 2 diabetes mellitus (T2DM) was observed
  • Smeeth et al. found an increased risk of incident liver disease in the first year after the index date
  • The cumulative incidence of T2DM after three years of statin treatment was 6.25%, corresponding to an excess risk of 2.25%
  • We found no increased risk of peripheral neuropathy, depression, common eye diseases, renal disorders or arthritis associated with taking statins. Studies of higher quality did not show previously reported protective effects of statins on fractures, venous thrombo-embolism or pneumonia
  • There was evidence of an increase in myopathy, raised liver enzymes and diabetes.
  • Nathan Goodyear on 19 Mar 15
     
    Statin use associated with increased myopathy, liver dysfunction, and type II Diabetes.  The authors conclude that the absolute risk is very low, yet OR was 1.47 for type II Diabetes (translated 47% increased odds of developing Diabetes as a result of statins) and OR of 2.63 in risk of myopathy (translated 163% increased odds of developing myopathy as a result of statins).  Seems the authors "low risk" statement is just applies to those without symptoms/side effects.  Physicians need to do a better job of understanding risks and customizing therapies.
Nathan Goodyear

Progesterone prevents development of neuropathic pain in a rat model: Timing and durati... - 0 views

www.ncbi.nlm.nih.gov/...PMC3085268

progesterone hormones hormone neuropathic pain neuropathy

shared by Nathan Goodyear on 30 Nov 15 - No Cached
  • Nathan Goodyear on 30 Nov 15
     
    Another study finds progesterone prevents neuropathic pain in animal model; timing is everything.
Nathan Goodyear

Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy - 1 views

www.ncbi.nlm.nih.gov/...PMC5067498

DCA dichloroacetate dichloracetic acid cancer colon cancer

shared by Nathan Goodyear on 18 Jan 18 - No Cached
  • inhibition of mitochondrial pyruvate dehydrogenase kinase
  • inhibition of aerobic glycolysis (the Warburg effect) and activation of mitochondrial potassium ion channels
  • angiogenesis blockade
  • ...5 more annotations...
  • changes in expression of HIF1-α
  • alteration of pH regulators V-ATPase and MCT1, and other cell survival regulators such as PUMA, GLUT1, Bcl2 and p53
  • DCA as a cancer stabilizing agent
  • A protocol of natural medications was developed to address the dose-limiting neurologic toxicity, in collaboration with a naturopathic physician (Andrews). The oral DCA regimen that was developed included three natural medications acetyl L-carnitine[29-31], R-alpha lipoic acid[32-34] and benfotiamine[35-37], for the primary purpose of neuropathy prevention
  • measurable benefits from DCA therapy in 60%-70% of cases
  • Nathan Goodyear on 18 Jan 18
     
    Good review of dichloracetate or DCA in antitumor activity.  DCA has been shown to have numerous anticancer properties.
Nathan Goodyear

Neutrophil extracellular traps as a unique target in the treatment of chemotherapy-indu... - 0 views

www.thelancet.com/...fulltext

cancer chemotherapy NETosis

shared by Nathan Goodyear on 23 Apr 23 - No Cached
  • Nathan Goodyear on 23 Apr 23
     
    "level of NETs in patients received chemotherapy increases significantly."
Nathan Goodyear

Pharmaceuticals | Free Full-Text | Chronic Cannabigerol as an Effective Therapeutic for... - 0 views

www.mdpi.com/...1442

cisplatin cannabigerol neuropathy CBG phytocannabinoids

shared by Nathan Goodyear on 20 Apr 24 - No Cached
  • Nathan Goodyear on 20 Apr 24
     
    10 mg/kg in males and 15 mg/kg in females without side effects
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