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Nathan Goodyear

https://www.researchgate.net/profile/Osama_Arafat/publication/234135338_METHYLCOBALAMIN... - 0 views

www.researchgate.net/...C-HYPOPHYSEAL-ADRENAL-AXIS.pdf

methylcobalamin methyl-B12 B12 hypertension norepinephrine adrenal medulla adrenal

shared by Nathan Goodyear on 18 Dec 17 - No Cached
  • Nathan Goodyear on 18 Dec 17
     
    Animal study points to methylB12 as the cause of an increase in adrenal medulla norepinephrine production.  This has significant implications in individuals with hypertension.
Nathan Goodyear

Intravenous methylcobalamin treatment for uremic ... [Intern Med. 1999] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10411351

IV intravenous therapy vitamin B12 neuropathy diabetic neuropathy peripheral neuropathy

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    IV vitamin B12 shown to safe and effective treatment of neuropathy in diabetic patients.
Nathan Goodyear

Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in c... - 0 views

www.ajcn.org/...425.short

vitamin B12 Folate Folinic Acid autism spectrum disorders

shared by Nathan Goodyear on 28 Jun 11 - No Cached
  • Nathan Goodyear on 28 Jun 11
     
    Active Vitamin B12 and Folate treatment benefits some children with autism spectrum disorders
Nathan Goodyear

The acute effect of high-dose intravenous vitamin C and other nutrients on blood pressu... - 0 views

www.ncbi.nlm.nih.gov/...PMC4864764

vitamin C IV vitamin C hypertension vitamin B12 blood pressure cardiovascular disease CVD

shared by Nathan Goodyear on 14 Aug 17 - No Cached
  • the reduction in BP within the first 10–20 min may be primarily attributed to a direct vasodilatory physiological effect, described as venodilation
  • BP reduction observed after 70–90 min is likely attributable to pharmacokinetically plausible vitamin C absorption and vasodilation because of nitric oxide release
  • Pharmacokinetic studies of IVC administration observed peak plasma levels within the first 90 min, with plasma levels reaching 13350 μmol/l for 50 g of IVC
  • ...6 more annotations...
  • Essential hypertension, associated with endothelial dysfunction because of an impaired nitric oxide/l-arginine pathway and impaired vasodilation can be restored by vitamin C
  • marked increase in BP response when IVB12 is administered
  • The mean BP increased significantly up to 12–16 mmHg systolic and diastolic independent of the dosage of vitamin B12
  • The production of norepinephrine, which can stimulate angiotensin-II production, which in turn influences BP, has been suggested as a possible mechanism for the increase in BP with IVB12
  • excess norephinephrine levels stimulate the sympathetic nervous system, leading to increased cortisol production, which has also been linked to increases in BP
  • Animal studies have found higher serum levels of norepinephrine (noradrenaline) in the adrenal medulla of rats receiving methylcobalamin (methyl-vitamin B12)
  • Nathan Goodyear on 14 Aug 17
     
    IV vitamin C in mostly normotensive patients (> 30 grams) reduced blood pressure.  Some of the patients were pre-hypertensive. Vitamin B12 increase the blood pressure.
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