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Nathan Goodyear

Mitochondrial medicine for aging and neurodegenera... [Neuromolecular Med. 2008] - PubM... - 0 views

www.ncbi.nlm.nih.gov/...18566920

mitochondrial medicine aging neurodegeneratve disease

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • This article discusses critical issues of mitochondria causing dysfunction in aging and neurodegenerative diseases, and discusses the potential of developing mitochondrial medicine, particularly mitochondrially targeted antioxidants, to treat aging and neurodegenerative diseases.
  • Nathan Goodyear on 07 Feb 11
     
    Great review of mitochondrial medicine to treat age-related and neurodegenerative disease
Nathan Goodyear

Coenzyme Q10 in neurodegenerative diseases. [Curr Med Chem. 2003] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...12871093

CoQ10 Parkinson's disease

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • supplemental coenzyme Q(10) can slow the functional decline in these disorders, particularly Parkinson's disease.
  • Nathan Goodyear on 07 Feb 11
     
    CoQ10 may slow some aspects of Parkinson's disease
Nathan Goodyear

Coenzyme Q10 as a possible treatment for neurodege... [Free Radic Res. 2002] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...12069110

coenzyme q10 CoQ10 Huntington's disease neurodegenerative

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • CoQ10 can significantly extend survival, delay motor deficits and delay weight loss and attenuate the development of striatal atrophy in a transgenic mouse model of HD
  • Nathan Goodyear on 07 Feb 11
     
    CoQ10 shown to shown to slow progression of the neurodegenerative disease: Huntington's disease
Nathan Goodyear

New Prevalence Study Suggests Dramatically Rising Numbers of People with Alzheimer's Di... - 0 views

www.nia.nih.gov/...PR20030818prevalence.htm

neurodegenerative disease Alzheimer's prevalence

shared by Nathan Goodyear on 20 Feb 11 - No Cached
  • Scientists project that some 13.2 million older Americans will have Alzheimer's disease (AD) by 2050
  • Nathan Goodyear on 20 Feb 11
     
    neurodegenerative disease on the rise, unless we become very proactive
Nathan Goodyear

JAD - Volume 17, Number 3 - 0 views

www.j-alz.com/...vol17-3.html

Alzheimer's disease chelation cinnamon coffee caffeine

shared by Nathan Goodyear on 23 Feb 11 - Cached
  • Challenges Associated with Metal Chelation Therapy in Alzheimer’s Disease
  • Cinnamon Extract Inhibits Tau Aggregation Associated with Alzheimer’s Disease In Vitro
  • Caffeine Reverses Cognitive Impairment and Decreases Brain Amyloid-β Levels in Aged Alzheimer’s Disease Mice
  • ...1 more annotation...
  • Caffeine Suppresses Amyloid-β Levels in Plasma and Brain of Alzheimer’s Disease Transgenic Mice
  • Nathan Goodyear on 23 Feb 11
     
    4 abstracts highlighting coffee, cinnamon, and chelation in Alzheimer's prevention and treatment
Nathan Goodyear

The Relationship between Alzheimer's Disease and Diabetes: Type 3 Diabetes? - ACAM Inte... - 0 views

acam.typepad.com/...diabetes-type-3-diabetes-.html

Diabetes Insulin Glucose Alzheimer's disease metabolic syndrome

shared by Nathan Goodyear on 17 Mar 11 - No Cached
  • AD has its foundation in neuroendocrinology
  • Referring to AD as type 3 diabetes has its foundation in the fact that the CNS in AD is characterized by a paucity of insulin and resistance of the insulin receptors
  • Nathan Goodyear on 17 Mar 11
     
    Insulin/Glucose dysregulation and Alzheimer's disease
Nathan Goodyear

Mitochondrial dysfunction in Parkinson's disease. [Biochim Biophys Acta. 2010] - PubMed... - 0 views

www.ncbi.nlm.nih.gov/...19733240

mitochondrial dysfunction Parkinson's Disease

shared by Nathan Goodyear on 16 May 11 - No Cached
  • nhibitor of complex I of the electron transport chain can induce parkinsonism
  • any lines of evidence suggest that mitochondrial dysfunction plays a central role in the pathogenesis of Parkinson's disease (PD)
  • Nathan Goodyear on 16 May 11
     
    Mitochondrial dysfunction in Parkinson's Disease
Nathan Goodyear

aging - Telomere Science Library - 0 views

www.telomerescience.com/...aging

Telomere length ageing disease

shared by Nathan Goodyear on 19 Jul 11 - No Cached
  • Nathan Goodyear on 19 Jul 11
     
    great resource for Telomere research.  Telomere shortening is clearly associated with aging and age related diseases.  Further research continues on the role played by Telomeres in ageing related diseases
Nathan Goodyear

Telomere Length Trajectory and Its Determinants in Persons with Coronary Artery Disease... - 0 views

www.telomerescience.com/...-from-the-heart-and-soul-study

Telomere length cardiovascular disease CVD

shared by Nathan Goodyear on 19 Jul 11 - No Cached
  • Nathan Goodyear on 19 Jul 11
     
    telomere length may play a role in cardiovascular disease development
Nathan Goodyear

HOMOCYSTEINE AND CARDIOVASCULAR DISEASE - Annual Review of Medicine, 49(1):31 - 0 views

www.annualreviews.org/...annurev.med.49.1.31

HOMOCYSTEINE cardiovascular disease CAD thromboembolism DVT artherosclerosis

shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism
  • Nathan Goodyear on 03 Aug 11
     
    elevated homocysteine increases risk for artherosclerosis, cardiovascular disease, and thromboembolism
Nathan Goodyear

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis -- ... - 0 views

www.bmj.com/...1202.abstract

homocysteine heart disease CAD cardiovascular DVT stroke

shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • There were significant associations between homocysteine and the three diseases
  • Nathan Goodyear on 03 Aug 11
     
    elevated homocysteine associated with ischemic heart disease, DVT, and stroke
Nathan Goodyear

Coenzyme Q10 Decreases Amyloid Pathology an... [J Alzheimers Dis. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21799249

CoQ10 excitotoxicity neurodegenerative disease Parkinson's MS Alzheimer's mitochondria

shared by Nathan Goodyear on 29 Sep 11 - No Cached
  • Nathan Goodyear on 29 Sep 11
     
    CoQ10 shown to benefit excitotoxic diseases such as Alzheimer's disease, Parkinson's, MS...
Nathan Goodyear

Nonfasting Apolipoprotein B and Triglyceride Levels as a Useful Predictor of Coronary H... - 0 views

atvb.ahajournals.org/...1918.long

lipoproteins apo B apo A1 apolipoproteins Apolipoprotein B Apolipoprotien A1 cholesterol HDL cardiovascular disease risk heart disease

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    non fasting apo B plus HDL is predictive of cardiovascular disease risk. Apo a1 was not predictive.  
Nathan Goodyear

Adult coeliac disease presenting with infertility. - 0 views

www.ncbi.nlm.nih.gov/...PMC2448462

infertility Celiac disease celiac disease men male hormone hormones

shared by Nathan Goodyear on 28 Jul 14 - No Cached
  • Nathan Goodyear on 28 Jul 14
     
    Case study of a woman with Celiac disease that presented with infertility.
Nathan Goodyear

Therapeutic Testosterone Administration Preserves Excitatory Synaptic Transmission in t... - 0 views

www.jneurosci.org/...12312.long

Testosterone polyneuropathy MS multiple Sclerosis Estriol hormones autoimmune disease

shared by Nathan Goodyear on 17 Mar 15 - No Cached
  • direct androgen receptor activation is not a mutually exclusive requirement of testosterone-mediated neuroprotection.
  • Testosterone treatment after EAE induction restores synaptic transmission and corresponding synaptic protein levels within the hippocampus during EAE
  • A growing body of evidence suggests that testosterone enhances hippocampal synaptogenesis
  • ...7 more annotations...
  • This study demonstrates that testosterone treatment either before or after EAE disease induction partially restores deficits in synaptic transmission, preserves presynaptic and postsynaptic integrity, and prevents hippocampal pathology.
  • treatment with a pregnancy estrogen, estriol, can prevent deficits in excitatory synaptic transmission in the hippocampus during EAE
  • testosterone is important to the maintenance of normal synaptic spine density in the hippocampus
  • estriol treatment was also capable of preserving levels of synaptic proteins that are known to orchestrate functional synaptic transmission within the hippocampus.
  • Estriol is a therapeutic candidate in MS because it has widespread effects on the immune system and the CNS
  • MS patients have significantly decreased relapse rates during the third trimester of pregnancy, when estriol levels are most elevated, and relapse rates rebound during the postpartum period coinciding with an abrupt decline in serum estriol levels
  • In nonpregnant MS patients, estriol treatment has been shown to significantly reduce gadolinium-enhancing lesion number and volumes measured by MRI
  • Nathan Goodyear on 17 Mar 15
     
    Testosterone restores/preserves nerve synapsis within the hippocampus in autoimmune demyelinating disease.  Testosterone appears to have neuroprotection.  The authors conclude that the majority of the protective effect was through aromatase activity.
Nathan Goodyear

Selenium in Human Health and Disease | Abstract - 0 views

online.liebertpub.com/...ars.2010.3275

selenium Se disease health prostate cancer GI cancer cancer diabetes CVD cardiovascular disease

shared by Nathan Goodyear on 10 Nov 14 - No Cached
  • Nathan Goodyear on 10 Nov 14
     
    Selenium deficiency has important implications in disease: including CVD, GI cancer, prostate cancer, and diabetes.
Nathan Goodyear

Extreme Concentrations of Endogenous Sex Hormones, Ischemic Heart Disease, and Death in... - 0 views

atvb.ahajournals.org/...471.abstract

Testosterone Estradiol Estrogen hormone hormones women female cardiovascular disease heart disease

shared by Nathan Goodyear on 29 Jan 15 - No Cached
  • Nathan Goodyear on 29 Jan 15
     
    low Estradiol and high Total Testosterone associated with high risk of ischemic heart disease.  This study looked at endogenous levels in women.  This data as well as others really brings into question the massive prescription Testosterone push in women.
Nathan Goodyear

Vitamin D and autoimmune thyroid diseases - 0 views

www.ncbi.nlm.nih.gov/...PMC4012880

vitamin d autoimmune disease autoimmune thyroid disease TPO thyroid autoimmune thyroid antibodies

shared by Nathan Goodyear on 07 Feb 16 - No Cached
  • Nathan Goodyear on 07 Feb 16
     
    low vitamin D implicated in increased anti thyroid antibodies and autoimmune thyroid disease.
Nathan Goodyear

Neuroprotective and disease-modifying effects of the ketogenic diet - 0 views

www.ncbi.nlm.nih.gov/...PMC2367001

ketogenic diet nutrition diet CNS brain Epilepsy alzheimer's disease Parkinson's disease

shared by Nathan Goodyear on 20 Feb 16 - No Cached
  • Nathan Goodyear on 20 Feb 16
     
    great review of the ketogenic diet in neuroprotective and treatment of excitotoxic disease.
Nathan Goodyear

Blood dehydroepiandrosterone sulphate (DHEAS) levels in pemphigoid/pemphigus and psoria... - 0 views

www.researchgate.net/...phigoidpemphigus_and_psoriasis

DHEA DHEAS dehydroepiandrostenedione hormones autoimmune disease autoimmune lupus psoriasis

shared by Nathan Goodyear on 03 Dec 15 - No Cached
  • Nathan Goodyear on 03 Dec 15
     
    low DHEA found in individuals with autoimmune disease.  The authors conclude that this may contribute to the cause of the disease(s)
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