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Nathan Goodyear

Plasma fatty acids as predictors of glycaemia and type 2 diabetes. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...26277381

diabetes glucose palmitoleic acid linoleic acid essential fatty acids Fats

shared by Nathan Goodyear on 18 Aug 15 - No Cached
  • Nathan Goodyear on 18 Aug 15
     
    Palmitoleic acid and estimated D6D activity found to positively correlate with diabetes and worsening glucose control;  In contrast, linoleum acid found to be inversely associated with glucose control and Diabetes development.
Alan Rann

Develop Your Personality Within Short Time Of Span - 0 views

cosmeticsurgeryloansau.blogspot.com/...-personality-within-short.html

personal loans for cosmetic surgery plastic surgery loans personal loans for cosmetic surgery' cosmetic surgery loans

shared by Alan Rann on 07 Jul 15 - No Cached
  • Alan Rann on 07 Jul 15
     
    Personal loans for cosmetic surgery help people to get rid of financial obstacles that blocking their way to get new personality. One can simply apply for these loans through online medium in either secured or unsecured way.
wheelchairindia9

Bronco Wheelchair - 0 views

disabilityproduct.in/...Bronco-Wheelchair

Bronco Wheelchair designed for easy and healthy Reclining Power Wheelchair Optional handbrake Comfort mobility

shared by wheelchairindia9 on 15 Sep 15 - No Cached
  • wheelchairindia9 on 15 Sep 15
     
    Bronco Wheelchair: Bronco Reclining Power Wheelchair Description: Comfort mobility is a professional Bronco Wheelchair and power scooter manufacturer established in 1978 in Taiwan. It operates with the policy of combining high quality with innovation. With dedication to research and development, Bronco wheelchair are exported around the world and earned solid reputation for its superior quality, comfort and convenience. Bronco wheelchair - comfortable, durable, designed for easy and healthy movement with full precautions. Bronco Reclining Power Wheelchair Specifications: Anchorage points Adjustable footplates LED front lights Detachable backrest Flip-back armrests Adjustable headrest Mechanic repairs Optional handbrake
Nathan Goodyear

Branched Chain Amino Acid Supplementation for Patients with Cirrhosis | Clinical Correl... - 0 views

www.clinicalcorrelations.org/?p=3544

BCCA branched chain amino acids liver cirrhosis hepatitis amino acids

shared by Nathan Goodyear on 05 Oct 15 - No Cached
  • low level of BCAAs in patients with cirrhosis is hypothesized to be one of multiple factors responsible for development of hepatic encephalopathy
  • supplementation of BCAAs is thought to facilitate ammonia detoxification by supporting synthesis of glutamine, one of the non-branched chain amino acids, in skeletal muscle and in the brain as well as diminishing the influx of AAAs across the blood-brain barrier
  • oral BCAA supplementation is more useful in chronic encephalopathic patients than is parenteral BCAA supplementation in patients with acute encephalopathy
  • ...35 more annotations...
  • malnutrition progressing to cachexia is another common manifestation of cirrhosis
  • Malnutrition can be mitigated with BCAA supplementation
  • Studies show that administration of amino acid formulas enriched with BCAAs can reduce protein loss, support protein synthesis, and improve nutritional status of patients with chronic liver disease
  • Leucine has been shown to be the most effective of the BCAAs because it acts via multiple pathways to stimulate protein synthesis
  • BCAAs metabolites inhibit proteolysis
  • Patients with cirrhosis have both insulin deficiency and insulin resistance
  • BCAAs (particularly leucine) help to reverse the catabolic, hyperglucagonemic state of cirrhosis both by stimulating insulin release from the pancreatic β cells and by decreasing insulin resistance allowing for better glucose utilization
  • Coadministration of BCAAs and glucose has been found to be particularly useful
  • BCAA supplementation improves protein-energy malnutrition by improving utilization of glucose, thereby diminishing the drive for proteolysis, inhibiting protein breakdown, and stimulating protein synthesis
  • Cirrhotic patients have impaired immune defense, characterized by defective phagocytic activity and impaired intracellular killing activity
  • another effect of BCAA supplementation is improvement of phagocytic function of neutrophils and possibly improvement in natural killer T (NKT) cell lymphocyte activity
  • BCAA supplementation may reduce the risk of infection in patients with advanced cirrhosis not only through improvement in protein-energy malnutrition but also by directly improving the function of the immune cells themselves
  • BCAA administration has also been shown to have a positive effect on liver regeneration
  • A proposed mechanism for improved liver regeneration is the stimulatory effect of BCAAs (particularly leucine) on the secretion of hepatocyte growth factor by hepatic stellate cells
  • BCAAs activate rapamycin signaling pathways which promotes albumin synthesis in the liver as well as protein and glycogen synthesis in muscle tissue
  • Chemical improvement with BCAA treatment is demonstrated by recovery of serum albumin and lowering of serum bilirubin levels
  • long-term oral BCAA supplementation was useful in staving off malnutrition and improving survival by preventing end-stage fatal complications of cirrhosis such as hepatic failure and gastrointestinal bleeding
  • The incidence of death by any cause, development of liver cancer, rupture of esophageal varices, or progression to hepatic failure was decreased in the group that received BCAA supplementation
  • Patients receiving BCAA supplementation also have a lower average hospital admission rate, better nutritional status, and better liver function tests
  • patients taking BCAA supplementation report improved quality of life
  • BCAAs have been shown to mitigate hepatic encephalopathy, cachexia, and infection rates, complications associated with the progression of hepatic cirrhosis
  • BCAAs make up 20-25% of the protein content of most foods
  • Highest levels are found in casein whey protein of dairy products and vegetables, such as corn and mushrooms. Other sources include egg albumin, beans, peanuts and brown rice bran
  • In addition to BCAAs from diet, oral supplements of BCAAs can be used
  • Oral supplementation tends to provide a better hepatic supply of BCAAs for patients able to tolerate PO nutrition as compared with IV supplementation, especially when treating symptoms of hepatic encephalopathy
  • Coadministration of BCAAs with carnitine and zinc has also been shown to increase ammonia metabolism further reducing the encephalopathic symptoms
  • Cirrhotic patients benefit from eating frequent, small meals that prevent long fasts which place the patient in a catabolic state
  • the best time for BCAA supplementation is at bedtime to improve the catabolic state during starvation in early morning fasting
  • A late night nutritional snack reduces symptoms of weakness and fatigability, lowers postprandial hyperglycemia, increases skeletal muscle mass,[25] improves nitrogen balance, and increases serum albumin levels.[26] Nocturnal BCAAs even improve serum albumin in cirrhotic patients who show no improvement with daytime BCAAs
  • Protein-energy malnutrition (PEM), with low serum albumin and low muscle mass, occurs in 65-90% of cases of advanced cirrhosis
  • hyperglucagonemia results in a catabolic state eventually producing anorexia and cachexia
  • BCAAs are further depleted from the circulation due to increased uptake by skeletal muscles that use the BCAAs in the synthesis of glutamine, which is produced in order to clear the ammonia that is not cleared by the failing liver
  • patients with chronic liver disease, particularly cirrhosis, routinely have decreased BCAAs and increased aromatic amino acids (AAAs) in their circulation
  • Maintaining a higher serum albumin in patients with cirrhosis is associated with decreased mortality and improved quality of life
  • the serum BCAA concentration is strongly correlated with the serum albumin level
  • Nathan Goodyear on 05 Oct 15
     
    great review of cirrhosis and BCCA supplementation.
Nathan Goodyear

Effects of hormone replacement therapy on the mammary gland of surgically postmenopausa... - 0 views

www.ajog.org/...abstract

HRT synthetic hormone replacement Premarin Provera. Prempro breast cancer

shared by Nathan Goodyear on 05 Nov 10 - No Cached
  • Nathan Goodyear on 05 Nov 10
     
    Premarin and provera together increase risk of breast cancer development
Nathan Goodyear

Obesity, inflammation, and insulin resistance. [Gastroenterology. 2007] - PubMed result - 1 views

www.ncbi.nlm.nih.gov/...17498510

obesity insulin inflammation

shared by Nathan Goodyear on 26 Jan 11 - No Cached
  • Nathan Goodyear on 26 Jan 11
     
    inflammation plays major role is obesity and other disease development
Nathan Goodyear

The role of copper in neurodegenerative disease. [Neurobiol Dis. 1999] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...10448050

Copper Alzheimer's disease

shared by Nathan Goodyear on 07 Feb 11 - No Cached
  • Nathan Goodyear on 07 Feb 11
     
    Copper imbalance contributes to development of Alzheimer's disease
Nathan Goodyear

Carbohydrate feeding during prolonged strenuous ex... [J Appl Physiol. 1983] - PubMed r... - 1 views

www.ncbi.nlm.nih.gov/...6350247

carbohydrate feeding fatigue exercise

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Nathan Goodyear on 08 Mar 11
     
    carbohydrates during exercise delay fatigue development
Nathan Goodyear

Selective Effect of Mercury on Th2-Type Cytokine Production in Humans | DeepDyve - Rese... - 0 views

www.deepdyve.com/...roduction-in-humans-5uFRL8JMwZ

mercury immune system autoimmune disease

shared by Nathan Goodyear on 23 Mar 11 - No Cached
  • Nathan Goodyear on 23 Mar 11
     
    Discussion of how Mercury impacts immune system dysfunction and then development of autoimmune disease
Nathan Goodyear

The managed immune system: protecting the womb to delay the tomb - 0 views

het.sagepub.com/...129.abstract

immune system disease

shared by Nathan Goodyear on 23 Mar 11 - No Cached
  • Nathan Goodyear on 23 Mar 11
     
    discussion of immune system dysfunction in children and disease development
Nathan Goodyear

VITAMIN A, INFECTION, AND IMMUNE FUNCTION* - Annual Review of Nutrition, 21(1):167 - 0 views

www.annualreviews.org/...annurev.nutr.21.1.167

vitamin A immune system

shared by Nathan Goodyear on 20 May 11 - No Cached
  • Vitamin A deficiency impairs innate immunity
  • Vitamin A is also required for adaptive immunity
  • Nathan Goodyear on 20 May 11
     
    Vitamin A very important in proper immune development and immune function
Nathan Goodyear

Telomere Length Trajectory and Its Determinants in Persons with Coronary Artery Disease... - 0 views

www.telomerescience.com/...-from-the-heart-and-soul-study

Telomere length cardiovascular disease CVD

shared by Nathan Goodyear on 19 Jul 11 - No Cached
  • Nathan Goodyear on 19 Jul 11
     
    telomere length may play a role in cardiovascular disease development
Nathan Goodyear

Telomere shortening and ageing of the immune system | Mendeley - 0 views

www.mendeley.com/...-ageing-of-the-immune-system-1

Telomere immmune system disease length ageing

shared by Nathan Goodyear on 19 Jul 11 - No Cached
  • The immune system is highly sensitive to shortening of telomeres
  • they can up-regulate telomerase, the telomere extending enzyme
  • In ageing immune system adaptive immunity deteriorates because of a progressive decline of naive T and B cells and decrease of absolute numbers of T and B lymphocytes
  • Nathan Goodyear on 19 Jul 11
     
    the immune system is very sensitive to shortening of telomere length. This change in the immune system can be a pivotal role in disease development
Nathan Goodyear

Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease - NEJM - 0 views

www.nejm.org/...NEJMoa011613

Alzheimer dementia disease homocysteine

shared by Nathan Goodyear on 03 Aug 11 - No Cached
  • Nathan Goodyear on 03 Aug 11
     
    An increased plasma homocysteine level is a strong, independent risk factor for the development of dementia and Alzheimer's disease.
Nathan Goodyear

The Effect of Fluoride on the Physiology of the Pineal Gland - 0 views

www.fluoridealert.org/...luke-1997.html

Flouride melatonin pineal gland puberty precocious

shared by Nathan Goodyear on 09 Aug 11 - No Cached
  • Nathan Goodyear on 09 Aug 11
     
    Flouride appears to decrease melatonin production from the pineal gland.   Flouride was associated with early puberty and accelerated development
Nathan Goodyear

Effects of Organochlorine Compounds on Menstrual Cycles - DERT - 0 views

www.niehs.nih.gov/...menses.cfm

DDT environmental toxins endocrine disruptors menstrual cycles

shared by Nathan Goodyear on 08 Sep 11 - No Cached
  • Nathan Goodyear on 08 Sep 11
     
    DDT effects female reproduction and development
Nathan Goodyear

Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for dev... - 0 views

www.ajcn.org/...281.abstract

long-chain fatty acid brain development function behavioral DHA Omega-3

shared by Nathan Goodyear on 06 Sep 11 - No Cached
  • Nathan Goodyear on 06 Sep 11
     
    changes in brain concentrations of DHA (omega-3) are positively associated with changes in cognitive or behavioral performance
Nathan Goodyear

Indoleamine 2,3 dioxygenase and quinolinic acid im... [Neuropathol Appl Neurobiol. 2005... - 0 views

www.ncbi.nlm.nih.gov/...16008823

indoleamine 2 3 Alzheimer's disease inflammation

shared by Nathan Goodyear on 20 Apr 11 - No Cached
  • kynurenine pathway is up-regulated in Alzheimer's disease (AD) brain
  • increases in the excitotoxin quinolinic acid (QUIN
  • indoleamine 2,3 dioxygenase (IDO) is abundant in AD compared with controls
  • ...1 more annotation...
  • QUIN may be involved in the complex and multifactorial cascade leading to neuro-degeneration in AD
  • Nathan Goodyear on 20 Apr 11
     
    immune system, inflammation, and brain come together to develop Alzheimer's disease
Nathan Goodyear

Normal gut microbiota modulates brain development and behavior - 0 views

www.pnas.org/...3047.abstract

gut brain development behavior balance gastrointestinal dysbiosis

shared by Nathan Goodyear on 29 Jun 11 - No Cached
  • Nathan Goodyear on 29 Jun 11
     
    mice model study that shows how gut bacterial balance can alter neurochemistry and cause behavior/developmental changes
Nathan Goodyear

Exposure to Bisphenol A Prenatally or in Adulthood Promotes TH2 Cytokine Production Ass... - 0 views

www.ncbi.nlm.nih.gov/...PMC2290985

BPA plastics endocrine disruptor immune T reg cells

shared by Nathan Goodyear on 01 Jul 11 - No Cached
  • BPA promotes the development of TH2 cells in adulthood and both TH1 and TH2 cells in prenatal stages by reducing the number of regulatory T cells.
  • Bisphenol A (BPA), an estrogenic endocrine-disrupting chemical (EDC
  • BPA is one of the most widespread EDCs.
  • ...12 more annotations...
  • BPA antagonizes the actions of thyroid hormone
  • Prenatal exposure to BPA has been shown to alter a variety of reproductive endocrine parameters, such as testosterone and luteinizing hormone levels
  • arly onset of sexual maturation of female mice
  • imbalanced T-helper (TH)1/TH2 immune responses have been demonstrated on exposure to BPA
  • indicating that BPA exerted its effects by reducing the number of Treg cells.
  • Exposure to BPA by subcutaneous injection in adulthood significantly promoted antigen-stimulated production of IL-4, IL-10, and IL-13 in TH2-skewed
  • BPA can leak from the placenta and accumulate in the fetus
  • We showed that prenatal exposure to BPA increased the production of a TH1 cytokine, IFN-γ, and a TH2 cytokine, IL-4, after the offspring developed, suggesting that prenatal exposure to BPA can induce persistent immunologic effects lasting into adulthood.
  • These results are consistent with a previous report that fetal exposure to BPA augmented TH1 and TH2 immune responses
  • our results clearly demonstrate that the production of TH2 cytokines is promoted by BPA in adult mice and in offspring during developmental exposure.
  • The decrease of Treg cells would predispose to immune dysfunction in aged individuals, explaining their higher risk of immune-mediated diseases, cancer, and infections.
  • BPA might cause these diseases. Thus, avoiding exposure to or promoting the excretion of BPA and other EDCs would help in preventing diseases and adverse health effects.
  • Nathan Goodyear on 01 Jul 11
     
    BPA as endocrine disruptor and as immune disruptor
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