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Nathan Goodyear

Associations of Maternal Prepregnancy Body Mass Index and Gestational Weight Gain With ... - 0 views

circ.ahajournals.org/...1381

obesity obese overweight pregnancy health cardiovascular children offspring

shared by Nathan Goodyear on 14 May 12 - No Cached
  • Nathan Goodyear on 14 May 12
     
    Obesity of pregnant mothers effect the future cardiovascular health of their future children. The time to work on the health of your future children, is before couples actually get pregnant.
Nathan Goodyear

Diagnostic Potential of Saliva: Current State and Future Applications -- Pfaffe et al. ... - 0 views

www.clinchem.org/...675

salivary testing evaluation hormone hormones BHRT diagnostic potential applications saliva

shared by Nathan Goodyear on 26 Nov 11 - No Cached
  • Nathan Goodyear on 26 Nov 11
     
    saliva testing described as the future of first-line evaluation for hormones
Nathan Goodyear

Metabolic syndrome and insulin resistance in Divis... [Med Sci Sports Exerc. 2009] - Pu... - 0 views

www.ncbi.nlm.nih.gov/...19915510

metabolic syndrome insulin resistance college football lineman

shared by Nathan Goodyear on 14 May 11 - No Cached
  • Linemen are at significant risk for metabolic syndrome and insulin resistance compared with other positions. This may be predictive of future health problems in Division 1 collegiate football players, especially linemen
  • There is a strong association between obesity and both metabolic syndrome and insulin resistance in Division 1 collegiate football players
  • Nathan Goodyear on 14 May 11
     
    college football lineman at increased risk of obesity, insulin resistance, and future health problems
Nathan Goodyear

Oncotarget | NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Id... - 0 views

www.oncotarget.com/index.php

vitamin C IV vitamin C cancer cancer stem cells milk thistle silymarin ascorbic acid bee propolis CAPE glycolytic inhibitor natural

shared by Nathan Goodyear on 08 Dec 17 - No Cached
  • Vitamin C was ~10 times more potent than 2-DG for the targeting of CSCs
  • Cancer stem-like cells (CSCs) are thought to be the root cause of chemotherapy-resistance and radio-resistance
  • ultimately leading to treatment failure in patients with advanced disease [1-3]. They have been directly implicated mechanistically in tumor recurrence and metastasis, resulting in poor patient survival
  • ...26 more annotations...
  • mitochondrial biogenesis may be a key driver of the CSC phenotype
  • Our results indicate that increased mitochondrial oxidative stress and high NADH levels are both key characteristics of the CSC metabolic phenotype
  • high levels of NAD(P)H auto-fluorescence are known to be a surrogate marker for mitochondrial “power”, high OXPHOS capacity and increased ATP production
  • CSCs may be strictly dependent on NAD(P)H to maintain their enhanced mitochondrial function
  • an intact NAD+ salvage pathway is strictly required for mammosphere formation, supporting our results using NAD(P)H auto-fluorescence, which enriched CSC activity by more than 5-fold.
  • Since glycolysis is especially critical for maintaining the TCA cycle, OXPHOS and overall mitochondrial function, we next assessed the effects of known glycolytic inhibitors
  • we show that two other natural products that function as effective glycolysis inhibitors, also inhibited mammosphere formation. More specifically, vitamin C (ascorbic acid), which induces oxidative stress and inhibits the activity of GAPDH (a key glycolytic enzyme) [17], also inhibited mammosphere formation, with an IC-50 of 1 mM (Figure 7B). Therefore, vitamin C was ~10 times more potent than 2-DG at targeting CSC propagation
  • silibinin (the major active constituent of silymarin, an extract of milk thistle seeds) [18], which specifically functions as an inhibitor of glucose uptake, blocked mammosphere formation, with an IC-50 between 200 and 400 µM
  • caffeic acid phenyl ester (CAPE), a key component of honey-bee propolis, has potent anti-cancer properties
  • Propolis has a strong history of medicinal use, dating back more than 2,000 years
  • Because of it aromatic ring structure (Figure 8), we speculated that CAPE might function as a potent inhibitor of oxidative mitochondrial metabolism
  • CAPE quantitatively inhibits the mitochondrial oxygen consumption rate (OCR) and, in turn, induces the onset of aerobic glycolysis (ECAR)
  • CAPE shows a clear selectivity for targeting CSCs and adherent cancer cells, relative to normal fibroblasts.
  • CAPE functions as a “natural” mitochondrial OXPHOS inhibitor, that preferentially targets the CSC sub-population. This could explain CAPE’s known anti-cancer properties
  • Our data directly shows that a small fraction of the total cell population, characterized by increased PGC1α activity, high mitochondrial ROS/H2O2 and high NADH levels, has the ability to survive and grow under anchorage-independent conditions, driving mammosphere formation
  • We highlight the utility of certain natural products, such as Silibinin, Vitamin C and CAPE, that could be used to therapeutically target CSCs. Silibinin is the major active component of silymarin, which is an extract prepared from milk thistle seeds.
  • high NADH is a property that is conserved between normal and cancerous stem cells
  • Previous studies have also shown that when non-CSCs and CSCs are both fed mitochondrial fuels (such as L-lactate or ketone bodies), that CSCs quantitatively produce more NADH in response to this stimulus
  • CSCs may be strictly dependent on NADH to maintain their enhanced mitochondrial function
  • The Noble Prize winner, Linus Pauling, was among the first to describe and clinically test the efficacy of Vitamin C, as a relatively non-toxic anti-cancer agent
  • Vitamin C has two mechanisms of action. First, it is a potent pro-oxidant, that actively depletes the reduced glutathione pool, leading to cellular oxidative stress and apoptosis in cancer cells. Moreover, it also behaves as an inhibitor of glycolysis, by targeting the activity of GAPDH, a key glycolytic enzyme.
  • Here, we show that Vitamin C can also be used to target the CSC population, as it is an inhibitor of energy metabolism that feeds into the mitochondrial TCA cycle and OXPHOS
  • Vitamin C may prove to be promising agent for new clinical trials, aimed at testing its ability to reduce CSC activity in cancer patients, as an add-on to more conventional therapies, to prevent tumor recurrence, further disease progression and metastasis
  • Interestingly, a breast cancer based clinical study has already shown that the use of Vitamin C, concurrent with or within 6 months of chemotherapy, significantly reduces both tumor recurrence and patient mortality
  • CAPE quantitatively reduces mitochondrial oxygen consumption (OCR), while inducing a reactive increase in glycolysis (ECAR). As such, it potently inhibits mammosphere formation with an IC-50 of ~2.5 µM. Similarly, it also significantly inhibits cell migration
  • we also demonstrate that 7 different inhibitors of key energetic pathways can be used to effectively block CSC propagation, including three natural products (silibinin, ascorbic acid and CAPE). Future studies will be necessary to test their potential for clinical benefit in cancer patients.
  • Nathan Goodyear on 08 Dec 17
     
    The future of cancer therapy is cancer stem cells.  Study finds that Vitamin C, silymarin, and bee propolis blocks mitochondrial energy pathways in cancer stem cells.  Vitamin C is a known glycolytic inhbitor. Vitamin C was found to inhibit glycolysis via GAPDH targeting to inhibit the energy pathways of the mitochondria in CSCs.  The authors propse that Vitamin C can be used as add on therapies for conventional therapies to specifically attack the CSCs and their contribution to recrurence, treatment resistance, and metastasis potential all in addition to the ability of vitamin C to reduce the side effects of chemotherapy.
Nathan Goodyear

Rapid determination of natural steroidal hormones in saliva for the clinical diagnoses - 0 views

www.ncbi.nlm.nih.gov/...PMC3351364

hormone hormones saliva salivary testing estrone estradiol estriol progesterone testosterone natural

shared by Nathan Goodyear on 15 Oct 12 - No Cached
  • Nathan Goodyear on 15 Oct 12
     
    recent study proves the scientific validity of sex hormone evaluation via saliva.  Most labs today use ELIZA.  The new future will be mass spectroscopy.
Nathan Goodyear

Breast Cancer Research | Full text | The growth response to androgen receptor signaling... - 0 views

breast-cancer-research.com/...R27

androgen receptors receptor AR breast cancer women

shared by Nathan Goodyear on 21 Nov 12 - No Cached
  • Nathan Goodyear on 21 Nov 12
     
    Androgen Receptors (AR) may play a role in some breast cancer growth and could be a target for future therapy.
market reports

Market Trends in Infection Control Market & Healthcare Facilities - 0 views

www.marketsandmarketsblog.com/sterilization-market.html

Infection Control Market

shared by market reports on 23 May 13 - No Cached
  • market reports on 23 May 13
     
    Future market trends in infection control market show the increased growth and demands for gamma, and e-beam sterilization services. These services are likely to take over the EtO sterilization process. This is the resultant of wide application area of both gamma and e-beam sterilization
Nathan Goodyear

ScienceDirect.com - The Journal of Steroid Biochemistry and Molecular Biology - Estroge... - 0 views

www.sciencedirect.com/...S0960076011001518

xenoestrogen xenoestrogens prostate male hormone estrogen receptor estrogen receptor alpha ER alpha estrogen receptor receptors environmental chemicals drugs

shared by Nathan Goodyear on 07 Jan 13 - No Cached
  • Nathan Goodyear on 07 Jan 13
     
    low dose xenoestrogen exposure increases prostate growth and future disease through fetal exposure and increased ER alpha expression.
Nathan Goodyear

Neural regulation of the immune system modulates hypertension-induced target-organ damage - 0 views

www.ashjournal.com/...fulltext

CVD neuroimmunology neurology immunology hypertension immune system

shared by Nathan Goodyear on 01 Oct 12 - No Cached
  • Nathan Goodyear on 01 Oct 12
     
    cool read:  the future of CVD treatment.  The link between neuroimmunology and cardiovascular disease.
Nathan Goodyear

Estrogen receptor α and β in the normal immune system and in lymphoid maligna... - 0 views

www.sciencedirect.com/...S0303720713002207

ER estrogen receptors ER beta cancer lymphoma hormone hormones receptors

shared by Nathan Goodyear on 25 Jun 13 - No Cached
  • Nathan Goodyear on 25 Jun 13
     
    ER beta receptors have future in the treatment of cancer.  ER beta is a known growth inhibitor and this study proposes that ER beta is a means to aid lymphoma treatment.
Nathan Goodyear

Inflammation and prostate cancer, Future Oncology, Future Medicine - 0 views

www.futuremedicine.com/...14796694.4.5.637

inflammation testosterone estradiol E2 T:E2 prostate cancer prostatitis

shared by Nathan Goodyear on 01 May 12 - No Cached
  • Nathan Goodyear on 01 May 12
     
    low T:E2 ratio increases inflammation in prostate.  This has implications in prostatitis and prostate cancer.
Nathan Goodyear

American College of Cardiology Foundation | Journal of the American College of Cardiolo... - 1 views

content.onlinejacc.org/article.aspx

EPCs endothelial progenitor cells CVD cardiovascular disease heart cardiology

shared by Nathan Goodyear on 10 Jul 12 - No Cached
  • Nathan Goodyear on 10 Jul 12
     
    Endothelial progenitor cells (EPCs) as the future of cardiovascular treatment?
Nathan Goodyear

Salivary biomarkers in psychobiological medicine - 0 views

www.ncbi.nlm.nih.gov/...PMC1891707

saliva salivary testing analysis inflammatory cytokines biomarker

shared by Nathan Goodyear on 30 May 12 - No Cached
  • Nathan Goodyear on 30 May 12
     
    saliva is the future of biomarker testing, such as inflammatory cytokines, neuro-endocrine evaluation...
Nathan Goodyear

MicroRNAs in the Aging Female Brain: A Putative Mechanism for Age-Specific Estrogen Eff... - 0 views

endo.endojournals.org/...2795.abstract

aging female brain estrogen HRT BHRT hormone hormones menopause neurology memory Estradiol

shared by Nathan Goodyear on 06 Aug 13 - No Cached
  • Nathan Goodyear on 06 Aug 13
     
    Estradiol appears to have an age dependent effect on the transcription of mRNA and brain neuroplasticity.  This has a future impact on the risk of cognitive decline and dementia in elderly women.  This is only the abstract, but points to one effect of early Estradiol effect on improved brain health versus late therapy.  
Dr. Jennifer Martinick

Diploma of Management - 0 views

aitp.com.au/...diploma-of-management

diploma of management

shared by Dr. Jennifer Martinick on 17 Sep 13 - No Cached
  • Dr. Jennifer Martinick on 17 Sep 13
     
    Learn how Diploma of Management creates future leaders with sound knowledge and expertise in effective business management.
Nathan Goodyear

C-Reactive Protein as a Cardiovascular Risk Factor : More Than an Epiphenomenon? -- Lag... - 0 views

circ.ahajournals.org/...96

CRP cardiovascular disease

shared by Nathan Goodyear on 04 Feb 11 - No Cached
  • CRP constitutes an independent cardiovascular risk factor
  • Nathan Goodyear on 04 Feb 11
     
    CRP is an independent marker for future cardiovascular disease
Nathan Goodyear

Health Care Overhaul May Push Employee Benefits Shift - 0 views

www.ncpa.org/...index.php

health health care employee benefits

shared by Nathan Goodyear on 26 Aug 11 - No Cached
  • Nathan Goodyear on 26 Aug 11
     
    The future of Employee benefits is changing
Nathan Goodyear

Obesity in middle age and future risk of dementia:... [BMJ. 2005] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...15863436

middle aged obesity and dementia

shared by Nathan Goodyear on 12 Apr 11 - No Cached
  • Obese people (body mass index > or = 30) had a 74% increased risk of dementia
  • Obesity in middle age increases the risk of future dementia independently of comorbid conditions.
  • Nathan Goodyear on 12 Apr 11
     
    middle-aged obesity and dementia
Nathan Goodyear

ScienceDirect - The Journal of Nutritional Biochemistry : Analytical metabolomics: nutr... - 0 views

www.sciencedirect.com/...S0955286311001963

biochemistry personalized health nutritional metabolomics

shared by Nathan Goodyear on 31 Oct 11 - No Cached
  • Nathan Goodyear on 31 Oct 11
     
    metabolomics?  the future of medicine is customized medicine
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