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Nathan Goodyear

Vitamin B6 supplementation can improve peripheral polyneuropathy in patients ... - 0 views

ndt.oxfordjournals.org/...1410.full

Vitamin B6 pyrodoxine P5P pyridoxal-5-phosphate neuropathy peripheral neuropathy vitamin

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    vitamin B6 was shown to improve peripheral neuropathy in renal failure patients.  
Nathan Goodyear

Vitamin B for treating peripheral... [Cochrane Database Syst Rev. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18646107

B vitamins peripheral neuropathy neuropathy Vitamin B vitamins B

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    Cochrane review did show that B vitamins improve peripheral neuropathy; though less than alpha lipoic acid.  And B vitamins are well tolerated.
Nathan Goodyear

Peripheral neuropathy: an underdiagnosed cause of erectile dysfunction - Vall... - 0 views

onlinelibrary.wiley.com/...64A32FF54A326602F0ECF9E.f02t04

ED erectile dysfunction men peripheral neuropathy

shared by Nathan Goodyear on 13 May 14 - No Cached
  • Nathan Goodyear on 13 May 14
     
    Study links peripheral neuropathy and ED in men.  Though, both are likely a reflection of low Testosterone as elevated aromatase activity.
Nathan Goodyear

Combination of vitamin C and rutin on neuropa... [Arch Pharm Res. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12009033

vitamin C neuropathy peripheral neuropathy C vitamin

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    Vitamin C plus rutin, in combination, shown to reduce oxidative stress markers in sciatic nerve.  Vitamin C will be an aid in therapy to treat peripheral neuropathy.
Nathan Goodyear

Peripheral neuropathy: an underdiagnosed cause of erectile dysfunction - Vall... - 1 views

onlinelibrary.wiley.com/...abstract

ED erectile dysfunction polyneuropathy neuropathy men men's health male health

shared by Nathan Goodyear on 16 Mar 15 - No Cached
  • Nathan Goodyear on 16 Mar 15
     
    Peripheral neuropathy involved in/associated with the pathogenesis of ED proposed by this study.
Nathan Goodyear

Intravenous methylcobalamin treatment for uremic ... [Intern Med. 1999] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10411351

IV intravenous therapy vitamin B12 neuropathy diabetic neuropathy peripheral neuropathy

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    IV vitamin B12 shown to safe and effective treatment of neuropathy in diabetic patients.
Nathan Goodyear

Diet-induced obesity and low testosterone increase neuroinflammation and impair neural ... - 0 views

www.ncbi.nlm.nih.gov/...PMC4190446

Testosterone neuroinflammation glia insulin resistance obesity diabetes brain CNS PNS inflammation low T low Testosterone TNF-alpha IL-1beta

shared by Nathan Goodyear on 28 Apr 15 - No Cached
  • both obesity and low testosterone are also risk factors for neural dysfunction, including cognitive impairment [58–61] and development of AD
  • Levels of obesity and testosterone are often inversely correlated
  • diet-induced obesity causes significant metabolic disturbances and impairs central and peripheral nervous systems.
  • ...23 more annotations...
  • both obesity and low testosterone are linked with promotion of inflammatory pathways [70–72] and exert harmful actions on the central [73–75] and peripheral [29,76] nervous systems
  • In general, obesity-related changes were worsened by low testosterone and improved by testosterone treatment; however, this relationship was not statistically significant in several instances. Further, our data suggest that a common pathway that may contribute to obesity and testosterone effects is regulation of inflammation
  • fasting blood glucose levels were independently and additively increased by GDX-induced testosterone depletion and high-fat diet
  • testosterone treatment significantly reduced fasting glucose under both the normal and high-fat diets, demonstrating potential therapeutic efficacy of testosterone supplementation
  • fasting insulin, insulin resistance (HOMA index), and glucose tolerance, low testosterone tended to exacerbate and or testosterone treatment improved outcomes.
  • testosterone status did not significantly affect body weight
  • testosterone’s effects likely do not indicate an indirect result on adiposity but rather regulatory action(s) on other aspects of metabolic homeostasis
  • Prior work in rodents has shown diet-induced obesity induces insulin resistance in rat brain [63] and that testosterone replacement improves insulin sensitivity in obese rats [64]. Our findings are consistent with the human literature, which indicates that (i) testosterone levels are inversely correlated to insulin resistance and T2D in healthy [30,65] as well as obese men [66], and (ii) androgen therapy can improve some metabolic measures in overweight men with low testosterone
  • it has been shown that TNFα has inhibitory effects on neuron survival, differentiation, and neurite outgrowth
  • Our data demonstrate that low testosterone and obesity independently increased cerebrocortical mRNA levels of both TNFα and IL-1β
  • Testosterone status also affected metabolic and neural measures
  • many beneficial effects of testosterone, including inhibition of proinflammatory cytokine expression
  • neuroprotection [80,81], are dependent upon androgen receptors, the observed effects of testosterone in this study may involve androgen receptor activation
  • testosterone can be converted by the enzyme aromatase into estradiol, which is also known to exert anti-inflammatory [82] and neuroprotective [83] actions
  • glia are the primary sources of proinflammatory molecules in the CNS
  • poorer survival of neurons grown on glia from mice maintained on high-fat diet
  • Since testosterone can affect glial function [86] and improve neuronal growth and survival [87–89], it was unexpected that testosterone status exhibited rather modest effects on neural health indices with the only significant response being an increase in survival in the testosterone-treated, high-fat diet group
  • significantly increased expression of TNFα and IL-1β in glia cultures derived from obese mice
  • testosterone treatment significantly lowered TNFα and IL-1β expression to near basal levels even in obese mice, indicating a protective benefit of testosterone across diet conditions
  • IL-1β treatment has been shown to induce synapse loss and inhibit differentiation of neurons
  • Testosterone status and diet-induced obesity were associated with significant regulation of macrophage infiltration
  • testosterone prevented and/or restored thermal nociception in both diet groups
  • a possible mechanism by which obesity and testosterone levels may affect the health of both CNS and PNS
  • Nathan Goodyear on 28 Apr 15
     
    Study points to obesity and low Testosterone contribution of neuroinflammation.  No effect of body weight was seen with TRT.  This animal model found similar positive effects of TRT in insulin sensitivity.  Obesity and low T increase inflammatory cytokine production: this study found an increase in TNF-alpha and IL-1beta and TRT reduced TNF-alpha and IL-1beta to near base-line.  Testosterone is neuroprotective and this study reviewed the small volume of evaded that pointed to benefit from estradiol.  Testosterone's effect on glial survival was positive but not significant.  Obesity and low T were found to be associated with increased macrophage infiltration in the PNS with increased TNF-alpha and IL-1beta.   Testosterone therapy improved peripheral neuropathy via its positive effects on nocicieption.
Nathan Goodyear

Obesity Surgery, Volume 14, Number 2 - SpringerLink - 0 views

www.springerlink.com/...825740k3r2735308

Vitamin B B vitamins vitamin gastric bypass neuropathy peripheral neuropathy Bariatric surgery obesity

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    B vitamin deficiency following gastric bypass resulting in neuropathy.
Nathan Goodyear

Effects of progesterone on neuropathic pain responses in an experimental animal model f... - 0 views

www.sciencedirect.com/...S0306452213008968

progesterone hormones hormone neuropathy neuropathic pain

shared by Nathan Goodyear on 30 Nov 15 - No Cached
  • Nathan Goodyear on 30 Nov 15
     
    Progesterone shown to improve neuropathy in animal model.
Nathan Goodyear

Cardiovascular Diabetology | Full text | Improvement of the diabetic foot upon testoste... - 0 views

www.cardiab.com/19

diabetes type II diabetes therapy treatment low T Testosterone cardiovascular disease PAD peripheral arterial disease foot

shared by Nathan Goodyear on 13 May 14 - No Cached
  • Nathan Goodyear on 13 May 14
     
    Case report of 3 cases finds improvement in diabetic foot complications, including neuropathy, in men treated with Testosterone.  This makes sense as the Testosterone will improve insulin function, improve HgbA1c and reduce inflammation in these men.
Nathan Goodyear

Chronic inorganic mercury induced peripheral neuropathy. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9875628

herbs herbal therapies Hg mercury polyneuropathy neuropathy

shared by Nathan Goodyear on 16 Mar 15 - No Cached
  • Nathan Goodyear on 16 Mar 15
     
    Only abstract available: chronic inorganic Hg associated with demyelinating sensorimotor polyneuropathy.  The exposure in this case study was through herbal supplements.
Nathan Goodyear

Unintended effects of statins from observational studies in the general population: sys... - 0 views

www.ncbi.nlm.nih.gov/...PMC3998050

statin therapy statins myopathy cholesterol side effects diabetes liver liver enzymes

shared by Nathan Goodyear on 19 Mar 15 - No Cached
  • A markedly increased risk of myopathy was observed
  • One cohort study (Women’s Health Initiative) of higher quality and larger sample size found stronger evidence of an increased risk of self-reported T2DM (OR=1.47; 95% CI 1.32 to 1.64) for the groups of women who reported statin use at baseline and three years later
  • Hippisley-Cox et al. found an increased risk of liver enzyme changes
  • ...5 more annotations...
  • weak evidence of an increased risk of type 2 diabetes mellitus (T2DM) was observed
  • Smeeth et al. found an increased risk of incident liver disease in the first year after the index date
  • The cumulative incidence of T2DM after three years of statin treatment was 6.25%, corresponding to an excess risk of 2.25%
  • We found no increased risk of peripheral neuropathy, depression, common eye diseases, renal disorders or arthritis associated with taking statins. Studies of higher quality did not show previously reported protective effects of statins on fractures, venous thrombo-embolism or pneumonia
  • There was evidence of an increase in myopathy, raised liver enzymes and diabetes.
  • Nathan Goodyear on 19 Mar 15
     
    Statin use associated with increased myopathy, liver dysfunction, and type II Diabetes.  The authors conclude that the absolute risk is very low, yet OR was 1.47 for type II Diabetes (translated 47% increased odds of developing Diabetes as a result of statins) and OR of 2.63 in risk of myopathy (translated 163% increased odds of developing myopathy as a result of statins).  Seems the authors "low risk" statement is just applies to those without symptoms/side effects.  Physicians need to do a better job of understanding risks and customizing therapies.
Nathan Goodyear

Neutrophil extracellular traps as a unique target in the treatment of chemotherapy-indu... - 0 views

www.thelancet.com/...fulltext

cancer chemotherapy NETosis

shared by Nathan Goodyear on 23 Apr 23 - No Cached
  • Nathan Goodyear on 23 Apr 23
     
    "level of NETs in patients received chemotherapy increases significantly."
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