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great review of the menopause transition and the effect of weight and hormones.  For example, muscle loss is found in menopause vs perimenopause.  Increased estrogen production occurs from non-ovary sites i.e. visceral and SQ fat.

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Tynor Hot and Cold Pack is a convenient device to provide hot fomentation or cold compress. Hot fomentation of the injured or inflamed area enhances the threshold of pain and thus reduces the perception of pain. It has a synergistic effect along with pain relieving drugs. Raising temperature of the injured tissue also enhances the blood profusion and the healing process. Hot fomentation has a relaxing effect. Cold compress helps in reduction of inflammation in injuries, protects by slowing the metabolic rate around the tissue, reduce oedema and bleeding. Cold compress helps in immediately lowering fever, in very high fever conditions. It can be used after an acute injury or surgical procedure. No heat or cryo burns. Requires no holding. Reusable. Easy application. Appealing aesthetics. Tynor Hot and Cold Pack Features Multi functionality Reduce swelling and odema at the site of injury. Muscles spasm and pain. Headache and minor injuries. Versatile design Can be used as either cold or hot pack. Reusable in either hot & cold condition. Temperature range - Can be used from 0 Cº to 75Cº. Longer temperature retention time. Fabric cover ensures no cryo burns or hot skin burns. Physical features Non-toxic, and biodegradable. Gel remains soft and flexible upto 0 degree. Durable, and puncture resistant. Soft, "frost free" PVC cover. Flexible conforms to the body contours. Easy to clean and maintain. Excellent workmanship. Good aesthetics. Elastic belt Holds the pack against the body, No need to hold by hand. Enhances convenience. Tynor Hot and Cold Pack Measurements

this study showed that oral testosterone did not increase CRP.  This is a different finding than other studies.  I question the use of the oral testosterone due to first pass metabolism.  This would result in less testosterone reaching the peripheral sites of aromatase activity.  

11-betaHSD1 expression and effect is site specific.

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documented cadmium sites in Louisiana

ER beta expression that is lost in prostate carcinogenesis occurs via methylation at the ER beta gene promoter sites 19CpG.  What is really interesting is that ER beta expression was present in all of the samples with BPH, but was absent in 83% of the prostate cancer samples.

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study highlights the mechanism of aluminum transport from the site of action to distant organs ie. brain. 

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low dose naltrexone plus vitamin D3 to treat cancer

Aluminum in vaccines shown to stimulate a massive autoimmune reaction.  These reactions can be localized or distant from site of injection.  Accumulation occurs in the brain and CNS.  The name give is macrophagic myofasciitis.

Polychlorinated biphenyl (PCBs) shown to disrupt thyroid hormone function through disruption of the transthyretin binding sites.  Not only is it a xenoestrogen, but it disrupts thyroid function too.

Only the abstract is available publicly.   Toll-like receptors, particularly TLR-4 has been shown to be associated with insulin resistance.  These TLRs have specific pathogen recognition sites.  TLRs are stimulated by fatty acids (FA) and endotoxemia from bacteria.  Thus, dietary intake of high trans fats, inflammation originating from the gut can be the source of insulin receptor dysfunction through TLRs.

Awesome review by Schoenfeld on the physiology of muscle hypertrophy.

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IgM levels > 60 g/l found to predict need for plasmapheresis due to hyperviscosity syndrome.

Waldentstrom's macroglobulinemia with lytic bone lesions.  Only abstract available here.  Treatment, other than chemo, is radiation to effected site.

Study looked at tumor microenvironment of metastasis structures (TMEMs) involved in metastasis. It has also been shown that taxane-based chemotherapies promote tumor regrowth by inducing angiogenesis. In this study, the tumor growth was slowed with taxanes chemotherapies, but it increased TMEMs and thus metastatic potential.