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Nathan Goodyear

Perspectives for metabolomics in testosterone replacement therapy - 0 views

joe.endocrinology-journals.org/...3.full

ADS androgen deficiency syndrome low T low Testosterone hormones metabolomics

shared by Nathan Goodyear on 30 Apr 15 - No Cached
  • Nathan Goodyear on 30 Apr 15
     
    androgen deficiency syndrome and metabolomics
Nathan Goodyear

ScienceDirect - The Journal of Nutritional Biochemistry : Analytical metabolomics: nutr... - 0 views

www.sciencedirect.com/...S0955286311001963

biochemistry personalized health nutritional metabolomics

shared by Nathan Goodyear on 31 Oct 11 - No Cached
  • Nathan Goodyear on 31 Oct 11
     
    metabolomics?  the future of medicine is customized medicine
Nathan Goodyear

Beyond the male sex hormone: deciphering the metabolic and vascular actions of testoste... - 0 views

joe.endocrinology-journals.org/...C1.full

AR androgen receptors androgen receptor testosterone androgen receptors Diabetes metabolic syndrome MetS CVD cardiovascular disease men hormone hormones male

shared by Nathan Goodyear on 08 May 13 - No Cached
  • androgen deprivation therapy results in unfavorable changes in body composition, insulin resistance, and dyslipidemia and predisposes men to develop atherosclerosis and an increased risk of cardiovascular mortality
  • The hypogonadal–obesity cycle hypothesis was originally proposed by Cohen in 1999 to explain the relationship between low testosterone levels and metabolic disease. It was based on the finding that obesity impairs testosterone levels by increasing the aromatization of testosterone to estradiol, while low testosterone levels promote increased fat deposition
  • adipocytokines contribute to low testosterone levels as well as to the processes underlying metabolic syndromes and type 2 diabetes
  • ...15 more annotations...
  • hypogonadal–obesity–adipocytokine hypothesis
  • The presence of estradiol and the adipocytokines TNF-α, IL6, and leptin (as a result of leptin resistance in obesity) inhibits the hypothalamic–pituitary–testicular axis response to decreasing androgen levels
  • An increasing number of studies have illustrated the potential for applying metabolomics to the field of androgen research
  • As early as the 1940s, the therapeutic use of testosterone was reported to improve angina pectoris in men with coronary artery disease
  • most of the epidemiological studies reported increased cardiovascular risk and mortality in men with low testosterone levels
  • long-term testosterone replacement appears to be a safe and effective means of treating hypogonadal elderly men
  • a recent interventional trial showed that testosterone treatment was associated with decreased mortality when compared with no testosterone treatment in an observational cohort of men with low testosterone levels
  • a number of short-term studies conducted support the notion that testosterone therapy reduces the cardiovascular risk
  • The majority of animal studies support the hypothesis that the actions of testosterone on vascular relaxation are both endothelium-dependent and -independent vasodilatory effects
  • Endothelial-dependent actions of testosterone increase the expression or activity of endothelial nitric oxide synthase and enhance nitric oxide production, which in turn activates cyclic guanosine monophosphate to induce vasorelaxation in smooth muscle cells
  • Endothelial-independent mechanisms of testosterone are believed to occur primarily via inhibition of voltage-operated Ca2+ channels and/or activation of K+ channels in smooth muscle cells
  • Testosterone may also inhibit intracellular Ca2+ influx via store-operated Ca2+ channels by blocking the response to prostaglandin F2α
  • testosterone has demonstrated anti-inflammatory effects to protect against atherogenesis in animal studies
  • both genomic AR activation to modulate gene transcription and non-genomic activation to modulate the rapid intracellular signaling pathways of ion channels may mediate testosterone effects on vascular function and inflammation.
  • Butenandt & Ruzicka first showed how testosterone is synthesized and responsible for masculine characteristics in the early 1930s
  • Nathan Goodyear on 08 May 13
     
    Awesome review on the current understanding of Testosterone and Diabetes, metabolic syndrome, and CVD.  This article even goes into the literature on androgen receptors.
Nathan Goodyear

High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota an... - 0 views

gut.bmj.com/1812

SCFA mediterranean diet gut gut flora gut microbiota diet nutrition

shared by Nathan Goodyear on 09 Nov 16 - No Cached
  • Nathan Goodyear on 09 Nov 16
     
    Mediterranean diet improve gut flora and SCFA
Nathan Goodyear

Metabolic profiles characterizing different phenotypes of polycystic ovary syndrome: pl... - 0 views

bmcmedicine.biomedcentral.com/...1741-7015-10-153

PCOS polycystic ovary syndrome glycolysis kreb's cycle TCA gluconeogenesis

shared by Nathan Goodyear on 11 Dec 17 - No Cached
  • Nathan Goodyear on 11 Dec 17
     
    Study found that PCOS was associated with increased glycolysis, reduced kreb's cycle activity, and decreased gluconeogenesis.  Also found a decrease in the BCAA/AAA ratio.
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