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Nathan Goodyear

Vitamin Intervention for Stroke Prevention Trial - 0 views

stroke.ahajournals.org/...2404.full

homocysteine vitamin B12 folic acid VISP stroke prevention vitamins

shared by Nathan Goodyear on 25 Jul 12 - No Cached
  • Nathan Goodyear on 25 Jul 12
     
    Vitamin B12, methyl cobalamin, is very important in lowering homocysteine levels through methionine synthase.  The VISP trial did not show efficacy in the intention to treat analysis.  However, analysis of the efficacy reveals that many clients had too low of vitamin B12 levels due to malabsorption and vitamin B12 levels should have been higher in the VISP intention to treat.
Nathan Goodyear

The acute effect of high-dose intravenous vitamin C and other nutrients on blood pressu... - 0 views

www.ncbi.nlm.nih.gov/...PMC4864764

vitamin C IV vitamin C hypertension vitamin B12 blood pressure cardiovascular disease CVD

shared by Nathan Goodyear on 14 Aug 17 - No Cached
  • the reduction in BP within the first 10–20 min may be primarily attributed to a direct vasodilatory physiological effect, described as venodilation
  • BP reduction observed after 70–90 min is likely attributable to pharmacokinetically plausible vitamin C absorption and vasodilation because of nitric oxide release
  • Pharmacokinetic studies of IVC administration observed peak plasma levels within the first 90 min, with plasma levels reaching 13350 μmol/l for 50 g of IVC
  • ...6 more annotations...
  • Essential hypertension, associated with endothelial dysfunction because of an impaired nitric oxide/l-arginine pathway and impaired vasodilation can be restored by vitamin C
  • marked increase in BP response when IVB12 is administered
  • The mean BP increased significantly up to 12–16 mmHg systolic and diastolic independent of the dosage of vitamin B12
  • The production of norepinephrine, which can stimulate angiotensin-II production, which in turn influences BP, has been suggested as a possible mechanism for the increase in BP with IVB12
  • excess norephinephrine levels stimulate the sympathetic nervous system, leading to increased cortisol production, which has also been linked to increases in BP
  • Animal studies have found higher serum levels of norepinephrine (noradrenaline) in the adrenal medulla of rats receiving methylcobalamin (methyl-vitamin B12)
  • Nathan Goodyear on 14 Aug 17
     
    IV vitamin C in mostly normotensive patients (> 30 grams) reduced blood pressure.  Some of the patients were pre-hypertensive. Vitamin B12 increase the blood pressure.
Nathan Goodyear

http://jpmph.org/upload/pdf/jpmph-45-387.pdf - 0 views

jpmph.org/...jpmph-45-387.pdf

Pb lead homocysteine

shared by Nathan Goodyear on 18 Sep 14 - No Cached
  • Nathan Goodyear on 18 Sep 14
     
    Blood lead levels correlate with homocysteine levels.  Methylation (B12, Folate, B6) plays a role regulating homocysteine levels as well. 
Nathan Goodyear

https://www.researchgate.net/profile/Osama_Arafat/publication/234135338_METHYLCOBALAMIN... - 0 views

www.researchgate.net/...C-HYPOPHYSEAL-ADRENAL-AXIS.pdf

methylcobalamin methyl-B12 B12 hypertension norepinephrine adrenal medulla adrenal

shared by Nathan Goodyear on 18 Dec 17 - No Cached
  • Nathan Goodyear on 18 Dec 17
     
    Animal study points to methylB12 as the cause of an increase in adrenal medulla norepinephrine production.  This has significant implications in individuals with hypertension.
Nathan Goodyear

Vitamin-Dependent Methionine Metabolism and Alcoholic Liver Disease - 0 views

advances.nutrition.org/...421.full

methionine metabolism Alcoholic liver disease vitamin B12 Folate B6 transmethylation methylation pathway

shared by Nathan Goodyear on 28 Oct 11 - No Cached
  • Nathan Goodyear on 28 Oct 11
     
    nice article discussing disrupted methionine metabolism and development of Alcoholic Liver Disease
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