Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Deg... - 0 views
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epigenetic modifications of single genes have been shown to affect the pathogenesis of T2D
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An FH of T2D is an independent predictor of future risk for the disease
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exercise for 6 months is associated with epigenetic changes, e.g., decreased DNA methylation of RUNX1 and MEF2A, two key transcription factors involved in exercise training (42–44), of THADA, previously associated with T2D (1), and of NDUFC2, which is part of the respiratory chain (45) was observed after exercise
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Six months of exercise induce epigenetic changes through decrease in methylation. This study was designed to look at those with a family risk of DM. They found a difference in the methylation status of muscle between those with a family h/o diabetes and those without. This would have implications in therapeutic difference prior to diagnosis. Even a increased VO2max and skeletal muscle mitochondrial density was found to be the result of decreased methylation of the NDUFC2 gene after exercise.