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The Diabetes Breakthrough Your Doctor Won't Tell You About - 0 views

bit.ly/2bgy1aC

Diabetes Breakthrough Your Doctor Won't Tell You About

shared by zamranilyas on 10 Aug 16 - No Cached

zamranilyas on 10 Aug 16

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Please Note: The material on this site is provided for informational purposes only and is not medical advice. Always consult your physician before beginning any diet or exercise program.

<div class="cArrow"> </div><div class="cContentInner">These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Please Note: The material on this site is provided for informational purposes only and is not medical advice. Always consult your physician before beginning any diet or exercise program.</div>

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Omega-3 fatty acids supplementation improves endothelial function and maximal oxygen up... - 0 views

www.tandfonline.com/...17461391.2014.949310

fish oil omega 3 omega-3 n-3 cycling athletes NO endurance sports endurance athletes endurance exercise

shared by Nathan Goodyear on 06 Jul 16 - No Cached

Nathan Goodyear on 06 Jul 16

supplementation of 2.6 grams of n-3 found to increase NO and VO2max in elite cycling athletes. This has applications for all endurance athletes.

<div class="cArrow"> </div><div class="cContentInner">supplementation of 2.6 grams of n-3 found to increase NO and VO2max in elite cycling athletes. This has applications for all endurance athletes. </div>

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Metabolic characteristics of keto-adapted ultra-endurance runners - Metabolism - Clinic... - 0 views

www.metabolismjournal.com/...abstract

endurance athletes endurance sports exercise carbohydrates ketogenic diet

shared by Nathan Goodyear on 20 Apr 16 - No Cached

Nathan Goodyear on 20 Apr 16

For endurance athletes, low carb and high fat diet utilizes the high fat oxidation in these athletes compared to a high carb diet. Glycogen stores did not differ between the two groups.

<div class="cArrow"> </div><div class="cContentInner">For endurance athletes, low carb and high fat diet utilizes the high fat oxidation in these athletes compared to a high carb diet. Glycogen stores did not differ between the two groups. </div>

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Is strength training associated with mortality benefits? A 15year cohort study of US ol... - 0 views

www.sciencedirect.com/...S0091743516300160

strength training resistance training mortality elderly exercise health

shared by Nathan Goodyear on 26 Apr 16 - No Cached

Nathan Goodyear on 26 Apr 16

resistance training is not just for the young; new study finds that resistance training in those > 65 reduced all-cause mortality odds.

<div class="cArrow"> </div><div class="cContentInner">resistance training is not just for the young; new study finds that resistance training in those > 65 reduced all-cause mortality odds.</div>

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Variations in urine excretion of steroid hormones after an acute session and after a 4-... - 0 views

link.springer.com/...10.1007%2Fs00421-006-0319-1

androgens Testosterone resistance training exercise male hormones

shared by Nathan Goodyear on 14 Feb 17 - No Cached

Nathan Goodyear on 14 Feb 17

4 week resistance training program found to increase androgens in urine; this suggests increased androgen production as a result of the resistance program

<div class="cArrow"> </div><div class="cContentInner">4 week resistance training program found to increase androgens in urine; this suggests increased androgen production as a result of the resistance program</div>

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How to Age Gracefully with Proper Posture - 0 views

www.posture-perfect.co.uk/...gracefully-with-proper-posture

pilates exercise chair buy office chair executive office chairs comfortable office chair chair for back pain

shared by jasminegibbons on 28 Feb 17 - No Cached

jasminegibbons on 28 Feb 17

Aging is inevitable but you can always slow it down. As I said, start with posture.

<div class="cArrow"> </div><div class="cContentInner">Aging is inevitable but you can always slow it down. As I said, start with posture.</div>

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jasminegibbons on 28 Feb 17

Aging is inevitable but you can always slow it down. As I said, start with posture.

<div class="cArrow"> </div><div class="cContentInner">Aging is inevitable but you can always slow it down. As I said, start with posture.</div>

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http://jap.physiology.org/content/jap/82/1/49.full.pdf - 0 views

jap.physiology.org/...49.full.pdf

exercise Testosterone protein high protein carbohydrate nutrition diet

shared by Nathan Goodyear on 12 Feb 17 - No Cached

Nathan Goodyear on 12 Feb 17

To much protein intake can be a bad thing. This study found that high protein intake and high protein/carbohydrate intake lowered basal Testosterone levels.

<div class="cArrow"> </div><div class="cContentInner">To much protein intake can be a bad thing. This study found that high protein intake and high protein/carbohydrate intake lowered basal Testosterone levels.</div>

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Changes in Ubiquitin Proteasome Pathway Gene Expression in Skeletal Muscle With Exercis... - 0 views

atvb.ahajournals.org/...2560.long

statins statin CoQ10 ubiquinone mitochondria muscle

shared by Nathan Goodyear on 16 Mar 12 - No Cached

Nathan Goodyear on 16 Mar 12

statin therapy shown to decrease genetic expression of the ubiquitin proteasome pathway. Not only do statins damage mitochondria through CoQ10 depletion, but this study shows a new component of the damage statins do: they actually change the human genetic expression. This should startle you.

<div class="cArrow"> </div><div class="cContentInner">statin therapy shown to decrease genetic expression of the ubiquitin proteasome pathway. Not only do statins damage mitochondria through CoQ10 depletion, but this study shows a new component of the damage statins do: they actually change the human genetic expression. This should startle you.</div>

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Reduced-Calorie Dietary Weight Loss, Exercise, and Sex Hormones in Postmenopausal Women... - 0 views

jco.ascopubs.org/...JCO.2011.37.9792.abstract

obesity obese overweight weight-loss aromatase breast cancer testosterone estradiol estrogen hormones women

shared by Nathan Goodyear on 22 May 12 - No Cached

Nathan Goodyear on 22 May 12

Not surprising, but nice to see in study. Dr. McTiernan showed that weight loss as little as 5% reduces breast cancer risk. The reason? Decreased Testosterone production in women due to insulin resistance and decreased fat for aromatase conversion of Testosterone to Estradiol and decreased androstenedione to estrone. This study confirms the importance of the obesity epidemic to health.

<div class="cArrow"> </div><div class="cContentInner">Not surprising, but nice to see in study. Dr. McTiernan showed that weight loss as little as 5% reduces breast cancer risk. The reason? Decreased Testosterone production in women due to insulin resistance and decreased fat for aromatase conversion of Testosterone to Estradiol and decreased androstenedione to estrone. This study confirms the importance of the obesity epidemic to health.</div>

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Exercise and Testosterone - 0 views

www.sast.org.tw/...FI1112060008_aO.pdf

testosterone training athletic performance athlete athletic muscle

shared by Nathan Goodyear on 26 Jun 12 - No Cached

Nathan Goodyear on 26 Jun 12

type and length of training effects testosterone secretion. Testosterone plays an important role in muscle performance and mass. Prolonged training can result in a decrease in testosterone level. This has significance with highly trained athletes. One pitfall of this study was the assessment of testosterone via serum.

<div class="cArrow"> </div><div class="cContentInner">type and length of training effects testosterone secretion. Testosterone plays an important role in muscle performance and mass. Prolonged training can result in a decrease in testosterone level. This has significance with highly trained athletes. One pitfall of this study was the assessment of testosterone via serum. </div>

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Effects of creatine supplementation on perf... [Mol Cell Biochem. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12701815

phosphocreatine creatine athletic performance exercise training

shared by Nathan Goodyear on 26 Jun 12 - No Cached

Nathan Goodyear on 26 Jun 12

review of the literature at the time found the majority of studies showed positive results with phosphocreatine supplementation.

<div class="cArrow"> </div><div class="cContentInner">review of the literature at the time found the majority of studies showed positive results with phosphocreatine supplementation.</div>

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Exercise-induced right ventricular dysfunction and structural remodelling in endurance ... - 0 views

eurheartj.oxfordjournals.org/...eurheartj.ehr397.abstract

endurance training athletes cardiac heart right ventricular function

shared by Nathan Goodyear on 28 Jan 12 - No Cached

Nathan Goodyear on 28 Jan 12

endurance training found to induce heart dysfunction. This was all in the right ventricular function, but significant dysfunction was found.

<div class="cArrow"> </div><div class="cContentInner">endurance training found to induce heart dysfunction. This was all in the right ventricular function, but significant dysfunction was found.</div>

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Effects of a Caloric Restriction Weight Loss Diet and Exercise on Inflammatory Biomarke... - 0 views

cancerres.aacrjournals.org/...2314.abstract

weight-loss inflammation CRP IL-6 overweight

shared by Nathan Goodyear on 16 May 12 - No Cached

Nathan Goodyear on 16 May 12

weight loss results in reduced IL-6, CRP, and other markers of inflammation.

<div class="cArrow"> </div><div class="cContentInner">weight loss results in reduced IL-6, CRP, and other markers of inflammation.</div>

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Fish oil compares favorably to montelukast Singular in reducing the - 0 views

www.greenmedinfo.com/...cing-severity-exercise-induced

fish oil fish oil n-3 omega 3 omega-3 asthma

shared by Nathan Goodyear on 12 Jan 14 - No Cached

Nathan Goodyear on 12 Jan 14

n-3 equivalent to singulair in the treatment of asthma.

<div class="cArrow"> </div><div class="cContentInner">n-3 equivalent to singulair in the treatment of asthma.</div>

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Lowered testosterone in male obesity: Mechanisms, morbidity and management Tang Fui MN,... - 0 views

www.ajandrology.com/article.asp

Testosterone male obesity overweight men hormone hormones low T Low T

shared by Nathan Goodyear on 15 Jan 14 - No Cached

The number of overweight people is expected to increase from 937 million in 2005 to 1.35 billion in 2030
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Similarly the number of obese people is projected to increase from 396 million in 2005 to 573 million in 2030
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By 2030, China alone is predicted to have more overweight men and women than the traditional market economies combined
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...37 more annotations...
diacylglycerol O-acyltransferase 2 (DGAT2), mechanistically implicated in this differential storage, [10] is regulated by dihydrotestosterone, [11] suggesting a potential role for androgens to influence the genetic predisposition to either the MHO or MONW phenotype.
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bariatric surgery achieves 10%-30% long-term weight loss in controlled studies
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The fact that obese men have lower testosterone compared to lean men has been recognized for more than 30 years
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Reductions in testosterone levels correlate with the severity of obesity and men
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epidemiological data suggest that the single most powerful predictor of low testosterone is obesity, and that obesity is a major contributor of the age-associated decline in testosterone levels.
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healthy ageing by itself is uncommonly associated with marked reductions in testosterone levels
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obesity blunts this LH rise, obesity leads to hypothalamic-pituitary suppression irrespective of age which cannot be compensated for by physiological mechanisms
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Reductions in total testosterone levels are largely a consequence of reductions in sex hormone binding globulin (SHBG) due to obesity-associated hyperinsulinemia
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although controversial, measurement of free testosterone levels may provide a more accurate assessment of androgen status than the (usually preferred) measurement of total testosterone in situations where SHBG levels are outside the reference range
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SHBG increases with age
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marked obesity however is associated with an unequivocal reduction of free testosterone levels, where LH and follicle stimulating hormone (FSH) levels are usually low or inappropriately normal, suggesting that the dominant suppression occurs at the hypothalamic-pituitary level
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adipose tissue, especially when in the inflamed, insulin-resistant state, expresses aromatase which converts testosterone to estradiol (E 2 ). Adipose E 2 in turn may feedback negatively to decrease pituitary gonadotropin secretion
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diabetic obesity is associated with decreases in circulatory E 2
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In addition to E 2 , increased visceral fat also releases increased amounts of pro-inflammatory cytokines, insulin and leptin; all of which may inhibit the activity of the HPT axis at multiple levels
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In the prospective Massachusetts Male Aging Study (MMAS), moving from a non-obese to an obese state resulted in a decline of testosterone levels
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weight loss, whether by diet or surgery, increases testosterone levels proportional to the amount of weight lost
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fat is androgen-responsive
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low testosterone may augment the effects of a hypercaloric diet
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In human male ex vivo adipose tissue, testosterone decreased adipocyte differentiation by 50%.
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Testosterone enhances catecholamine-induced lipolysis in vitro and reduces lipoprotein lipase activity and triglyceride uptake in human abdominal adipose tissue in vivo
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in men with prostate cancer receiving 12 months of androgen deprivation therapy, fat mass increased by 3.4 kg and abdominal VAT by 22%, with the majority of these changes established within 6 months
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severe sex steroid deficiency can increase fat mass rapidly
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bidirectional relationship between testosterone and obesity
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increasing body fat suppresses the HPT axis by multiple mechanisms [30] via increased secretion of pro-inflammatory cytokines, insulin resistance and diabetes; [19],[44] while on the other hand low testosterone promotes further accumulation of total and visceral fat mass, thereby exacerbating the gonadotropin inhibition
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androgens may play a more significant role in VAT than SAT
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men undergoing androgen depletion for prostate cancer show more marked increases in visceral compared to subcutaneous fat following treatment
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- Nathan Goodyear on 16 Jan 14
  
  Interesting: low T increases VAT, yet T therapy does not reduce VAT, yet T therapy reduces SAT.
  
  <div class="cArrow"> </div><div class="cContentInner">Interesting: low T increases VAT, yet T therapy does not reduce VAT, yet T therapy reduces SAT.</div>
  
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irisin, derived from muscle, induces brown fat-like properties in rodent white fat
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androgens can act via the PPARg-pathway [37] which is implicated in the differentiation of precursor fat cells to the energy-consuming phenotype
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low testosterone may compound the effect of increasing fat mass by making it more difficult for obese men to lose weight via exercise
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pro-inflammatory cytokines released by adipose tissue may contribute to loss of muscle mass and function, leading to inactivity and further weight gain in a vicious cycle
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Sarcopenic obesity, a phenotype recapitulated in men receiving ADT for prostate cancer, [55] may not only be associated with functional limitations, but also aggravate the metabolic risks of obesity;
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observational evidence associating higher endogenous testosterone with reduced loss of muscle mass and crude measures of muscle function in men losing weight
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genuine reactivation of the HPT axis in obese men requires more substantial weight-loss
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A number of intervention studies have confirmed that both diet- and surgically-induced weight losses are associated with increased testosterone, with the rise in testosterone generally proportional to the amount of weight lost
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men, regardless of obesity level, can benefit from the effect of weight loss.
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inconsistent effect of testosterone on VAT
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Nathan Goodyear on 15 Jan 14

to be read

<div class="cArrow"> </div><div class="cContentInner">to be read</div>

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