Group items tagged

This study looked at a small number of men with low T.  Therapy was abruptly stopped and the effects were followed.  Insulin function declined.  There was a trend to increased glucose and IL-6.

Small study of 13 men found that weight loss following bariatric surgery resulted in improved HPA function in 10/13.  Three men had resistant HPA dysfunction.  Free Testosterone was followed.

low T is found in 20-70% of men with HIV.  What is interesting about this article is that Total Testosterone was found to be a poor assessment of biological active Testosterone.  Free Testosterone assessed in the am was shown to be a better functional assessment in these men.  Serum is a poor choice though.  The process of equilibrium dialysis to calculate free Testosterone is filled with variables that will effect reliability.  Increases SHBG was found associated.

Men with type II diabetes have lower Testosterone levels when compared to none diabetics.  This study found an increased mortality with low T in those with type II Diabetes.  The main association was found with bioavailable Testosterone.  Total Testosterone is proving useless as a functional tool.  Additionally, Testosterone therapy reduced mortality in those with Diabetes.

estrogen therapy in surgical menopause preserves memory.  Rapid decline in estrogen levels post surgical menopause is associated with cognitive/memory decline.  Versus placebo, estrogen therapy preserved memory function.

Study finds that Testosterone therapy improves insulin sensitivity, muscle strength and function in women with advanced CHF.  No levels were noted.  If this is similar to men, I would expect a low Testosterone, which Testosterone replacement would then increase physiologic performance. 

Interesting study finds that men with low serum Total Testosterone, elevated RBP4 and low SHBG at baseline predict weight regain.  Thus Testosterone should be used as a biomarker of failure in weight loss and if low, Testosterone therapy should be employed to improved metabolic function.  Other parameters, such as leptin, adiponectin, prolactin, progesterone...were not predictive.

Study finds that higher protein to carbohydrate intake has a positive effect on inflammatory cytokines, oxidative stress, improves insulin sensitivity and improves Beta cell function in premenopausal, non diabetic obese women.

Great article chronicles the biochemistry of "over nutrition" and inflammation through NF-kappaB activation and its impact on the brain.

The environment is playing a role in reduced testicular function in men.

Glyphosate inhibits CYP 450 enzymes.  The author states it well: "glyphosate enhances the damaging effects fo other food borne chemical residues and environnmental toxins.  Additionally, Glyphosate disrupts gut bacterial function in the human gut. This dysbiosis is well known to cause systemic disease, such as obesity, diabetes...

Good article on the immunomodulation effect of vitamin D.  The importance of vitamin D goes back to pregnancy.   Vitamin D deficiencies during pregnancy inhibit appropriate invariant Natrual killer cells, which play important regulatory effect in autoimmune disease.  Even with restoration of vitamin D levels with replacement, the full positive effects of vitamin D are not seen due to limited iNKT potential.

ER beta is a new potential mode of therapy in colon cancer.  ER beta stimulation has been shown to inhibit colon cancer cell growth.

Study highlights the differences of estrogen production, between black and white women, due to peripheral aromatase activity.  Again highlighting the importance of customized health care and the uselessness of serum hormones.  The function is occurring in the tissue, not the serum.

Another ill conceived conclusion by the authors.  IF you are going to study something, know everything about it.  They authors make a major statement about vitamin D, yet they seem to understand a basic understanding of vitamin dosing.  The authors stated that dosing 2,000 IU of vitamin D in those with levels < 50 provided no benefit.  That is of course correct, because 2,000 IU daily won't hold any levels stable, let alone increase levels to 70-80 where they need to be.  The authors of this study are stuck in the traditional RDC thinking here. What is interesting is that low vitamin D was associated with CVD, MS, dyslipidemia, inflammation, glucose dysmetabolism, infections, mood disorders, decline in cognition, impaired physical functioning, and all-cause mortality,  But, vitamin D supplementation is only good for bones.  The authors of this study make a mockery of medicine.

Here is an interesting finding:  low free T3 is significantly associated with increased cardiovascular and all-cause mortality in 7 prospective study on hospitalized patients.

good discussion on incretins and their role in glucose homeostasis. 

Combination of DHA, EPA, choline, phospholipids, Folate, B12, B6, vitamin C and E, and selenium improves memory and cognitive function in those with mild Alzheimer's disease.

Estrogen improves vascular function in postmenopausal women.  The mechanism of action is through the increased nitric oxide production with estrogen therapy.  This increase in nitric oxide reduces endothelial dysfunction.

Myo-inositol improves PCOS.  Specifically, myo-inositol improved insulin sensitivity, reduced insulin levels and restored HPA function.  IN these women with amenorrhea and oligomenorrhea, menestrual cycle regularity was restored.