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Nathan Goodyear

Methionine restriction induces apoptosis of prosta... [Cancer Lett. 2002] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...11880182

methionine restriction cancer prostate apoptosis cell death

shared by Nathan Goodyear on 10 Feb 11 - No Cached
  • Tumors are relatively more sensitive to methionine restriction than corresponding normal tissues
  • Nathan Goodyear on 10 Feb 11
     
    Restriction of the amino acid Methionine induces cell death of prostate cancer cells
Nathan Goodyear

Food Sources of Methionine - 0 views

nutrient.javalime.com/...506

food sources methionine

shared by Nathan Goodyear on 10 Feb 11 - Cached
  • Nathan Goodyear on 10 Feb 11
     
    Food sources of Methionine
Nathan Goodyear

Vitamin-Dependent Methionine Metabolism and Alcoholic Liver Disease - 0 views

advances.nutrition.org/...421.full

methionine metabolism Alcoholic liver disease vitamin B12 Folate B6 transmethylation methylation pathway

shared by Nathan Goodyear on 28 Oct 11 - No Cached
  • Nathan Goodyear on 28 Oct 11
     
    nice article discussing disrupted methionine metabolism and development of Alcoholic Liver Disease
Nathan Goodyear

Hyperhomocysteinemia, deep vein thrombosi... [J Formos Med Assoc. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17908667

vitamin B12 homocysteine DVT blood clots MS methionine synthase metformin DM diabetes insulin resistance IR

shared by Nathan Goodyear on 23 Jan 12 - No Cached
  • Nathan Goodyear on 23 Jan 12
     
    Vitamin B12 deficiency will decrease methionine synthase activity, which will result in elevated homocysteine and the risk of DVT increases as a result.  In this article, the cause of the vitamin B12 depletion was metformin.  Diabetics and those with insulin resistance are already at an increased risk of blood clots.
Nathan Goodyear

S-adenosyl-l-methionine (SAMe) as antidepressant: ... [Acta Neurol Scand Suppl. 1994] -... - 0 views

www.ncbi.nlm.nih.gov/...7941964

SAMe depression

shared by Nathan Goodyear on 09 Dec 10 - No Cached
  • The efficacy of SAMe in treating depressive syndromes and disorders is superior with that of placebo and comparable to that of standard tricyclic antidepressants. Since SAMe is a naturally occurring compound with relatively few side-effects, it is a potentially important treatment for depression
  • Nathan Goodyear on 09 Dec 10
     
    S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies.
Nathan Goodyear

Vitamin Intervention for Stroke Prevention Trial - 0 views

stroke.ahajournals.org/...2404.full

homocysteine vitamin B12 folic acid VISP stroke prevention vitamins

shared by Nathan Goodyear on 25 Jul 12 - No Cached
  • Nathan Goodyear on 25 Jul 12
     
    Vitamin B12, methyl cobalamin, is very important in lowering homocysteine levels through methionine synthase.  The VISP trial did not show efficacy in the intention to treat analysis.  However, analysis of the efficacy reveals that many clients had too low of vitamin B12 levels due to malabsorption and vitamin B12 levels should have been higher in the VISP intention to treat.
Nathan Goodyear

S-Adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis sympt... - 0 views

www.ncbi.nlm.nih.gov/...PMC387830

SAMe osteoarthritis arthritis

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    SAMe equivalent to celebrex for the treatment of osteoarthritis pain.
Nathan Goodyear

Influence of Oral S-Adenosylmethionine on Plasma 5-Methyltetrahydrofolate, S-Adenosylho... - 0 views

jpet.aspetjournals.org/...845.long

SAMe 5-MTHF homocysteine

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    SAMe replacement, 400 mg, did not raise homocysteine.  But, it did increase 5-MTHF.
Nathan Goodyear

Efficacy and tolerability of oral and intramuscular S-adenosyl- l-methionine 1,4-butane... - 0 views

www.ajcn.org/...1172S.full

SAMe depression major depression

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    Head to head study of SAMe and imipramine for major depression found SAMe to be equivalent in efficacy to imipramine, but with fewer side effects.
Nathan Goodyear

PsychiatryOnline | American Journal of Psychiatry | S-Adenosyl Methionine (SAMe) Augmen... - 0 views

ajp.psychiatryonline.org/article.aspx

SAMe SSRI depression major depression psychiatry

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    SAMe, in SSRI non-responders, resulted in a 46.1% response and a 35.8% remission compared to placebo.
Nathan Goodyear

Dietary Supplement S-Adenosyl-l-Methionine (AdoMet) Effects on Plasma Homocysteine Leve... - 0 views

www.ncbi.nlm.nih.gov/...PMC2875864

SAMe homocysteine dietary supplement

shared by Nathan Goodyear on 25 Jun 12 - No Cached
  • Nathan Goodyear on 25 Jun 12
     
    SAMe replacement, up to 800 mg, did not raise homocysteine levels.
Nathan Goodyear

Specific Contribution of Methionine and Choline in Nutritional Nonalcoholic Steatohepat... - 0 views

www.ncbi.nlm.nih.gov/...PMC2881778

SAMe methylation GSH glutathione NASH nonalcoholic steatohepatitis NAFLD non-alcoholic fatty liver

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    review of SAMe, methylation, and Glutathione in the development of Nonalcoholic Steatohepatitis (NASH).  This would serve as a potential treatment for those with NAFLD.
Nathan Goodyear

The role of S-adenosyl methionine in preventing FOLFOX-induced liver toxicity: a retros... - 0 views

informahealthcare.com/...14740338.2011.562888

SAMe methylation cancer CBS cystathionine Beta-synthase glutathione GSH chemotherapy

shared by Nathan Goodyear on 27 Jun 12 - No Cached
  • Nathan Goodyear on 27 Jun 12
     
    SAMe shown to lower liver toxicity in chemotherapy treatment.  SAMe could be a powerful chemotherapeutic adjuvant.  This makes since, because cancer is known to be a hypomethylated state.  Low methyl donors will reduce CBS activity and thus lower glutathione.  This will result in increased oxidative stress and inflammation in the liver.  SAMe will open the CBS activity up and increase glutathione production.
Nathan Goodyear

S-adenosyl methionine improves early viral responses and interferon-stimulated gene ind... - 0 views

www.ncbi.nlm.nih.gov/...PMC3021477

SAMe Hepatitis C virus viral infection

shared by Nathan Goodyear on 27 Jun 12 - No Cached
  • Nathan Goodyear on 27 Jun 12
     
    SAMe shown to be beneficial as an early response treatment in Hepatitis C. Maybe as a treatment for flu?
Nathan Goodyear

Progressive systemic sclerosis and S-adenosylmethionine. - ResearchGate - 0 views

www.researchgate.net/...rosis_and_S-adenosylmethionine

scleroderma SAMe S-adenosyl-L-methionine autoimmune disease

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    This study used IV SAMe at 600 mg daily for 2 months and then followed up with 400 mg TID and found significant improvement in skin findings.
Nathan Goodyear

http://ajcn.nutrition.org/content/76/5/1151S.full.pdf - 0 views

ajcn.nutrition.org/...1151S.full.pdf

SAMe S-adenosyl-L-methionine

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    Great review article on SAMe.
Nathan Goodyear

JISSN | Full text | International Society of Sports Nutrition position stand: creatine ... - 0 views

www.jissn.com/6

creatine sports nutrition exercise

shared by Nathan Goodyear on 27 Jan 14 - No Cached
  • the energy supplied to rephosphorylate adenosine diphosphate (ADP) to adenosine triphosphate (ATP) during and following intense exercise is largely dependent on the amount of phosphocreatine (PCr) stored in the muscle
  • Creatine is chemically known as a non-protein nitrogen
  • It is synthesized in the liver and pancreas from the amino acids arginine, glycine, and methionine
  • ...26 more annotations...
  • Approximately 95% of the body's creatine is stored in skeletal muscle
  • About two thirds of the creatine found in skeletal muscle is stored as phosphocreatine (PCr) while the remaining amount of creatine is stored as free creatine
  • The body breaks down about 1 – 2% of the creatine pool per day (about 1–2 grams/day) into creatinine in the skeletal muscle
  • The magnitude of the increase in skeletal muscle creatine content is important because studies have reported performance changes to be correlated to this increase
  • "loading" protocol. This protocol is characterized by ingesting approximately 0.3 grams/kg/day of CM for 5 – 7 days (e.g., ≃5 grams taken four times per day) and 3–5 grams/day thereafter [18,22]. Research has shown a 10–40% increase in muscle creatine and PCr stores using this protocol
  • Additional research has reported that the loading protocol may only need to be 2–3 days in length to be beneficial, particularly if the ingestion coincides with protein and/or carbohydrate
  • A few studies have reported protocols with no loading period to be sufficient for increasing muscle creatine (3 g/d for 28 days)
  • Cycling protocols involve the consumption of "loading" doses for 3–5 days every 3 to 4 weeks
  • Most of these forms of creatine have been reported to be no better than traditional CM in terms of increasing strength or performance
  • Recent studies do suggest, however, that adding β-alanine to CM may produce greater effects than CM alone
  • These investigations indicate that the combination may have greater effects on strength, lean mass, and body fat percentage; in addition to delaying neuromuscular fatigue
  • creatine phosphate has been reported to be as effective as CM at improving LBM and strength
  • Green et al. [24] reported that adding 93 g of carbohydrate to 5 g of CM increased total muscle creatine by 60%
  • Steenge et al. [23] reported that adding 47 g of carbohydrate and 50 g of protein to CM was as effective at promoting muscle retention of creatine as adding 96 g of carbohydrate.
  • It appears that combining CM with carbohydrate or carbohydrate and protein produces optimal results
  • Studies suggest that increasing skeletal muscle creatine uptake may enhance the benefits of training
  • Nearly 70% of these studies have reported a significant improvement in exercise capacity,
  • Long-term CM supplementation appears to enhance the overall quality of training, leading to 5 to 15% greater gains in strength and performance
  • Nearly all studies indicate that "proper" CM supplementation increases body mass by about 1 to 2 kg in the first week of loading
  • short-term adaptations reported from CM supplementation include increased cycling power, total work performed on the bench press and jump squat, as well as improved sport performance in sprinting, swimming, and soccer
  • Long-term adaptations when combining CM supplementation with training include increased muscle creatine and PCr content, lean body mass, strength, sprint performance, power, rate of force development, and muscle diameter
  • subjects taking CM typically gain about twice as much body mass and/or fat free mass (i.e., an extra 2 to 4 pounds of muscle mass during 4 to 12 weeks of training) than subjects taking a placebo
  • The gains in muscle mass appear to be a result of an improved ability to perform high-intensity exercise via increased PCr availability and enhanced ATP synthesis, thereby enabling an athlete to train harder
  • there is no evidence to support the notion that normal creatine intakes (< 25 g/d) in healthy adults cause renal dysfunction
  • no long-term side effects have been observed in athletes (up to 5 years),
  • One cohort of patients taking 1.5 – 3 grams/day of CM has been monitored since 1981 with no significant side effects
  • Nathan Goodyear on 27 Jan 14
     
    Nice review of the data, up to the publication date, on creatine.
Nathan Goodyear

ScienceDirect - Journal of Psychiatric Research : Neuroendocrine effects of S-adenosyl-... - 0 views

www.sciencedirect.com/science

SAMe dopamine depression

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Our results, at least in depressed men, seem to support the hypothesis of a stimulating effect of SAMe on the dopaminergic system
  • Nathan Goodyear on 08 Mar 11
     
    SAMe stimulates dopamine secretion in depressed men
Nathan Goodyear

Effects of Mercury on Methionine Synthase: Implications for Disordered Methylation in A... - 0 views

www.autism.com/pro_research_methionine.asp

autism methylation

shared by Nathan Goodyear on 12 Jul 11 - No Cached
  • Nathan Goodyear on 12 Jul 11
     
    great read on role of disordered methylation in Autism
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