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Nathan Goodyear

Timing Protein Intake Increases Energy Expenditure 24 h afte... : Medicine & Science in... - 0 views

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    protein supplementation (compared to carbohydrates)  prior to heavy resistance training resulted in prolonged increase in resting energy expenditure at 24 hours.  The supplementation in this study was 18 grams of whey protein.  This study reveals the lingering effect of diet on benefits of exercise.
Nathan Goodyear

LH secretion and testosterone concentrations are blunted after resistance exercise in men - 0 views

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    testosterone secretion is blunted for about 12-24 hours after exercise.  The quicker the testosterone rebounds, the faster the muscles rebound and build.
Nathan Goodyear

Access : The role of exercise and PGC1|[alpha]| in inflammation and chronic disease : N... - 0 views

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    study shows increased activity and exercise delays onset of chronic disease.   Inactivity and obesity decreased the age of 
Nathan Goodyear

Cordyceps sinensis promotes exercise endurance capacity of rats by activating skeletal ... - 0 views

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    mouse model finds cordyceps improves exercise endurance.  This has, largely, not translated to human studies, though very few studies are available.  
Nathan Goodyear

Effect of Cs-4® (Cordyceps sinensis) on Exercise Performance in Healthy Older... - 0 views

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    Cordyceps improved lactate threshold and improved exercise performance in healthy, older people.  The dosing was 333mg TID.
Nathan Goodyear

Cambridge Journals Online - British Journal of Nutrition - Abstract - Post-exercise whe... - 0 views

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    Whey protein hydrolysate shown to be superior to amino acids in recovery phase of exercise.  
Nathan Goodyear

Testosterone Deficiency, Cardiac Health, and Older Men - 0 views

  • Studies have shown pharmacological doses of testosterone to relax coronary arteries when injected intraluminally [39] and to produce modest but consistent improvement in exercise-induced angina and reverse associated ECG changes [40]. The mechanism of action is via blockade of calcium channels with effect of similar magnitude to nifedipine
    • Nathan Goodyear
       
      This directly refutes the recent studies (3) that Testosterone therapy increases cardiovascular events.
    • Nathan Goodyear
       
      Testosterone acts as a calcium channel blocker inducing vasodilation.
  • men with chronic stable angina pectoris, the ischaemic threshold increased after 4 weeks of TRT and a recent study demonstrates improvement continuing beyond 12 months [
  • Exercise capacity in men with chronic heart failure increased after 12 weeks
  • ...36 more annotations...
  • Studies have shown an inverse relationship between serum testosterone and fasting blood glucose and insulin levels
  • Medications such as chronic analgesics, anticonvulsants, 5ARIs, and androgen ablation therapy are associated with increased risk of testosterone deficiency and insulin resistance
  • Women with T2D or metabolic syndrome characteristically have low SHBG and high free testosterone
    • Nathan Goodyear
       
      This stands in polar opposite of that with men.
  • Hypogonadism is a common feature of the metabolic syndrome
  • The precise interaction between insulin resistance, visceral adiposity, and hypogonadism is, as yet, unclear but the important mechanisms are through increased aromatase production, raised leptin levels, and increase in inflammatory kinins
  • levels of testosterone are reduced in proportion to degree of obesity
  • Men should be encouraged to combine aerobic exercise with strength training. As muscle increases, glucose will be burned more efficiently and insulin levels will fall. A minimum of 30 minutes exercise three times weekly should be advised
  • Testosterone increases levels of fast-twitch muscle fibres
  • By increasing testosterone, levels of type 2 fibres increase and glucose burning improves
  • Weight loss will increase levels of testosterone
  • studies now clearly show that low testosterone leads to visceral obesity and metabolic syndrome and is also a consequence of obesity
  • In the case of MMAS [43], a baseline total testosterone of less than 10.4 nmol/L was associated with a greater than 4-fold incidence of type 2 diabetes over the next 9 years
  • There is high level evidence that TRT improves insulin resistance
  • Low testosterone predicts increased mortality and testosterone therapy improves survival in 587 men with type 2 diabetes
  • A similar retrospective US study involved 1031 men with 372 on TRT. The cumulative mortality was 21% in the untreated group versus 10% ( ) in the treated group with the greatest effect in younger men and those with type 2 diabetes
  • the presence of ED has been shown to be an independent risk factor, particularly in hypogonadal men, increasing the risk of cardiac events by over 50%
  • A recent online publication on ischaemic heart disease mortality in men concluded optimal androgen levels are a biomarker for survival
  • inverse associations between low TT or FT (Table 2) and the severity of CAD
  • A recent 10 year study from Western Australia involving 3690 men followed up from 2001–2010 concluded that TT and FT levels in the normal range were associated with decreased all-cause and cardiovascular mortality, for the first time suggesting that both low and DHT are associated with all-cause mortality and higher levels of DHT reduced cardiovascular risk
  • TDS is associated with increased cardiovascular and all-cause mortality
  • The effect of treatment with TRT reduced the mortality rate of treated cohort (8.4%) to that of the eugonadal group whereas the mortality for the untreated remained high at 19.2%
  • hypogonadal men had slightly increased triglycerides and HDL
  • Men with angiographically proven CAD (coronary artery disease) have significantly lower testosterone levels [29] compared to controls ( ) and there was a significant inverse relationship between the degree of CAD and TT (total testosterone) levels
  • TRT has also been shown to reduce fibrinogen to levels similar to fibrates
  • men treated with long acting testosterone showed highly significant reductions in TC, LDL, and triglycerides with increase in HDL, associated with significant reduction in weight, BMI, and visceral fat
  • Low androgen levels are associated with an increase in inflammatory markers
  • A decline was noted in IL6 and TNF-alpha
  • In some studies, a decline in diastolic blood pressure has been observed, after 3–9 months [24, 26] and in systolic blood pressure
  • In the Moscow study, C-reactive protein was reduced by TRT at 30 weeks versus placebo
  • No studies to date show an increase in LUTS/BPH symptoms with higher serum testosterone levels
  • TRT has been shown to upregulate PDE5 [65] and enhance the effect of PDE5Is (now an accepted therapy for both ED and LUTS), it no longer seems logical to advice avoidance of TRT in men with mild to moderate BPH.
    • Nathan Goodyear
       
      What about just starting with normalization of Testosterone levels first.
  • Several meta-analyses have failed to show a link between TRT and development of prostate cancer [66] but some studies have shown a tendency for more aggressive prostate cancer in men with low testosterone
    • Nathan Goodyear
       
      And if one would have looked at their estrogen levels, I guarantee they would have been found to be elevated.
  • low bioavailable testosterone and high SHBG were associated with a 4.9- and 3.2-fold risk of positive biopsy
  • Current EAU, ISSAM, and BSSM guidance [1, 2] is that there is “no evidence TRT is associated with increased risk of prostate cancer or activation of subclinical cancer.”
  • Men with prostate cancer, treated with androgen deprivation, develop an increase of fat mass with an altered lipid profile
  • Erectile dysfunction is an established marker for future cardiovascular risk and the major presenting symptom leading to a diagnosis of low testosterone
Nathan Goodyear

Exercise normalizes levels of MAG and Nogo-A growth inhibitors after brain trauma - Chy... - 0 views

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    exercise aids repair after TBI through BDNF.
Nathan Goodyear

Exercise and the brain: something to chew on - 0 views

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    The absolute best way to promote neurogenesis is through exercise.  This is through an increase in BDNF.  There are ways to augment this: curcumin, n-3, nutrition...  The concept that the brain doesn't heal is out the window.
Nathan Goodyear

Effect of 12 weeks of periodized resistance training upon total plasma adiponectin conc... - 0 views

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    balance: exercise is no different. Cardio plus resistance training increases adiponectin over resistance training alone.
Nathan Goodyear

Effects of endurance exercise on free testosterone concentration and the binding affini... - 0 views

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    exercise increases Testosterone production via catecholamine mechanism.  Free Testosterone increases independent from SHBG affinity.
Nathan Goodyear

RPE, blood glucose, and carbohydrate oxidation dur... [Med Sci Sports Exerc. 1991] - Pu... - 0 views

  • The data suggest that ingestion of carbohydrate beverages during endurance cycling can maintain plasma glucose and CHO oxidation during the latter stages of prolonged exercise
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    carbohydrate drinks help to maintain glucose levels in exercise
Nathan Goodyear

Effect of moderate-intensity exercise session on p... [Horm Metab Res. 2008] - PubMed r... - 0 views

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    Best time to eat protein is immediately after exercise
Nathan Goodyear

Reversal of fatigue during prolonged exercise by c... [J Appl Physiol. 1987] - PubMed r... - 0 views

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    prolonged interval to fatigue in those with glucose infusion/ngestion during exercise
Nathan Goodyear

The role of lactate in the exercise-induced human growth hormone response: evidence fro... - 0 views

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    passing lactate threshold in exercise stimulates HGH release Evidence supported by following people with McArdle disease
Nathan Goodyear

The exercise-induced growth hormone response in at... [Sports Med. 2003] - PubMed result - 0 views

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    Want to increase your HGH?  Exercise!
Nathan Goodyear

The Effect of Abdominal Exercise on Abdominal Fat. [J Strength Cond Res. 2011] - PubMed... - 0 views

  • Six weeks of abdominal exercise training alone was not sufficient to reduce abdominal subcutaneous fat and other measures of body composition
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    Abdominal exercise doesn't decrease abdominal fat in 6 week study.
Nathan Goodyear

Minimum amount of physical activity for reduced mortality and extended life expectancy:... - 0 views

  • 15 min a day or 90 min a week of moderate-intensity exercise might be of benefit
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    Just 15 mins a day of exercise reduce mortatlity
Nathan Goodyear

Leucine-enriched essential amino acid supplementation during moderate steady state exer... - 0 views

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    leucine shown to increase muscle protein synthesis post exercise
Nathan Goodyear

Leucine Regulates Translation Initiation of Protein Synthesis in Skeletal Muscle after ... - 0 views

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    Leucine, a branch chain amino acid, important in promoting protein synthesis and thus muscle growth.  Very important post-exercise and in athletes
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