excellent article on the imaging of excitotoxicity. Glutamate excitotoxicity is a key component in neurodegenerative diseases: Alzheimers, Parkinsons, ALS, MS...
neuroinflammaiton, also described as excitotoxicity, found in the brains of children/young adults that lived in high air pollution areas. Neuroinflammation (IL-6, IL-1, TNF-alpha, IFN-gamma...) found in the brains of these children and young adults. This is the same process found in Alzheimers and other excitotoxicity disease states. Addtionally, it is also involved in most chronic diseases of aging.
Granted, this study was in an animal model of MS, but signaling through ER-beta was shown to decrease inflammation from astrocytes and microglial cells in the brain. These immune cells are known to play prominent roles in excitotoxic diseases such as MS. So, again, it is not just about the message, but also about how the message is interpreted.
lengthy but extremely thorough explanation of excitotoxicity and Autism. This is heavily referenced and should be read by all! A good discussion on how immune stimulation in the developing brain contributes to ASD...hint: vaccines.
short and brief discussion of how microglial inflammation cause neurodegeneration via excitotoxicity. Dr. Blaylock is the author of this short article.
Fantastic discussion and review of the biochemical effects of vaccinations on the developing child's brain. This article is authored by Dr. Blaylock, a neurosurgeon and expert in excitotoxicity.
inflammation, glutamate excitotoxicity and depression. A very nice review of how inflammation can remotely contribute to other arenas of dysfunction, ie. depression.
This review summarizes new insights based on the interaction of mitoenergetic failure, glutamate excitotoxicity, and amyloid
toxicity in the exacerbation of AD.
Under certain conditions, glutamate has a toxic action resulting from an activation of specific glutamate receptors, which leads to acute or chronic death of nerve cells.