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Nathan Goodyear

Moderate protein intake improves total and region... [Metabolism. 2008] - PubMed - NCBI - 0 views

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    moderate protein intake defined here as 25%.  The physiologic effects of moderate protein intake the same as high protein intake--40%.  This study finds an improvement in insulin senstivity in the short term.  
Nathan Goodyear

Comparative Studies of the Estrogen Receptors β and α and the Androgen Recept... - 0 views

  • ER-β is predominately immunolocalized in basal cells and to a lesser extent in stromal cells of the morphologically normal human prostate
  • ER-α is detected in stromal cells and rarely in basal cells of the normal gland
  • AR was predominately localized in the nuclei of differentiated secretory cells and variably in basal cells of the normal acinar/duct unit as well as in stromal cells
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  • Hall and colleagues44 have reported that ER-β functions as a transdominant inhibitor of ER-α transcription and that it acts to decrease overall cellular sensitivity to estradiol
  • The expression of ER-β was diminished in high-grade dysplasias when compared to normal glands and lower grade lesions.
  • The transition from normal to low/moderate dysplastic glands in the peripheral zone was marked by the appearance of ER-β homogeneously immunostained nuclei in secretory as well as basal cells with no changes in the localization of the other receptors.
  • proliferative signals mediated by AR in basal cells or by ER-α and AR in stromal cells may be opposed by the purported growth-inhibitory action of ER-β25, 26, 27, 28 localized in basal cells.
  • The diminution of ER-β expression in high-grade dysplasias and grade 4/5 cancers may be therefore related to the alteration of DNA methylation pattern in CpG islands of the promoter, resulting in down-regulation of the receptor at the transcriptional level
  • based on the proposed anti-proliferative function of the receptor,25, 26, 27, 28 the presence of ER-β in secretory cells of low/moderate-grade lesions may represent a transient abortive attempt to counter growth of these cells
  • the attrition of receptor-positive basal cells in the high-grade dysplasias may signify a continuing loss of growth inhibitory function mediated by ER-β in these precursor lesions
  • Our findings in prostate therefore differ from those reported for human colon cancer in which Folley and colleagues48 demonstrated that a selective loss of ER-β protein but not receptor message expression occurs in these neoplasms
  • Our findings therefore differed from those of Bonkhoff and colleagues33 who found immunostaining for the receptor in high-grade dysplasias and grade 4/5 carcinomas. Using in situ hybridization these authors also reported that a high percentage of dysplasias and carcinomas in their study contained cells that expressed ER-α message
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    Very nice study.  The authors looked at normal prostate, early disease and late stage prostate cancer.  The authors found that ER beta expression, as a general rule, was lost as progression occurred to the high-grade dysplasias and grad 4/5 carcinomas of the prostate.  Early low/moderate dysplasia was associated with an increase in ER beta--the authors propose that this was due to an attempt of the basal epithelium to counter the paracrine effect of ER alpha.   In contrast, androgen receptors appeared to be equally expressed across all.
Nathan Goodyear

Exercise improves survival rates for colorectal cancer patients - Dana-Farber Cancer In... - 0 views

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    Men with colorectal cancer that engage in "moderate" exercise live longer than those that don't.  Moderate was described as 1 hour of walking 6 days weekly.
Nathan Goodyear

Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory funct... - 0 views

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    moderate exercise improves the memory of rats in diabetes model.
Nathan Goodyear

L-Carnitine Improves the Asthma Control in Children with Moderate Persistent Asthma - 0 views

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    L-carnitine is effective as adjunct in the treatment of moderate persistent asthma.
Nathan Goodyear

Cognitive improvement in mild to moderate Alzheime... [Clin Ther. 2003] - PubMed - NCBI - 0 views

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    alpha-GPC provides improvement in mild to moderate dementia found in Alzheimer's disease.
Nathan Goodyear

Evaluation of efficacy and safety of niacinamide gel in the treatment of mild to modera... - 0 views

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    small study over 12 weeks found that 4% Niacinamide gel reduced mild/moderate acne.  The dosing was twice daily.
Nathan Goodyear

Current alcohol consumption and its relationship to incident dementia: results from a 3... - 0 views

  • ight-to-moderate alcohol consumption is inversely related to incident dementia
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    light to moderate alcohol intake helps to reduce dementia risk
Nathan Goodyear

Evaluation of the potential role of chelation therapy in treatment of low to moderate l... - 0 views

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    treatment of  low/moderate lead exposures with chelation therapy
Nathan Goodyear

Age-related hormonal adaptations, muscle circumference and strength development with 8w... - 0 views

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    Moderate resistance training program over 8 weeks associated with increased Testosterone production in young and middle age lean men.  Growth hormone was also increased in both groups.  ACTH and cortisol decreased in this lean men.  
Nathan Goodyear

Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Post-Tr... - 0 views

  • In this study, we have demonstrated microscopic pathology ranging from minimal to moderate in multiple different tissues previously reported to be involved with LD, including the nervous system (central and peripheral), heart, skeletal muscle, joint-associated tissues, and urinary bladder 12 to 13 months following tick-inoculation of rhesus macaques by Bb strain B31
  • Based on histomorphology, inflammation consisted predominantly of lymphocytes and plasma cells, with rare scattered histiocytes
  • in rare instances, morphologically intact spirochetes were observed in inflamed brain and heart tissue sections from doxycycline-treated animals
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  • colocalization of the Bb 23S rRNA probe was not observed in any of the sections of experimental inoculated animals shown to harbor rare persistent spirochetes (Supplemental Figure S1). Previous in vitro work has shown large decreases in Bb rRNA levels when in a stationary phase of growth despite the majority of spirochetes remaining viable
  • The possibility that the spirochetes were intact but dead also exists, though this may be unlikely given the precedence for viable but non-cultivable B. burgdorferi post-treatment
  • The doxycycline dose utilized in this study (5mg/kg) was based on a previous pharmacokinetic analysis of oral doxycycline in rhesus macaques proven to be comparable to levels achieved in humans and was meant to mimic treatment of disseminated LD
  • In addition to the brain of two treated animals, rare morphologically intact spirochetes immunoreactive to OspA were observed in the heart of one treated animal
  • Although we did not measure the doxycycline levels in the cerebrospinal fluid, they have been found to be 12% to 15% of the amount measured in serum
  • We and others have demonstrated the development of a drug-tolerant persister population when B. burgdorferi are treated with antibiotics in vitro
  • The adoption of a dormant or slow-growing phenotype likely allows the spirochetes to survive and re-grow following removal of antibiotic
  • The basic premise that antibiotic tolerance may be an adaptation of the sophisticated stringent response required for the enzootic cycle by the spirochetes is described in a recent review as well
  • Although current IDSA guidelines recommend intravenous ceftriaxone (2g daily for 30 days) over oral doxycycline for treatment of neuroborreliosis, a randomized clinical trial failed to show any enhanced efficacy of I.V. penicillin G to oral doxycycline for treatment of Lyme neuroborreliosis (no treatment failures were reported in this study of 54 patients).
  • we can speculate that the minimal to moderate inflammation that was observed, especially within the CNS and PNS can, in part, explain the breadth of symptoms experienced by late stage Lyme disease patients, such as cognitive impairment and neuralgia.
  • Erythema migrans, the clinical hallmark of early localized Lyme disease, was observed in one of the rhesus macaques from this study.
  • In 2014, a trailblazing study in mice demonstrated a dramatic decline in B. burgdorferi DNA in the tissues for up to eight months after antibiotic treatment followed by the resurgence of B. burgdorferi growth 12 months after treatment
  • This study provides evidence that the slow-growing spirochetes which persist after treatment, but are not cultivable in standard growth media may remain viable.
  • The first well-documented indication of Lyme disease (LD) in the United States occurred in the early 1970s
  • Lyme, Connecticut.
  • Lyme disease is now known to be caused by multiple closely related genospecies classified within the Bb sensu lato complex, representing the most common tick-borne human disease in the Northern Hemisphere
  • approximately 30,000 physician-reported cases occur annually in the United States, the annual incidence has been estimated to be 10-fold higher by the Centers for Disease Control and Prevention.6
  • Current antibiotic therapy guidelines outlined by the Infectious Disease Society of America (IDSA) are successful in the treatment of LD for the majority of LD patients, especially when administered early in disease immediately following identification of erythema migrans (EM)
  • ‘post-treatment Lyme disease syndrome’ (PTLDS)
  • host-adapted spirochetes that persist in the tissues, probably in small numbers, inaccessible or impervious to antibiotic
  • inflammatory responses to residual antigens from dead organisms
  • residual tissue damage following pathogen clearance;
  • autoimmune responses, possibly elicited by antigenic mimicry
  • Experimental studies on immunocompetent mice, dogs, and rhesus macaques have provided evidence for the persistence of Bb spirochetes subsequent to antibiotic treatment in the form of residual spirochetes detected within tissue by IFA and PCR, and recovered by xenodiagnoses
  • Ten male rhesus macaques
  • half (five) of the NHP received antibiotic treatment, consisting of 5 mg/kg oral doxycycline twice per day.
  • Minimal and focal lymphoplasmacytic inflammation
  • inflammation was observed in the leptomeninges overlying a section of temporal cerebral cortex
  • Minimal localized lymphoplasmacytic choroiditis
  • Peripheral nerves contained minimal to moderate lymphoplasmacytic inflammation with a predilection for collagen-rich epineurium and perivascular spaces
  • Inflammation was observed in 56% (5/9) of the NHPs irrespective of treatment group
  • For all animals, inflammation was reserved to perineural tissue
  • The treatment lasted 28 days
  • Minimal to mild lymphoplasmacytic inflammation of either the myocardial interstitium (Figure 2Figure 2A), pericardium (Figure 2Figure 2B), or combination therein was observed in 60% of NHPs
  • A single morphologically intact spirochete, as indicated by positive red immunofluorescence (Figure 2Figure 2C), was observed in the myocardium of one treated animal
  • mild, multifocal lymphoplasmacytic inflammation was observed in one doxycycline-treated animal
  • three animals exhibited minimal to mild lymphoplasmacytic inflammation affecting joint-associated structures
  • 10% to -20% of human patients treated
  • Multiple randomized placebo-controlled studies which evaluated sustained antimicrobial therapy concluded that there is no benefit in alleviating patients’ symptoms and indicated that long-term antibiotic therapy may even be detrimental to patients due to potential associated complications (ie, catheter infection and/or clostridial colitis)
  • and the rapid clearance of dead spirochetes in a murine model
  • higher doses may be needed to combat neuroborreliosis
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    persistent borrelia burgdorferia were found in the brain (2) and the heart (1) up to 13 months post standard antibiotic treatment suggesting borrelia burdorferia, the cause of Lyme, can persist in a chronic, persistant state poste acute treatment.
Nathan Goodyear

The effect of combined estrogen and progester... [Ann Intern Med. 2005] - PubMed - NCBI - 0 views

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    HRT, particularily estrogen therapy, is shown to increase mild to moderate flares of lupus.
Nathan Goodyear

VSL#3 probiotic-mixture induces remission... [Am J Gastroenterol. 2005] - PubMed - NCBI - 0 views

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    high dose probiotic shown to provide significant benefit, even remission in those with mild/moderate ulcerative colitis.
Nathan Goodyear

Inflammation and exercise: Inhibition of monocytic intracellular TNF producti... - 0 views

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    20 minutes of moderate exercise found to decrease inflammation, specifically TNF.
natgeo127

Have Your Desserts While Losing Weight! - 0 views

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    You can definitely lose weight while enjoying desserts! My recipes use all natural sugars, and yes, honey is one of them. Your body processes natural sugars much differently than processed sugars (white sugar, brown sugar, etc.), and in moderate amounts (such as those in my recipes) it is not going to affect your weight loss efforts. Also, you'll notice that my recipes contain fiber and proteins and fats...
Nathan Goodyear

Efficacy of a novel, natural extract of (-)-hydroxycitric acid (HCA-SX) and a combinati... - 0 views

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    chromium, as well as gymnema, shown to aid in weight loss for the moderately obese.
Nathan Goodyear

Emerald | Policing: An International Journal of Police Strategies & Management | Post-t... - 0 views

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    elevated cortisol levels found in moderate/severe PTSD in police officers.  Again, saliva testing was used for cortisol evaluation.
Nathan Goodyear

Magnesium significantly improves severe acute asthma in children. - 0 views

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    IV magnesium shown to provide benefit in children with moderate/severe asthma.
Nathan Goodyear

Alpha lipoic appears to be an effective neuroprotective agent in - 0 views

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    Alpha lipoic acid at relatively low oral dosing found to slow progression of moderate dementia as compared to cholinesterase inhibitors.
Nathan Goodyear

PLOS ONE: Healthy Lifestyles Reduce the Incidence of Chronic Diseases and Dementia: Evi... - 0 views

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    Despite evidence that non-smoking, normal BMI, regular exercise, high fruit/vegetable intake and low/moderate alcohol intake, less than 1% of men change lifestyle.  Translation:  many don't want health even when presented with evidence of its benefits and the means to achieve it.   This study found a decrease in cognitive decline in individuals undergoing these lifestyle changes.
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