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Nathan Goodyear

Chemical toxins: a hypothesis to explain the globa... [J Altern Complement Med. 2002] -... - 0 views

www.ncbi.nlm.nih.gov/...12006126

chemical toxins obesity overweight

shared by Nathan Goodyear on 06 Apr 11 - No Cached
  • Because the obesity epidemic occurred relatively quickly, it has been suggested that environmental causes instead of genetic factors maybe largely responsible
  • exponential production and usage of synthetic organic and inorganic chemicals. Many of these chemicals are better known for causing weight loss at high levels of exposure but much lower concentrations of these same chemicals have powerful weight-promoting actions.
  • his paper presents a hypothesis that the current level of human exposure to these chemicals may have damaged many of the body's natural weight-control mechanisms. Furthermore, it is posited here that these effects, together with a wide range of additional, possibly synergistic, factors may play a significant role in the worldwide obesity epidemic.
  • Nathan Goodyear on 06 Apr 11
     
    Toxins as chemical cause of obesity problem?
Nathan Goodyear

Environmental Chemicals in Pregnant Women in the United States: NHANES 2003-2004 - 0 views

www.ncbi.nlm.nih.gov/...PMC3114826

environmental chemicals toxins pregnant women pregnant women

shared by Nathan Goodyear on 04 Dec 12 - No Cached
  • Nathan Goodyear on 04 Dec 12
     
    2011 study finds that 43 toxic chemicals of 163 evaluated found in "virtually all" 268 pregnant women in small study.  Many of these chemical have not been commercially available for 30 years.
Nathan Goodyear

Prenatal exposure to endocrine-disrupting chemicals linked to breast cancer - 0 views

www.sciencedaily.com/...100521102633.htm

prenatal exposure endocrine disrupting chemicals BPA DES breast cancer

shared by Nathan Goodyear on 20 Feb 11 - Cached
  • Prenatal Exposure to Endocrine-Disrupting Chemicals Linked to Breast Cancer
  • Nathan Goodyear on 20 Feb 11
     
    prenatal exposure to chemicals linked to increase risk of breast cancer
Nathan Goodyear

Basic properties and molecular mechanisms of exogenous chemical carcinogens. (2010) | L... - 0 views

www.labmeeting.com/...exogenous-chemical-carcinogens

toxins chemicals carcinogens

shared by Nathan Goodyear on 28 Mar 11 - No Cached
  • Nathan Goodyear on 28 Mar 11
     
    environmental chemicals as carcinogens
Nathan Goodyear

Actions of Estrogens and Endocrine Disrupting Chemicals on Human Prostate Stem/Progenit... - 0 views

www.ncbi.nlm.nih.gov/...PMC3249013

prostate cancer EDC xenoestrogens endocrine disrupting chemicals estrogen men male hormone hormones

shared by Nathan Goodyear on 06 Feb 14 - No Cached
  • Nathan Goodyear on 06 Feb 14
     
    Endocrine Disrupting chemicals, xenoestrogens, alter the hormone receptors very early. Increased estrogenic load with the change in ER increase prostate cancer.
Nathan Goodyear

Do Artificial Food Colors Promote Hyperactivity in Children... : Journal of Development... - 0 views

journals.lww.com/...romote_Hyperactivity_in.7.aspx

ADD ADHD chemicals artificial coloring sweetners

shared by Nathan Goodyear on 17 Apr 11 - No Cached
  • his study is consistent with accumulating evidence that neurobehavioral toxicity may characterize a variety of widely distributed chemicals.
  • Nathan Goodyear on 17 Apr 11
     
    ADD and ADHD are a product of chemicals we eat
Nathan Goodyear

Chemical Toxins and Obesity: Paula F. Baillie-Hamilton, M.B., B.S., D.Phil., Explains t... - 0 views

www.liebertonline.com/...107628002320351343

chemical toxins obesity

shared by Nathan Goodyear on 06 Apr 11 - No Cached
  • Nathan Goodyear on 06 Apr 11
     
    chemical toxins and obesity
fitspresso

https://www.fitspresso-co.com/ - 0 views

www.fitspresso-co.com

fitspresso fit spresso us uk buy usa 2023 pros 2022 2024 pills order price weight loss espresso fitespresso review amazon tablet reviews customer supplement does it work

shared by fitspresso on 27 Sep 23 - No Cached
  • fitspresso on 27 Sep 23
     
    FitSpresso™ | Official Site fitspresso-co.com FitSpresso Only $39/Bottle Limited Time Offer! FitSpresso Special Deal + Special 51% Discount Save $660 + 180 Days Money Back Guarantee FitSpresso Herpesyl Five Star A dietary product formulated to assist users in reducing weight can increase other advantages that can support overall health. This product can assist users in getting closer to the desirable body weight. Regular Price: 149/per bottle Only for: $39/per bottle Buy Now What IsFitSpresso? FitSpresso is promoted as a natural supplement that comes in the form of diet pills, and it can aid in rapid and efficient weight loss, similar to many other supplements. The term "natural supplements refers to a nutritional supplement that is made entirely of natural, chemical-free materials. You can utilize these organic ingredients to aid in natural weight loss. It can speed up your body's metabolism and assist with other crucial processes. All parts of our bodies are impacted by weight increase, and not only do we need to deal with the increased weight, but we also need to deal with the numerous problems and illnesses that come along with it. This refers to the risk of developing chronic cardiac conditions, low blood pressure, and, in some circumstances, problems with blood sugar. However, FitSpresso even with its bright and bold claims, can help you efficiently manage your weight and completely avoid these extra uncomfortable problems. FitSpresso is a supplement that comes in the form of a pill, which makes it tasty, simple to swallow, and handy. According to the manufacturer, these diet tablets are GMO-free and toxic-free, making them edible. This is why we have things such as weight loss supplements. Thanks to modern advancements, we can just take a dietary supplement pill to bring about significant weight loss in a completely healthy and natural manner. Not only this, but dietary supplements can also support healthy blood sugar levels and help with
Nathan Goodyear

Endocrine-Disrupting Chemicals: Associated Disorders and Mechanisms of Action - 0 views

www.ncbi.nlm.nih.gov/...PMC3443608

xenoestrogens environmental toxins

shared by Nathan Goodyear on 11 Mar 13 - No Cached
  • Nathan Goodyear on 11 Mar 13
     
    good review of current knowledge on endocrine disrupting chemicals, more commonly known as xenoestrogens.
Nathan Goodyear

Dog sperm quality decline is blamed on pet food chemicals | New Scientist - 0 views

www.newscientist.com/...s-blamed-on-pet-food-chemicals

sperm count low T low Testosterone environment EDC endocrine disrupting chemicals male fertility

shared by Nathan Goodyear on 10 Aug 16 - No Cached
  • Nathan Goodyear on 10 Aug 16
     
    26 year study of dogs finds declining sperm count equivalent to that in men.  The decline was found to occur at a rate of 1.2% to 2.5% annually over course of study.  The authors pointed to EDC's in food.
Nathan Goodyear

Medical Hypothesis: Xenoestrogens As Preventable Causes of Breast Cancer - 0 views

www.ncbi.nlm.nih.gov/...envhper00375-0014.pdf

xenoestrogens environmental toxins chemicals cancer

shared by Nathan Goodyear on 18 Mar 12 - No Cached
  • Nathan Goodyear on 18 Mar 12
     
    good review of some of the literature pointing to the impact of environmental chemicals (xenoestrogens) and cancer
Nathan Goodyear

One year follow-up study of the association between chemical castration, sex hormones, ... - 0 views

www.sciencedirect.com/...S0306453003002208

hormone hormones depression memory beta-amyloid Testosterone Estradiol

shared by Nathan Goodyear on 03 Feb 14 - No Cached
  • Nathan Goodyear on 03 Feb 14
     
    Chemical castration as seen in androgen deprivation therapy resulted in precipitous decline in Testosterone and Estradiol in men.  Associated increased in beta-amylloid found.
Nathan Goodyear

Low Serum Testosterone Levels Are Associated with Elevated Urinary Mandelic Acid, and S... - 0 views

www.ncbi.nlm.nih.gov/...25996772

low T low Testosterone Testosterone mandolin acid strontium environmental chemicals toxins environmental toxins

shared by Nathan Goodyear on 27 May 15 - No Cached
  • Nathan Goodyear on 27 May 15
     
    analysis of 110 chemicals finds inverse association with Testosterone and elevated mandelic acid and strontium.
Nathan Goodyear

Environmental Chemicals in Pregnant Women in the U... [Environ Health Perspect. 2011] -... - 0 views

www.ncbi.nlm.nih.gov/...21233055

environmental chemicals health pregnancy

shared by Nathan Goodyear on 02 Mar 11 - No Cached
  • Conclusions: Pregnant women in the U.S. are exposed to multiple chemicals
  • Nathan Goodyear on 02 Mar 11
     
    Pregnancy and toxins
Nathan Goodyear

Inhibitory effects of some possible endocrine-di... [Environ Sci. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16184081

endocrine disrupting chemicals hormone hormones cortisol cortisone endocrine disruptors EDC 11-betaHSD 11-betaHSD1 11beta-HSD2

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    11beta-HSD type I and type II are no equally expressed across all tissues.  Endocrine disrupting chemicals (EDC) inhibit both.
Nathan Goodyear

PLOS ONE: Persistent Organic Pollutants and Early Menopause in U.S. Women - 0 views

journals.plos.org/...article

EDC endocrine disrupting chemicals women hormone hormones female xenoestrogens endocrine disruptors menopause

shared by Nathan Goodyear on 30 Jan 15 - No Cached
  • Nathan Goodyear on 30 Jan 15
     
    study identifies 15 Endocrine Disrupting Chemicals that lead to earlier Menopause.  Maybe we should change it to Chemopause.
Nathan Goodyear

A relationship in adrenal androgen levels between mothers and their children from a dio... - 0 views

www.sciencedirect.com/...S0048969717316911

EDC endocrine disrupting chemicals hormones endocrine disruptors agent orange DHEA androstenedione

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • Nathan Goodyear on 04 Oct 17
     
    Endocrine Disrupting Chemicals from 1970 still disrupting hormones today.  Three fold increase in DHEA in 3 year old children via saliva and androstenedione in mothers compared to controls.
Nathan Goodyear

Ibuprofen alters human testicular physiology to produce a state of compensated hypogona... - 0 views

www.pnas.org/...1715035115.full

ibuprofen Testosterone epigenetics hormones low Testosterone low T

shared by Nathan Goodyear on 09 Jan 18 - No Cached
  • The levels of LH in the ibuprofen group had increased by 23% after 14 d of administration
  • This increase was even more pronounced at 44 d, at 33%
  • We found an 18% decrease (P = 0.056) in the ibuprofen group compared with the placebo group after 14 d (Fig. 1A) and a 23% decrease (P = 0.02) after 44 d (Fig. 1C). Taken together, these in vivo data suggest that ibuprofen induced a state of compensated hypogonadism during the trial, which occurred as early as 14 d and was maintained until the end of the trial at 44 d
  • ...27 more annotations...
  • We first investigated testosterone production after 24 and 48 h of ibuprofen exposure to assess its effects on Leydig cell steroidogenesis. Inhibition of testosterone levels was significant and dose-dependent (β = −0.405, P = 0.01 at 24 h and β = −0.664, P < 0.0001 at 48 h) (Fig. 2A) and was augmented over time
  • The AMH data show that the hypogonadism affected not only Leydig cells but also Sertoli cells and also occurred as early as 14 d of administration
  • Sertoli cell activity showed that AMH levels decreased significantly with ibuprofen administration, by 9% (P = 0.02) after 14 d (Fig. 1B) and by 7% (P = 0.05) after 44 d compared with the placebo group
  • Examination of the effect of ibuprofen exposure on both the ∆4 and ∆5 steroid pathways (Fig. 2B) showed that it generally inhibited all steroids from pregnenolone down to testosterone and 17β-estradiol; the production of each steroid measured decreased at doses of 10−5–10−4 M. Under control conditions, production of androstenediol and dehydroepiandrosterone (DHEA) was below the limit of detection except in one experiment with DHEA
  • Measuring the mRNA expression of genes involved in steroidogenesis in vitro showed that ibuprofen had a profound inhibitory effect on the expression of these genes (Fig. 3 B–D), consistent with that seen above in our ex vivo organ model. Taken together, these data examining effects on the endocrine cells confirm that ibuprofen-induced changes in the transcriptional machinery were the likely reason for the inhibition of steroidogenesis.
  • Suppression of gene expression concerned the initial conversion of cholesterol to the final testosterone synthesis. Hence, expression of genes involved in cholesterol transport to the Leydig cell mitochondria was impaired
  • A previous study reported androsterone levels decreased by 63% among men receiving 400 mg of ibuprofen every 6 h for 4 wk
  • We next examined the gene expression involved in testicular steroidogenesis ex vivo and found that levels of expression of every gene that we studied except CYP19A1 decreased after exposure for 48 h compared with controls
  • the changes in gene expression indicate that the transcriptional machinery behind the endocrine action of Leydig cells was most likely impaired by ibuprofen exposure.
  • Together, these data show that ibuprofen also directly impairs Sertoli cell function ex vivo by inhibiting transcription
  • ibuprofen use in men led to (i) elevation of LH; (ii) a decreased testosterone/LH ratio and, to a lesser degree, a decreased inhibin B/FSH ratio; and (iii) a reduction in the levels of the Sertoli cell hormone AMH
  • The decrease in the free testosterone/LH ratio resulted primarily from the increased LH levels, revealing that testicular responsiveness to gonadotropins likely declined during the ibuprofen exposure. Our data from the ex vivo experiments support this notion, indicating that the observed elevation in LH resulted from ibuprofen’s direct antiandrogenic action
  • AMH levels were consistently suppressed by ibuprofen both in vivo and ex vivo, indicating that this hormone is uncoupled from gonadotropins in adult men. The ibuprofen suppression of AMH further demonstrated that the analgesic targeted not only the Leydig cells but also the Sertoli cells, a feature encountered not only in the human adult testis but also in the fetal testis
  • ibuprofen displayed broad transcription-repression abilities involving steroidogenesis, peptide hormones, and prostaglandin synthesis
  • a chemical compound, through its effects on the signaling compounds, can result in changes in the testis at gene level, resulting in perturbations at higher physiological levels in the adult human
  • The analgesics acetaminophen/paracetamol and ibuprofen have previously been shown to inhibit the postexercise response in muscles by repressing transcription
  • Previous ex vivo studies on adult testis have indeed pointed to an antiandrogenicity, only on Leydig cells, of phthalates (41), aspirin, indomethacin (42), and bisphenol A (BPA) and its analogs
  • ibuprofen’s effects were not restricted to Leydig and Sertoli cells, as data showed that the expression of genes in peritubular cells was also affected
  • short-term exposure
  • In the clinical setting, compromised Leydig cell function resulting in increased insensitivity to LH is defined as compensated hypogonadism (4), an entity associated with all-cause mortality
  • compensated hypogonadic men present with an increased likelihood of reproductive, cognitive, and physical symptoms
  • an inverse relationship was recently reported between endurance exercise training and male sexual libido
  • AMH concentrations are lower in seminal plasma from patients with azoospermia than from men with normal sperm levels
  • inhibin B is a key clinical marker of reproductive health (32). The function of AMH, also secreted by Sertoli cells, and its regulation through FSH remain unclear in men
  • the striking dual effect of ibuprofen observed here on both Leydig and Sertoli cells makes this NSAID the chemical compound, of all the chemical classes considered, with the broadest endocrine-disturbing properties identified so far in men.
  • after administration of 600 mg of ibuprofen to healthy volunteers
  • 14 d or at the last day of administration at 44 d
  • Nathan Goodyear on 09 Jan 18
     
    ibuprofen alters genetic expression that results in decreased Testosterone production.
Nathan Goodyear

False Positive finger stick blood glucose readings after high-dose intravenous vitamin C - 0 views

www.riordanclinic.org/...89024578.pdf

IV vitamin C vitamin C glucose vitamin C

shared by Nathan Goodyear on 18 Jun 13 - No Cached
  • Nathan Goodyear on 18 Jun 13
     
    IV vitamin C > 15 grams falsely elevates finger sticks on glucose. Glucose and vitamin C are very similar chemically. This, however, is a false reading.
Nathan Goodyear

ScienceDirect.com - The Journal of Steroid Biochemistry and Molecular Biology - Estroge... - 0 views

www.sciencedirect.com/...S0960076011001518

xenoestrogen xenoestrogens prostate male hormone estrogen receptor estrogen receptor alpha ER alpha estrogen receptor receptors environmental chemicals drugs

shared by Nathan Goodyear on 07 Jan 13 - No Cached
  • Nathan Goodyear on 07 Jan 13
     
    low dose xenoestrogen exposure increases prostate growth and future disease through fetal exposure and increased ER alpha expression.
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