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obesity is known to increase inflammation. Now obesity, adipose tissue, is shown to increase oxidative stress and reduce glutathione levels.  The loss of glutathione is implicated the development of many chronic disease states.  

nice article discussing disrupted methionine metabolism and development of Alcoholic Liver Disease

Another animal study finds Testosterone plays a role in bladder cancer development.  The study used anti androgen and 5 alpha reductase inhibitor therapy to see if these add on therapies provided anything to ADR whether via castration or pituitary suppression--the answer was no.  The authors concluded that Testosterone played more of a role with AR versus the more active 5alpha-DHT metabolite.

Now this is an interesting study.  In utero exposure to letrozole (femara) which is an aromatase inhibitor, is associated with same sex preference.  Only abstract available, but this study points to environment, hormone effects in early development and future sexual preference.  No difference in serum hormone levels were seen.  

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Good review of data on vitamin D, Vitamin D receptors and cancer risk.  Studies have shown that low Vitamin D levels are associated with increased cancer risk and that higher vitamin D levels are associated with reduced cancer risk.  The ability to fully map out vitamin Ds role in the physiology is probably difficult due to the heterogeneity of cancer development and physiology.

urinary estrogen metabolites shown to provide insight into breast cancer risk.  This study suggested that a low 2:16 OHE ratio increase breast cancer risk.

bipolar androgen therapy proposed as a mechanism to restore AR sensitivity in those men with castration resistant prostate cancer.  This was a very small pilot study.  The effects on PSA were limited in effect as all men eventually developed PSA increase

ultra distance triathlon athletes lost 2.5 kg weight during event.  Athletes that developed hyponatremia appeared to be fluid overloaded during event.

Metabolic Syndrome increases the risk of prostate cancer in men.  No surprise here as low T and hyperinsulinemia are both implicated in development of high grade prostate cancer.

Upregulation of TK-1 found to be an early event in breast tumor development. This has implications in precancerous tissue and elevations correlate to stage of cancer. TK-1 has also been found to correlate with Cancer recurrence.

Study finds ER-beta plays more significant role in the development of Colon cancer than ER-alpha in women.  HRT in women reduces colon cancer risk in comparison to breast, which is increased.  Shows the different tissue expression of ER-alpha and ER-beta, as well as the HRT itself.

Really fascinating article on tumor signaling. The article points to a complex signaling between cancer cells and stromal fibroblasts that results in myofibroblast transformation that increases the microenvironment favorability of cancer. This article points to oxidative stress as the primary driving force.  

Exercise associated muscle cramps or EAMC is not worked out.  The theories include dehydration, mineral/electrolyte deficiencies, and neuromuscular activity.

Ferritin more than just associated with diabetes; appears to play a role in the development of diabetes.

Will there ever be a cure for cancer?  Would it surprise you if I said it already exists? It is called diet.  New study finds that high sugar intake increased breast cancer development and spread through increased 12-lipoxygenase--inflammation.

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