strongly supports an association between levels of androgens and leptin in both men and women
The association between androgen levels and leptin seems to be dependent of fat distribution in men
There is a growing bulk of evidence suggesting that testosterone may influence leptin levels. Testosterone administration reduces leptin levels in hypogonadal27,28 and eugonadal men
testosterone suppression by GnRH agonist treatment of central precocious puberty in boys increases leptin levels
Testosterone levels decreased with increasing central obesity in healthy men, while they increase with increasing obesity in healthy women, the latter irrespective of menstrual status
this could be due to obesity-related hyperleptinemia that inhibits testosterone secretion at the testicular level.46,47 These changes, which are proposed to be components of the insulin resistance syndrome,48 are associated with increased risk for cardiovascular disease in both men and women
in the more obese subjects, the higher leptin levels due to increased adiposity might reduce secretion of testosterone
loss of regulation of leptin by testosterone in obese men and women could be an important feature of the insulin resistance syndrome