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Nathan Goodyear

Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Ce... - 0 views

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    Animal study finds that regular exercise reduces cancer cell growth through immune system activation. Also, regular exercise reduced the incidence of cancer in the mouse models.  
Nathan Goodyear

The Single Nucleotide Polymorphism Gly482Ser in the PGC-1α Gene Impairs Exerc... - 0 views

  • Oxidative slow-twitch type I fibres (henceforth briefly called ‘slow fibres’) contain MHC-Iβ. They use oxidative phosphorylation (OXPHOS) to generate ATP and are thus highly fatigue resistant and preferentially activated during endurance exercise. Slow fibres comprise high amounts of mitochondria, myoglobin and lipid droplets, and are well supplied by capillaries
  • there are three types of fast-twitch fibres (types IIA, IID/X, IIB, with the corresponding MHC isoforms IIa, IId/x, IIb) which are all used for rapid high-force generation. Oxidative-glycolytic fast-twitch type IIA fibres have intermediate amounts of mitochondria, lipid droplets and capillaries, and are intermediately resistant to fatigue (as compared to type I and types IIB and IID/X). Glycolytic fast-twitch type IID/X fibres are poor in mitochondria, lipids and capillaries and more susceptible to fatique than type IIA. Glycolytic fast-twitch type IIB fibres have the lowest amounts of mitochondria, lipid droplets and capillaries, but generate the highest contraction velocities
  • Several studies have shown that PGC-1α is upregulated after endurance training
  • ...3 more annotations...
  • upregulation of PGC-1α expression enhances and/or maintains mitochondrial biogenesis, eventually leading to an increased mitochondrial content of the muscle fibres.
  • PGC-1α also plays an important role in the pathogenesis of insulin resistance and T2D
  • carriers of the Gly482Ser SNP have a reduced cardiorespiratory fitness and a higher risk for metabolic syndrome and T2D
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    Those that carry the risk SNP for Gly482Ser for the PGC-1alpha gene dont' transform type II to type I and thus decrease the effectiveness of aeorbic exercise training, decreased oxidative phosphorylation, decreased lipid oxidation, increased lipid accumulaiton in muscle, and increased risk of IR, obesity, and diabetes.
Nathan Goodyear

Thieme E-Journals - International Journal of Sports Medicine / Abstract - 0 views

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    Only abstract available here: compound resistance treaining in highly trained young men found to increase GH and Testosterone over isolation exercises. Those that trained > 2 years had significnt increase in Testosterone pre/post exercise compared to no statistical change in those traing < 2 years.
Nathan Goodyear

ApoB but not LDL-cholesterol is reduced by exercise training in overweight healthy men.... - 0 views

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    exercise in overweight, otherwise healthy men reduced ApoB.
Nathan Goodyear

The Growth Hormone/Insulin-Like Growth Factor-I Axis in Exercise and Sport - 0 views

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    Review of the physiological roles of GH and IGF-1 during exercise.  The focus is on maximizing the normal physiologic response, not supra physiologic.
Nathan Goodyear

Exercise-related Changes in Estrogen Metabolism May Lower Breast Cancer Risk - 0 views

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    Aerobic exercise improves estrogen metabolism and may reduce risk of breast cancer.
Nathan Goodyear

Statement on Exercise: Benefits and Recommendations for Physical Activity Programs for ... - 1 views

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    benefits of regular exercise.
Nathan Goodyear

Metabolic Signatures of Exercise in Human Plasma - 0 views

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    Nice article that describes the biochemical benefits of exercise.
Nathan Goodyear

Total testosterone levels, metabolic parameters, cardiac remodeling and exercise capaci... - 0 views

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    Low Total testosterone associated with poor exercise capacity, increased obesity, poor glucose control including diabetes, increased cardiac hypertrophy in those with CAD.  Simply put, low T in men is associated with metabolic dysregulation.
Nathan Goodyear

Testosterone and cortisol in relationship to dietary nutrients and resistance exercise - 0 views

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    resistance training increases testosterone post exercise.  Dietary protein increased basal testosterone production.
Nathan Goodyear

Physical activity and exercise for erectile dysfunction: systematic review and meta-ana... - 0 views

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    review study points out that exercise, predominantly cardio, improved ED in men.
Nathan Goodyear

Exercise increases mitochondrial glutamate oxidation in the mouse cerebral cortex - App... - 0 views

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    exercise found to reduce glutamate excitotoxicity in mouse study.
Nathan Goodyear

Aerobic exercise boosts testosterone for overweight men - Medical News Today - 0 views

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    Study yet to be published.  This is a review from the American Physiological Society's meeting in Arizona recently.  Twelve weeks of aerobic exercise in obese men elevated Testosterone levels.
Nathan Goodyear

Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory funct... - 0 views

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    moderate exercise improves the memory of rats in diabetes model.
Nathan Goodyear

Acute exercise suppresses hypothalamic PTP1B protein level and improves insulin and lep... - 0 views

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    exercise found to improve central insulin and leptin resistance in obese animal model.  The mechanism was via a decrease in inflammation through decrease in PTP1B protein transcription.
Nathan Goodyear

Exercise protects against high-fat diet-induced hypothalamic inflammation. - PubMed - NCBI - 0 views

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    regular treadmill exercise reduced hypothalamic inflammation, improved insulin resistance, improved leptin resistance, improved glucose tolerance, and decreased microglia activation in high-fat animal model.
Nathan Goodyear

Exercise therapy versus arthroscopic partial meniscectomy for degenerative meniscal tea... - 0 views

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    Don't first run to the knife: exercise found to be equivalent to surgery for those 34-60 with meniscal tears
Nathan Goodyear

Dietary Weight Loss and Exercise Effects on Serum Biomarkers of Angiogenesis in Overwei... - 0 views

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    only abstract available here.  Weight loss, through diet and exercise, decreased proteins important to tumor angiogenesis; thus weight loss associated with a reduction in VEGF, PEDF, and PAI-1 may reduce cancer risk, particularly in the overweight and obese. This is all the result of inflammation originating from obesity.
Nathan Goodyear

Exercise during pregnancy in normal-weight women and risk of preterm birth: a... - 0 views

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    Exercise is not only safe in pregnancy, it is good for the pregnancy and the baby. This idea that pregnancy is a disease or a condition has got to stop; science continues to prove that is not the case.
Nathan Goodyear

Protein Ingestion Prior To Sleep Improv... [Med Sci Sports Exerc. 2012] - PubMed - NCBI - 0 views

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    protein intake post exercise improves recovery. In this study, they had young men take in 20 gm of protein prior to bed after resistance training at 8 pm.
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