Study reveals that the more medications a man takes, the more symptoms of ED he has. This was found to be independent from variables such as hypertension, diabetes... ED symptoms started at 1 medication
arimidex, also known as anastrozole, is shown to be an effective aromatase inhibitor in men. These case studies used arimidex to successfully stimulate testosterone production by limiting testosterone to estrogen production. This was found to be useful in the treatment of gynecomastia.
Review finds that low SHBG and higher Testosterone levels are associated with increased CVD risk in post menopausal women. Exact relationship is undetermined.
Study finds little link to Testosterone replacement therapy to elevation in PSA in "healthy" men. All the members of this study had negative prostate biopsies prior to therapy.
testosterone may have a protective role in the development of metabolic syndrome and subsequent diabetes mellitus and cardiovascular disease in aging men
The freely diffusible plasma fraction is distributed extensively
throughout tissues, reaching highest concentrations in bone, teeth, liver,
lungs, kidneys, brain and spleen
Inorganic lead does not
undergo any metabolic transformation or digestion in the intestines, or
detoxification in the liver.5
With chronic exposure over a long period of time, most absorbed lead
ends up in bone
The total bodily content of lead is called the
body burden; in a steady state, about 90 percent of the body burden is bound to
bone.2
n general, lead is excreted quite slowly from the
body (with the biologic half-life estimated at 10 years). Since excretion is
slow, accumulation in the body occurs easily.2
hronic toxicity is an
insidious illness with protean manifestations.3,6 Symptoms may include arthralgias, headache,
weakness, depression, loss of libido, impotence and vague gastrointestinal
difficulties.
Late effects may include chronic renal failure, hypertension,
gout and chronic encephalopathy.6
Small study found that 2 months of clomid therapy increased LH, FSH, total Testosterone, and free Testosterone over placebo. Improvement in ED was minimal and most in young men. This is consistent with other studies that have found that less effects are seen in those with multiple comorbidities.
Nice study that looked at climid to restore HPA function and increase Testosterone stimulation and production. This study also does a good job of reviewing the mechanisms of low T. Low T is really a biomarker of poor health in men.
Studies have shown that ED may be an early biomarker of general endothelial dysfunction, atherosclerosis and CVD
testosterone treatment of hypogonadal young and older men improves sexual function, increases lean mass and decreases fat mass
In men with low serum testosterone (for example, <8 or 230 nmol l−1) with obesity, metabolic syndrome and diabetes mellitus, treatment with testosterone is warranted
In obese middle-aged men, testosterone treatment reduced visceral adipocity, insulin resistance, serum cholesterol and glucose levels
testosterone replacement has a favorable impact on body mass, insulin secretion and sensitivity, lipid profile and blood pressure in hypogonadal men with the metabolic syndrome as well as type 2 diabetes mellitus
Testosterone significantly inhibits lipoprotein lipase activity, which reduces triglycerides uptake into adipocytes in the abdominal adipose tissue
testosterone treatment decreased endogenous inflammatory cytokines (tumor necrosis factor-α and IL-1β) and lipids (total cholesterol) and increased IL-10 in hypogonadal men
Testosterone treatment reduced leptin and adiponectin levels in hypogonadal type 2 diabetic men after 3 months of testosterone replacement
available data clearly show a relationship between obesity, low testosterone levels and ED
Obesity adversely affects endothelial function and lowers serum testosterone levels through the development of insulin resistance and metabolic syndrome
Metabolic disturbances as well as production of cytokines and adipokines by inflamed fat cells may be causal factors in the development of ED
The onset of ED and the associated risk of CVD may be delayed through lifestyle modifications that affect obesity, such as diet and exercise
Very low testosterone levels contribute to the development of ED in obesity, metabolic syndrome and type 2 diabetes mellitus
Obesity is associated with low total testosterone levels that can be explained at least partially by lower sex hormone-binding globulin (SHBG) in obese men
epidemiological studies have shown a negative correlation between BMI and total testosterone and to a lesser extent with free and bioavailable (biologically active) testosterone levels
Pharma Sust 250mg injections treat hypogonadism disorders in men, after the illness, impotence due to lack of hormones, menstrual symptoms in men such as reducing sexual pleasure and physiological activities.
Side effects:
The drug can cause erectile dysfunction, signs of excessive sexual stimulation, reduced sperm count, decreased volume of ejaculation, water & salt retention.
In pre-puberty boys: develop sex early, increase the frequency of erectile dysfunction, enlargement of the penis, and early growth of bone heads.
Impotensi kerap terjadi khususnya oleh pria yang sudah berumur 40 tahun ke atas dan ada beberapa faktor yang melatarbelakanginya baik karena faktor kesehatan maupun psikologis.