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Nathan Goodyear

Diet and Risk of Colorectal Cancer Subtypes Classified by F nucleatum | Colorectal Canc... - 0 views

jamanetwork.com/...2598745

gut microbiota gut flora gut microbiome gut bacteria nutrition diet colon cancer cancer

shared by Nathan Goodyear on 30 Jan 17 - No Cached
  • Nathan Goodyear on 30 Jan 17
     
    Study finds Diet effect colon cancer risk through gut bacteria. Diet higher in fiber and whole grains found to have lower risk of F nucleatum + colon cancer.
Jadibuti jadibuti.net

Fuller's Earth - 0 views

jadibuti.net/fullers-earth

Fullers Earth Multani Mitti

shared by Jadibuti jadibuti.net on 29 May 16 - No Cached
  • Jadibuti jadibuti.net on 29 May 16
     
    Multani Mitti or Fuller's earth has been used by Indian women for centuries to take care of their skincare problems like acne, blackheads, etc. Though most modern women now prefer to use branded products, they could still try using the humble F ...
  • Jadibuti jadibuti.net on 29 May 16
     
    Multani Mitti or Fuller's earth has been used by Indian women for centuries to take care of their skincare problems like acne, blackheads, etc. Though most modern women now prefer to use branded products, they could still try using the humble F ...
Nathan Goodyear

Testosterone replacement therapy in hypogonadal men a... [J Urol. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...14634413

PSA testosterone replacement therapy prostate cancer

shared by Nathan Goodyear on 25 Sep 13 - No Cached
  • Nathan Goodyear on 25 Sep 13
     
    Interesting: 1 year f/u of 75 men on Testosterone therapy and high grade prostate intraepithelial neoplasia had no increase in PSA.
Nathan Goodyear

Testosterone deficiency is associated with ... [Eur J Endocrinol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23999642

low Testosterone T therapy TRT hypogonadism mortality type II diabetes diabetes men male hormone hormones

shared by Nathan Goodyear on 13 May 14 - No Cached
  • Nathan Goodyear on 13 May 14
     
    So many studies point to Testosterone is just an association with CVD and CAD.  This study finds that Testosterone therapy in those with low T and type II diabetes have a reduction in mortality 8.4% versus 19.2% in those untreated.  This study also found an increase in mortality in those with low Testosterone versus those with normal Testosterone.  This was a 6 year f/u of 581 men.
Nathan Goodyear

http://onlinelibrary.wiley.com/store/10.1002/hep.23588/asset/23588_ftp.pdf;jsessionid=C... - 0 views

onlinelibrary.wiley.com/...1B8C9AB3A1148DC5338C3DC.f04t03

autoimmune hepatitis liver enzymes minocycline nitrofurantoin autoimmune hepatitis

shared by Nathan Goodyear on 06 Jan 15 - No Cached
  • Nathan Goodyear on 06 Jan 15
     
    More than 90% of drug induced autoimmune hepatitis is due to minocycline and nitrofurantoin.  No cirrhosis occurred in f/u.
Nathan Goodyear

Revisiting the ALA/N (α-Lipoic Acid/Low-Dose Naltrexone) Protocol for People ... - 0 views

ict.sagepub.com/...416.short

alpha lipoic acid IV intravenous ALA pancreatic cancer cancer LDN low dose naltrexone

shared by Nathan Goodyear on 08 Sep 14 - No Cached
  • Nathan Goodyear on 08 Sep 14
     
    Case study of 3 patients with Pancreatic cancer treated with IV alpha lipoic acid and LDN therapy.  This is a f/u to a patient treated and still living--case study published in '06.  Only, the abstract is currently available to the general public.  
Nathan Goodyear

Combined conjugated esterified estrogen plus methyltestosterone sup... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25011395

breast cancer cancer Estrogen Testosterone women hormones hormone HRT

shared by Nathan Goodyear on 06 Feb 15 - No Cached
  • Nathan Goodyear on 06 Feb 15
     
    10 year f/u study of combined conjugated esterified estrogen and methyl testosterone in postmenopausal women finds no increase breast cancer risk.
Nathan Goodyear

Testosterone Replacement Therapy Following Radical Prostatectomy - The Journal of Sexua... - 0 views

www.jsm.jsexmed.org/...fulltext

Testosterone low T low Testosterone testosterone therapy prostate cancer cancer prostate PSA

shared by Nathan Goodyear on 10 Oct 16 - No Cached
  • Nathan Goodyear on 10 Oct 16
     
    larger study post radical prostatectomy for prostate cancer finds that no increase in PSA with Testosterone therapy in men with non-detectable PSA levels.  F/u was 13 months.
Nathan Goodyear

Testosterone Replacement Therapy in Patients with Prostate Cancer After Radical Prostat... - 0 views

www.ncbi.nlm.nih.gov/...PMC4544840

Testosterone low T low Testosterone Testosterone therapy prostate cancer PSA biochemical recurrence male hormones hormones cancer prostate

shared by Nathan Goodyear on 10 Oct 16 - No Cached
  • Nathan Goodyear on 10 Oct 16
     
    One of the largest studies to date on Testosterone therapy in men post radical prostatectomy for prostate cancer.  This study supports the use of Testosterone therapy in this men with close f/u. A higher biochemical recurrence rate was found in the control group versus the treatment group, though there were 4 with biochemical recurrences in the treatment group.
Nathan Goodyear

Testosterone administration to men with testosterone deficiency syndrome after external... - 0 views

www.ncbi.nlm.nih.gov/...18671790

Testosterone low T low Testosterone men male hormones prostate cancer cancer saturation theory prostate

shared by Nathan Goodyear on 10 Oct 16 - No Cached
  • Nathan Goodyear on 10 Oct 16
     
    small study of men post prostate cancer radiotherapy: only 1 of the 5 had a transient rise in PSA, though the level was still below the 1.5 ng/ml threshold.  This fits within the saturation theory concept. F/u in this study was 14.5 months.  Abstract only available here.
Nathan Goodyear

Reduction in the Incidence of Type 2 Diabetes With the Mediterranean Diet - 0 views

www.ncbi.nlm.nih.gov/...PMC3005482

cardiovascular disease Mediterranean diet diabetes nutrition insulin resistance inflammation

shared by Nathan Goodyear on 29 Aug 17 - No Cached
  • Nathan Goodyear on 29 Aug 17
     
    Mediterranean diet + EVOO or + nuts reduced diabetes risk those in high risk by 52%.  This was a 4 year f/u study.  A reduction of circulating inflammatory biomarkers was also noted.  Insulin resistance was noted to be improved as early as 3 months, but weight was not changed statistically throughout this study
Nathan Goodyear

Beyond the male sex hormone: deciphering the metabolic and vascular actions of testoste... - 0 views

joe.endocrinology-journals.org/...C1.full

AR androgen receptors androgen receptor testosterone androgen receptors Diabetes metabolic syndrome MetS CVD cardiovascular disease men hormone hormones male

shared by Nathan Goodyear on 08 May 13 - No Cached
  • androgen deprivation therapy results in unfavorable changes in body composition, insulin resistance, and dyslipidemia and predisposes men to develop atherosclerosis and an increased risk of cardiovascular mortality
  • The hypogonadal–obesity cycle hypothesis was originally proposed by Cohen in 1999 to explain the relationship between low testosterone levels and metabolic disease. It was based on the finding that obesity impairs testosterone levels by increasing the aromatization of testosterone to estradiol, while low testosterone levels promote increased fat deposition
  • adipocytokines contribute to low testosterone levels as well as to the processes underlying metabolic syndromes and type 2 diabetes
  • ...15 more annotations...
  • hypogonadal–obesity–adipocytokine hypothesis
  • The presence of estradiol and the adipocytokines TNF-α, IL6, and leptin (as a result of leptin resistance in obesity) inhibits the hypothalamic–pituitary–testicular axis response to decreasing androgen levels
  • An increasing number of studies have illustrated the potential for applying metabolomics to the field of androgen research
  • As early as the 1940s, the therapeutic use of testosterone was reported to improve angina pectoris in men with coronary artery disease
  • most of the epidemiological studies reported increased cardiovascular risk and mortality in men with low testosterone levels
  • long-term testosterone replacement appears to be a safe and effective means of treating hypogonadal elderly men
  • a recent interventional trial showed that testosterone treatment was associated with decreased mortality when compared with no testosterone treatment in an observational cohort of men with low testosterone levels
  • a number of short-term studies conducted support the notion that testosterone therapy reduces the cardiovascular risk
  • The majority of animal studies support the hypothesis that the actions of testosterone on vascular relaxation are both endothelium-dependent and -independent vasodilatory effects
  • Endothelial-dependent actions of testosterone increase the expression or activity of endothelial nitric oxide synthase and enhance nitric oxide production, which in turn activates cyclic guanosine monophosphate to induce vasorelaxation in smooth muscle cells
  • Endothelial-independent mechanisms of testosterone are believed to occur primarily via inhibition of voltage-operated Ca2+ channels and/or activation of K+ channels in smooth muscle cells
  • Testosterone may also inhibit intracellular Ca2+ influx via store-operated Ca2+ channels by blocking the response to prostaglandin F2α
  • testosterone has demonstrated anti-inflammatory effects to protect against atherogenesis in animal studies
  • both genomic AR activation to modulate gene transcription and non-genomic activation to modulate the rapid intracellular signaling pathways of ion channels may mediate testosterone effects on vascular function and inflammation.
  • Butenandt & Ruzicka first showed how testosterone is synthesized and responsible for masculine characteristics in the early 1930s
  • Nathan Goodyear on 08 May 13
     
    Awesome review on the current understanding of Testosterone and Diabetes, metabolic syndrome, and CVD.  This article even goes into the literature on androgen receptors.
Nathan Goodyear

F as in Fat: How Obesity Threatens America's Future 2012 - Trust for America's Health - 0 views

www.healthyamericans.org/...100

obesity fat overweight health

shared by Nathan Goodyear on 20 Sep 12 - No Cached
  • Nathan Goodyear on 20 Sep 12
     
    Obesity rate of 60%?  Just maybe...and very soon.
Nathan Goodyear

Cytokine profiles in localized scleroderma and relationship to clinical features - 0 views

www.ncbi.nlm.nih.gov/...PMC3632442

morphea autoimmune disease children scleroderma inflammation

shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Evaluation of the literature reveals a Th2 predominant cytokine profile in the biological specimens (sera, PBMCs, and tissue) of those with SSc
  • the literature available from studies in LS show that Th1, Th2, and Th17 cytokines may contribute equally to the pathogenesis of the disease
  • Classically, Th1 cells have been known to secrete IL-2, IFN-γ, and TNF-α, and are stimulated by IL-2 and IL-12
  • ...3 more annotations...
  • Th2 cells have been shown to be activated by IL-4 and produce IL-4, IL-5, IL-10 and IL-13
  • Th17 cells, a more recently identified Th cell subset that has altered the classic Th1/Th2 paradigm, produce IL-17 A/F, IL-21, and IL-22. IL-1, IL-6, IL-23, and TGF-β are now known to play important roles in the differentiation and propagation of the Th17 cell lineage
  • there is an overall notion that pro-inflammatory Th1 and Th17 associated cytokines are elevated during the early stages of scleroderma, whereas Th2 cytokines mainly correlate with disease damage and fibrosis extent
  • Nathan Goodyear on 22 Jan 14
     
    morphea
Nathan Goodyear

ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF-M... - 0 views

www.sciencedirect.com/...S1535610810000826

prostate cancer 3-beta androstanediol male hormone hormones ER HIF-1alpha VEGF estrogen receptor receptors ER beta ER-beta

shared by Nathan Goodyear on 21 Jan 14 - No Cached
  • Loss of ERβ1 expression also resulted in a significant increase in migration and invasion (Figure 2F), functions characteristic of an EMT
  • we hypothesized that ERβ functions as a “gatekeeper” of the epithelial phenotype
  • breast and prostate are different with respect to ER expression and function
  • Nathan Goodyear on 21 Jan 14
     
    The process of androgen deprivation therapy needs to be re-evaluated.  Why?  First, the CVD side effects associated with the androgen depletion.  Second, the depletion of 3 beta androstanediol that has been shown to bind to ER beta and inhibit growth.  As in this study that finds that ER beta activity slows prostate cancer through destabilizing of HIF-1 alpha and by inhibiting VEGF.
Nathan Goodyear

Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydrox... - 0 views

www.ncbi.nlm.nih.gov/...PMC154104

progesterone metabolites breast cancer 5alpha-reductase 5-alpha pregnene 5-alpha pregnenes 4-pregnene 4-pregnenes

shared by Nathan Goodyear on 30 Jan 14 - No Cached
  • Exposure of human breast cell lines (MCF-7, MCF-10A, and ZR-75-1) to 5α-pregnanes results in changes associated with neoplasia, including increased proliferation and decreased attachment [1], depolymerization of F-actin [2] and decreases in adhesion plaque-associated vinculin
  • Exposure to 4-pregnenes results, in general, in opposite (anti-cancer-like) effects
  • 5αR1 has been detected in various androgen-independent organs, such as the liver and brain
  • ...10 more annotations...
  • 5αR2 has been found predominantly in androgen-dependent organs, such as epididymis and prostate
  • The 5α-pregnanes:4-pregnenes ratio was about 8-fold higher in tumorous than in nontumorous breast tissue after an 8-hour incubation with [14C]progesterone
  • Studies with breast cell lines, showing that 5α-pregnanes stimulate proliferation and decrease attachment of cells
  • both tissue and breast cell line studies suggest that an elevated level of progesterone 5α-reductase activity may be an indicator of breast tumorigenesis, regardless of presence or absence of ER and/or PR
  • 5αR1 is the main isoform expressed in human breast carcinomas [29] and that 5αR2 may not be associated with risk of breast cancer
  • the differences in 5α-pregnane production between the cells is due primarily to a difference in 5αR1 expression
  • As in the case of 5α-reductase activity, the presence or absence of ER and PR do not appear to be related to 5α-reductase expression.
  • the conversion of progesterone to the cancer promoting 5α-pregnanes is significantly higher in the human tumorigenic breast cell lines
  • lthough both 5αR1 and 5αR2 are expressed by these cells, the elevated 5α-reductase activity appears to be the result of significantly greater expression of 5αR1
  • Changes in progesterone metabolizing enzyme expression (resulting in enzyme activity changes) may be responsible for promoting breast cancer progression due to increased production of tumor-promoting 5α-pregnanes and decreased production of anti-cancer 20α – and 3α-4-pregnenes
  • Nathan Goodyear on 30 Jan 14
     
    balance of enzyme production between 5alpha-reductase and 20alpha-hydroxysteroid oxidoreductase and 3alpha(beta)-hydroxysteroid oxidoreductase play role in carcinogenesis and proliferation in the balance of production of progesterone metabolites. The 5alpha pregnenes are pro carcinogenic  and the 4-pregnenes are anti carcinogenic.
Nathan Goodyear

Estrogen excess associated with novel gain-of-f... [N Engl J Med. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12736278

gynecomastia Man Boobs hypogonadotropic hypogonadism low T Testosterone aromatase estrogen estradiol men male hormone hormones

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • Nathan Goodyear on 03 Mar 14
     
    Presentation of a familial incidence of male gynecomastia and hypogonadotropic hypogonadism via peripheral aromatase activity.
Nathan Goodyear

Evidence that mercury from silver dental f... [Sci Total Environ. 1994] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8191275

mercury Hg dental fillings MS multiple Sclerosis

shared by Nathan Goodyear on 18 Mar 14 - No Cached
  • Nathan Goodyear on 18 Mar 14
     
    this study suggest, that in some, Hg fillings can contribute to MS.  I believe that detoxification compromise also is required.
Nathan Goodyear

Oestrogen and the colon: potential mechanisms f... [Lancet Oncol. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18374292

estrogen colon cancer ER beta ER-beta

shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • Nathan Goodyear on 19 Nov 13
     
    Estrogen shown to provide protection against colon cancer.  The authors of this study propose that it may be due to ERbeta.
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